Frontier applications of retinal nanomedicine: progress, challenges and perspectives [0.03%]
视网膜纳米药物的前沿应用：进展、挑战与展望
Zhimin Tang,Fuxiang Ye,Ni Ni et al.
Zhimin Tang et al.
The human retina is a fragile and sophisticated light-sensitive tissue in the central nervous system. Unhealthy retinas can cause irreversible visual deterioration and permanent vision loss. Effective therapeutic strategies are restricted t...
Influences of lead-based perovskite nanoparticles exposure on early development of human retina [0.03%]
铅基钙钛矿纳米颗粒暴露对人类视网膜早期发育的影响
Cao Yang,Zhulin Du,Linqiang Mei et al.
Cao Yang et al.
Background: Lead-based perovskite nanoparticles (Pb-PNPs) are widely utilized in the photovoltaic industry. However, due to their poor stability and high water solubility, lead often gets released into the environment, wh...
Li Yan,Zeyang Liu,Yulian Zeng et al.
Li Yan et al.
Long-term exposure to ultraviolet B (UVB) radiation induces the accumulation of free radicals in the skin, resulting in oxidative damage and accelerated aging. As a natural anti-oxidant, squalene has been applied as a cosmetic additive. Non...
Emerging strategies against accelerated blood clearance phenomenon of nanocarrier drug delivery systems [0.03%]
针对纳米载药系统加速血液清除现象的策略进展
Jianquan Pan,Yanyan Wang,Yunna Chen et al.
Jianquan Pan et al.
Nanocarrier drug delivery systems (NDDS) have gained momentum in the field of anticancer or nucleic acid drug delivery due to their capacity to aggrandize the targeting efficacy and therapeutic outcomes of encapsulated drugs. A disadvantage...
Decellularized tissue matrices hydrogels functionalized with extracellular vesicles promote macrophage reprogramming and neural stem cell differentiation for spinal cord injury repair [0.03%]
负载细胞外囊泡的脱细胞组织基质水凝胶通过促进巨噬重编程和神经干细胞分化修复脊髓损伤
Ming Deng,Ping Xie,Hongyang Xue et al.
Ming Deng et al.
This study investigates the application of decellularized tissue matrices (DSCM) hydrogels functionalized with extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) for spinal cord injury (SCI) treatment. The primary fo...
Zinc-copper bimetallic nanoplatforms trigger photothermal-amplified cuproptosis and cGAS-STING activation for enhancing triple-negative breast cancer immunotherapy [0.03%]
锌铜双金属纳米平台触发光热放大铜死亡和cGAS-STING激活以增强三阴性乳腺癌免疫治疗
Bangyi Zhou,Mengyao Chen,Zhixing Hao et al.
Bangyi Zhou et al.
Triple-negative breast cancer (TNBC) is characterized by high rates of metastasis and recurrence, along with a low sensitivity to immunotherapy, resulting in a paucity of effective therapeutic strategies. Herein, we have developed polydopam...
RSL3-loaded nanoparticles amplify the therapeutic potential of cold atmospheric plasma [0.03%]
负载RSL3的纳米粒子增强了冷大气等离子体的治疗潜力
Xiaona Cao,Mo Chen,Tianxu Fang et al.
Xiaona Cao et al.
Cold atmospheric plasma (CAP) has exhibited exciting potential for cancer treatment. Reactive oxygen and nitrogen species (RONS), the primary constituents in CAP, contribute to cancer cell death by elevating oxidative stress in cells. Howev...
Yangwei Qian,Chenxi Wang,Ruru Xu et al.
Yangwei Qian et al.
It is urgent to exploit multifunctional materials and combined approaches for efficient antitumor effects. Copper-based metal-organic frameworks (Cu-MOFs) have excellent performances in catalysis, biocompatibility, photothermal conversion, ...
Engineered neutrophil membrane-camouflaged nanocomplexes for targeted siRNA delivery against myocardial ischemia reperfusion injury [0.03%]
工程中性粒细胞膜伪装纳米复合材料靶向传递siRNA用于心肌缺血再灌注损伤治疗
Yaohui Jiang,Rongyan Jiang,Zequn Xia et al.
Yaohui Jiang et al.
Small interfering RNA (siRNA) therapies hold great potential for treating myocardial ischemia-reperfusion injury (MIRI); while their practical application is limited by the low bioavailability, off-target effects, and poor therapeutic effic...
Polyzwitterion-branched polycholic acid nanocarriers based oral delivery insulin for long-term glucose and metabolic regulation in diabetes mellitus [0.03%]
用于糖尿病长期血糖和代谢调节的口服递送胰岛素多 zwiterion 支化多胆酸纳米载体
Wenkai Zhang,Yue Wang,Xiangqi Zhang et al.
Wenkai Zhang et al.
Diabetes represents a global health crisis that necessitates advancements in prevention, treatment, and management. Beyond glucose regulation, addressing weight management and associated complications is imperative. This study introduces an...