Radionuclide-labelled nanoparticles for cancer combination therapy: a review [0.03%]
放射核素标记的纳米颗粒在癌症联合治疗中的应用：综述
Na Sun,Tao Wang,Song Zhang
Na Sun
Radionuclide therapy (RT) is widely used to advanced local cancers. However, its therapeutic efficacy is limited to the radiation resistance of cancer cells. Combination therapy aims to circumvent tumor resistance, and the combination of RT...
ROS-responsive nanoparticles for bioimaging and treating acute lung injury by releasing dexamethasone and improving alveolar macrophage homeostasis [0.03%]
响应 ROS 的纳米颗粒通过释放地塞米松和改善肺泡巨噬细胞稳态用于生物成像及急性肺损伤治疗
Wenna Fan,Yongyao Tang,Yamin Liu et al.
Wenna Fan et al.
Background: Acute lung injury (ALI) triggers the activation of pulmonary macrophages, which in turn produce excessive amounts of reactive oxygen species (ROS). ...
Three-arm polyrotaxanes with multidirectional molecular motions as the nanocarrier for nitric oxide-enhanced photodynamic therapy against bacterial biofilms in septic arthritis [0.03%]
具有多方向分子运动的三臂聚轮烷作为硝化物增强光动力疗法载体用于败血性关节炎中细菌生物被膜的治疗
Shixin Liu,Yuanfang Jiang,Yu Zhang et al.
Shixin Liu et al.
Bacterial biofilms are one of the major contributors to the refractoriness of septic arthritis. Although nitric oxide (NO)-enhanced photodynamic (PDT) therapy has been involved in biofilm eradication, the anti-biofilm efficacy is usually hi...
High-throughput screening-based design of multifunctional natural polyphenol nano-vesicles to accelerate diabetic wound healing [0.03%]
基于高通量筛选的多功能天然聚酚纳米囊泡的设计以加速糖尿病伤口愈合
Xiaoying Zhao,Shenkai Su,Chenyu Wu et al.
Xiaoying Zhao et al.
Oxidative stress is a major pathological factor that impedes the diabetic wound healing process. Procyanidins (PC) form nanoparticle-vesicles (PPNs) through hydrogen bonding and exhibit good drug delivery capability; however, their applicat...
An encounter between metal ions and natural products: natural products-coordinated metal ions for the diagnosis and treatment of tumors [0.03%]
金属离子与天然产物的偶遇：基于天然产物配位修饰金属离子的肿瘤诊疗研究
Xinyue Liu,Suyi Liu,Xingyue Jin et al.
Xinyue Liu et al.
Natural products-coordinated metal ions to form the nanomedicines are in the spotlight for cancer therapy. Some natural products could be coordinated with metal ions forming nanomedicines via simple and green environmental self-assembly, wh...
Microfluidic-engineered Chinese herbal nanocomposite hydrogel microspheres for diabetic wound tissue regeneration [0.03%]
用于糖尿病创面组织再生的微流控工程中药纳米复合水凝胶微球
Peng Guo,Pengkun Lei,Lin Luo et al.
Peng Guo et al.
Microfluidic-engineered hydrogel microspheres have emerged as a promising avenue for advancements in tissue engineering and regenerative medicine, particularly through the precise manipulation of fluids to achieve personalized composite bio...
Fu-Xing-Zi Li,Jun-Jie Liu,Li-Min Lei et al.
Fu-Xing-Zi Li et al.
Cold temperatures have been shown to slow skin wound healing. However, the specific mechanisms underlying cold-induced impairment of wound healing remain unclear. Here, we demonstrate that small extracellular vesicles derived from cold-expo...
Microenvironment-optimized gastrodin-functionalized scaffolds orchestrate asymmetric division of recruited stem cells in endogenous bone regeneration [0.03%]
微环境优化的石菖蒲素功能化支架调控内源性募集干细胞的不对称分裂以促进骨再生
Shilin Pan,Yao Li,Lu Wang et al.
Shilin Pan et al.
The regeneration of osteoporotic bone defects remains challenging as the critical stem cell function is impaired by inflammatory microenvironment. Synthetic materials that intrinsically direct osteo-differentiation versus self-renewal of re...
Endothelial cell-derived exosomes trigger a positive feedback loop in osteogenesis-angiogenesis coupling via up-regulating zinc finger and BTB domain containing 16 in bone marrow mesenchymal stem cell [0.03%]
内皮细胞来源的外泌体通过上调骨髓间充质干细胞ZBTB16在成骨-血管化偶联中触发正反馈调节机制
Lu Liu,Nan Zhou,Songning Fu et al.
Lu Liu et al.
The close spatial and temporal connection between osteogenesis and angiogenesis around type H vasculature is referred as "osteogenesis-angiogenesis coupling", which is one of the basic mechanisms of osteogenesis. Endothelial cells (ECs), bo...
Physical, biochemical, and biological characterization of olive-derived lipid nanovesicles for drug delivery applications [0.03%]
基于橄榄提取物的脂质纳米载体的物理、生化及生物学特性研究及其在药物递送领域的应用价值探讨
Zhu Zhao,Jerome Lacombe,Laurianne Simon et al.
Zhu Zhao et al.
Extracellular vesicles (EVs) have shown great promise as drug delivery system (DDS). However, their complex and costly production limit their development for clinical use. Interestingly, the plant kingdom can also produce EV-like nanovesicl...