Albumin-seeking near-infrared-II probe evaluating blood-brain barrier disruption in stroke [0.03%]
一种用于评估中风时血脑屏障破坏的白蛋白寻找近红外Ⅱ探针
Hong-Jing Zhu,Ying-Ying Sun,Yijing Du et al.
Hong-Jing Zhu et al.
Background: Blood-brain barrier (BBB) disruption after stroke is closely associated with brain tissue edema and neuronal injury, which requires accurate assessment. However, there is a lack of appropriate BBB imaging moda...
Biomimetic mesenchymal stem cell membrane-coated nanoparticle delivery of MKP5 inhibits hepatic fibrosis through the IRE/XBP1 pathway [0.03%]
仿生间质干细胞膜包被的纳米颗粒递送MKP5通过IRE/XBP1信号通路抑制肝纤维化
Yafei Tian,Dandan Sun,Na Liu et al.
Yafei Tian et al.
Hepatic fibrosis is a common disease with high morbidity and mortality rates. The complex and poorly understood mechanisms underlying hepatic fibrosis represent a significant challenge for the development of more effective therapeutic strat...
Dendritic mesoporous silica-delivered siRNAs nano insecticides to prevent Sogatella furcifera by inhibiting metabolic detoxification and reproduction [0.03%]
用于抑制代谢解毒和繁殖的树突状介孔二氧化硅递送的siRNA纳米杀虫剂以预防稻飞虱
Changwei Gong,Wei Wang,Yanxin Ma et al.
Changwei Gong et al.
Background: Migratory insect infestation caused by Sogatella furcifera is a serious threat to rice production. The most effective method available for S. furcifera control is intensive insecticide spraying, which cause wi...
Targeting the tumor microenvironment with biomaterials for enhanced immunotherapeutic efficacy [0.03%]
基于生物材料的肿瘤微环境重编程以增强免疫治疗效力
Yekai Feng,Qinglai Tang,Bin Wang et al.
Yekai Feng et al.
The tumor microenvironment (TME) is a complex system characterized by low oxygen, low pH, high pressure, and numerous growth factors and protein hydrolases that regulate a wide range of biological behaviors in the tumor and have a profound ...
Dual-modal overcoming of physical barriers for improved photodynamic cancer therapy via soft organosilica nanocapsules [0.03%]
通过柔软的有机硅纳米胶囊实现双模克服物理障碍改善光动力癌症治疗
Wei Lu,Yang Li,Xiaojun Zhang et al.
Wei Lu et al.
Amidst the burgeoning field of cancer nanomedicine, dense extracellular matrices and anomalous vascular structures in the tumor microenvironment (TME) present substantial physical barriers to effective therapeutic delivery. These physical b...
Sele-targeted siRNA liposome nanoparticles inhibit pathological scars formation via blocking the cross-talk between monocyte and endothelial cells: a preclinical study based on a novel mice scar model [0.03%]
靶向递送siRNA的脂质体纳米颗粒通过抑制单核细胞和内皮细胞之间的相互作用来抑制病理性瘢痕的形成：基于新型小鼠瘢痕模型的临床前研究
Luyu Li,Yong Wang,Jing Meng et al.
Luyu Li et al.
Background: Pathological scars (PS) are one of the most common complications in patients with trauma and burns, leading to functional impairments and aesthetic concerns. Mechanical tension at injury sites is a crucial fac...
Multifunctional nanocomposites utilizing ruthenium (II) complex/manganese (IV) dioxide nanoparticle for synergistic reinforcing radioimmunotherapy [0.03%]
用于协同增强放射免疫治疗的钌（II）配合物/锰（IV）二氧化纳米粒子多功能纳复合材料
Jian Peng,Dong-Ling Quan,Guang Yang et al.
Jian Peng et al.
Radiotherapy (RT) stands as a frontline treatment modality in clinical breast oncology, yet challenges like ROS reduction, high toxicity, non-selectivity, and hypoxia hinder efficacy. Additionally, RT administered at different doses can ind...
Time-series metabolomic analysis revealed altered metabolism of cynomolgus monkeys after injecting exosomes [0.03%]
时间序列代谢组分析揭示了注射外泌体后的食蟹猴代谢改变过程
Xinmei Hu,Cancan Wang,Yu Xiao et al.
Xinmei Hu et al.
Background: Recent years, exosomes have been increasing used to treat diseases, but there is little research on how exosomes affect the metabolism of the body after entering. Therefore, in this study, we discussed the cha...
Polydopamine(PDA)-coated diselenide-bridged mesoporous silica-based nanoplatform for neuroprotection by reducing oxidative stress and targeting neuroinflammation in intracerebral hemorrhage [0.03%]
聚多巴胺（PDA）涂层二硒代桥连介孔硅基纳米平台通过降低氧化应激和靶向神经炎症来保护颅内出血的神经元
Fangfang Zhou,Yongju He,Meiru Zhang et al.
Fangfang Zhou et al.
Oxidative stress (OS) and neuroinflammation are critical pathological processes in secondary brain injury (SBI) after intracerebral hemorrhage(ICH), and their intimate interactions initiate and aggravate brain damage. Thus, targeting oxidat...
Probiotics alleviate chronic ethanol exposure-induced anxiety-like behavior and hippocampal neuroinflammation in male mice through gut microbiota-derived extracellular vesicles [0.03%]
益生菌通过肠道微生物群衍生的细胞外囊泡缓解慢性酒精暴露引起的雄性小鼠类似焦虑的行为和海马神经炎症
Jiaxin Pei,Chaoxu Zhang,Qian Zhang et al.
Jiaxin Pei et al.
Background: Probiotics can colonize both the human and animal bodies and consist of active microorganisms that are beneficial to health. The use of probiotics has been shown to alleviate certain neurological diseases and ...