A self-adjuvant multiantigenic nanovaccines simultaneously activate the antiviral and antitumor immunity for the treatment of cancers [0.03%]
一种自我辅助的多抗原纳米疫苗可同时激活抗病毒和抗癌免疫以治疗癌症
Zhongjie Wang,Hanlin Chen,Ruiqi Ming et al.
Zhongjie Wang et al.
Background: Tumor cell-derived extracellular vesicles (tEVs) have garnered significant attention as promising antigen delivery vehicles for the development of cancer vaccines. However, their practical applications are hin...
Promotion of NLRP3 autophagosome degradation by PV-K nanodevice for protection against macrophage pyroptosis-mediated lung injury [0.03%]
PV-K纳米设备促进NLRP3自噬溶酶体降解以防止巨噬细胞焦亡介导的肺损伤
Yan Fan,Jian Mei,Yuehao Shen et al.
Yan Fan et al.
Acute respiratory distress syndrome (ARDS) has emerged as a significant global health challenge, with no definitive curative treatment available. Recent evidence suggests that pyroptosis of immune cells plays a pivotal role in the pathogene...
Polydopamine-based nano-protectant for prolonged boar semen preservation by eliminating ROS and regulating protein phosphorylation via D2DR-mediated cAMP/PKA signaling pathway [0.03%]
基于聚多巴胺的纳米保护剂通过消除ROS和调控cAMP/PKA信号通路介导的蛋白磷酸化实现延长公猪精液保存期限
Lirui Wang,Manyi Xiong,Jian Zhang et al.
Lirui Wang et al.
Preservation of porcine semen is essential for artificial insemination and genetic improvement in pig breeding programs. However, the overproduction of reactive oxygen species (ROS) and lower levels of protein phosphorylation emerge as two ...
Correction: Cold exposure-induced plasma exosomes impair bone mass by inhibiting autophagy [0.03%]
校正：冷暴露诱导的血浆外泌体通过抑制自噬影响骨质
Li-Min Lei,Fu-Xing-Zi Li,Xiao Lin et al.
Li-Min Lei et al.
Published Erratum
Journal of nanobiotechnology. 2025 Feb 28;23(1):154. DOI:10.1186/s12951-025-03130-6 2025
AG73-GelMA/AlgMA hydrogels provide a stable microenvironment for the generation of pancreatic progenitor organoids [0.03%]
AG73-GelMA/AlgMA水凝胶为胰腺祖细胞类器官的形成提供了稳定的微环境
Jian Wan,Yang Xu,Tianmu Qi et al.
Jian Wan et al.
Patient specific induced pluripotent stem cells (iPSCs) derived β cells represent an effective means for disease modeling and autologous diabetes cell replacement therapy. In this study, an AG73-5%gelatin methacryloyl (GelMA) /2% alginate ...
Pectin-Zein-IPA nanoparticles promote functional recovery and alleviate neuroinflammation after spinal cord injury [0.03%]
果胶-清蛋白-IPA纳米颗粒促进脊髓损伤后的功能恢复并减轻神经炎症
Xianghang Chen,Beini Wang,Abdullah Al Mamun et al.
Xianghang Chen et al.
Introduction: Spinal cord injury (SCI) impairs the balance of gut microbiomes, which further aggravates inflammation in the injured areas and inhibits axonal regeneration. The intestinal microbiome plays an important role...
The blood-brain barriers: novel nanocarriers for central nervous system diseases [0.03%]
血脑屏障：中枢神经系统疾病新型纳米载体
Jiajun Liu,Ting Wang,Jian Dong et al.
Jiajun Liu et al.
The central nervous system (CNS) diseases are major contributors to death and disability worldwide. However, the blood-brain barrier (BBB) often prevents drugs intended for CNS diseases from effectively crossing into the brain parenchyma to...
Visualizing spatiotemporal pattern of vascularization by SWIR fluorescence imaging in a mouse model of perforator flap transplantation [0.03%]
通过SWIR荧光成像在穿支皮瓣移植小鼠模型中可视化血管化的时空模式
Sijia Feng,Mo Chen,Huizhu Li et al.
Sijia Feng et al.
Vascularization as a spatiotemporally interlaced process involving angiogenesis and vascular remodeling, has seldom been investigated comprehensively regarding the interrelationship of the two intertwining but sequential processes. Here, a ...
A novel perspective on the regulation of cardiac cell beating: cardiac cell under mechanical stimulation acts as "cell activation button" to activate adjacent cardiac cell [0.03%]
心脏细胞搏动调节的新观点：机械刺激下的心脏细胞作为“细胞激活按钮”来激活相邻的心脏细胞
Zhaotong Chu,Yujie Zhang,Yidi Zhang et al.
Zhaotong Chu et al.
The regulation of cardiac cell beating is of great significance for understanding cardiac coordination mechanisms and the treatment of cardiovascular diseases. Inspired by this natural "cell regulates cell" mode in which sinoatrial node cel...
MSCs-EVs harboring OA immune memory reprogram macrophage phenotype via modulation of the mt-ND3/NADH-CoQ axis for OA treatment [0.03%]
携带OA免疫记忆的MSCs-EVs通过调节mt-ND3/NADH-CoQ轴来重新编程巨噬细胞表型以治疗OA
Jingdi Zhan,Jing Zou,Qiming Pang et al.
Jingdi Zhan et al.
Background: Osteoarthritis (OA) is a prevalent degenerative joint disease and current therapies are insufficient to halt its progression. Mesenchymal stem cells-derived extracellular vesicles (MSCs-EVs) offer promising th...