Synergic effects of core-shell nanospheres and magnetic field for sciatic nerve regeneration in decellularized artery conduits with Schwann cells [0.03%]
磁性核壳纳米球在脱细胞动脉移植物中联合促进雪旺氏细胞修复坐骨神经损伤中的作用研究
Majid Sharifi,Majid Salehi,Somayeh Ebrahimi-Barough et al.
Majid Sharifi et al.
Numerous conduits have been developed to improve peripheral nerve regeneration. However, challenges remain, including remote control of conduit function, and programmed cell behaviors like orientation. We synthesized Fe3O4-MnO2@Zirconium-ba...
Astragali radix vesicle-like nanoparticles improve energy metabolism disorders by repairing the intestinal mucosal barrier and regulating amino acid metabolism in sleep-deprived mice [0.03%]
黄芪根泡状纳米颗粒通过修复肠黏膜屏障及调控睡眠剥夺小鼠氨基酸代谢改善能量代谢障碍
Yue Yuan,Wenjing Gao,Yunxiao Gao et al.
Yue Yuan et al.
Background: Sleep disorder is widespread and involves a variety of intricate factors in its development. Sleep deprivation is a manifestation of sleep disorder, can lead to energy metabolism disturbances, weakened immune ...
An integrated "Engage & Evasion" approach for mononuclear phagocyte system escape and efficient extracellular vesicle therapy [0.03%]
一种用于单核吞噬细胞系统逃避和有效治疗的外泌体疗法集成“吸引与逃逸”策略
Hongman Liu,Mengting Li,Bing Xiang et al.
Hongman Liu et al.
Ischemic diseases are major contributors to global morbidity and mortality, posing a substantial threat to human health. Extracellular vesicles (EVs) play an essential role in enhancing neovascularization in ischemic tissues, thereby facili...
An antioxidant nanozyme for targeted cardiac fibrosis therapy post myocardial infarction [0.03%]
一种抗氧化纳米酶用于心肌梗死后的心脏纤维化治疗
Ziyi Gu,Xueliang Liu,Zhen Qi et al.
Ziyi Gu et al.
The excessive release of reactive oxygen species (ROS) after myocardial infarction (MI) disrupts the natural healing process, leading to cardiac fibrosis and compromising patient prognosis. However, the clinical application of many antioxid...
Metabolizable alloy clusters assemble nanoinhibitor for enhanced radiotherapy of tumor by hypoxia alleviation and intracellular PD-L1 restraint [0.03%]
一种可通过代谢的合金簇，用于通过缓解放疗肿瘤缺氧及抑制胞内PD-L1来增强放疗的纳米抑制剂
Guanwen Ding,Shengnan Liu,Xiangshan Yang et al.
Guanwen Ding et al.
Background: Cancer radiotherapy (RT) still has limited clinical success because of the obstacles including radioresistance of hypoxic tumors, high-dose X-ray-induced damage to adjacent healthy tissue, and DNA-damage repai...
Adipose-derived exosomes ameliorate skeletal muscle atrophy via miR-146a-5p/IGF-1R signaling [0.03%]
脂肪来源的外泌体通过miR-146a-5p/IGF-1R信号通路缓解骨骼肌萎缩
Mengran Qin,Jiahao Zhu,Lipeng Xing et al.
Mengran Qin et al.
The study of muscle disorders has gained popularity, with a particular emphasis on the relationship between adipose tissue and skeletal muscle. In our investigation, we discovered that the deletion of miR-146a-5p specifically in adipose tis...
Novel insight and perspectives of nanoparticle-mediated gene delivery and immune-modulating therapies for pancreatic cancer [0.03%]
纳米颗粒介导的基因递送和免疫调节疗法在胰腺癌治疗中的新见解及展望
Xinqiao Wang,Xue Yin,Yuxin Li et al.
Xinqiao Wang et al.
Current standard-of-care therapies have failed to improve the survival of patients with metastatic pancreatic cancer (PCA). Therefore, exploring novel therapeutic approaches for cancer targeting is of utmost need. During the past few years,...
Synergistic SDT/cuproptosis therapy for liver hepatocellular carcinoma: enhanced antitumor efficacy and specific mechanisms [0.03%]
协同SDT/铜死亡疗法治疗肝细胞癌：增强的抗肿瘤功效和特异性机制研究
Yucao Sun,Yichi Chen,Bolin Wu et al.
Yucao Sun et al.
The efficacy of sonodynamic therapy (SDT), an emerging approach for tumor treatment, is hindered by the high levels of the antioxidant glutathione (GSH) in the tumor microenvironment (TME). In this study, we constructed nanobubbles loaded w...
In situ size amplification strategy reduces lymphatic clearance for enhanced arthritis therapy [0.03%]
原位尺寸放大策略减少淋巴结清除以增强关节炎治疗效果
Xianyan Qin,Luhan Zhang,Yang-Bao Miao et al.
Xianyan Qin et al.
Rheumatoid arthritis (RA) is an autoimmune disorder characterized by painful swelling and inflammation, arising from the immune system attacking on healthy cells. However, arthritic sites often experience increased lymph flow, hastening dru...
Exosome-delivered NR2F1-AS1 and NR2F1 drive phenotypic transition from dormancy to proliferation in treatment-resistant prostate cancer via stabilizing hormonal receptors [0.03%]
外泌体递送的NR2F1-AS1和NR2F1通过稳定激素受体驱动治疗抵抗性前列腺癌从休眠向增殖的表型转变
Wenbin Chen,Yiyou Mao,YiYuan Zhan et al.
Wenbin Chen et al.
Cancer cells acquire the ability to reprogram their phenotype in response to targeted therapies, yet the transition from dormancy to proliferation in drug-resistant cancers remains poorly understood. In prostate cancer, we utilized high-pla...