ROS-responsive simvastatin nano-prodrug based on tertiary amine-oxide zwitterionic polymer for atherosclerotic therapy [0.03%]
基于叔胺氧化两性离子聚合物的ROS响应型辛伐他汀纳米前药用于动脉粥样硬化治疗
Haiqin Yang,Mengcheng Guo,Qingran Guan et al.
Haiqin Yang et al.
Atherosclerosis (AS) is a major cause of cardiovascular disease and is characterized by high levels of reactive oxygen species (ROS) and lipid deposition. This study utilized ROS-responsive oxalate bonds to conjugate simvastatin (SV) and te...
Overcoming ice: cutting-edge materials and advanced strategies for effective cryopreservation of biosample [0.03%]
克服冰晶问题：用于生物样本有效冻存的先进材料和策略
Miaorong Huang,Minhua Hu,Gengyuan Cai et al.
Miaorong Huang et al.
Cryopreservation techniques have been widely used, especially in biomedical applications and preservation of germplasm resources. Ideally, biological materials would maintain functional integrity as well as a normal structure and can be rec...
Oxygen-delivery nanoparticles enhanced immunotherapy efficacy monitored by granzyme B PET imaging in malignant tumors [0.03%]
氧输送纳米颗粒增强免疫治疗效果通过颗粒酶B的PET影像监测在恶性肿瘤中的应用
Xingyi Wang,Hanyi Fang,Wenzhu Hu et al.
Xingyi Wang et al.
Limited treatment response and inadequate monitoring methods stand firmly before successful immunotherapy. Recruiting and activating immune cells in the hypoxic tumor microenvironment is the key to reversing immune suppression and improving...
Sustainable nanophytosome-based therapies against multidrug-resistant Escherichia coli in urinary tract infections: an in Vitro and in vivo study [0.03%]
针对尿路感染的可持续纳米植物体疗法对抗多重耐药大肠杆菌：一项体外和体内研究
Ming Ming Wen,Ibrahim A Abdelwahab,Rania Abozahra et al.
Ming Ming Wen et al.
Background: Urinary tract infection (UTI) is a prevalent bacterial infection impacting a significant number of individuals globally. The rise in multidrug-resistant (MDR) E. coli strains as the predominant cause of UTIs p...
Multifunctional hydrogel targeting senescence to accelerate diabetic wound healing through promoting angiogenesis [0.03%]
多功能水凝胶通过促进血管生成以加速糖尿病伤口愈合针对细胞衰老的目标
Hao Yang,Yongfei Chen,Yanchao Rong et al.
Hao Yang et al.
Diabetic wound healing remains a significant clinical challenge because of hyperglycaemia-induced cellular senescence, impaired angiogenesis, and chronic inflammation. To address these issues, we developed a multifunctional hydrogel (GelMA/...
An exploration of the ocular mysteries linking nanoparticles to the patho-therapeutic effects against keratitis [0.03%]
探索纳米颗粒通过眼部神秘联系对抗角膜炎的病理治疗效果
Siying Qu,Shuihua Zheng,Sibtain Muhammad et al.
Siying Qu et al.
Microbial keratitis, a sight-threatening corneal infection, remains a significant global health concern. Conventional therapies using antimicrobial agents often suffers from limitations such as poor drug penetration, side effects, and occur...
Cerium-doped Prussian blue biomimetic nanozyme as an amplified pyroptosis inhibitor mitigate Aβ oligomer-induced neurotoxicity in Alzheimer's disease [0.03%]
铈掺杂的仿生普鲁士蓝纳米酶作为增强的热凋亡抑制剂减轻阿尔茨海默病中Aβ寡聚体诱导的神经毒性
Jing Ma,Yu Tian,Chengzhong Du et al.
Jing Ma et al.
Antioxidant enzyme therapy shows promise for treating Alzheimer's disease (AD), but significant challenges remain in achieving effective blood-brain barrier (BBB) penetration and sustained therapeutic effects. We developed a novel neutrophi...
Noninvasive molecular imaging using anti-Trop-2 aptamer for targeted therapy of small cell lung cancer [0.03%]
利用抗Trop-2适配体进行非侵入性分子成像以实现小细胞肺癌的靶向治疗
Yamei Chen,Xuwei Liu,Yang Sun et al.
Yamei Chen et al.
Recent advancements in antibody-drug conjugates (ADCs) targeting trophoblast surface cell antigen 2 (Trop-2) have brought important progress in the field of targeted therapy. This progress also holds promise for the treatment of small cell ...
Atomically-precise Au22(Lys-Cys-Lys)16 nanoclusters for radiation sensitization [0.03%]
用于辐射增敏的原子精确Au22(Lys-Cys-Lys)16纳米团簇
Elham Zeinizade,Goonay Yousefalizideh,Parimah Aminfar et al.
Elham Zeinizade et al.
Radiotherapy is a leading method for cancer treatment, effectively eliminating cancer cells but often causing collateral damage to surrounding healthy tissue. Radiosensitizers aim to enhance the therapeutic effects of radiotherapy while min...
NebulaPlate: a droplet microfluidic platform to analyze platelet aggregation [0.03%]
NebulaPlate：分析血小板聚集的液滴微流控平台
Zheyi Jiang,Meng Wei,Jiawei Zhu et al.
Zheyi Jiang et al.
The accurate assessment of platelet activity is crucial in clinical practice and scientific research owing to the pivotal role of platelets in the progression of cardiovascular conditions, such as arterial thrombotic diseases. However, conv...