Iris C Swart,Oliver J Debski-Antoniak,Aneta Zegar et al.
Iris C Swart et al.
The continued emergence and zoonotic threat posed by coronaviruses highlight the urgent need for effective antiviral strategies with broad reactivity to counter new emerging strains. Nanobodies (or single-domain antibodies) are promising al...
Microenvironment-responsive NIR-IIb multifunctional nanozyme platform for bacterial imaging and specialized anti-anaerobic bacteria periodontal therapy [0.03%]
微环境响应型近红外二区多功能纳米酶平台用于细菌成像及专性厌氧菌牙周病治疗
Suai Lin,Tiehan Cui,Yuxin Jiang et al.
Suai Lin et al.
Periodontitis is a chronic inflammatory disease caused by plaque. In order to remove pathogens and promote tissue repair, the following steps need to be taken simultaneously: localizing the diseased area, improving the anaerobic microenviro...
Extracellular vesicle-mediated bidirectional communication between the liver and other organs: mechanistic exploration and prospects for clinical applications [0.03%]
肝脏和其它器官之间通过细胞外囊泡进行的双向交流：从机理探索到临床应用展望
Wenhui Mo,Yunke Peng,Yanyi Zheng et al.
Wenhui Mo et al.
The liver, functioning as an endocrine organ, secretes a variety of substances that influence the activities of other body organs. Conversely, molecules generated by organs such as bone, the gut, and adipose tissue can also impact liver fun...
Multi-stimuli-responsive pectin-coated dendritic mesoporous silica nanoparticles with Eugenol as a sustained release nanocarrier for the control of tomato bacterial wilt [0.03%]
具有多刺激响应性的多孔硅纳米颗粒作为持续释放载体控制番茄细菌性枯萎病的研究
Xueping Guo,Huiyan Li,Zhihao Li et al.
Xueping Guo et al.
Background: Environmentally responsive nanoscale biocide delivery system enhances smart, regulated, and synergistic biocide application with precise biocide release. In this study, pectin-modified dendritic mesoporous sil...
NaHS@Cy5@MS@SP nanoparticles improve rheumatoid arthritis by inactivating the Hedgehog signaling pathway through sustained and targeted release of H2S into the synovium [0.03%]
通过持续和靶向释放H2S至滑膜，NaHS@Cy5@MS@SP纳米颗粒通过灭活刺猬信号通路改善类风湿关节炎
Xue-Xue Zhu,An-Jing Xu,Wei-Wei Cai et al.
Xue-Xue Zhu et al.
Background: Aberrant proliferation and inflammation of fibroblast-like synoviocytes (FLSs) significantly contribute to the pathogenesis of rheumatoid arthritis (RA). Deficiency of hydrogen sulfide (H2S) is a driving force...
Probiotic nanocomposite materials with excellent resistance, inflammatory targeting, and multiple efficacies for enhanced treatment of colitis in mice [0.03%]
具有优异耐受性、抗炎靶向性和多种功效的益生菌纳米复合材料可提高小鼠结肠炎治疗效果
Yuewen Huang,Hongting Cai,Huipeng Liu et al.
Yuewen Huang et al.
The occurrence of inflammatory bowel disease (IBD) is relevant to impaired intestinal mucosal barrier and disordered gut microbiota, subsequently leading to excessive production of reactive oxygen species (ROS) and elevated levels of inflam...
Injectable celastrol-loading emulsion hydrogel for immunotherapy of low-immunogenic cancer [0.03%]
用于低免疫原性癌症免疫治疗的注射型载雪莲草酯乳液水凝胶
Yu Liu,Jia Zhang,Chunyu Lai et al.
Yu Liu et al.
Immunotherapy, exemplified by immune checkpoint blockade (ICB), has been extensively employed in antitumor treatments. Nevertheless, its efficacy in addressing low-immunogenic tumors has not yielded satisfactory results, primarily due to th...
SynBioNanoDesign: pioneering targeted drug delivery with engineered nanomaterials [0.03%]
合成生物纳米设计：开创工程纳米材料的靶向药物传递技术
Qian Cai,Rui Guo,Dafu Chen et al.
Qian Cai et al.
Synthetic biology and nanotechnology fusion represent a transformative approach promoting fundamental and clinical biomedical science development. In SynBioNanoDesign, biological systems are reimagined as dynamic and programmable materials ...
Efficient delivery of anlotinib and radioiodine by long circulating nano-capsules for active enhanced suppression of anaplastic thyroid carcinoma [0.03%]
长循环纳米胶囊有效输送安罗替尼和放射性碘对分化型甲状腺癌的主动增强抑制作用
Linlin Zhang,Chuanying Zhu,Shuo Huang et al.
Linlin Zhang et al.
131I therapy is clinically unfeasible for anaplastic thyroid carcinoma (ATC), due to lack of active targets and ATC's resistance to radiation. Novel radionuclide-labeled targeted nano-drug delivery systems have exhibited the potential of pr...
Regulating macrophage phenotypes with IL4I1-mimetic nanoparticles in IDD treatment [0.03%]
利用IL4I1模拟纳米颗粒调节巨噬细胞表型用于IDD治疗
Jiaying Luo,Guoxin Jin,Shaoqian Cui et al.
Jiaying Luo et al.
Intervertebral disc degeneration (IDD) is a degenerative spinal condition characterized by disc structural damage, narrowing of joint spaces, and nerve root compression, significantly reducing patients' quality of life. To address this chal...