Circulating plasma derived exosomes from systemic lupus erythematosus aggravate lupus nephritis through miR-122-5p/FOXO3-mediated macrophage activation [0.03%]
系统性红斑狼疮循环血浆来源的外泌体通过miR-122-5p/FOXO3介导的巨噬细胞活化加重狼疮性肾炎
Juan Ji,Qian He,Yunfei Xia et al.
Juan Ji et al.
Systemic lupus erythematosus (SLE) is a chronic and systemic autoimmune disease characterized by dysregulation in both innate and adaptive immunity. Polarization of macrophages into M1/M2 macrophages affects the development of lupus. Exosom...
Bacteria-activated macrophage membrane coated ROS-responsive nanoparticle for targeted delivery of antibiotics to infected wounds [0.03%]
一种细菌激活的巨噬细胞膜包被的ROS响应型载抗生素纳米颗粒用于感染伤口治疗研究
Ying Luo,Xiaoli Jia,Xiaozhuo Wu et al.
Ying Luo et al.
Bacterial infections and antibiotic resistance represent significant global public health challenges, necessitating the development of innovative antibacterial agents with targeted delivery capabilities. Our study utilized macrophages' natu...
Cartilage-targeting peptide-modified cerium oxide nanoparticles alleviate oxidative stress and cartilage damage in osteoarthritis [0.03%]
软骨靶向肽修饰的纳米氧化铈通过减轻氧化应激和软骨损伤治疗骨关节炎
Huangming Zhuang,Xunshan Ren,Huajie Li et al.
Huangming Zhuang et al.
Background: Osteoarthritis (OA) is a degenerative joint disease that leads to a substantial decline in the well-being of older individuals. Chondrocyte senescence and the resultant damage to cartilage tissue, induced by e...
Regulation of dynamic spatiotemporal inflammation by nanomaterials in spinal cord injury [0.03%]
纳米材料调节脊髓损伤的动态时空炎症反应
Zeping Liu,Chunyu Xiang,Xu Zhao et al.
Zeping Liu et al.
Spinal cord injury (SCI) is a common clinical condition of the central nervous system that can lead to sensory and motor impairment below the injury level or permanent loss of function in severe cases. Dynamic spatiotemporal neuroinflammati...
Sparstolonin B potentiates the antitumor activity of nanovesicle-loaded drugs by suppressing the phagocytosis of macrophages in vivo [0.03%]
Sparstolonin B通过体内抑制巨噬细胞的吞噬作用来增强纳米囊载药物抗肿瘤活性
Yuefeng Zhang,Zuo Mou,Wei Song et al.
Yuefeng Zhang et al.
Background: Extracellular vesicles (EVs) and extruded nanovesicles (ENVs) are promising nanovesicles (NVs) for drug delivery. However, the application of these NVs is strongly hindered by their short half-life in the circ...
Development and evaluation of a single domain antibody targeting folate receptor alpha for radioligand therapy [0.03%]
靶向叶酸受体α的单结构城抗体的开发及放射配体治疗评估
Jonatan Dewulf,Sam Massa,Laurent Navarro et al.
Jonatan Dewulf et al.
Background: Folate receptor alpha (FRα) overexpression is seen in many cancers. Radioligand therapy (RLT) has emerged as a promising tool to target FRα and has been investigated previously, but further progression was l...
Osteoblastic ferroptosis inhibition by small-molecule promoting GPX4 activation for peri-prosthetic osteolysis therapy [0.03%]
小分子活化GPX4治疗假体周围骨溶解诱导的成骨细胞铁死亡抑制研究
Xin Liu,Wei Wang,Feng Zhu et al.
Xin Liu et al.
Peri-prosthesis osteolysis (PPO) represents the most severe complication of total joint arthroplasty (TJA) surgery and imposes the primary cause of prosthesis failure and subsequent revision surgery. Antiresorptive therapies are usually pre...
Synergistic enhancement of low-dose radiation therapy via cuproptosis and metabolic reprogramming for radiosensitization in in situ hepatocellular carcinoma [0.03%]
通过铜死亡和代谢重编程协同增强低剂量放疗以增敏原位肝癌放射治疗的效果
Ni Shao,Yongqing Yang,Genwen Hu et al.
Ni Shao et al.
Background: Radiotherapy (RT) is a primary clinical approach for cancer treatment, but its efficacy is often hindered by various challenges, especially radiation resistance, which greatly compromises the therapeutic effec...
Single-cell RNA sequencing uncovers heterogenous immune cell responses upon exposure to food additive (E171) titanium dioxide [0.03%]
单细胞RNA测序揭示食品添加剂二氧化钛(E171)暴露后异质性免疫细胞反应
Haribalan Perumalsamy,Xiao Xiao,Hyoung-Yun Han et al.
Haribalan Perumalsamy et al.
The prospective use of food additive titanium dioxide (E171 TiO2) in a variety of fields (food, pharmaceutics, and cosmetics) prompts proper cellular cytotoxicity and transcriptomic assessment. Interestingly, smaller-sized E171 TiO2 can tra...
Ultrasound nanodroplets loaded with Siglec-G siRNA and Fe3O4 activate macrophages and enhance phagocytosis for immunotherapy of triple-negative breast cancer [0.03%]
载有Siglec-G siRNA和Fe3O4的超声纳米液滴激活巨噬细胞并增强吞咽作用用于三阴性乳腺癌免疫治疗
Ci Yin,Guojuan Wang,Qin Zhang et al.
Ci Yin et al.
Background: The progression of triple-negative breast cancer is shaped by both tumor cells and the surrounding tumor microenvironment (TME). Within the TME, tumor-associated macrophages (TAMs) represent a significant cell...