Bright NIR-II emissive cyanine dye-loaded lipoprotein-mimicking nanoparticles for fluorescence imaging-guided and targeted NIR-II photothermal therapy of subcutaneous glioblastoma [0.03%]
一种用于荧光成像引导和靶向近红外二区光热治疗皮下胶质母细胞瘤的载cyanine染料的类脂蛋白仿生纳米粒
Haiyan Huang,Menlong Li,Jingsi Gu et al.
Haiyan Huang et al.
Cyanine dye-containing nanoparticles have widely been used in "all-in-one" NIR fluorescence imaging (FI)-guided photothermal therapy (PTT) because of their intrinsically large extinction coefficient and available physical and chemical modul...
A shielded cascade of targeted nanocarriers spanning multiple microenvironmental barriers for inflammatory disease therapy [0.03%]
一种防护级联靶向纳米载体跨越多种微环境屏障用于炎症疾病治疗
Fengyi Liu,Xu Wang,Mingxing Ren et al.
Fengyi Liu et al.
Background: The multi-biological barriers present in the inflammatory microenvironment severely limit the targeted aggregation of anti-inflammatory drugs in the lesion area. However, conventional responsive drug carriers ...
Gene editing tool-loaded biomimetic cationic vesicles with highly efficient bacterial internalization for in vivo eradication of pathogens [0.03%]
高效负载基因编辑工具的仿生阳离子囊泡用于体内病原体消除
Xueli Jia,Bochuan Yuan,Wanmei Wang et al.
Xueli Jia et al.
In the post-COVID-19 era, drug-resistant bacterial infections emerge as one of major death causes, where multidrug-resistant Acinetobacter baumannii (MRAB) and drug-resistant Pseudomonas aeruginosa (DRPA) represent primary pathogens. Howeve...
Resistant starch grafted cerium-sulfasalazine infinite coordination polymers synergistically remold intestinal metabolic microenvironment for inflammatory bowel disease therapy [0.03%]
抗性淀粉嫁接铈-磺胺水杨酸无限协调聚合物协同重塑肠道代谢微环境用于炎症性肠病治疗
Jing Zhang,Liyuan Zhao,Along Liang et al.
Jing Zhang et al.
Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease which is closely related with the overproduced reactive oxygen species (ROS), increased pro-inflammatory cytokines and disordered intestinal microbes. However, current t...
Targeted lipid nanoparticles distributed in hydrogel treat osteoarthritis by modulating cholesterol metabolism and promoting endogenous cartilage regeneration [0.03%]
靶向脂质纳米颗粒在软骨水凝胶中递送治疗骨关节炎及调节胆固醇代谢和促进内源性软骨再生研究
Zhibo Zhao,Peng Wang,Ziyang Li et al.
Zhibo Zhao et al.
Osteoarthritis (OA) is the most common disease in aging joints and has characteristics of cartilage destruction and inflammation. It is currently considered a metabolic disease, and the CH25H-CYP7B1-RORα axis of cholesterol metabolism in c...
Hyaluronic acid-functionalized supramolecular nanophotosensitizers for targeted photoimmunotherapy of triple-negative breast cancer [0.03%]
用于三阴性乳腺癌靶向光免疫治疗的透明质酸功能化超分子纳米光敏剂
Haiyan Zhang,Hongxin Liu,Zhigang Xie et al.
Haiyan Zhang et al.
Triple-negative breast cancer (TNBC) is recognized as a particularly aggressive subtype of breast cancer that is devoid of effective therapeutic targets. Immune checkpoint inhibitors (ICIs) have demonstrated promising results in TNBC treatm...
Advances in molecular imaging and targeted therapeutics for lymph node metastasis in cancer: a comprehensive review [0.03%]
癌症淋巴结转移分子影像及靶向治疗进展：综述
Yunhao Wu,Jin Shang,Xinyue Zhang et al.
Yunhao Wu et al.
Lymph node metastasis is a critical indicator of cancer progression, profoundly affecting diagnosis, staging, and treatment decisions. This review article delves into the recent advancements in molecular imaging techniques for lymph nodes, ...
Targeted nanoparticle delivery unleashes synergistic photothermal and immunotherapeutic effects against hepatocellular carcinoma [0.03%]
靶向纳米颗粒递送释放协同光热和免疫治疗效应以治疗肝细胞癌
Amal Babu,Sathiyamoorthy Padmanaban,Sahil Chahal et al.
Amal Babu et al.
The substantial mortality and morbidity of hepatocellular carcinoma, representing 90% of liver cancers, poses a significant health burden. The effectiveness of traditional hepatocellular carcinoma treatments such as surgical resection, radi...
Adipose-derived stem cell exosomes attenuates myofibroblast transformation via inhibiting autophagy through TGF-β/Smad2 axis in oral submucosal fibrosis [0.03%]
脂肪来源干细胞外泌体通过TGF-β/Smad2轴抑制自噬从而减轻口腔黏膜纤维化中肌成纤维细胞转化
Jinhao Xu,Yujing Wang,Zifei Shao et al.
Jinhao Xu et al.
Oral submucous fibrosis (OSF) is a precancerous condition that poses substantial health risks. OSF is mainly caused by betel nut chewing behavior, but its pathogenesis is still unclear and there is no effective treatment strategy. The trans...
Zinc-based radioenhancers to activate tumor radioimmunotherapy by PD-L1 and cGAS-STING pathway [0.03%]
基于锌的放射增效剂通过PD-L1和cGAS-STING途径激活肿瘤放射免疫治疗
Mengjiao Xu,Chao Xu,Yu Qiu et al.
Mengjiao Xu et al.
Radiotherapy and immunotherapy have already become the primary form of treatment for non-small-cell lung cancer (NSCLC), but are limited by high radiotherapy dose and low immune response rate. Herein, a multi-pronged strategy using a radio-...