Young fibroblast-derived migrasomes alleviate keratinocyte senescence and enhance wound healing in aged skin [0.03%]
年轻成纤维细胞衍生的迁移体可缓解老年皮肤角质细胞衰老并促进伤口愈合
Hanlin Tu,Yingliang Shi,Yi Guo et al.
Hanlin Tu et al.
Background: Alterations in intercellular communication driven by cellular senescence constitute an important factor in skin aging. Migrasome, a newly discovered vesicular organelle, efficiently participates in intercellul...
Mitochondria-targeted nanovesicles for ursodeoxycholic acid delivery to combat neurodegeneration by ameliorating mitochondrial dysfunction [0.03%]
针对线粒体的牛磺胆酸纳米载体通过改善线粒体功能障碍来对抗神经退行性疾病
Shizheng Zhang,Mengmeng Li,Yuan Li et al.
Shizheng Zhang et al.
Mitochondria are pivotal in sustaining oxidative balance and metabolic activity within neurons. It is well-established that mitochondrial dysfunction constitutes a fundamental pathogenic mechanism in neurodegeneration, especially in the con...
Regulation of immune microenvironments by polyetheretherketone surface topography for improving osseointegration [0.03%]
聚醚醚酮表面形态对免疫微环境的调控作用及其对骨整合的影响
Yuqing Zhao,Yanxin An,Fan Wu et al.
Yuqing Zhao et al.
Optimizing the immune microenvironment is essential for successful implant osseointegration. In this study, four different nano/microstructures were fabricated on polyetheretherketone (PEEK) substrates by varying the agitation speed during ...
CREB1/CRTC2 regulated tubular epithelial-derived exosomal miR-93-3p promotes kidney injury induced by calcium oxalate via activating M1 polarization and macrophage extracellular trap formation [0.03%]
CREB1/CRTC2调控的管状上皮源性外泌体miR-93-3p通过激活M1极化和巨噬细胞胞外诱捕结构的形成促进草酸钙诱导的肾脏损伤
Yushi Sun,Bojun Li,Baofeng Song et al.
Yushi Sun et al.
Background: Calcium oxalate (CaOx) crystals are known to cause renal injury and trigger inflammatory responses. However, the role of exosome-mediated epithelial-macrophage communication in CaOx-induced kidney injury remai...
MXene-based nanosheet for enhanced glioma therapy via photonic hyperthermia to boost the abscopal effect of radioimmunotherapy [0.03%]
基于MXene纳米片通过光子热疗增强胶质瘤疗法以促进放免疫疗法的旁观者效应
Huan Zhu,Zhaoyuan Zhang,Rong Jiang et al.
Huan Zhu et al.
Radiotherapy (RT) effectiveness is limited by low DNA damage in tumor cells, surrounding tissue harm, and tumor radioresistance with active DNA repair. Herein, we have engineered a two-dimensional nanomaterial consisting of MXene nanosheets...
Ginseng exosomes modulate M1/M2 polarisation by activating autophagy and target IKK/IкB/NF-кB to alleviate inflammatory bowel disease [0.03%]
人参外泌体通过激活自噬作用调节M1/M2极化，并靶向IKK/IкB/NF-кB以减轻炎症性肠病
Song Yang,Liangliang Fan,Lijia Yin et al.
Song Yang et al.
Background: Exosomes are involved in intercellular communication and regulation of the inflammatory microenvironment. In a previous study, we demonstrated that fresh ginseng exosomes (GEs) alleviated inflammatory bowel di...
Renal-clearable and tumor-retained nanodots overcoming metabolic reprogramming to boost mitochondrial-targeted photodynamic therapy in triple-negative breast cancer [0.03%]
可被肾脏清除并可在肿瘤内保留的纳米点克服代谢重编程以提升三阴性乳腺癌线粒体光动力治疗效果
Defan Yao,Yanshu Wang,Xue Dong et al.
Defan Yao et al.
Background: Targeting tumor metabolism reprogramming has demonstrated a synergistic antitumor effect in photodynamic therapy of triple-negative breast cancer (TNBC). However, such a combination therapeutic regimen has enc...
Recent advances and challenges in metal-based antimicrobial materials: a review of strategies to combat antibiotic resistance [0.03%]
基于金属的抗菌材料在对抗抗生素耐药性策略方面的最新进展和挑战综述
Chuanda Zhu,Zhenli Diao,Yuanyuan Yang et al.
Chuanda Zhu et al.
Despite the availability of a series of classical antibiotic drugs, bacterial infections continue to represent a significant and urgent threat to global human health. The emergence of drug-resistant bacteria and the slow pace of antibiotic ...
Platelet hitchhiking vascular-disrupting agents for self-amplified tumor-targeting therapy [0.03%]
用于自我增强的肿瘤靶向治疗的血小板结合血管破坏药物
Hongyu Chu,Yajun Xu,Yuezhan Shan et al.
Hongyu Chu et al.
The vascular-disrupting agent DMXAA (5,6-dimethylxanthone-4-acetic acid) exhibits potent anticancer activity by targeting tumor vasculature and activating immune responses via the cGAS-STING pathway. However, its clinical application is hin...
Co-delivery of axitinib and PD-L1 siRNA for the synergism of vascular normalization and immune checkpoint inhibition to boost anticancer immunity [0.03%]
轴息尼和PD-L1 siRNA的共传递用于血管正常化和免疫检查点抑制的协同作用以增强抗癌免疫
Yanhong Liu,Liming Gong,Jing Feng et al.
Yanhong Liu et al.
Immune checkpoint inhibition (ICI) has become the mainstay of immunotherapy for the treatment of renal cell carcinoma (RCC). However, only a small portion of patients exhibit a positive response to PD-1/PD-L1 blockade therapy and the key re...