Coptis chinensis-derived extracellular vesicle-like nanoparticles delivered miRNA-5106 suppresses NETs by restoring zinc homeostasis to alleviate colitis [0.03%]
黄连来源的类细胞外囊泡递送miRNA-5106通过恢复锌稳态抑制NETs从而缓解结肠炎
Yi Yang,Lanmengxi Yang,Haiyi Deng et al.
Yi Yang et al.
Background: Inflammatory bowel disease (IBD) is a chronic disorder marked by persistent inflammation and damage to the intestinal mucosa. Despite significant advances in treatment, there remains an unmet need for more eff...
Nano-orchestrated magnetotactic-like navigation for electromagnetic theranostics and immune enhancement via photoautotrophic oxygenation, mild hyperthermia, and ferroptosis [0.03%]
基于光自养氧供给、微波低热和铁死亡的仿磁趋性亚毫米级电磁诊疗免疫增强导航疗法
Chi-Hung Hsiao,Yung-Wei Lin,Chia-Hung Liu et al.
Chi-Hung Hsiao et al.
Overcoming the hypoxic tumor microenvironment (TME) and immune suppression remains a significant challenge in solid bladder tumor therapies. This study introduces a translational system of nano-orchestrated magnetotactic-like system, integr...
Overcoming acquired immunotherapy resistance in non-small cell lung cancer using ginsenoside Rb1-loaded, peptide-enhanced exosome delivery systems [0.03%]
基于人参皂苷Rb1的功能化外泌体递送系统克服非小细胞肺癌的免疫治疗耐药性
Xiangyuan Jin,Tanghesi Wuyun,Yu Zhang et al.
Xiangyuan Jin et al.
Non-small cell lung cancer (NSCLC) remains a major global health challenge, with limited therapeutic success due to drug resistance and the immunosuppressive tumor microenvironment (TME). This study explores a novel strategy to overcome acq...
Enzyme-sequential responsive core-satellite nanomedicine enables activatable near-infrared-II photoacoustic imaging-guided chemotherapy cascade-enhanced radiotherapy [0.03%]
酶序响应型核心卫星纳米药物实现近红外二区激活式声成像引导的化疗协同放疗
Wenjing Xiao,Xiao Yang,Mengzhen Wang et al.
Wenjing Xiao et al.
The standard treatment for various types of cancers typically involves the combination of concurrent localized radiotherapy and systemic chemotherapy. However, no treatment options have been reported that utilize chemotherapy cascade-enhanc...
Transdermal delivery of CRISPR/Cas9-mediated melanoma gene therapy via polyamines-modified thermosensitive hydrogels [0.03%]
聚胺修饰的热敏水凝胶介导的表皮递送CRISPR / Cas9肿瘤基因治疗
Meng Li,Songli Zhou,Suqin Zhang et al.
Meng Li et al.
The main obstacles to the clinical application of the CRISPR/Cas9 system are off-target effects and low delivery efficiency. There is an urgent need to develop new delivery strategies and technologies. Three types of in situ injectable hydr...
Nanoscale engineered exosomes for dual delivery of Sirtuin3 and insulin to ignite mitochondrial recovery in myocardial ischemia-reperfusion [0.03%]
用于心肌缺血再灌注的Sirtuin3和胰岛素协同传递的纳米工程外泌体以触发线粒体恢复
Jiaxin Yang,Xinyi Yun,Weihan Zheng et al.
Jiaxin Yang et al.
Background: Acute myocardial infarction remains a leading cause of mortality, with ischemia-reperfusion (I/R) injury causing severe myocardial damage through mitochondrial dysfunction. While mesenchymal stem cell-derived ...
Engineering a bivalent nanoparticle vaccine with PCV2 capsid protein and PRRSV epitopes [0.03%]
一种二价纳米颗粒亚单位疫苗(PCV2衣壳蛋白和PRRS抗原表位结合疫苗)的设计及评价
Jun Ma,Xun Xiao,Yanrong Zhou et al.
Jun Ma et al.
Background: Coinfection with multiple viruses is a common occurrence in the pig industry. Porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) are two significant pathogens, wit...
Polystyrene microplastics exacerbate mitophagy through mitochondrial dysfunction in the duck lung [0.03%]
聚苯乙烯微塑料通过线粒体功能障碍加重鸭肺线粒体自噬作用
Tiantian Gu,Minghua Kong,Mingcai Duan et al.
Tiantian Gu et al.
Microplastics (MPs) are widespread environmental pollutants that can enter the human body through the food chain, potentially leading to lung damage. However, the underlying mechanisms responsible for this damage remain unclear. Ducks, a co...
Coordination acid-engineered Prussian Blue affects glycometabolic reprogramming in microglia for epileptic treatment [0.03%]
调控酸催化的普鲁士蓝影响微胶质细胞的糖代谢重构用于癫痫治疗
Yao Zhao,Feixiang Chen,Chen Chen et al.
Yao Zhao et al.
Seizures induce significant immune and metabolic stress in microglia, but the interaction between these processes remains unclear. This study, utilizing single-nucleus RNA sequencing data from temporal lobe epilepsy (TLE) patients, reveals ...
Secretome enriched with small extracellular vesicles derived from human gingiva-derived mesenchymal stem cells enhances rat tongue muscle regeneration [0.03%]
人牙龈间充质干细胞源性小细胞外囊泡富集的分泌组促进舌肌再生
Qunzhou Zhang,Puhan He,Shihong Shi et al.
Qunzhou Zhang et al.
Background: Accumulating evidence demonstrates that the therapeutic effects of stem cells are most likely attributed to their secretome, composed of a myriad of bioactive factors, including small extracellular vesicles (E...