Phage-guided rapid enrichment of copper-protocatechuic acid nanoparticles for targeted antibacterial therapy [0.03%]
噬菌体引导的铜-原儿茶酸纳米颗粒快速富集用于靶向抗菌治疗
Fang Liu,Haojie Chen,Yue Huang et al.
Fang Liu et al.
The effective treatment of bacterial infections requires rapid and selective enrichment of antibacterial agents on bacterial surfaces within infectious microenvironments. Transition metal ion-based antibacterial agents show broad-spectrum b...
Photoreceptor-targeted engineered exosomes encapsulating black phosphorus quantum dots for alleviating photoreceptor degeneration [0.03%]
装载黑磷量子点的工程化外泌体靶向视杆细胞治疗视网膜退行性疾病的研究
Jia Liang,Xiangqing Hei,Lu Chen et al.
Jia Liang et al.
Photoreceptor degeneration is a major cause of irreversible visual impairment worldwide, most notably in retinitis pigmentosa (RP). Here, we developed a dual-targeted therapeutic nanoplatform by loading black phosphorus quantum dots (BPQDs)...
Effects and mechanism of carrier-free self-assembled nanoparticles of natural products in attenuating pulmonary edema [0.03%]
天然产物无载体自组装纳米粒抗肺水肿效应及机制研究
Jin Yan,Kaixin Liu,Yuqi Yan et al.
Jin Yan et al.
Background: Pulmonary edema, a life-threatening condition in acute lung injury/acute respiratory distress syndrome (ALI/ARDS), is driven by dysregulated inflammation, barrier disruption, and alveolar fluid accumulation. E...
Lymph node metastasis-related circHELQ promotes progression and acts as a nanotherapeutic target in colorectal cancer [0.03%]
与淋巴结转移相关的circHELQ促进结直肠癌进展并成为纳米治疗靶点
Jingwen Peng,Wen Song,Mengzhen Lei et al.
Jingwen Peng et al.
Introduction: Studies have highlighted the important roles of circRNAs in various cancers. However, their specific functions in the lymph node metastasis (LNM) of colorectal cancer (CRC) remain largely unclear. ...
SERSome-based metabolic profiling of aqueous humor for cataract subtyping with molecule-level interpretability [0.03%]
基于SERSome的房水代谢谱学及其分子水平可解释性用于白内障亚型分类
Li Ning,Xinyuan Bi,Yepei Qin et al.
Li Ning et al.
Cataract is among the leading cause of vision impairment worldwide and it is essential to uncover molecule-level characteristics of different cataract subtypes for personalized treatment. Compared to existing diagnostic techniques, surface-...
Advanced metal-phenolic networks for tissue regeneration: opportunities and challenges [0.03%]
金属酚类聚合物网络在组织再生中的机遇与挑战
Meng Luo,Hongzhang Deng
Meng Luo
Owing to their commendable biocompatibility, unique physicochemical properties, and highly tunable structural characteristics, metal polyphenolic networks (MPNs) have emerged as a highly promising class of functional materials, exhibiting b...
Targeting mitochondrial-ER homeostasis via autophagy inhibition with celastrol-based nanotherapy for triple-negative breast cancer [0.03%]
基于雷公藤红素的纳米疗法通过自噬抑制靶向线粒体-内质网稳态治疗三阴性乳腺癌
Yuhao Ye,Xin Zhang,Qi Tong et al.
Yuhao Ye et al.
The functional crosstalk between mitochondria and the endoplasmic reticulum (ER) serves as a critical adaptive mechanism in cancer cells, wherein mitochondrial damage-induced ER stress can paradoxically activate protective mitophagy to rest...
Glutathione-depleting self-immolative nanoparticles boost cuproptosis-driven metalloimmunotherapy for triple-negative breast cancer [0.03%]
用于三阴性乳腺癌的金属免疫治疗的谷胱甘肽耗尽型自消解纳米颗粒促进铜死亡诱导疗法
Yunhai Fu,Xiaoyu Wang,Yinqi Li et al.
Yunhai Fu et al.
Despite advances in immunotherapy, triple-negative breast cancer (TNBC) remains a major therapeutic challenge owing to its marked aggressiveness, low immunogenicity, and limited responsiveness to immune checkpoint blockade (ICB). Herein, th...
Peptide nanoarchitectonics of biomimetic nanozyme synergistically inhibits smooth muscle cell proliferation and promotes endothelial repair to reduce poststenting complications [0.03%]
肽纳米结构仿生纳米酶协同抑制平滑肌细胞增殖并促进内皮修复以减少支架植入术后并发症
Xiyue Rong,Wenli Zhang,Sijin Chen et al.
Xiyue Rong et al.
Drug-eluting stents are effective for treating cardiovascular disease (CVD), but the procedure can cause mechanical damage to the endothelium, and the released antiproliferative agents delay reendothelialization and impair barrier function,...
Plant-derived extracellular vesicles as emerging cardioprotective agents for cardiovascular diseases [0.03%]
植物衍生的细胞外囊泡作为心血管疾病的新一代心脏保护剂
Qian Li,Zhen Wang,Qianqian Huang et al.
Qian Li et al.
Cardiovascular diseases (CVDs) remain a leading cause of global morbidity and mortality. Their complex and multifactorial pathogenesis, involving endothelial dysfunction, chronic inflammation, oxidative stress, metabolic dysregulation, and ...