Harnessing smart nanomaterials to reprogram neutrophil plasticity in immune modulation [0.03%]
利用智能纳米材料重新编程中性粒细胞的免疫调节塑性功能
Jiaxin Luo,Jingxia Chen,Jing Zhou et al.
Jiaxin Luo et al.
Neutrophils are the most abundant type of white blood cells in the immune system and play a complex and intricate regulatory role in disease progression. Their critical contribution to maintaining homeostasis through migration, activation, ...
Tungsten disulfide atomic crystals with RONS scavenging and liver targeting capabilities for acetaminophen-induced acute liver injury therapy [0.03%]
用于治疗对乙酰氨基酚致急性肝损伤的具有RONS清除和肝靶向功能的二硫化钨原子晶体
Ziwen Xiao,Yu Liu,Zhenchao Tao et al.
Ziwen Xiao et al.
The ongoing progression of acetaminophen (APAP)-induced liver injury (AILI) resulting from excessive APAP intake can lead to acute liver failure (ALF). This process involves an imbalanced antioxidant system, upregulated inflammatory respons...
Rational engineering of nanoplatforms with hierarchical targeting hepatic tumor and subcellular mitochondria for enhanced image-guided photodynamic therapy [0.03%]
用于肝肿瘤和亚细胞线粒体分层靶向的纳米平台的理性工程化，以增强图像引导的光动力疗法
Xiaofei Shang,Wenjie Shao,Wuqi Dong et al.
Xiaofei Shang et al.
The main challenge of photosensitizer in image-guided photodynamic therapy (PDT) is the balance between the high singlet oxygen yields and strong fluorescence performance, while simultaneously targeting certain types of cancer to achieve op...
A novel scalable method for the production of rennet-treated milk-derived extracellular vesicles for improved curcumin oral delivery [0.03%]
一种新型可扩展方法生产凝乳酶处理的牛奶源细胞外囊泡以改善口服黄酮素递送
Emily Schifano,Francesco Vari,Luca Buccini et al.
Emily Schifano et al.
Background: Extracellular vesicles (EVs) are lipid bilayer-enclosed nanoparticles secreted by all cell types and are gaining increasing attention as natural, biocompatible drug delivery nanovehicles. Among the various sou...
Photothermal nano-agents: an innovative trident weapon for accurate and effective treatment of alzheimer's disease [0.03%]
光热纳米剂：阿尔茨海默病精准有效治疗的创新武器
Jianfei Chen,Xiaowei Zhang,Jinpan Sun et al.
Jianfei Chen et al.
Alzheimer's disease (AD) is a degenerative neurological illness for which effective therapy alternatives are currently lacking. Photothermal therapy (PTT) employs the localized thermal effects of nano-photothermal agents (NPTAs) under near-...
Targeting ferroptosis to rescue osteogenic differentiation in BRONJ-affected jawbone mesenchymal stem cells: the role of miR-145-3p and exosome-mediated therapy [0.03%]
靶向铁死亡以拯救颌骨间充质干细胞成骨分化：miR-145-3p和外泌体介导治疗的作用
Yi Shuai,Bo Chen,Tao Jiang et al.
Yi Shuai et al.
Background: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a severe, therapy-refractory condition driven by ferroptotic disruption of jawbone-derived mesenchymal stem cells (MSCs) biology. We dissect this mech...
Drug loaded cerium oxide nanozymes prevent radiation-Induced cataracts via suppressing the cGAS-STING pathway [0.03%]
载药的二氧化铈纳米酶通过抑制cGAS-STING信号通路预防放射性白内障
Qifang Chen,Peilin Gu,Hongwei Li et al.
Qifang Chen et al.
Radiation-induced cataracts (RIC), a significant cause of blindness, arise from oxidative damage and inflammation in the lens epithelium, and there has been a lack of effective targeted therapeutic drugs in clinic. Here, we proposed and dev...
Bletilla striata polysaccharide microneedles with astragaloside Ⅳ loaded ZIF-8 nanoparticles for wound healing and anti-scar treatment [0.03%]
用于伤口愈合和抗瘢痕治疗的Bletilla striata多糖微针及其负载 Astragaloside IV 的ZIF-8纳米颗粒
Rezhemu Jimo,Jun Ma,Shixing Edi et al.
Rezhemu Jimo et al.
Pathological scars (PS) represent a common complication arising post wound healing, potentially resulting in disfigurement and impaired skin functionality in severe instances. Addressing the clinical challenge wherein conventional single tr...
Fe-MOF loaded with capmatinib to reverse immunosuppressive microenvironment and inhibit tumor metastasis after radiofrequency ablation [0.03%]
负载卡马替尼的铁基金属有机框架材料逆转射频消融后肿瘤免疫抑制微环境及转移抑制作用研究
Jinchao Zhao,Lei Lei,Cheng Zeng et al.
Jinchao Zhao et al.
Incomplete radiofrequency ablation (iRFA) of hepatocellular carcinoma (HCC) has the risk to exacerbate the tumor immunosuppressive microenvironment and promote lung metastasis. There is an urgent need to reverse the immunosuppressive microe...
Cascade-targeting copper homeostasis nano-regulators for mild-photothermal boosted cuproptosis/ferroptosis mediated breast cancer therapy [0.03%]
用于温和光热促进铜依赖性细胞死亡/铁死亡协同治疗乳腺癌的级联靶向铜稳态纳米调节器
Xuejun Liang,Shiji Fang,Yanan Xin et al.
Xuejun Liang et al.
Inducing cuproptosis in tumor cells is significantly impeded by the challenges of arduous copper ion delivery in vivo and the unbreakable intracellular copper homeostasis, which leads to insufficient mitochondrial copper accumulation. Here,...