Advancement on localized targeting via intra-articular administration of lipid-based vesicular nanoparticles for osteoarthritis management [0.03%]
用于关节局部给药的脂质基囊泡纳米颗粒制剂在骨关节炎治疗中的进展
Sourav Mohanto,Avinaba Das,Alima Misiriya et al.
Sourav Mohanto et al.
Engineered lipid hybrid nanoparticles for targeted delivery of SH2 superbinder and breast cancer therapy [0.03%]
一种用于靶向递送SH2超结合剂的工程脂质杂化纳米颗粒及治疗乳腺癌的方法
Yuhe Zhu,Yazhou Sang,Linna Du et al.
Yuhe Zhu et al.
SH2 Superbinder (SH2S) is an engineered polypeptide tool derived from the SH2 domain. It exhibits significantly enhanced binding capacity for tyrosine-phosphorylated proteins to treat various cancers. However, its clinical application is li...
Protocatechualdehyde-functionalized BMSC-derived exosomes orchestrate calcium signaling in the immunoinflammatory microenvironment to promote periodontal regeneration [0.03%]
儿茶酚醛修饰的BMSC来源外泌体通过调节免疫炎症微环境中的钙信号促进牙周组织再生
Le Fan,Tianyou Wang,Meirui Ma et al.
Le Fan et al.
The significant global burden of periodontitis has increased over the past few decades. However, the regeneration and reconstruction of periodontal tissue remain major challenges in clinical practice. Successful periodontal treatment relies...
Hyaluronic acid-based reduction responsive nanoparticles for Improved anti-psoriasis effects of traditional Chinese herb monomer oleanolic acid via blocking YAP-AREG axis [0.03%]
一种基于透明质酸的响应性纳米粒子用于改善传统中药单体皂苷抗银屑病效果：通过抑制YAP-AREG信号轴实现
Ying Han,Junjie Ren,Yue Su et al.
Ying Han et al.
Background: Oleanolic acid (OA), a pentacyclic triterpenoid abundantly present in various traditional Chinese herbs, exhibits promising anti-psoriatic potential owing to its broad pharmacological activities. Nevertheless,...
Nanomedicine-enabled disruption of glucose metabolism and synergistic antitumor therapy [0.03%]
纳米医学介导的葡萄糖代谢扰乱及协同抗肿瘤治疗研究进展
Jiang Ni,Ang Ma,Qiufang Gao et al.
Jiang Ni et al.
68Ga/177Lu-labeled nectin4-targeted covalent bicyclic peptide: a novel nectin-4-targeted radioligands for theranostic of urothelial carcinoma [0.03%]
一种新型nectin-4靶向放射配体：用于尿路上皮癌诊疗的68Ga/177Lu标记nectin4靶向环肽
Li Sun,Bin Zhu,Ke Zuo et al.
Li Sun et al.
Nectin-4 is markedly overexpressed in urothelial carcinoma (UC) and represents a promising theranostic target for both radiotherapy and positron emission tomography (PET) imaging. The Food and Drug Administration (FDA)-approved Nectin-4-tar...
Fluoroalkylated antimicrobial peptides enables cytosolic delivery and eradication of intracellular Staphylococcus aureus [0.03%]
氟烷基化抗菌肽能够进入细胞并清除胞内金黄色葡萄球菌
Tao Gao,Tiexin Liu,Junjie Shen et al.
Tao Gao et al.
Intracellular bacteria survive are difficult to eradicate by conventional antibiotics. Antimicrobial peptides (AMPs) have garnered increasing attention due to their ability to exert broad-spectrum antibacterial effects through various mecha...
Microenvironment-responsive nanomotors enable enhanced biofilm penetration and immune reprogramming for peri-implantitis therapy [0.03%]
微环境响应型纳米马达增强生物膜渗透及免疫重编程用于种植体周围炎治疗
Wanmeng Wang,Jiahao Yun,Lipeng Niu et al.
Wanmeng Wang et al.
Background: Peri-implantitis is driven by persistent multispecies biofilms and a pathological inflammatory microenvironment characterized by elevated reactive oxygen species (ROS), acidic pH, and sustained pro-inflammator...
Multifunctional nanoplatforms deciphering immune resistance in bone tumors: cooperative delivery, immune reprogramming and microenvironment remodeling [0.03%]
用于解码骨肿瘤免疫抵抗的多功能纳米平台：协同递送、重编免疫和重塑微环境
Jiahang Li,Chao Yang,Liming Wang et al.
Jiahang Li et al.
Bone tumors, encompassing primary sarcomas such as osteosarcoma and secondary skeletal metastases from carcinomas, present a stubborn clinical problem. Their treatment is hampered by three interconnected barriers: the physical impediment of...
Au clusterzymes encapsulated in nanogel activated by alternating magnetic field to promote white fat browning and combat obesity [0.03%]
用于促进白色脂肪褐变及对抗肥胖的交变磁场激活的纳米凝胶封装金团簇酶体系
Yeying Li,Mengfan Xu,Xiaona Wang et al.
Yeying Li et al.
Obesity, a major global public-health challenge, is a well-established risk factor for numerous metabolic disorders. In this study, we developed a novel nanosystem based on Au clusterzymes (AuCZy) encapsulated in chitosan (CS) and functiona...