NGO ameliorates psoriasis by modulating mitochondrial function and suppressing pSTAT3-IL-17-expressing CD8+ TRM cells [0.03%]
非编码RNA通过调节线粒体功能及抑制pSTAT3-IL-17表达的CD8⁺记忆T细胞治疗银屑病
Tae Ho Kim,Chae Rim Lee,Kyoung Min Choi et al.
Tae Ho Kim et al.
Psoriasis is a chronic autoimmune skin disorder characterized by keratinocyte hyperproliferation, persistent inflammation, and frequent relapse. Tissue-resident memory T (TRM) cells, particularly IL-17- and phosphorylated STAT3 (pSTAT3)-exp...
Machine learning for extracellular vesicles enables diagnostic and therapeutic nanobiotechnology [0.03%]
机器学习在外泌体领域的应用开启了诊断和治疗纳米生物学技术的新纪元
Ashutosh Tiwari,Widodo,Dyah Ika Krisnawati et al.
Ashutosh Tiwari et al.
Extracellular vesicles (EVs) are emerging as naturally bioactive nanomaterials with intrinsic biocompatibility and targeting potential. Recent integration of machine learning (ML) into EV research has accelerated advances in molecular profi...
Low-dose X-ray-activated radiodynamic therapy via a lutetium-coordinated nanoplatform synergizing PARP inhibition and ferroptosis [0.03%]
一种镥配位的纳米平台通过低剂量X射线激活协同PARP抑制和铁死亡的放射动力学疗法
Wanli Song,Chuanyi Zhao,Youqing Mai et al.
Wanli Song et al.
Low-dose X-ray-activated radiodynamic therapy (RDT) is a promising strategy for precision oncology. However, its therapeutic efficacy is limited by tumor radioresistance and insufficient generation of reactive oxygen species (ROS). Here, we...
High-performance photothermal GA-MoSe2 nanosheet for rapid and sensitive point-of-care detection of C-reactive protein [0.03%]
高性能光热GA-MoSe2纳米片快速灵敏床边检测C反应蛋白
Do Hyeon Kim,Chang Hyeon Ha,Han Been Lee et al.
Do Hyeon Kim et al.
In the aftermath of the global COVID-19 pandemic, there is a critical need to develop rapid and sensitive diagnostic devices for point-of-care testing (POCT). Despite the numerous benefits of paper-based colorimetric lateral flow immunoassa...
A highly photothermal stability Au@Cu2 - xSe nanoprobe for photoacoustic-imaging guided dual enhanced NIR- II photothermal/chemodynamic therapy [0.03%]
一种用于双增强近红外二区光声成像引导的高效热稳定性金@亚铜化硒纳米探针
Bei Li,Zhengqiang Chen,Yong Sun et al.
Bei Li et al.
The deep-seated locations and hypoxic microenvironments of tumors critically hinder conventional phototherapies. To overcome these limitations, we engineered a novel Au@Cu2 - xSe nanoprobe via precise aspect ratio control of gold nanorods f...
Extracellular vesicles from alveolar macrophages promotes pulmonary fibrosis through suppression of lung alveolar regeneration [0.03%]
肺泡巨噬细胞源性胞外囊泡通过抑制肺泡再生促进肺纤维化
Jiali Min,Yu Zhang,Jiahui Yang et al.
Jiali Min et al.
Pulmonary fibrosis (PF) is a type of progressive interstitial lung disease characterized by varying degrees of lung interstitial fibrosis. Lung alveolar regeneration failure in PF is critical for mediating this incurable disease. Here, we r...
NK cell biomimetic MOF nanoplatform disrupts hypoxia adaption for complete tumor ablation [0.03%]
仿生MOF纳米平台破坏低氧适应性以实现肿瘤完全消融
Li Chen,Yang Li,Jingwen Yu et al.
Li Chen et al.
Single-atom Pt doped nanoceria for enhanced cell phagocytosis and nanozyme activities in keratitis immune regulation [0.03%]
单原子Pt掺杂纳米氧化铈在角膜免疫调节中的增强吞噬作用和类酶活性
Jianguo Zhao,Wanqing Lou,Yixin Wang et al.
Jianguo Zhao et al.
During keratitis treatment, oxidative stress and inflammation often result in corneal neovascularisation, scarring, and reduced light transmittance. In this study, single-atom Pt/CeO2 is synthesized, exhibiting significantly enhanced catala...
Schwann cell-derived extracellular vesicles inhibit osteoclastogenesis through the PTEN/AKT axis in peripheral nerve-bone crosstalk [0.03%]
施万细胞源性外泌体通过PTEN/AKT信号轴抑制外周神经-骨交叉 talk 中破骨细胞的生成
Huijian Yang,Biao Yu,Ruiyang Li et al.
Huijian Yang et al.
Osteoclasts, the sole bone-resorbing cells, play a central part in bone homeostasis, and their overactivation is implicated in bone diseases such as osteoporosis. Schwann cells (SCs), the primary glial cells of the peripheral nervous system...
Improved X-ray absorption capability of Core-shell nano-transducer in situ enhances γ-ray-excited radioluminescence imaging in vivo [0.03%]
核壳纳米换能器增强γ射线激发的放射发光在体成像的能力
Rong Guo,Tianye Cao,Shaowen Yang et al.
Rong Guo et al.
Background: Radioluminescence imaging (RLI) using nanoscintillators offers great potential for biomedical applications, yet remains constrained by low quantum efficiency and the reliance of Cerenkov imaging on high-energy...