Advances in 3D printing combined with tissue engineering for nerve regeneration and repair [0.03%]
结合组织工程的3D打印在神经再生与修复中的进展
Weifang Liao,Yuying Shi,Zuguang Li et al.
Weifang Liao et al.
The repair of nerve damage has long posed a challenge owing to limited self-repair capacity and the highly differentiated nature of nerves. While new therapeutic and pharmacologic interventions have emerged in neurology, their regenerative ...
Inhibition of METTL14 overcomes CDK4/6 inhibitor resistance driven by METTL14-m6A-E2F1-axis in ERα-positive breast cancer [0.03%]
METTL14抑制可克服ERα阳性乳腺癌中由METTL14-m6A-E2F1轴驱动的CDK4/6抑制剂耐药性
Chenlin Liu,Dong Fan,Jiahui Sun et al.
Chenlin Liu et al.
CDK4/6i, the first-line drug for treating ERα-positive breast cancer, significantly improves clinical outcomes. However, CDK4/6i resistance often develops and remains a major hurdle, and the underlying mechanisms remain challenging to full...
Opportunities and challenges of bacterial extracellular vesicles in regenerative medicine [0.03%]
细菌外泌体在再生医学中的机遇与挑战
Jiming Guo,Zhijie Huang,Qinjing Wang et al.
Jiming Guo et al.
Extracellular vesicles (EVs) are membrane-bound vesicles that are shed or secreted from the cell membrane and enveloped by a lipid bilayer. They possess stability, low immunogenicity, and non-cytotoxicity, exhibiting extensive prospects in ...
Correction: Engineered a dual-targeting biomimetic nanomedicine for pancreatic cancer chemoimmunotherapy [0.03%]
纠正：工程化双靶向仿生纳米药物用于胰腺癌化疗免疫治疗
Meng Wang,Qida Hu,Junmin Huang et al.
Meng Wang et al.
Published Erratum
Journal of nanobiotechnology. 2025 Jan 4;23(1):6. DOI:10.1186/s12951-024-03033-y 2025
Facile universal strategy of presenting multifunctional short peptides for customizing desired surfaces [0.03%]
一种展示多功能短肽用于定制所需表面的简便通用策略
Ruofei Lu,Bingyang Zhao,Kaiyuan Huo et al.
Ruofei Lu et al.
Interfacial properties determine biomaterial performances, such as cell adhesion, signal exchange, and biomineralization, which affect the tissue repair cycle and efficiency of clinical applications. Peptides, as short protein sequences tha...
Mesoporous Prussian blue nanoparticle neuroconduit for the biological therapy targeting oxidative stress reduction, inflammation inhibition, and nerve regeneration [0.03%]
用于生物治疗的介孔普鲁士蓝纳米粒子神经导管，可降低氧化应激、抑制炎症和促进神经再生
Junyi Zhu,Yijia Zhang,Yinuo Sun et al.
Junyi Zhu et al.
The applications of nanomaterials in regenerative medicine encompass a broad spectrum. The functional nanomaterials, such as Prussian blue and its derivative nanoparticles, exhibit potent anti-inflammatory and antioxidant properties. By com...
Targeting AURKA with multifunctional nanoparticles in CRPC therapy [0.03%]
靶向AURKA的多功能纳米颗粒在治疗CRPC中的应用
Bin Deng,Binghu Ke,Qixing Tian et al.
Bin Deng et al.
Castration-resistant prostate cancer (CRPC) presents significant therapeutic challenges due to its aggressive nature and poor prognosis. Targeting Aurora-A kinase (AURKA) has shown promise in cancer treatment. This study investigates the ef...
Nanoparticle and microparticle-based systems for enhanced oral insulin delivery: A systematic review and meta-analysis [0.03%]
基于纳米颗粒和微粒的口服胰岛素递送增强系统：系统性评审与元分析
Carlos E Romero-Carmona,Juan I Chávez-Corona,Enrique Lima et al.
Carlos E Romero-Carmona et al.
Diabetes mellitus (DM) prevalence is rising worldwide. Current therapies comprising subcutaneous insulin injections can cause adverse effects such as lipodystrophy, local reactions like redness and swelling, fluid retention, and allergic re...
Role of PCBP2 in regulating nanovesicles loaded with curcumin to mitigate neuroferroptosis in neural damage caused by heat stroke [0.03%]
PCBP2调节载姜黄素纳米囊泡作用于中暑所致神经损伤的抑铁抗 ferrtroptosis 机制研究
Fei Guo,Yizhan Wu,Guangjun Wang et al.
Fei Guo et al.
Objective: This study aims to elucidate the mechanisms by which nanovesicles (NVs) transport curcumin(CUR) across the blood-brain barrier to treat hypothalamic neural damage induced by heat stroke by regulating the expres...
Copper-coordination driven brain-targeting nanoassembly for efficient glioblastoma multiforme immunotherapy by cuproptosis-mediated tumor immune microenvironment reprogramming [0.03%]
铜配位驱动的脑靶向纳米组装体通过铜死亡介导的肿瘤免疫微环境重编程有效治疗多形性胶质母细胞瘤
Yang Chen,Hailong Tian,Xiaodian Zhang et al.
Yang Chen et al.
Limited drug accumulation and an immunosuppressive microenvironment are the major bottlenecks in the treatment of glioblastoma multiforme (GBM). Herein, we report a copper-coordination driven brain-targeting nanoassembly (TCe6@Cu/TP5 NPs) f...