Multifunctional glycyrrhizic acid-loaded nanoplatform combining ferroptosis induction and HMGB1 blockade for enhanced tumor immunotherapy [0.03%]
兼具诱导铁死亡和阻断HMGB1功能的多功用甘草酸纳米平台可提升肿瘤免疫治疗效果
Xuan Sha,Chuanbing Wang,Yang Liu et al.
Xuan Sha et al.
Inducing ferroptotic cell death has been recognized as a promising approach in cancer therapy. However, ferroptosis can provoke tumor infiltration by myeloid-derived suppressor cells (MDSCs) through HMGB1 secretion, causing a tumor suppress...
Exosomal miR-499a-5p from human umbilical cord mesenchymal stem cells attenuates liver fibrosis via targeting ETS1/GPX4-mediated ferroptosis in hepatic stellate cells [0.03%]
人脐带间充质干细胞的外泌体miR-499a-5p通过靶向肝星状细胞中的ETS1/GPX4介导的铁死亡来减轻肝纤维化
Zheng Wang,Mengqin Yuan,Lichao Yao et al.
Zheng Wang et al.
Liver fibrosis is a leading cause of liver-related mortality worldwide, yet effective therapies remain limited. Mesenchymal stem cells (MSCs) have recently shown promise in treating liver fibrosis due to their anti-inflammatory and anti-fib...
Influence of salt solution on the physicochemical properties and in vitro/ in vivo expression of mRNA/LNP [0.03%]
盐溶液对mRNA/LNP的物理化学性质及体内外表达的影响
Siyuan Tang,Lei Huang,Jiahao Ge et al.
Siyuan Tang et al.
Lipid nanoparticles (LNPs) have revolutionized nucleic acid delivery, enabling significant advances in mRNA-based therapeutics. While extensive research has focused on lipid composition, the impact of preparation solutions on LNP performanc...
Functionalized extracellular vesicles of mesenchymal stem cells for regenerative medicine [0.03%]
用于再生医学的间充质干细胞功能化细胞外囊泡
Donghyeon Yoo,Se Young Jung,Dabin Go et al.
Donghyeon Yoo et al.
Stem cell-derived extracellular vesicles (EVs) have emerged as a safe and potent alternative to regenerative medicine in recent decades. Furthermore, the adjustment of EV functions has been recently enabled by certain stem cell precondition...
The immunogenic potential of an optimized mRNA lipid nanoparticle formulation carrying sequences from virus and protozoan antigens [0.03%]
携带病毒和原虫抗原序列的优化mRNA脂质纳米颗粒制剂的免疫潜力
Renata S Fernandes,Gabriela de Assis Burle-Caldas,Sarah Aparecida Rodrigues Sergio et al.
Renata S Fernandes et al.
Background: Lipid nanoparticles (LNP) are a safe and effective messenger RNA (mRNA) delivery system for vaccine applications, as shown by the COVID-19 mRNA vaccines. One of the main challenges faced during the development...
A multiple-crosslinked injectable hydrogel for modulating tissue microenvironment and accelerating infected diabetic wound repair [0.03%]
用于调节组织微环境和加速感染糖尿病伤口愈合的多重交联注射水凝胶
Zhengduo Zhang,Yuanyuan Ding,Huipu Yuan et al.
Zhengduo Zhang et al.
Elevated oxidative stress and inflammation, bacterial infections, and vascular impairment undoubtedly impede the normal diabetic wound healing process, which has encouraged the development of high-performance dressings for wound management....
Biomimetic gold nano-modulator for deep-tumor NIR-II photothermal immunotherapy via gaseous microenvironment remodeling strategy [0.03%]
通过气体微环境重塑策略实现深部肿瘤近红外二区光热免疫治疗的仿生金纳米调制器
Honglin Huang,Zhengxin Xie,Ningxi Li et al.
Honglin Huang et al.
Introduction: Effective immunotherapeutic treatment of solid tumors has been greatly challenged by the complex hostile tumor immunosuppressive microenvironment (TIME), which typically involves hypoxia and immunosuppressio...
Blocking copper transporter protein-dependent drug efflux with albumin-encapsulated Pt(IV) for synergistically enhanced chemo-immunotherapy [0.03%]
利用白蛋白包裹的Pt(IV)阻断铜转运蛋白依赖的药物外排以协同增强化学免疫治疗
Man Fang,Lei Cao,Zhao Zhang et al.
Man Fang et al.
Non-small cell lung cancer (NSCLC) represents the most prevalent form of lung cancer, exerting a substantial impact on global health. Cisplatin-based chemotherapy is the standard treatment for NSCLC, but resistance and severe side effects p...
Protective effects of bone marrow mesenchymal stem cell-derived exosomes loaded cerium dioxide nanoparticle against deoxynivalenol-induced liver damage [0.03%]
骨髓间充质干细胞来源的富铈纳米粒子外泌体对脱氧雪腐镰刀菌烯醇致肝损伤的保护作用
Zitong Meng,Mingmeng Tang,Shiyin Xu et al.
Zitong Meng et al.
Background: Deoxynivalenol (DON), a mycotoxin produced by Fusarium species, posed significant threats to food safety and human health due to its widespread prevalence and detrimental effects. Upon exposure, the liver, whi...
Functions and application of circRNAs in vascular aging and aging-related vascular diseases [0.03%]
circRNA在血管衰老和衰老相关血管疾病中的功能及应用
Sha-Qi He,Bei Huang,Feng Xu et al.
Sha-Qi He et al.
Circular RNAs (circRNAs), constituting a novel class of endogenous non-coding RNAs generated through the reverse splicing of mRNA precursors, possess the capacity to regulate gene transcription and translation. Recently, the pivotal role of...