Physical stimuli-responsive DNA hydrogels: design, fabrication strategies, and biomedical applications [0.03%]
物理刺激响应的DNA水凝胶：设计、制造策略及生物医学应用
Rumi Acharya,Sayan Deb Dutta,Hemadri Mallik et al.
Rumi Acharya et al.
Physical stimuli-responsive DNA hydrogels hold immense potential for tissue engineering due to their inherent biocompatibility, tunable properties, and capacity to replicate the mechanical environment of natural tissue, making physical stim...
DNAzyme hydrogels specifically inhibit the NLRP3 pathway to prevent radiation-induced skin injury in mice [0.03%]
DNAzyme水凝胶特异性抑制NLRP3通路以预防小鼠发生放射性皮肤损伤
Daijun Zhou,Zhihui Li,Linbo Bao et al.
Daijun Zhou et al.
Radiation-induced skin injury (RISI) is a frequent complication of radiotherapy, yet current preventive strategies exhibit suboptimal efficacy. Our previous publications have consistently demonstrated the effectiveness of biomaterials and h...
Revolutionizing lung cancer treatment: harnessing exosomes as early diagnostic biomarkers, therapeutics and nano-delivery platforms [0.03%]
revolution化的肺癌治疗：利用外泌体作为早期诊断的生物标志物、治疗药物和纳米输送平台
Qiyao Xiao,Minhong Tan,Ge Yan et al.
Qiyao Xiao et al.
Lung cancer, known for its high morbidity and mortality rates, remains one of the most critical health challenges globally. Conventional treatment options, such as chemotherapy and surgery, are often limited by high costs, significant side ...
Reducing severity of inflammatory bowel disease through colonization of Lactiplantibacillus plantarum and its extracellular vesicles release [0.03%]
通过植物乳杆菌定植及其胞外囊泡释放来降低炎症性肠病的严重程度
Yuanyuan Wu,Xinyue Huang,Qianbei Li et al.
Yuanyuan Wu et al.
Inflammatory bowel disease (IBD) is characterized by compromised intestinal barrier function and a lack of effective treatments. Probiotics have shown promise in managing IBD due to their ability to modulate the gut microbiota, enhance inte...
Intranasal delivery of engineered extracellular vesicles promotes neurofunctional recovery in traumatic brain injury [0.03%]
工程细胞外囊泡的鼻内递送促进创伤性脑损伤后的神经功能恢复
Pengtao Li,Sishuai Sun,Xingyu Zhu et al.
Pengtao Li et al.
Traumatic brain injury (TBI) is a leading cause of disability in adults, significantly affecting patients' quality of life. Extracellular vesicles (EVs) derived from human adipose-derived mesenchymal stem cells (hADSCs) have demonstrated th...
Selenium nanoparticles activate selenoproteins to mitigate septic lung injury through miR-20b-mediated RORγt/STAT3/Th17 axis inhibition and enhanced mitochondrial transfer in BMSCs [0.03%]
硒纳米颗粒通过miR-20b介导的RORγt/STAT3/Th17轴抑制和增强BMSC中的线粒体转移来激活硒蛋白以减轻脓毒症肺损伤
Wan-Jie Gu,Feng-Zhi Zhao,Wei Huang et al.
Wan-Jie Gu et al.
Sepsis-induced acute lung injury (ALI) remains a critical clinical challenge with complex inflammatory pathogenesis. While bone marrow mesenchymal stem cells (BMSCs) demonstrate therapeutic potential through anti-inflammatory and cytoprotec...
Sijie Tang,Huiying Cheng,Xueyan Zang et al.
Sijie Tang et al.
Small extracellular vesicles (sEVs) play a critical role in the progression, diagnosis, and treatment of prostate cancer (PCa), particularly within the tumor microenvironment (TME). Acting as novel biomarkers and agents for targeted biologi...
ZnO-Cu/Mn nanozyme for rescuing the intestinal homeostasis in Salmonella-induced colitis [0.03%]
ZnO- Cu/Mn纳米酶用于解救沙门氏菌诱导性结肠炎中的肠道稳态失衡
Aimin Wu,Chen Liang,WenShuang Chen et al.
Aimin Wu et al.
Salmonella is one of the most common foodborne pathogens, which can cause severe enteritis and intestinal microbiota imbalance. However, there are limited strategies currently available for preventing or treating Salmonella-induced colitis....
miRNA let-7f-5p-encapsulated labial gland MSC-derived EVs ameliorate experimental Sjögren's syndrome by suppressing Th17 cells via targeting RORC/IL-17A signaling axis [0.03%]
通过靶向RORC/IL-17A信号轴封装miRNA let-7f-5p的唇腺MSC衍生外泌体通过抑制Th17细胞改善实验性干燥综合征
Yufei Xie,Maosheng Chai,Yixiao Xing et al.
Yufei Xie et al.
Sjögren's syndrome (SS) is an autoimmune disease primarily affecting salivary glands, with xerostomia as a distinct clinical manifestation. This disease also poses a significantly increased risk of lymphoma, severely impacting patients' qu...
Micro/Nanoplastics in plantation agricultural products: behavior process, phytotoxicity under biotic and abiotic stresses, and controlling strategies [0.03%]
种植农作物中的微/纳米塑料：行为过程、生物和非生物压力下的植物毒性及控制策略
Zhihao Lin,Donghui Xu,Yiming Zhao et al.
Zhihao Lin et al.
With the extensive utilization of plastic products, microplastics/nanoplastics (MPs/NPs) contamination not only poses a global hazard to the environment, but also induces a new threat to the growth development and nutritional quality of pla...