3D printed shape-memory piezoelectric scaffolds with in-situ self-power properties for bone defect repair [0.03%]
用于骨缺损修复的具有原位自供电性能的3D打印形状记忆压电支架
Bing Li,Yichao Ma,Kanwal Fatima et al.
Bing Li et al.
Electrical stimulation has been shown to regulate early immunity and late-stage osteogenesis in bone repair. However, achieving in-situ electrical stimulation in the form of self-power in vivo during the initial postoperative stages when th...
Single-atom Zr doped heterojunction enhanced piezocatalysis for implant infection therapy through synergistic metal immunotherapy with sonodynamic and physical puncture [0.03%]
单原子Zr掺杂异质结增强压电催化通过协同金属免疫疗法与声动力和物理穿刺治疗植入感染
Xing Zhou,Jingbo Xie,Xingchen Zhou et al.
Xing Zhou et al.
Recent common clinical treatments for implant bacterial infections involve replacing inert implants and using antibiotics. However, these methods remain limited in their effectiveness for pathogen clearance, immune regulation, and osteogene...
In situ construction of heterojunctions to regulate the biodegradation behavior of copper carriers for tumor-specific cuproptosis-enhanced sono-immunotherapy [0.03%]
原位构建异质结以调控铜载体的生物降解行为实现肿瘤特异性铜死亡增强型声动力免疫治疗
Xiqian Cao,Lingwei Mao,Yijun Tian et al.
Xiqian Cao et al.
Cuproptosis, a novel approach utilizing copper carriers to trigger programmed cell death, exhibits promise for enhancing traditional therapies and activating robust adaptive immune responses. However, the uncontrolled release of Cu ions ris...
Recombinant human collagen hydrogels with different stem cell-derived exosomes encapsulation for wound treatment [0.03%]
用于伤口处理的不同干细胞衍生外泌体包封的重组人胶原水凝胶
Xiaoman Zeng,Jingjing Gan,Danqing Huang et al.
Xiaoman Zeng et al.
Exosomes-loaded hydrogels have potential value in wound treatment. Current studies focus on improving hydrogels' biocompatibility and optimizing different stem cell-derived exosomes for better therapeutic effect. Herein, we present a novel ...
Nanocomposite-based PCR reactors to enhance thermal rate and fluorescence intensity in hand-held qPCR device [0.03%]
基于纳米复合材料的PCR反应器可提升手持式qPCR设备中的热速率和荧光强度
Jiyeon Han,Tiara A M,Seongryeong Kim et al.
Jiyeon Han et al.
A photonic quantitative polymerase chain reaction (qPCR) has usually implemented a polydimethylsiloxane (PDMS) based disposable inexpensive PCR reactor, worked as the photothermal cycler, to show potential as a point-of-care test (PoCT) for...
Radiotherapy-derived engineered stem cell exosomes improve anti-glioma immunotherapy by promoting the formation of tertiary lymphoid structure and improve the release of type I interferon [0.03%]
放射治疗衍生的工程化干细胞外泌体通过促进三级淋巴结构形成和提高I型干扰素的释放来改善抗胶质瘤免疫治疗
Man Li,Lisen Lu,Qiuhong Bao et al.
Man Li et al.
The absence of signaling pathways related to intrinsic immune activation in tumor cells and the immunosuppressive microenvironment limit lymphocyte infiltration, constitutes an "immune-desert" tumor displaying insensitivity to various immun...
Recombinant high-density lipoprotein targeted delivery of celastrol to promote foam cells lipophagy against early atherosclerosis [0.03%]
重组高密度脂蛋白介导雷公藤红素靶向泡沫细胞溶酶体途径治疗早发性动脉粥样硬化
Yang Li,Xiaoxia Xue,Liuchunyang Yu et al.
Yang Li et al.
Introduction: Atherosclerosis serving as the main underlying factor of cardiovascular disease (CVD) remains the primary cause of mortality and morbidity globally, while the deposition of massive cholesterol in macrophage-...
Microalgae-based biodegradable embolic agent for the treatment of hepatocellular carcinoma through transarterial embolization [0.03%]
基于微藻的可降解栓塞剂通过经动脉栓塞治疗肝细胞癌
Kaiyue Wang,Danni Zhong,Lingxiao Yang et al.
Kaiyue Wang et al.
Transarterial chemoembolization (TACE) serves as a locoregional therapy for hepatocellular carcinoma (HCC) patients. Nevertheless, the rapid dissociation of conventional TACE (cTACE) preparations, attributed to the instability of the emulsi...
Rationally designed NIR-II excitable and endoplasmic reticulum-targeted molecular phototheranostics for imaging-guided enhanced photoimmunotherapy of triple-negative breast cancer [0.03%]
合理设计的近红外二区可激发内质网靶向分子光疗诊断技术用于影像引导增强三阴性乳腺癌光免疫治疗
Fen Liu,Qiang Kang,Hao Xiao et al.
Fen Liu et al.
Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer characterized by an extremely poor prognosis. Photoimmunotherapy has emerged as a promising strategy for the treatment of TNBC. This approach works by sele...
Diselenide-based nanoparticles enhancing the radioprotection to the small intestine of mice [0.03%]
基于硒化物的纳米颗粒可增强小鼠的小肠辐射防护作用
Yichi Huang,Jiaze Li,Sen Wang et al.
Yichi Huang et al.
The widespread application of ionizing radiation (IR) in medicine, while beneficial, also poses potential risks that necessitate effective countermeasures. Both 2-(3-aminopropylamino) ethanethiol (WR-1065) and curcumin are recognized as rad...