Enhancing hepatocellular carcinoma therapy with DOX-loaded SiO2 nanoparticles via mTOR-TFEB pathway autophagic flux inhibition [0.03%]
通过mTOR-TFEB途径自噬流抑制以加载DOX的SiO2纳米粒子增强肝细胞癌治疗
Huanyu Chen,Jun Liu,Zhichao Cao et al.
Huanyu Chen et al.
Chemotherapeutic drugs often fail to provide long-term efficacy due to their lack of specificity and high toxicity. To enhance the biosafety and reduce the side effects of these drugs, various nanocarrier delivery systems have been develope...
Rational design of a triple-type HPV53/56/66 vaccine with one preferable base particle incorporating two identified immunodominant sites [0.03%]
一种基于单一结构单元同时包含两种HPV主要免疫原位点的三型疫苗的设计
Ciying Qian,Jie Chen,Yurou Yang et al.
Ciying Qian et al.
The numerous high-risk carcinogenic types of human papillomavirus (HR-HPV) that lack vaccine protection underscore the urgent need to develop broader-spectrum HPV vaccines. This study addresses this need by focusing on HR-HPV types 53, 56, ...
Ultrabright contrast agents with synergistic Raman enhancements for precise intraoperative imaging and photothermal ablation of orthotopic tumor models [0.03%]
用于原位肿瘤模型精准术中影像及光热消融的超亮对比剂和拉曼协同增强技术
Yiqun Ma,Shuchi Xia,Annan Hu et al.
Yiqun Ma et al.
Background: Intraoperative imaging is critical for achieving precise cancer resection. Among available techniques, Raman spectral imaging emerges as a promising modality due to its high spatial resolution and signal stabi...
Therapeutic delivery of oxygen using artificial oxygen carriers demonstrates the possibility of treating a wide range of diseases [0.03%]
使用人工氧载体输送氧气进行治疗展示了治疗广泛疾病的可能性
Nijaya Mohanto,Himangsu Mondal,Young-Joon Park et al.
Nijaya Mohanto et al.
Artificial oxygen carriers have emerged as potential substitutes for red blood cells in situations of major blood loss, including accidents, surgical procedures, trauma, childbirth, stomach ulcers, hemorrhagic shock, and blood vessel ruptur...
Biofunctionalized patterned platform as microarray biochip to supervise delivery and expression of pDNA nanolipoplexes in stem cells via mechanotransduction [0.03%]
用于监督经机械转导的干细胞中pDNA纳米脂复合物递送和表达的生物功能化微图案化平台-微阵列芯片
Mingkui Shen,Yan Hou,Shihui Xu et al.
Mingkui Shen et al.
Biochips are widely applied to manipulate the geometrical morphology of stem cells in recent years. Patterned antenna-like pseudopodia are also probed to explore the influence of pseudopodia formation on gene delivery and expression on bioc...
Correction: Silver nanoparticle induced immunogenic cell death can improve immunotherapy [0.03%]
纠正：银纳米颗粒诱导的免疫原性细胞死亡可以改善免疫治疗
Ara Sargsian,Xanthippi Koutsoumpou,Hermon Girmatsion et al.
Ara Sargsian et al.
Published Erratum
Journal of nanobiotechnology. 2025 Jan 17;23(1):21. DOI:10.1186/s12951-024-03081-4 2025
M cells targeted H. pylori antigen SAM-FAdE displayed on bacterium-like particles induce protective immunity [0.03%]
靶向M细胞的幽门螺旋杆菌抗原SAM-FAdE菌样颗粒疫苗诱导保护性免疫反应
Furui Zhang,Jiale Chen,Zhen Zhang et al.
Furui Zhang et al.
Background: Helicobacter pylori (H. pylori), a specific bacterium capable of surviving in the acidic environment of the stomach, has been recognized as a group of causative agents of gastric cancer. Therefore, the develop...
Organoid development and applications in gynecological cancers: the new stage of tumor treatment [0.03%]
类器官在妇科肿瘤治疗中的发展和应用：治疗新阶段
Yang Li,Meiying Qin,Ning Liu et al.
Yang Li et al.
Gynecologic cancers (GCs), including cervical cancer (CC), ovarian cancer (OC), endometrial cancer (EC), as well as vulvar and vaginal cancers, represent major health threats to women, with increasing incidence rates observed globally. Conv...
MOF-derived intelligent arenobufagin nanocomposites with glucose metabolism inhibition for enhanced bioenergetic therapy and integrated photothermal-chemodynamic-chemotherapy [0.03%]
一种用于增强生物能治疗的智能 Arenobufagin 纳米复合材料，具有代谢抑制功能，并集成了光热和化学动力及化疗效应的多功能MOF衍生材料
Lihua Chen,Jiaying Yang,Lingyu Jia et al.
Lihua Chen et al.
Bioenergetic therapy based on tumor glucose metabolism is emerging as a promising therapeutic modality. To overcome the poor bioavailability and toxicity of arenobufagin (ArBu), a MOF-derived intelligent nanosystem, ZIAMH, was designed to f...
Critical updates on oral insulin drug delivery systems for type 2 diabetes mellitus [0.03%]
口服胰岛素递药系统治疗二型糖尿病的新进展ritical updates on oral insulin drug delivery systems for type 2 diabetes mellitus
Chan Yew Low,Wei Ling Gan,Su Jeat Lai et al.
Chan Yew Low et al.
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by insulin resistance, leading to elevated blood sugar levels. Exogenous insulin can counteract the diminished response to insulin and effectively controlling blood gluco...