Emerging strategies for nitric oxide production and their topical application as nanodressings to promote diabetic wound healing [0.03%]
用于促进糖尿病伤口愈合的纳米敷料 topical 应用的一氧化氮生成新策略
Dan Xia,Ying Guo,Ruodan Xu et al.
Dan Xia et al.
The challenges associated with prolonged healing or non-healing of chronic diabetic wounds contribute significantly to the increased incidence of lower limb amputation. A pivotal factor in the impediment of healing is the reduced production...
Avian influenza mRNA vaccine encoding hemagglutinin provides complete protection against divergent H5N1 viruses in specific-pathogen-free chickens [0.03%]
禽流感mRNA疫苗的血凝素抗原对无特定病原鸡感染不同H5N1病毒株具有完全保护力
Zhaoyang Wang,Chongyu Tian,Jiahang Zhu et al.
Zhaoyang Wang et al.
Background: The rapid mutation of avian influenza virus (AIV) poses a significant threat to both the poultry industry and public health. Herein, we have successfully developed an mRNA-LNPs candidate vaccine for H5 subtype...
Dual-mode-driven nanomotors targeting inflammatory macrophages for the MRI and synergistic treatment of atherosclerosis [0.03%]
双模式驱动的纳米马达靶向炎症性巨噬细胞用于动脉粥样硬化磁共振成像和协同治疗
Min Wei,Qiaoji Jiang,Shuang Bian et al.
Min Wei et al.
With the progress of atherosclerosis (AS), the arterial lumen stenosis and compact plaque structure, the thickening intima and the narrow gaps between endothelial cells significantly limit the penetration efficiency of nanoprobe to plaque, ...
Epidermal stem cell derived exosomes-induced dedifferentiation of myofibroblasts inhibits scarring via the miR-203a-3p/PIK3CA axis [0.03%]
表皮干细胞源外泌体通过 miR-203a-3p/PIK3CA 轴将肌成纤维细胞去分化为皮肤再生中抗瘢痕的干细胞样细胞
Shixin Zhao,Haoran Kong,Dahu Qi et al.
Shixin Zhao et al.
Hypertrophic scar (HS) is a common fibroproliferative disorders with no fully effective treatments. The conversion of fibroblasts to myofibroblasts is known to play a critical role in HS formation, making it essential to identify molecules ...
Anti-inflammatory coupled anti-angiogenic airway stent effectively suppresses tracheal in-stents restenosis [0.03%]
一种抗炎及抗血管生成化气道内支架可有效抑制气管内支架再狭窄
Yanan Zhao,Yiming Liu,Jiheng Shan et al.
Yanan Zhao et al.
Excessive vascularization during tracheal in-stent restenosis (TISR) is a significant but frequently overlooked issue. We developed an anti-inflammatory coupled anti-angiogenic airway stent (PAGL) incorporating anlotinib hydrochloride and s...
CT-sensitized nanoprobe for effective early diagnosis and treatment of pulmonary fibrosis [0.03%]
用于有效早期诊断和治疗肺纤维化的CT敏化纳米探针
Jiwei Hou,Qijian Ji,Tianyu Tang et al.
Jiwei Hou et al.
Early diagnosis is critical for providing a timely window for effective therapy in pulmonary fibrosis (PF); however, achieving this remains a significant challenge. The distinct honeycombing patterns observed in computed tomography (CT) for...
Prominosomes - a particular class of extracellular vesicles containing prominin-1/CD133? [0.03%]
prominosome-一种含 prominin-1/cd133 的细胞外囊泡？
Jana Karbanová,Kristina Thamm,Christine A Fargeas et al.
Jana Karbanová et al.
Extracellular membrane vesicles (EVs) offer promising values in various medical fields, e.g., as biomarkers in liquid biopsies or as native (or bioengineered) biological nanocarriers in tissue engineering, regenerative medicine and cancer t...
A new NCL-targeting aptamer-drug conjugate as a promising therapy against esophageal cancer [0.03%]
一种针对NCL的新适配体-药物缀合物有望成为治疗食道癌的疗法
Xue Zheng,Ying Wang,Huaiyu Duan et al.
Xue Zheng et al.
Esophageal cancer (EC) is one of the most common highly malignant tumors of the digestive system, with a poor prognosis under current treatment regimens. Nucleolin (NCL) is overexpressed in many tumors, and drugs specifically targeting NCL ...
Peripheral nerves modulate the peri-implant osteogenesis under type 2 diabetes through exosomes derived from schwann cells via miR-15b-5p/Txnip signaling axis [0.03%]
外周神经通过雪旺细胞衍生的微泡中的miR-15b-5p / TxnIp信号轴在2型糖尿病中调节 peri-植入骨发生
Yingying Wang,Fang Qu,Yaqin Wu et al.
Yingying Wang et al.
Studies have shown that the prognosis of dental implant treatment in patients with diabetes is not as good as that in the non-diabetes population. The nerve plays a crucial role in bone metabolism, but the role and the mechanism of peripher...
aPD-L1-facilitated theranostic and tumor microenvironment remodeling of pancreatic cancer via docetaxel-loaded phase-transformation nanoparticles triggered by low-intensity pulsed ultrasound [0.03%]
通过低强度脉冲超声触发的多西他赛载相变纳米粒介导的胰腺癌免疫治疗及肿瘤微环境重塑研究
Yi Tang,Qingling Shen,Peng Lin et al.
Yi Tang et al.
Early diagnosis of pancreatic ductal adenocarcinoma (PDAC) is challenging because of its depth, which often leads to misdiagnosis during ultrasound examinations. The unique PDAC tumor microenvironment (TME) is characterized by significant f...