A novel preclinical strategy for diabetic wound: CITED2-loaded hydrogel spray targeted macrophage reprogramming [0.03%]
一种新颖的糖尿病伤口临床前策略：CITED2载药水凝胶喷雾剂实现巨噬细胞重编程
Xichao Jian,Jingjie Shao,Shihan Tang et al.
Xichao Jian et al.
Diabetic wounds resent a considerable clinical challenge due to impaired healing, which results from persistent inflammation and dysregulated macrophage polarization. This study identifies CITED2 as a critical regulator of diabetic wound re...
A novel pH-responsive nanoreactor for pyroptosis induction: multifaceted ROS amplification drives potent immunotherapy against triple-negative breast cancer [0.03%]
一种新型的pH响应型纳米反应器通过多方面ROS放大诱导焦亡从而用于治疗三阴性乳腺癌的高效免疫疗法
Wenjia Liu,Ying Wang,Xiangyu Hao et al.
Wenjia Liu et al.
Triple-negative breast cancer (TNBC) is associated with rapid progression and poor sensitivity to monotherapies, necessitating combination strategies to enhance tumor immunogenicity, reprogram the tumor microenvironment (TME), and convert i...
Beyond apoptosis: nanomedicine enabled reprogramming of tumor cell death for next-generation radiosensitization [0.03%]
超越凋亡：启用纳米医学肿瘤细胞死亡重编程的下一代放射增敏疗法
Xin Ye,Yunfeng Tao,Yu Min et al.
Xin Ye et al.
Radiotherapy remains a cornerstone in the clinical management of malignancies, leveraging DNA damage and oxidative stress to eradicate tumor cells. Nonetheless, the emergence of intrinsic and acquired radioresistance significantly compromis...
Size-shrinking nanoparticles with high drug-protein payload for efficient, non-invasive treatment of corneal neovascularization [0.03%]
高效无创治疗角膜新生血管的药物-蛋白载量高且尺寸缩小的纳米颗粒
Xiaoling Xie,Zhenyang Xiang,Ruhui Yang et al.
Xiaoling Xie et al.
Corneal neovascularization (CNV) is one of the leading causes of corneal blindness, affecting millions of people worldwide. Anti-vascular endothelial growth factor agents, such as Bevacizumab (Beva), offer high specificity and low side effe...
Extremophyte-derived exosome-like nanovesicles remodel intestinal barrier dysfunction by multi-dimensional intervention: physical barrier repair with immune homeostasis and microbiome regulation [0.03%]
极端植物源外泌体类似纳米囊泡通过多维度干预重塑肠屏障功能障碍：物理屏障修复、免疫稳态和微生态调节
Dan Li,Linqian Du,Gaoyang Yi et al.
Dan Li et al.
Background: Intestinal barrier is the body's largest immune structure and essential for nutrient absorption. Its dysfunction allows the translocation of pathogenic substances into circulation, thereby driving the pathogen...
An ECM-mimetic hydrogel for disc repair: reconstituting hypoxia and alleviating NPC senescence to halt intervertebral disc degeneration [0.03%]
一种用于椎间盘修复的ECM模拟水凝胶：重构低氧，缓解NPC衰老以阻止椎间盘退变
Yifan Wang,Minglang Zou,Junyao Cheng et al.
Yifan Wang et al.
Intervertebral disc degeneration, the leading cause of chronic low back pain, remains incurable with traditional conservative therapies limited to symptomatic alleviation. We present an ECM-mimetic injectable hydrogel (HPTC) synthesized via...
The role of AI-assisted drug repurposing in neurological disorders: a systematic review of validation strategies, challenges and opportunities [0.03%]
人工智能辅助药物再定位在神经性疾病中的作用：系统分析验证策略、挑战及机遇
Fengshou Chen,Limei Wang,Hao Liu et al.
Fengshou Chen et al.
Neurological disorders refer to a diverse group of conditions that affect the brain, peripheral nerves, and spinal cord and impair socioemotional, cognitive, motor, and sensory functions. Alzheimer's disease (AD), Multiple Sclerosis (MS), P...
Bioinspired layer-by-layer nanoengineering for dental hard tissue regeneration and caries prevention [0.03%]
受生物启发的分层纳米工程技术在牙硬组织再生和龋齿防治中的应用研究
Yuyan Li,Jue Lan,Lingshan Ran et al.
Yuyan Li et al.
Dental caries, a chronic disease resulting from bacterial demineralization of dental hard tissues, poses a significant global health challenge. Remineralization therapy presents a promising strategy to arrest caries progression and restore ...
Mechano-reprogramming of tumor-associated macrophages by engineering nanogel stiffness for suppression of tumor development [0.03%]
通过工程纳米凝胶刚度对肿瘤相关巨噬细胞进行机械编程以抑制肿瘤发展
Haochen Lin,Zheng Li,Ao Hua et al.
Haochen Lin et al.
Nanoparticle mechanical properties, as critical factors in tumor targeting drug delivery, have recently been revealed to regulate cellular biological functions. While macroscopic mechanical stimuli are demonstrated to reprogram tumor-associ...
Tetrasulfide-bridged virus-like particles enable host-sparing cascade membrane-metabolic disruption for drug-resistant bacterial keratitis [0.03%]
四硫化物桥联病毒样颗粒通过宿主保守的膜-代谢扰动途径治疗耐药细菌性角膜炎
Wenlong Li,Qingdong Bao,Qinghua Li et al.
Wenlong Li et al.
Drug-resistant bacterial keratitis remains difficult to treat because anatomical barriers and biofilm-associated tolerance restrict antibacterial access and efficacy. Intensifying bactericidal activity can enhance bacterial clearance, but m...