M1 macrophage-derived migrasomes ameliorate temporomandibular joint osteoarthritis via autophagy [0.03%]
M1 巨噬细胞衍生的迁徙体通过自噬缓解颞下颌关节骨关节炎
Guoliang Sa,Zhongyang Zou,Haoyu Zhou et al.
Guoliang Sa et al.
Diameter-dependent effects of nanopillar arrays on PEEK bioactivity and soft tissue integration [0.03%]
纳米柱阵列对peek生物活性和软组织整合的直径依赖性影响
Xi Liu,Yuqi Zhao,Hui Liu et al.
Xi Liu et al.
Poly-Ether-Ether-Ketone (PEEK) is a promising material for bony structure defects reconstruction due to its favorable mechanical properties and radiolucency. However, its clinical application is limited by poor soft tissue integration resul...
Dual tumor microenvironment-responsive albumin nanoplatform integrates conditional PROTAC activation with starvation and ferroptosis for synergistic cancer therapy [0.03%]
一种双肿瘤微环境响应型白蛋白纳米平台通过条件性PROTAC激活与饥饿及铁死亡诱导实现协同抗肿瘤作用
Lingting Lin,Binyu Chen,Yourui Yang et al.
Lingting Lin et al.
Background: Proteolysis-targeting chimeras (PROTACs) have emerged as a promising cancer therapeutic approach by targeting protein degradation to address undruggable targets and drug resistance associated with conventional...
Microneedle-based delivery of cell membrane vesicles as IL-17RA decoys for Psoriasis treatment [0.03%]
用于银屑病治疗的基于微针的细胞膜囊泡递送以IL-17RA为诱饵
Bin Tu,Weifeng Fang,Lin Liu et al.
Bin Tu et al.
The dysregulation of IL-17/IL-17 receptor A (IL-17RA) signaling axis is a central driver of multiple autoimmune diseases. In contrast to targeting individual IL-17 cytokines, blocking IL-17RA simultaneously inhibits the receptor engagement ...
Photothermal reprogramming of synovial M1 macrophages reshapes the pro-inflammatory microenvironment to reverse temporomandibular joint osteoarthritis [0.03%]
光热重新编程滑膜M1巨噬细胞重塑促炎微环境以逆转颞下颌关节骨关节炎
Yanyi Wang,Jiangyan Ren,Tingyu Ren et al.
Yanyi Wang et al.
Temporomandibular joint osteoarthritis (TMJOA) involves progressive synovial inflammation-driven cartilage degeneration. While thermotherapy empirically alleviates symptoms, its immunomodulatory mechanism remains elucidated. Here, we reveal...
Photothermal-responsive MXene/curcumin-copper composite hydrogel with antioxidant, immunoregulatory, and angiogenic functions for diabetic wound healing [0.03%]
一种用于糖尿病伤口愈合的具有抗氧化、免疫调节和促血管生成功能的光热响应MXene/姜黄素-铜复合水凝胶
Tao Liao,Xiaomei Wu,Jinyu Wang et al.
Tao Liao et al.
Advanced strategies for the diagnosis, treatment, and vaccination of monkeypox [0.03%]
猴痘诊断、治疗和疫苗接种的先进策略
Wei Wang,Qiuxia Gao,Yongchao Li et al.
Wei Wang et al.
Monkeypox (Mpox), a zoonotic disease caused by the mpox virus, has been endemic mainly in West and Central Africa for a long time, with only a few cases in other parts of the world. However, recent multi-country outbreaks in non-endemic are...
Multifunctional copper-based nanoparticles potentiate colorectal cancer immunotherapy via synergistic metabolic remodeling and cGAS-STING pathway activation [0.03%]
多功能铜基纳米粒子通过协同代谢重塑和cGAS-STING途径激活增强结直肠癌免疫治疗
Maopu Tu,Xiaoyu Deng,Zhiyong Zhou et al.
Maopu Tu et al.
Microsatellite-stable (MSS) colorectal cancer (CRC) resists immunotherapy due to its immunosuppressive tumor microenvironment (TME). The cGAS-STING pathway, a key regulator of innate immunity, offers a promising strategy to overcome the imm...
Methyl gallate and hyaluronic acid-nanoconjugate targeting HSP90β for osteoarthritis therapy [0.03%]
甲基棓酸酯和透明质酸-纳米缀合物靶向HSP90β用于治疗骨关节炎
Anping Shen,Xuan Mo,Yan Chen et al.
Anping Shen et al.
Background: Osteoarthritis (OA) is a joint disease with complicated pathophysiologic process, however, the lack of effective therapeutic targets and corresponding pharmaceuticals severely limits treatment options. ...
Ferroptosis-driven in situ vaccine-like antitumor effects: NIR-triggered IFBM hydrogel synergizes with sorafenib to unleash systemic antitumor immunity [0.03%]
铁死亡驱动的原位疫苗样抗肿瘤效应：近红外触发的IFBM水凝胶与索拉非尼协同作用以释放系统性抗肿瘤免疫响应
Zilong Jiang,Rui Fu,Pengping Li et al.
Zilong Jiang et al.
The immunosuppressive tumor microenvironment and immune evasion mechanisms inhibit the development of effective antitumor responses and enduring immune memory, thereby diminishing the efficacy of cancer immunotherapy. In situ vaccines (ISVs...