MIL-53(Fe)-Glucose self-assembled complex for enhanced angiogenesis and endothelial tip cell activation [0.03%]
用于增强血管生成和内皮尖细胞活化的MIL-53(Fe)-葡萄糖自组装复合物
Jie Wu,Leyi Liu,Runze Li et al.
Jie Wu et al.
Critical bone defects continue to pose a critical challenge in clinical settings. Facilitating rapid and thorough vascularization during bone regeneration is advantageous for the repair of substantial bone defects. Presently, the applicatio...
Human serum albumin-based KBiF4@HSA nanoclusters for dual-energy computed tomography and glutathione-scavenging radiotherapy of breast cancer [0.03%]
人血清白蛋白基KBiF4@HSA纳米团簇用于乳腺癌的双能量CT和谷胱甘肽清除型放射治疗
Yuelin Huang,Zhenghai Lu,Huanhuan Liu et al.
Yuelin Huang et al.
Background: Breast cancer remains the most common malignancy among women worldwide. While traditional computed tomography (CT) scans and image-guided radiotherapy are widely used for breast cancer diagnosis and treatment,...
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acids: advances and challenges [0.03%]
外泌体作为靶向大脑递送治疗性核酸的纳米载体：进展与挑战
Nima Sanadgol,Mohsen Abedi,Masoud Hashemzaei et al.
Nima Sanadgol et al.
Recent advancements in gene expression modulation and RNA delivery systems have underscored the immense potential of nucleic acid-based therapies (NA-BTs) in biological research. However, the blood-brain barrier (BBB), a crucial regulatory ...
Baicalin targets YTHDC2 and alleviates male reproductive toxicity caused by co-exposure to nanoplastics and manganese through m6A-dependent pathway [0.03%]
靶向YTHDC2的柴胡皂苷d通过m6A依赖性通路缓解纳米塑料和锰共暴露引起的雄性生殖毒性
Yi Wen,Tingwei Pan,Lu Liu et al.
Yi Wen et al.
Nanoplastics (NPs) pollution has become a pressing global environmental issue. NPs possess the ability to adsorb heavy metals, thereby acting as vectors that facilitate the entry of these toxic substances into living organisms. However, the...
Bacterial extracellular biomolecules-derived multimodal manganese nanoparticles control watermelon Fusarium wilt by dysregulating fusaric acid biosynthesis pathway and precise tuning of rhizosphere metabolome [0.03%]
细菌外源生物分子衍生的多模态锰纳米颗粒通过调控菌丝代谢组精细调节和扰乱伏革酸生物合成途径控制瓜萎病
Muhammad Noman,Temoor Ahmed,Mohammad Shafiqul Islam et al.
Muhammad Noman et al.
Fusarium wilt, caused by Fusarium oxysporum f. sp. niveum (Fon), poses a significant threat to watermelon production globally. Traditional control methods often rely on chemical fungicides, which pose environmental risks and limited long-te...
Targeting circulating tumor cell‒neutrophil interactions: nanoengineered strategies for inhibiting cancer metastasis [0.03%]
靶向循环肿瘤细胞-中性粒细胞相互作用：抑制癌症转移的纳米工程技术策略
Yong Su,Mingjing Leng,Qingqing Yang et al.
Yong Su et al.
Metastasis remains the leading cause of cancer-related mortality, with a persistently poor prognosis for metastatic cancer patients despite extensive therapeutic efforts. Circulating tumor cells (CTCs), which detach from primary tumors and ...
An immune activator encapsulating PD-L1 siRNA for augmented immune checkpoint blockade immunotherapy through Zn2+ overload triggered pyroptosis [0.03%]
一种免疫激活剂，通过Zn2+超载触发细胞焦亡递送PD-L1 siRNA，以增强免疫检查点阻断免疫疗法
Liming Gong,Yanhong Liu,Jing Feng et al.
Liming Gong et al.
Breast cancer as a "cold" tumor presents an immunosuppressive microenvironment and inferior T-lymphocyte infiltration, leading to poor efficacy of immune checkpoint blockade (ICB) therapies. It is urgent to develop new effective combination...
BPQDs@Lipo-YSA Nanoplatform Triggers Mitophagy via PRKN/AKT1 to Drive Immunogenic Cell Death in Lung Adenocarcinoma [0.03%]
BPQD@Lipo-YSA纳米平台通过PRKN/AKT1触发线粒体自噬驱动肺腺癌免疫原性细胞死亡
Li Ai,Zhijuan Liu,Ran Li et al.
Li Ai et al.
Background: Lung adenocarcinoma, the most common type of non-small cell lung cancer (NSCLC), is a leading cause of cancer-related deaths globally due to its high incidence and treatment difficulty. Despite recent advancem...
Biosynthesized nanoparticles of Tibetan medicine mercuric sulfide preparation to promote endocytosis and realize drug crossing through blood brain barrier [0.03%]
藏药朱砂药材生物合成纳米颗粒促进内吞实现药物穿越血脑屏障研究
Wenjing Jia,Huilan Yue,Liying Liu et al.
Wenjing Jia et al.
β-HgS as the main component of Tibetan medicine Zuotai (ZT) is widely used in the treatment of central nervous system diseases. Although the synergism of HgS has been clinically verified for more than 2000 years, its synergetic mechanism i...
A self-adhesive hierarchical nanofiber patch for dynamic and multistage management of full-thickness cutaneous wounds [0.03%]
一种自粘分层纳米纤维补丁用于全层皮肤伤口的动态和多阶段管理
Lihuang Wu,Yuqi Wang,Xinyue Zhao et al.
Lihuang Wu et al.
Full-thickness cutaneous wounds pose a significant threat to global health due to their complex healing demands. Standard clinical wound dressings often fall short in providing the adaptability and functionality required for the entire heal...