Ultrasound-driven atherosclerosis nanomedicine: from mechanical, cavitation, and sonodynamic therapies to bedside translation [0.03%]
超声驱动的动脉粥样硬化纳米药物：从机械、空化和声动力疗法到临床应用
Yusang Shao,Jiayong Luo,Shuangshuang Tu et al.
Yusang Shao et al.
Atherosclerosis (AS) is a leading cause of cardiovascular mortality worldwide, highlighting an urgent need for innovative, non-invasive therapies to address plaque instability and acute cardiovascular events. Ultrasound technology has emerg...
PEGylated black-phosphorus nanosheet-alginate hydrogels enable local PRRX1 delivery to drive fibroblast reprogramming in intestinal fibrosis [0.03%]
聚乙二醇化黑磷纳米片-海藻酸盐水凝胶通过局部递送PRRX1驱动肠纤维化部位成纤维细胞重编程
Yidong Chen,Jiamin Li,Junrong Li et al.
Yidong Chen et al.
Intestinal fibrosis drives stricturing complications in Crohn's disease (CD), yet the core stromal regulators remain incompletely defined. Here, we profile paired fibrotic and non-fibrotic ileum from CD patients using single-cell RNA sequen...
Bioengineered hollow nanoflowers to synergistically modulate inflammation, angiogenesis and osteogenesis for enhancing repair of bone defects [0.03%]
协同调节炎症、血管生成和骨形成的生物工程空心纳米花朵促进骨缺陷修复
Hanyu Sun,Xiaoyu Wang,Pugeng Li et al.
Hanyu Sun et al.
Background: Inadequate control of inflammation and insufficient vascularization remain major challenges in repair of bone defects. Here, we developed a multifunctional nanoflower, Au NPs@ZIF-8/Ga, by loading gallic acid (...
Polystyrene nanoplastics disrupt epididymal initial segment by perturbing NK cell differentiation and epithelial homeostasis [0.03%]
聚苯乙烯纳米塑料通过干扰自然杀伤细胞分化和上皮细胞稳态扰乱附睾初期段功能
Tong Chen,Jiaochen Luan,Tingfei Jiang et al.
Tong Chen et al.
Spermatozoa exit the testis in an immotile and immature state, and obtain motility and maturity in the epididymis with the most abundant functions acquired in its initial segment (IS). The reshaping of polystyrene nanoplastics (PS-NPs) expo...
Extracellular vesicles derived from Kaempferia Galanga L. show promise for targeted oral therapy in the treatment of ulcerative colitis [0.03%]
从Kaempferia Galanga L.衍生的细胞外囊泡在溃疡性结肠炎靶向口服治疗中显示出潜力
Lizhen Lin,Xinghong Zhou,Baizhao Peng et al.
Lizhen Lin et al.
Ulcerative colitis (UC) is characterised by chronic intestinal inflammation and its global prevalence is increasing. Although a variety of drugs have been approved for the clinical treatment of UC, their application is often limited by unsa...
Ergosterol-loaded brain-targeted liposomes attenuate stroke via gut microbiota-metabolite-brain axis modulation [0.03%]
载有麦角固醇的脑靶向脂质体通过调节肠道微生物群-代谢物-大脑轴来缓解中风作用研究
Mingzhu Gao,Yang Ye,Qi Chen et al.
Mingzhu Gao et al.
Ischemic stroke lacks effective neurorestorative options. We developed a lactoferrin-guided, long-circulating liposomal formulation of ergosterol (Erg) to enhance brain delivery and probed its mechanism along the gut-brain axis. The liposom...
Hollow spiky MnOx nanocarriers amplify radiotherapy-induced pyroptosis for eliciting antitumor immunity [0.03%]
空心锰氧化物纳米载药剂增强放射治疗诱导的细胞焦亡以激发抗肿瘤免疫响应
Yifan Zhang,Yuqian Liu,Bin Hu et al.
Yifan Zhang et al.
Radiotherapy (RT) is a primary modality in clinical cancer treatment. However, its ability to induce tumor cell apoptosis offers limited activation of anti-tumor immunity. Pyroptosis, characterized by cell swelling, membrane rupture, and th...
Folate-modified biomimetic nanovesicles loaded with a PU.1 inhibitor alleviate atherosclerosis by suppressing inflammation [0.03%]
叶酸修饰的生物仿生纳米囊泡载运PU.1抑制剂通过抑炎缓解动脉粥样硬化
Leye Yan,Xinyan Hu,Jianan He et al.
Leye Yan et al.
Atherosclerosis is a chronic inflammatory disease affecting arterial walls and remains a leading cause of morbidity and mortality worldwide. While anti-inflammatory therapy is widely recognized as a critical component in the management of a...
Kupffer cells biomimetic nanoparticles alleviate sepsis related liver injury [0.03%]
模拟枯氏细胞的纳米颗粒可改善脓毒症相关肝损伤
Chunhua Ma,Yingzhi Zhou,Zhaocong Yang et al.
Chunhua Ma et al.
The mechanism of sepsis related liver injury (SRLI) is unclear and its treatment method is unsatisfactory. The aim of this study was to investigate the effects of BRCC3 on SRIL and preparation of kupffer cells membrane encapsulated ZIF-8 lo...
Hypoxia-activated paclitaxel prodrugs enable PD-L1 degradation to potentiate cancer chemo-immunotherapy [0.03%]
缺氧激活的紫杉醇前药能够降解PD-L1以增强化学免疫疗法的作用
Shiyu Zhou,Qiang Zhang,Hui Han et al.
Shiyu Zhou et al.
The combination of chemotherapy and immune checkpoint blockade therapy shows great potential in tumor treatment, but their integration remains a great challenge. Herein, hypoxia-responsive prodrugs integrating paclitaxel (PTX) and bromodoma...