Extracellular vesicles in metabolic perspective: mechanism and targeted therapy [0.03%]
代谢视角下的细胞外囊泡：机制与靶向治疗
Qifeng Sheng,Zebin Wu,Wenming Li et al.
Qifeng Sheng et al.
Intercellular metabolic communication is essential for maintaining homeostasis and normal physiological function. Extracellular vesicles (EVs), as key mediators of cell-to-cell communication, are increasingly recognized for their close asso...
Programmable macrophage-polarizing nanoparticles for MRI-guided early detection and treatment of pulmonary metastases [0.03%]
用于磁共振引导的肺转移早期检测和治疗的可编程巨噬细胞极化纳米粒子
Meiju Sui,Kairu Xie,Yingying Luo et al.
Meiju Sui et al.
Metastatic lung cancer remains a leading cause of cancer-related mortality worldwide, underscoring the urgent need for early detection and intervention strategies. Current diagnostic and therapeutic methods often fall short in sensitivity a...
Lipid metabolism and lipid signaling in extracellular vesicles ontogeny: from biogenesis to functional execution [0.03%]
细胞外囊泡发生过程中的脂代谢与脂信号转导：从生物发生成到功能执行
Jiaxin Zhang,Jiali Li,Yuzhou Zheng et al.
Jiaxin Zhang et al.
This review explores the bidirectional relationship between lipids and extracellular vesicles (EVs) throughout the EV lifecycle. Lipid metabolism and lipid signaling influence EV biogenesis, cargo sorting, release, and targeting. EVs are ke...
Biomimetic ferritin nanocages for synergistic co-delivery of metformin and rapamycin restore neurodevelopmental homeostasis in autism spectrum disorders [0.03%]
类铁蛋白仿生纳米笼协同递送二甲双胍和雷帕霉素恢复自闭症谱系障碍的神经发育平衡
Yizhe Shen,Lele Yu,Liujiao Wang et al.
Yizhe Shen et al.
Autism spectrum disorder (ASD) is a multifactorial neurodevelopmental disorder with limited treatment options, largely due to its complex etiology and the inadequate delivery of therapeutics to the central nervous system. Herein, we report ...
Orally administered degradable nanoarmor-assisted probiotics for remodeling the gut microenvironment and treating osteoporosis [0.03%]
一种口服降解纳米盔甲辅助益生菌重塑肠道微环境及治疗骨质疏松的方法
Zhiqiang Li,Xueqiang Deng,Chengpeng Qiu et al.
Zhiqiang Li et al.
Improving the intestinal microenvironment and regulating the intestinal flora are highly important in the treatment of osteoporosis. Although previous studies have shown that oral probiotics can prevent or reverse bone loss, their survival ...
Nanopore-based sensing for biomarker detection: from fundamental principles to translational diagnostics [0.03%]
基于纳米孔的生物标志物检测传感技术：从基本原理到转化诊断学
Narlawar Sagar Shrikrishna,Sonu Gandhi
Narlawar Sagar Shrikrishna
Nanopore-based sensing has emerged as a transformative approach for biomarker detection, offering label-free, single-molecule analysis with exceptional sensitivity and specificity. By monitoring ionic current modulations as individual molec...
PDLIM4 drives gastric cancer malignant progression and cisplatin resistance by inhibiting HSP70 ubiquitination and degradation via competitive interaction with STUB1 [0.03%]
PDLIM4通过与STUB1竞争性结合抑制HSP70泛素化降解驱动胃癌恶性进展和顺铂耐药性
Chao Zhu,Meng Chen,Linwei Fan et al.
Chao Zhu et al.
Gastric cancer (GC) frequently shows malignant progression and resistance to chemotherapy due to complex molecular regulatory processes, leading to a poor prognosis. Our study elucidates that PDZ and LIM domain protein 4 (PDLIM4) are highly...
Nanomedicine targeting the PD-1/PD-L1 axis in autoimmune diseases: breaking conventional barriers to restore immune tolerance [0.03%]
靶向PD-1 / PD-L1轴的纳米药物在自身免疫性疾病中的应用：打破常规界限以恢复免疫耐受性
Gang Xiang,Yuanxu Cui,Pan Wang et al.
Gang Xiang et al.
Autoimmune diseases (ADs) arise from the breakdown of self-tolerance, leading to pathogenic immune responses against healthy tissues. The PD-1/PD-L1 immune checkpoint is pivotal for maintaining peripheral tolerance by suppressing autoreacti...
Customized extracellular vesicles targeting lysosomal biogenesis deliver therapeutic cargo for intervertebral disc degeneration treatment [0.03%]
定制靶向溶酶体生物发生的细胞外囊泡递送治疗 IDD 的药物载荷
Zhiwei Liao,Zixuan Ou,Bide Tong et al.
Zhiwei Liao et al.
Extracellular vesicles (EVs) have gained prominence as advanced drug delivery systems due to their inherent merits. Recent advancements highlight their utility in transporting therapeutic proteins with significant progress in targeted thera...
Spontaneous hydrogen-releasing nanoenzyme alleviates osteoarthritis via oxidative stress reduction and mitochondrial dysfunction reversal [0.03%]
一种自发释放氢的纳米酶通过减少氧化应激和逆转线粒体功能障碍来缓解骨关节炎
Qi Wang,Minyi Zhang,Weihao Jiang et al.
Qi Wang et al.
Osteoarthritis (OA), a chronic and degenerative joint disease, has become increasingly prevalent due to the aging population, posing a significant societal burden. However, despite progress, effective therapeutic options for osteoarthritis ...