Drug delivery strategies with lipid-based nanoparticles for Alzheimer's disease treatment [0.03%]
基于脂质的纳米颗粒载药系统用于阿尔茨海默病治疗策略研究进展
Young-Ju Jang,Seong-Jun Kang,Hyun Su Park et al.
Young-Ju Jang et al.
Alzheimer's disease (AD) is a distinctive form of dementia characterized by age-related cognitive decline and memory impairment. A key hallmark of AD is the irreversible overaccumulation of beta-amyloid (Aβ) in the brain, associated with n...
Radiotherapy plus a self-gelation powder encapsulating tRF5-GlyGCC inhibitor potentiates natural kill cell immunity to prevent hepatocellular carcinoma recurrence [0.03%]
放射治疗结合包埋tRF5-GlyGCC抑制剂的自凝胶粉末增强自然杀伤细胞免疫以预防肝细胞癌复发
Yihang Gong,Fanxin Zeng,Feng Zhang et al.
Yihang Gong et al.
Hepatocellular carcinoma (HCC) recurrence postresection represents a thorny problem in clinical practice, of which impaired natural killer (NK) cell cytotoxicity represents one of crucial causes. Apart from recurrence, hepatectomy-induced a...
RBD-displaying OMV nanovaccine boosts immunity against SARS-CoV-2 [0.03%]
表达RBD的OMV纳米疫苗增强对SARS-CoV-2的免疫力
Rang Feng,Ruo-Yi Xue,Chang Liu et al.
Rang Feng et al.
Background: Since the emergence of SARS-CoV-2, the causative agent of COVID-19, the global health landscape has confronted an unprecedented and formidable challenge. The SARS-CoV-2 receptor-binding domain (RBD) is a key a...
Methylprednisolone substituted lipid nanoparticles deliver C3 transferase mRNA for combined treatment of spinal cord injury [0.03%]
甲基强的松龙替代脂质纳米颗粒递送C3转化酶mRNA联合治疗脊髓损伤
Haoru Dong,Zongxing He,Shiyi Cai et al.
Haoru Dong et al.
Spinal cord injury (SCI), characterized by the disruption of neural pathways and an increase in inflammatory cell infiltration, leads to profound and lasting neurological deficits, with a high risk of resulting in permanent disability. Curr...
Bidirectional regulation of reactive oxygen species for radiosensitization in nasopharyngeal carcinoma [0.03%]
放射增敏中活性氧的双向调控作用研究鼻咽癌中的放射增敏中活性氧的双向调节作用
Jie Chen,Chengyu Feng,Yufei Lan et al.
Jie Chen et al.
Radiotherapy (RT) is the primary treatment modality for nasopharyngeal carcinoma (NPC). However, the tumor microenvironment (TME)-induced radioresistance often compromises its therapeutic efficacy. Herein, we propose an innovative bidirecti...
A new scheme for boosting in situ Fenton-like reaction in plant pathogenic tissues for selective structural degradation of capsid proteins [0.03%]
一种在植物病原组织中促进就地类芬顿反应的选择性降解壳蛋白结构的新方案
Jun Ma,Ming Chen,Yujie Wang et al.
Jun Ma et al.
Safe prevention and control of plant viruses is a global challenge. Inducing viral capsid protein (CP) degradation via hydroxyl radicals (∙OH) generated by an in situ Fenton-like reaction within plant pathogenic tissues is proposed for com...
Platycodon grandiflorum-derived extracellular vesicles suppress triple-negative breast cancer growth by reversing the immunosuppressive tumor microenvironment and modulating the gut microbiota [0.03%]
Platycodon grandiflorum 衍生的外泌体通过逆转免疫抑制性肿瘤微环境和调节肠道微生物群来抑制三阴性乳腺癌生长
Min Yang,Jia Guo,Jinxian Li et al.
Min Yang et al.
Despite the approval of several artificial nanotherapeutics for the treatment of triple-negative breast cancer (TNBC), significant challenges, including unsatisfactory therapeutic outcomes, severe side effects, and the high cost of large-sc...
Enhanced brightness and photostability of dye-sensitized Nd-doped rare earth nanocomposite for in vivo NIR-IIb vascular and orthotopic tumor imaging [0.03%]
用于体内NIR-IIb血管和原位肿瘤成像的敏化Nd掺杂稀土纳米复合材料的增强亮度和光稳定性
Syue-Liang Lin,Shih-Po Su,Yuan-Zhen Yang et al.
Syue-Liang Lin et al.
Rare-earth doped nanoparticles (RENPs) have shown promise in biomedical imaging, particularly within the NIR-IIb region, due to their deep tissue penetration and minimal light scattering. However, challenges such as low extinction coefficie...
Synergistic strategies for glioblastoma treatment: CRISPR-based multigene editing combined with immune checkpoint blockade [0.03%]
胶质母细胞瘤的协同治疗策略：结合免疫检查点抑制的CRISPR多基因编辑疗法
Xiaolin Liu,Xiao Liu,Xiaonan Luo et al.
Xiaolin Liu et al.
Glioblastoma (GBM) is a primary brain tumor known for its high levels of aggressiveness and resistance to current treatments such as radiotherapy and chemotherapy. As a result, there is a pressing need for innovative therapeutic approaches ...
Nano-delivery platform with strong protection and efficient delivery: preparation of self-assembled RNA pesticide with dual RNAi targets against Apolygus lucorum [0.03%]
具有强保护和高效递送的纳米递药平台：用于同时靶向Apolygus lucorum的双链RNA农药自组装体系构建
Heng Qiao,Qinhong Jiang,Jing Zhao et al.
Heng Qiao et al.
Background: RNA pesticide is regarded as the "third revolution in the history of pesticides". However, the double-stranded RNA (dsRNA) is easily degraded in the environment, and its delivery efficiency is not sufficient f...