Single BMSC-derived cartilage organoids for gradient heterogeneous osteochondral regeneration by leveraging native vascular microenvironment [0.03%]
基于天然血管微环境的单个间充质干细胞来源软骨器官体用于梯度异质性骨软骨再生
Zhenying Chen,Qitao Bo,Chao Wang et al.
Zhenying Chen et al.
Heterogeneous osteochondral regeneration remains a significant challenge due to the distinct microenvironments across the cartilage, calcified cartilage, and subchondral bone layers. The natural gradient of vascularization from the superfic...
Self-healing adhesive oxidized guar gum hydrogel loaded with mesenchymal stem cell exosomes for corneal wound healing [0.03%]
负载间充质干细胞外泌体的氧化瓜尔胶自愈性水凝胶促进角膜伤口愈合
Ruoyan Wei,Yunzhe Wang,Ziqing Feng et al.
Ruoyan Wei et al.
Hydrogels have shown great potential and value in wound healing. In this study, we construct a mesenchymal stem cell exosomes (MSC-Exos) laden natural biopolymer-based hydrogel with transparent, self-healing, injectable, and tissue adhesive...
Streptococcus mutans-derived extracellular vesicles promote skin wound healing via tRNA cargo [0.03%]
链球菌衍生的细胞外囊泡通过转运RNA促进皮肤伤口愈合
Su Young Oh,Dong Yeon Kim,Kah Young Lee et al.
Su Young Oh et al.
Background: The human oral cavity harbors a diverse microbiota, including Streptococcus species. Oral mucosal wounds heal rapidly, although the exact cause remains unclear. This study investigates the impact of Streptococ...
Ultrasmall platinum single-atom enzyme alleviates oxidative stress and macrophage polarization induced by acute kidney ischemia-reperfusion injury through inhibition of cell death storm [0.03%]
超小型铂单原子酶通过抑制细胞死亡风暴缓解急性肾脏缺血再灌注损伤诱导的氧化应激和巨噬细胞极化现象
Keng Ye,Kongwen Lin,Chengkun Wu et al.
Keng Ye et al.
Acute kidney injury (AKI), characterized by a rapid decline in renal function, is associated with impaired mitochondrial function and excessive reactive oxygen species (ROS). Therefore, the exploration of ROS scavengers provides promising n...
Macrophage-derived exosomes in cancer: a double-edged sword with therapeutic potential [0.03%]
巨噬细胞来源的外泌体在癌症中的研究进展：一把具有治疗潜力的双刃剑
Long Liu,Siying Zhang,Yuqing Ren et al.
Long Liu et al.
Solid cancer contains a complicated communication network between cancer cells and components in the tumor microenvironment (TME), significantly influencing the progression of cancer. Exosomes function as key carriers of signaling molecules...
Hypoxia-responsive core-cross-linked supramolecular nanoprodrug based on dendritic drug-drug conjugates for synergetic anticancer therapy [0.03%]
基于树枝状药物-药物共聚物的超分子纳普药用于协同抗肿瘤治疗
Yue Ding,Yu Xie,Liangshun Zheng et al.
Yue Ding et al.
Background: Recently, the strategy of self-assembling dendritic drug-drug conjugates into supramolecular nanoprodrug was widely explored in biomedical applications. Herein, we construct a hypoxia-responsive core-cross-lin...
Carbon dot-based treatment for bacterial pneumonia by promoting a PI3K-mediated M1 polarization of macrophages [0.03%]
基于碳点的治疗细菌性肺炎的方法可促进PI3K介导的巨噬细胞M1极化反应
Xuan Jiang,Jun Wang,Lin Gan et al.
Xuan Jiang et al.
As the incessant emergence of drug-resistant bacterial strains, bacterial pneumonia poses a serious threat to the public health worldwide. There is an urgent need to explore unconventional therapeutic strategies. Carbon dots are usually des...
Erythrocyte membrane camouflaged celastrol and bilirubin self-assembly for rheumatoid arthritis immunotherapy based on STING inhibition and RONS clearance [0.03%]
基于STING抑制和RONS清除的类风湿性关节炎免疫治疗的红细胞膜伪装的青蒿素和胆红素自组装体系
Yanguo Su,Rui Chen,Bingjie Wang et al.
Yanguo Su et al.
Activation of cGAS-STING signaling pathway and accumulation of reactive oxygen and nitrogen species (RONS) are important issues facing the treatment of rheumatoid arthritis (RA). Here, we report a biomimetic nano-Chinese medicine (HA-RM-Cel...
Drug-loaded indocyanine green J-aggregates activate metalloimmunotherapy for sustained photothermal therapy of hepatocellular carcinoma [0.03%]
载药吲哚菁绿J聚集体激活金属免疫治疗以实现肝癌的持续光热治疗
Kaiming He,Desheng Chen,Dongzi Zhu et al.
Kaiming He et al.
Hepatocellular carcinoma (HCC) poses a significant therapeutic challenge, driving the need for novel treatment strategies. This study investigates the combination of photothermal therapy (PTT) and metalloimmunotherapy for HCC treatment usin...
Microglia-targeting nanosystems that cooperatively deliver Chinese herbal ingredients alleviate behavioral and cognitive deficits in Alzheimer's disease model mice [0.03%]
靶向小胶质细胞的纳米递送系统协同输送中药成分可改善阿尔茨海默病模型小鼠的行为和认知缺陷
Peng Zhou,Quan Chao,Chen Li et al.
Peng Zhou et al.
The effective treatment of Alzheimer's disease (AD) is challenging because of its complex and controversial pathological mechanisms. Moreover, multiple barriers, such as the blood-brain barrier (BBB), reduce drug delivery efficiency. Microg...