Inhalable biomimetic polyunsaturated fatty acid-based nanoreactors for peroxynitrite-augmented ferroptosis potentiate radiotherapy in lung cancer [0.03%]
可吸入仿生多不饱和脂肪酸纳米反应器增强辐射治疗肺癌
Yiting Chen,Xueli Huang,Ruining Hu et al.
Yiting Chen et al.
The limited efficacy and poor tumor accumulation remain crucial challenges for radiotherapy against lung cancer. To address these limitations, we rationally developed a polyunsaturated fatty acid (PUFA)-based nanoreactor (DHA-N@M) camouflag...
Dual-responsive nanoparticles targeting ACE-II senescence for therapeutic mitigation of acute lung injury [0.03%]
靶向ACE-II衰老的双重响应型纳米颗粒用于急性肺损伤的治疗干预
Linlin Gao,Fushuang Zheng,Zhiling Fu et al.
Linlin Gao et al.
Acute lung injury (ALI) is a life-threatening condition characterized by severe pulmonary dysfunction, with alveolar type II epithelial cell (ACE-II) senescence playing a pivotal role in its progression. In this study, we developed pH/react...
Improving epilepsy management by targeting P2 × 7 receptor with ROS/electric responsive nanomicelles [0.03%]
基于ROS/电响应性纳米胶束的P2×7受体靶向策略在癫痫治疗中的应用研究
Zhaohong Kong,Jian Jiang,Min Deng et al.
Zhaohong Kong et al.
Background: The intricate pathogenesis of epilepsy, characterized by abnormal neuronal discharges and neuroinflammation, underscores the critical involvement of the adenosine triphosphate (ATP)-P2X purinoceptor 7 (P2 × 7...
Microneedle-aided nanotherapeutics delivery and nanosensor intervention in advanced tissue regeneration [0.03%]
用于组织工程的微针介导的纳米药物输送和纳米传感器干预研究
Churong Xu,Fei Wu,Zhouyi Duan et al.
Churong Xu et al.
Microneedles (MNs) have been extensively used as transdermal therapeutics delivery devices since 1998 due to their capacity to penetrate physiological barriers with minimal invasiveness. Recent advances demonstrate the potential of MNs in i...
Exosome-powered neuropharmaceutics: unlocking the blood-brain barrier for next-gen therapies [0.03%]
外泌体赋能神经药学：解锁下一代疗法的血脑屏障
Sepehr Mehdizadeh,Mobin Mamaghani,Somayyeh Hassanikia et al.
Sepehr Mehdizadeh et al.
Background: The blood-brain barrier (BBB) presents a formidable challenge in neuropharmacology, limiting the delivery of therapeutic agents to the brain. Exosomes, nature's nanocarriers, have emerged as a promising soluti...
Lanthanide-specific doping in vacancy-engineered piezocatalysts induces lysosomal destruction and tumor cell pyroptosis [0.03%]
通过空位工程的压电催化剂中的稀土元素掺杂诱导溶酶体破坏和肿瘤细胞焦亡
Xiaoyan Li,Ying Wang,Xinyue Cao et al.
Xiaoyan Li et al.
Background: Reactive oxygen species (ROS)-mediated pyroptosis provides a robust strategy for overcoming apoptosis resistance in breast cancer therapy. Nevertheless, the low efficiency of pyroptosis remains an undeniable c...
Insulin/PHMB-grafted sodium alginate hydrogels improve infected wound healing by antibacterial-prompted macrophage inflammatory regulation [0.03%]
胰岛素/PHMB交联的海藻酸钠水凝胶通过促抗菌和调节巨噬细胞炎症来促进感染伤口愈合
Dan Liu,Tianyi Yu,Shan Ma et al.
Dan Liu et al.
Background: Non-healing chronic wounds with high susceptibility to infection represent a critical challenge in modern healthcare. While growth factors play a pivotal role in regulating chronic wound repair, their therapeu...
Editorial Expression of Concern: The potential use of nanozymes as an antibacterial agents in oral infection, periodontitis, and peri-implantitis [0.03%]
关于潜在利用纳米酶作为口腔感染、牙周炎和种植体周围炎抗菌剂的社论存疑意见
Mohammad Hosseini Hooshiar,Ashkan Badkoobeh,Shirin Kolahdouz et al.
Mohammad Hosseini Hooshiar et al.
Hemoglobin-loaded hollow mesoporous carbon-gold nanocomposites enhance microwave ablation through hypoxia relief [0.03%]
载血红蛋白空心介孔碳-金纳米复合材料通过缓解缺氧增强微波消融疗效
Yitian Zhang,Bitao Li,Jiawen He et al.
Yitian Zhang et al.
Microwave ablation, as a critical minimally invasive technique for tumor treatment, remains challenging in achieving an optimal balance between incomplete and excessive ablation. In addition to selectively elevating the temperature of tumor...
A novel nanomedicine for osteosarcoma treatment: triggering ferroptosis through GSH depletion and inhibition for enhanced synergistic PDT/PTT therapy [0.03%]
一种用于治疗骨肉瘤的新型纳米药物：通过耗尽和抑制GSH以增强协同PDT / PTT疗法来触发铁死亡
Tangbing Xu,Qiming Ma,Chi Zhang et al.
Tangbing Xu et al.
Osteosarcoma treatment remains challenging due to the limitations of single-modality therapies. To address this, we designed a carrier-free nanomedicine SRF@CuSO4.5H2O@IR780 (CSIR) for synergistic ferroptosis, photodynamic therapy (PDT), an...