Surface-engineered bio-manufactured gas vesicles for multimodal imaging of glioma [0.03%]
表面工程生物制造气体囊泡用于胶质瘤的多模式成像
Juanjuan Li,Yutong Cui,Xiaoli Jiang et al.
Juanjuan Li et al.
Integrated imaging techniques offer enhanced medical insights into the central nervous system by combining different modalities. In glioma diagnosis, the challenge often lies in delivering contrast agents effectively across the blood-brain ...
Retraction Note: Structure based innovative approach to analyze aptaprobe-GPC3 complexes in hepatocellular carcinoma [0.03%]
撤稿说明：基于结构的分析肝细胞癌中适配体探针-GPC3复合物的创新方法
Woo-Ri Shin,Dae-Young Park,Ji Hun Kim et al.
Woo-Ri Shin et al.
Intraperitoneal administration of mRNA encoding interleukin-12 for immunotherapy in peritoneal carcinomatosis [0.03%]
腹腔内注射编码白细胞介素-12的mRNA用于腹膜癌病的免疫治疗
Leire Arrizabalaga,Claudia Augusta Di Trani,Myriam Fernández-Sendin et al.
Leire Arrizabalaga et al.
Peritoneal carcinomatosis is an advanced stage of cancer with very limited treatment options. Locoregional immunotherapy is being evaluated as a way to improve efficacy and limit toxicity. This study assessed the efficacy of a cationic poly...
Inflammatory memory-activated biomimetic nanovesicles regulate neutrophil plasticity and metabolic reprogramming for rapid diabetic wound healing via targeting miR-193a-5p/TLR4/JNK/P38 MAPK pathways [0.03%]
炎症记忆激活的生物仿生纳米囊通过靶向miR-193a-5p/TLR4/JNK/P38 MAPK通路调节中性粒细胞可塑性和代谢重编程以实现快速糖尿病伤口愈合
Yunlong Fan,Jiaman Yang,Yulin Xie et al.
Yunlong Fan et al.
Diabetic wound therapy faces significant challenges due to the complexity of the wound microenvironment, especially dysregulated immune cell responses and persistent pro-inflammatory sate. Targeting immune cells to reverse pathological woun...
Production of minicell-like structures by Escherichia coli biosynthesizing cadmium fluorescent nanoparticles: a novel response to heavy metal exposure [0.03%]
大肠杆菌生产镉荧光纳米粒样的小型细胞结构：对重金属暴露的一种新型响应
Felipe Valenzuela-Ibaceta,Sergio A Álvarez,José M Pérez-Donoso
Felipe Valenzuela-Ibaceta
The bacterial synthesis of fluorescent semiconductor nanoparticles or quantum dots (QDs), presents a sustainable method for producing nanomaterials with customized optical properties and significant technological potential. However, the und...
Iron chelators loaded on myocardiocyte mitochondria-targeted nanozyme system for treating myocardial ischemia-reperfusion injury in mouse models [0.03%]
用于治疗小鼠心肌缺血再灌注损伤的铁螯合心肌细胞线粒体靶向纳米酶系统
Ke Zhu,Kun Wang,Rongting Zhang et al.
Ke Zhu et al.
Ferroptosis plays a critical role in myocardial ischemia-reperfusion injury (MIRI), posing a significant clinical challenge. Nanoenzymes like cerium oxide (CeO2) hold promise for mitigating oxidative damage and inhibiting ferroptosis, but t...
A shark-derived broadly neutralizing nanobody targeting a highly conserved epitope on the S2 domain of sarbecoviruses [0.03%]
靶向sarbecovirus S2区域的高度保守表位的广谱中和纳米体
Bo Feng,Cuiyun Li,Zhaoyong Zhang et al.
Bo Feng et al.
The continuously evolving Omicron subvariants has diminished the effectiveness of almost all RBD-targeted antibodies in neutralizing these subvariants. The development of broad-spectrum neutralizing antibodies is desired for addressing both...
Carrier-free nanoparticles-new strategy of improving druggability of natural products [0.03%]
无载体纳米颗粒-提高天然产物成药性的新策略
Yaqi Yao,Zhenna Xu,Haoran Ding et al.
Yaqi Yao et al.
There are abundant natural products resources and extensive clinical use experience in China. However, the active components of natural products generally have problems such as poor water solubility and low bioavailability, which limit thei...
Eriodictyol-cisplatin coated nanomedicine synergistically promote osteosarcoma cells ferroptosis and chemosensitivity [0.03%]
姜黄素-顺铂纳米药物协同促进骨肉瘤细胞铁死亡及化疗敏感性
Zili Lin,Yusheng Li,Ziyi Wu et al.
Zili Lin et al.
The ever-increasing chemoresistance of osteosarcoma (OS) has been observed in the recent decades, impeding OS therapeutic improvement and posing an urgency to exploit to the alternative and/or supplementary therapies for the optimization of...
Biomaterial-based vascularization strategies for enhanced treatment of peripheral arterial disease [0.03%]
基于生物材料的血管化策略增强外周动脉疾病的治疗效果
Haojie Wang,Fuxin Lin,Yibin Zhang et al.
Haojie Wang et al.
Peripheral arterial disease (PAD) poses a global health challenge, particularly in its advanced stages known as critical limb ischemia (CLI). Conventional treatments often fail to achieve satisfactory outcomes. Patients with CLI face high r...