Oxygen vacancy-engineered bimetallic nanozymes for disrupting electron transport chain and synergistic multi-enzyme activity to reverse oxaliplatin resistance in colorectal cancer [0.03%]
用于破坏电子传递链并协同多种酶活性以逆转结直肠癌顺铂耐药的氧空位工程双金属纳米酶
Dong Zhong,Xiaoxin Yang,Jinhui Yang et al.
Dong Zhong et al.
In colorectal cancer treatment, chemotherapeutic agents induce reactive oxygen species (ROS) production, which promotes NAD+ accumulation in tumor cells, reducing treatment sensitivity and worsening patient prognosis. Targeted depletion of ...
Engineered bone-targeting apoptotic vesicles as a minimally invasive nanotherapy for heterotopic ossification [0.03%]
工程化骨靶向凋亡小体作为异位骨化的微创纳米疗法
Like Tang,Yuchen Wang,Shihua Mao et al.
Like Tang et al.
Heterotopic Ossification (HO), refers to pathological extra skeletal bone formation, and there are currently no reliable methods except surgery to reverse these unexpected calcified tissues. Apoptotic vesicles (ApoEVs) are membrane-bound ve...
A novel tri-mode detection platform for ampicillin and drug resistance genes by CRISPR-driven luminescent nanozymes [0.03%]
一种新型三模式检测平台：通过CRISPR驱动的发光纳米酶检测氨苄西林和耐药基因
Tao Zhang,Guiling Liu,Siwei Sun et al.
Tao Zhang et al.
The antibiotic residues pose significant risks for bacterial resistance. To address the practical requirements for rapid, accurate, and on-site detection of antibiotic residues and monitoring the abundance of associated resistance genes, we...
Synphilin-1 regulates mechanotransduction in rigidity sensing through interaction with zyxin [0.03%]
Synphilin-1通过与Zyxin的互作调节刚度感应中的机械转导
Seok Gi Kim,Jinyan Li,Ji Su Hwang et al.
Seok Gi Kim et al.
Background: Synphilin-1 has been studied extensively in the context of Parkinson's disease pathology. However, the biophysical functions of synphilin-1 remain unexplored. To investigate its novel functionalities herein, c...
PEGylated gas vesicles: a promising novel ultrasound contrast agent for diagnosis and guiding radiofrequency ablation of liver tumor [0.03%]
聚乙二醇化气体囊泡：一种颇具潜力的新型超声诊断和射频消融肝肿瘤造影剂
Kezhi Yu,Yongquan Huang,Yuanyuan Wang et al.
Kezhi Yu et al.
Ultrasound contrast agents (UCAs) play an important role in diagnosis and the imaging-guided treatment of liver tumor in clinical settings. However, most commercially available UCAs are micro-sized and fabricated through a chemical synthesi...
Visualization of HSP70-regulated mild-photothermal therapy for synergistic tumor treatment: a precise space-time mild-temperature photothermal ablation strategy [0.03%]
HSP70调控的温和光热治疗可视化用于协同肿瘤治疗：一种精准时空温控消融策略
Binyue Zhang,Yanchun Ma,Qi Liu et al.
Binyue Zhang et al.
Mild-temperature photothermal therapy (MPTT) advances anticancer management by regulating reactive oxygen species (ROS) and lipid peroxides (LPO) to inhibit the overexpression of heat shock protein 70 (HSP70), thus decreasing the cellular h...
Biomaterial-based strategies for bone cement: modulating the bone microenvironment and promoting regeneration [0.03%]
基于生物材料的骨水泥策略：调节骨微环境和促进再生
Jiawei Jiang,Juan Wang,Pan Fan et al.
Jiawei Jiang et al.
Osteoporotic bone defect and fracture healing remain significant challenges in clinical practice. While traditional therapeutic approaches provide some regulation of bone homeostasis, they often present limitations and adverse effects. In o...
Correction: Lactobacillus acidophilus extracellular vesiclescoated UiO-66-NH2@siRNA nanoparticles for ulcerative colitis targeted gene therapy and gut microbiota modulation [0.03%]
订正：乳酸菌酸杆菌胞外囊泡包被的UiO-66-NH2@siRNA纳米颗粒用于溃疡性结肠炎靶向基因治疗和肠道微生态调节
Chenyang Cui,Jiaze Tang,Jie Chen et al.
Chenyang Cui et al.
Published Erratum
Journal of nanobiotechnology. 2025 May 13;23(1):341. DOI:10.1186/s12951-025-03413-y 2025
Comprehensive wound healing using ETN@Fe7S8 complex by positively regulating multiple programmed phases [0.03%]
基于ETN@Fe7S8复合材料积极调控伤口愈合多阶段的综合促愈策略
Mengxia Chen,Ting Liu,Xiaonan Wang et al.
Mengxia Chen et al.
Wound healing requires coordinated progression through multiple programmed phases including hemostasis, infection control, inflammatory resolution, proliferation, and tissue remodeling. Many nanomaterials have shown great potential to promo...
Sequentially assembled co-delivery nanoplatform of SIRT1 protein and SOX9-expressing plasmid for multipronged therapy of intervertebral disc degeneration [0.03%]
用于多管齐下治疗椎间盘退变的SIRT1蛋白和SOX9表达质粒共递送顺序组装纳米平台
Xiaoyu Zhang,Qianping Guo,Jiawei Fang et al.
Xiaoyu Zhang et al.
Nucleus pulposus cells (NPCs) undergo metabolic disorders and matrix pathological remodeling under the influence of various adverse factors during intervertebral disc degeneration (IVDD), whereas post-translational modifications (PTMs) can ...