Zinc-copper bimetallic nanoplatforms trigger photothermal-amplified cuproptosis and cGAS-STING activation for enhancing triple-negative breast cancer immunotherapy [0.03%]
锌铜双金属纳米平台触发光热放大铜死亡和cGAS-STING激活以增强三阴性乳腺癌免疫治疗
Bangyi Zhou,Mengyao Chen,Zhixing Hao et al.
Bangyi Zhou et al.
Triple-negative breast cancer (TNBC) is characterized by high rates of metastasis and recurrence, along with a low sensitivity to immunotherapy, resulting in a paucity of effective therapeutic strategies. Herein, we have developed polydopam...
RSL3-loaded nanoparticles amplify the therapeutic potential of cold atmospheric plasma [0.03%]
负载RSL3的纳米粒子增强了冷大气等离子体的治疗潜力
Xiaona Cao,Mo Chen,Tianxu Fang et al.
Xiaona Cao et al.
Cold atmospheric plasma (CAP) has exhibited exciting potential for cancer treatment. Reactive oxygen and nitrogen species (RONS), the primary constituents in CAP, contribute to cancer cell death by elevating oxidative stress in cells. Howev...
Yangwei Qian,Chenxi Wang,Ruru Xu et al.
Yangwei Qian et al.
It is urgent to exploit multifunctional materials and combined approaches for efficient antitumor effects. Copper-based metal-organic frameworks (Cu-MOFs) have excellent performances in catalysis, biocompatibility, photothermal conversion, ...
Engineered neutrophil membrane-camouflaged nanocomplexes for targeted siRNA delivery against myocardial ischemia reperfusion injury [0.03%]
工程中性粒细胞膜伪装纳米复合材料靶向传递siRNA用于心肌缺血再灌注损伤治疗
Yaohui Jiang,Rongyan Jiang,Zequn Xia et al.
Yaohui Jiang et al.
Small interfering RNA (siRNA) therapies hold great potential for treating myocardial ischemia-reperfusion injury (MIRI); while their practical application is limited by the low bioavailability, off-target effects, and poor therapeutic effic...
Polyzwitterion-branched polycholic acid nanocarriers based oral delivery insulin for long-term glucose and metabolic regulation in diabetes mellitus [0.03%]
用于糖尿病长期血糖和代谢调节的口服递送胰岛素多 zwiterion 支化多胆酸纳米载体
Wenkai Zhang,Yue Wang,Xiangqi Zhang et al.
Wenkai Zhang et al.
Diabetes represents a global health crisis that necessitates advancements in prevention, treatment, and management. Beyond glucose regulation, addressing weight management and associated complications is imperative. This study introduces an...
Combination therapy with lipid prodrug liposomes reshapes disease-associated neutrophils to promote the cancer-immunity cycle [0.03%]
含有类脂前药的脂质体组合疗法重塑与疾病相关中性粒细胞以促进癌症免疫循环
Dezhi Sui,Yanzhi Song,Yihui Deng
Dezhi Sui
Neutrophils play a critical role in the cancer-immunity cycle and are associated with poor clinical outcomes. Recent research has primarily focused on the targeted delivery, phenotypic reversal, and reprogramming of tumor-associated neutrop...
Targeting GDF15 to enhance immunotherapy efficacy in glioblastoma through tumor microenvironment-responsive CRISPR-Cas9 nanoparticles [0.03%]
通过肿瘤微环境响应性CRISPR-Cas9纳米颗粒靶向GDF15以提高胶质母细胞瘤免疫疗法的疗效
Cheng Zou,Xiao Liu,Weizhong Wang et al.
Cheng Zou et al.
Despite the outstanding clinical success of immunotherapy, its therapeutic efficacy in glioblastoma (GBM) is still limited. To identify critical regulators of GBM immunity, we constructed a mouse single-guide RNA (sgRNA) library correspondi...
Somatostatin receptor-targeted polymeric nanoplatform for efficient CRISPR/Cas9 gene editing to enhance synergistic hepatocellular carcinoma therapy [0.03%]
针对somatostatin受体的聚合物纳米平台实现高效的CRISPR / Cas9基因编辑以增强肝细胞癌的协同治疗
Suqin Zhang,Meng Li,Jingyi Zeng et al.
Suqin Zhang et al.
The CRISPR/Cas9 system-based gene therapy can fundamentally address the issues of cancer occurrence, development, progression, and metastasis. However, the lack of targeting and effectiveness hinders gene therapy from entering clinical appl...
Metal-organic framework nanoparticles activate cGAS-STING pathway to improve radiotherapy sensitivity [0.03%]
金属有机框架纳米颗粒通过激活cGAS-STING通路提高放疗敏感性
Xinyao Hu,Hua Zhu,Yang Shen et al.
Xinyao Hu et al.
Tumor immunotherapy aims to harness the immune system to identify and eliminate cancer cells. However, its full potential is hindered by the immunosuppressive nature of tumors. Radiotherapy remains a key treatment modality for local tumor c...
Injectable platelet-mimicking silk protein-peptide conjugate microspheres for hemostasis modulation and targeted treatment of internal bleeding [0.03%]
用于止血调节和内部出血靶向治疗的可注射仿血小板丝蛋白-肽接枝微球
Yajun Shuai,Yu Qian,Meidan Zheng et al.
Yajun Shuai et al.
Uncontrolled deep bleeding, commonly encountered in surgical procedures, combat injuries, and trauma, poses a significant threat to patient survival and recovery. The development of effective hemostatic agents capable of precisely targeting...