Baicalein based nano-delivery system restores mitochondrial homeostasis through PPAR signaling pathway to promote wound healing in diabetes [0.03%]
基于 baicalein 的纳米输送系统通过 PPAR 信号通路恢复线粒体稳态以促进糖尿病伤口愈合
Danlei Qin,Weiting Hu,Yanqin Guo et al.
Danlei Qin et al.
Wound healing in diabetes is a substantial clinical challenge due to the hyperglycemic microenvironment, high pH, bacterial infection, persistent inflammation, and impaired cellular functions, attributed to mitochondrial dysfunction. Here, ...
Integration of active ingredients from traditional Chinese medicine with nano-delivery systems for tumor immunotherapy [0.03%]
基于纳米递送系统的中药活性成分整合在肿瘤免疫治疗中的应用
Hao Zheng,Yiquan Chen,Wei Luo et al.
Hao Zheng et al.
Tumor immune escape presents a significant challenge in cancer treatment, characterized by the upregulation of immune inhibitory molecules and dysfunction of immune cells. Tumor immunotherapy seeks to restore normal anti-tumor immune respon...
Outer membrane vesicles of Porphyromonas gingivalis impede bone regeneration by inducing ferroptosis via the Hippo-YAP signaling pathway [0.03%]
牙龈卟啉单胞菌外膜囊泡通过Hippo-YAP信号通路诱导铁死亡从而阻碍骨再生
Xinghong Luo,Yanzhen Wang,Tingting Ning et al.
Xinghong Luo et al.
Background: Although increasing evidence confirms that oral microbiota imbalance is a critical factor inhibiting bone regeneration, the specific mechanisms have remained unexplored. This study aims to use periodontitis as...
Enhanced therapeutic effects of all-trans retinoic acid nanostructured lipid carrier composite gel drug delivery system for alopecia areata [0.03%]
全反式维甲酸纳米结构脂质载体复合凝胶给药系统治疗斑秃的疗效观察
Lingling Zheng,Yang Du,Lulu Zhang et al.
Lingling Zheng et al.
Background: Alopecia areata (AA) affects approximately 2% of the global population and causes psychological distress. All-trans retinoic acid (ATRA) has the potential to promote hair regeneration; however, its clinical us...
The biological activity and potential of probiotics-derived extracellular vesicles as postbiotics in modulating microbiota-host communication [0.03%]
益生菌衍生的外泌体后生物活性及其在调节微生物组-宿主通讯中的潜力
Xiaoming Zhang,Ye Wang,Qiyu E et al.
Xiaoming Zhang et al.
Probiotics such as Lactobacillus and Bifidobacterium spp. have been shown to be critical for maintaining host homeostasis. In recent years, key compounds of postbiotics derived from probiotic metabolism and cellular secretion have been iden...
A spreadable self-gelling hemostatic powder sensitizes CAR-NK cell therapy to prevent hepatocellular carcinoma recurrence postresection [0.03%]
一种可涂布的自凝止血粉可使CAR-NK细胞治疗敏化以预防肝切除术后肝细胞癌复发
Yusheng Cheng,Yihang Gong,Xin Li et al.
Yusheng Cheng et al.
Adoptive natural killer cell therapy (ANKCT) harbors great potential for combating postsurgical hepatocellular carcinoma (HCC) recurrence, but its efficacy is limited by tumor microenvironment (TME)-meditated repression on NK cell function ...
NIR-responsive Cu2 - xSe@Fc nanoparticles for photothermal- ferroptosis combination therapy in esophageal cancer [0.03%]
用于食道癌光热铁死亡联合治疗的近红外响应Cu2-xSe@Fc纳米粒子
Linlin Shi,Ying Yu,Jiayi Li et al.
Linlin Shi et al.
Esophageal cancer (EC) represents a highly recurrent and aggressive malignancy within the digestive system. However, conventional therapeutic strategies exhibit notable limitations in their clinical applications. Photothermal therapy (PTT),...
Advances in microneedle-based drug delivery system for metabolic diseases: structural considerations, design strategies, and future perspectives [0.03%]
用于代谢性疾病微针给药系统的最新进展：结构考虑、设计策略和未来展望
Yao Li,Qiu Chen,Tingting Wang et al.
Yao Li et al.
As the prevalence of metabolic diseases such as diabetes and obesity continue to rise, the search for more effective and convenient treatments has become a crucial issue in medical research. Microneedles (MNs), as an innovative drug deliver...
Dual-source powered sea urchin-like nanomotors for intravesical photothermal therapy of bladder cancer [0.03%]
用于膀胱癌体内光热治疗的双源驱动海胆状纳米马达
Yixuan Mou,Zhenghong Liu,Wentao Xu et al.
Yixuan Mou et al.
Bladder cancer (BCa) ranks as the 9th most prevalent malignancy worldwide, featured by its high risk of recurrence. Intravesical therapy constitutes the most important modality to tackle BCa, but its efficiency is often compromised due to t...
M2-ApoBDs as a therapeutic strategy for systemic lupus erythematosus: targeted macrophage reprogramming and treg differentiation [0.03%]
M2-ApoBDs治疗系统性红斑狼疮的策略：靶向巨噬细胞重编程及诱导Tregs分化
Juan Ji,Shaoying Yang,Yongxin Xu et al.
Juan Ji et al.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that affects various organs and systems, significantly impacting patients' health and quality of life. Conventional drugs, including glucocorticoids and standard immunosupp...