Co-encapsulation of norcantharidin prodrugs and lomitapide in nanoparticles to regulate CCL4 expression by inhibiting Wnt/β-catenin pathway for improved anti-tumor immunotherapy [0.03%]
norcantharidin前药与lomitapide共载于纳米粒中通过抑制Wnt/β-catenin通路调控CCL4表达以增强抗肿瘤免疫治疗
Feng Zhao,Liming Gong,Ping Wang et al.
Feng Zhao et al.
In the absence of tumor antigen specificity, direct chemokine administration carries the risk of significant "on-target, off-tumor" toxicities, highlighting the need for small-molecule approaches with reduced immunogenicity. This study inve...
Correction: Hypoxia-responsive core-cross-linked supramolecular nanoprodrug based on dendritic drug-drug conjugates for synergetic anticancer therapy [0.03%]
纠正：基于树枝状药物-药物共轭物的缺氧响应型超分子纳米前药用于协同抗肿瘤治疗
Yue Ding,Yu Xie,Liangshun Zheng et al.
Yue Ding et al.
Published Erratum
Journal of nanobiotechnology. 2025 May 21;23(1):368. DOI:10.1186/s12951-025-03462-3 2025
A dual-targeting bio-liposomes nanodrug repair endothelial cell dysfunction and restore macrophage cholesterol flow homeostasis to treat early atherosclerosis [0.03%]
双重靶向生物脂质体纳米药物修复内皮细胞功能障碍并恢复巨噬细胞胆固醇流动稳态以治疗动脉粥样硬化早期病变
Qi Zhang,Shengchao Ma,Xue Kang et al.
Qi Zhang et al.
Hyperhomocysteinemia (HHy) can lead to vascular endothelial cell dysfunction, progressive inflammation and lipid metabolism disorder, which finally result in the onset and development of atherosclerosis, a major contributor to cardiovascula...
Multi-enzymatic biomimetic cerium-based MOFs mediated precision chemodynamic synergistic antibacteria and tissue repair for MRSA-infected wounds [0.03%]
用于耐甲氧西林金黄色葡萄球菌感染伤口的多酶仿生铈基MOF介导的精准化学动力学协同抗菌及组织修复研究
Shiqi Chen,Yifan Li,Qiang Ma et al.
Shiqi Chen et al.
Antibiotic-resistant pathogens represent a significant global public health challenge, particularly in refractory infections associated with biofilms. Urgent development of innovative, safe, and therapeutically adaptive strategies to combat...
Harnessing intracellular bacteria in bladder by intravesical delivery of antibiotics-loaded nanodiamonds to reduce the recurrence of urinary tract infection [0.03%]
负载抗生素的纳米金刚石用于膀胱给药以减少尿路感染的复发
Carmen Oi Kwan Law,Hoi Man Leung,Meijun Wang et al.
Carmen Oi Kwan Law et al.
Treating urinary tract infections (UTIs) effectively is a difficult task due to the emergence of antibiotic-resistant bacteria and limited antibiotic access to intracellular bacteria within the bladder lining. Numerous studies of the antibi...
Advancing cancer gene therapy: the emerging role of nanoparticle delivery systems [0.03%]
癌症基因治疗的发展：纳米颗粒递送系统的作用日益重要
Maoze Wang,Huina Liu,Jinling Huang et al.
Maoze Wang et al.
Gene therapy holds immense potential due to its ability to precisely target oncogenes, making it a promising strategy for cancer treatment. Advances in genetic science and bioinformatics have expanded the applications of gene delivery techn...
Targeting phosphatidylserine in tumor cell membranes with a zinc-containing molecule to efficiently combat tumor metastasis [0.03%]
利用含锌分子靶向肿瘤细胞膜中的磷脂酰丝氨酸有效防治肿瘤转移
Xiao-Hong Zhou,Jia-Wei Wang,Wei You et al.
Xiao-Hong Zhou et al.
Metal drugs, such as platinum drugs, are widely used in tumor treatment. However, most traditional tumor treatments face the risk of failure due to the ineffective control over drug resistance and tumor metastasis. Targeting the cell membra...
A self-assembled multicomponent RNA nano-biopesticide for increasing the susceptibility of destructive bean flower thrips to insecticides via dsNrf2 [0.03%]
一种可自我组装的多组分RNA纳米生物农药可通过dsNrf2增加毁灭性刀豆花蓟马对杀虫剂的敏感性
Jiajia Zhao,Zeng Wang,Jiaming Yin et al.
Jiajia Zhao et al.
High resistance of bean flower thrips (BFT, Megalurothrips usitatus) has led to the unscientific application of insecticides to cause famous "toxic cowpea" incidents in China. Nuclear factor erythroid 2-related factor 2 (Nrf2) plays an impo...
Structural optimization of Sr/Zn-phosphate conversion coatings triggered by ions preloading on micro/nanostructured titanium surfaces for bacterial infection control and enhanced osteogenesis [0.03%]
离子预加载触发的微/纳米结构钛表面Sr/Zn磷酸盐转化膜结构优化用于控制细菌感染和促进成骨作用
Kangqing Zuo,Aonan Li,Taoning Si et al.
Kangqing Zuo et al.
Phosphate conversion coatings on metallic implants can synergistically integrate functional components and structural regulation, offering excellent biocompatibility and osteogenic activity. However, the passive oxide layer on the titanium ...
Silicon-coated carbon quantum dots composite nanomaterials mediate pest resistance activation in tobacco (Nicotiana tabacum) [0.03%]
硅包覆碳量子点纳米复合材料介导烟草对病虫害抵抗性的激活作用
Kang-Li He,Jing-Han Yang,Fu-Xiao Yu et al.
Kang-Li He et al.
Background: Plant resistance inducers based on nanomaterials (NMs) are a cutting-edge and promising field of interdisciplinary research, focused on developing environmentally and ecologically friendly alternatives for pro...