Oral administration of probiotic spores-based biohybrid system for efficient attenuation of Salmonella Typhimurium-induced colitis [0.03%]
一种基于芽孢菌的生物杂化系统高效缓解鼠伤寒沙门氏菌诱导结肠炎口服给药研究
Mengya Niu,Luo Zhao,Shuang Gong et al.
Mengya Niu et al.
Salmonella Typhimurium (S. Tm), a Gram-negative pathogenic bacterium, is one of the most common causes of invasive bacterial diseases. Antibiotic therapy remains the principal therapeutic modality for treating S. Tm infection. However, due ...
An orally-administered nanotherapeutics with gold nanospheres supplying for rheumatoid arthritis therapy by re-shaping gut microbial tryptophan metabolism [0.03%]
一种口服纳米药物通过重塑肠道微生物色氨酸代谢治疗类风湿关节炎
Chuan Yang,Langlang Xie,Zihan Deng et al.
Chuan Yang et al.
Dysbiosis of gut microbiota significantly exacerbates the progression of rheumatoid arthritis (RA). Targeting gut microbiota may present a promising therapeutic strategy for RA. Gold nanospheres (GNS), known for excellent biocompatibility, ...
Tumor microenvironment responsive Mn-based nanoplatform activate cGAS-STING pathway combined with metabolic interference for enhanced anti-tumor therapy [0.03%]
基于Mn的纳米平台激活cGAS-STING信号通路联合代谢干扰响应肿瘤微环境以增强抗肿瘤治疗
E Wen,Yu Tian,Yu Chen et al.
E Wen et al.
Despite the encouraging developments in tumor immunotherapy, the complex tumor microenvironment (TME) and abnormal energy metabolism persist as key factors facilitating immune escape. Recent research has emphasized the significant potential...
A lyophilizable LNP vaccine enables STING-reinforced postoperational adjuvant immunotherapy [0.03%]
一种可冻干的LNP疫苗能够强化术后佐剂免疫疗法并激活STING信号通路
Yi Yang,Jiaxin Guo,Jialong Qi et al.
Yi Yang et al.
Immune checkpoint blockade therapy (iCBT) has revolutionized cancer treatment, however, there is a low response rate, especially in treating postsurgical reoccurring tumors. Vaccine based immunotherapy can sensitize iCBT, but its developmen...
From bench to bedside: the research status and application opportunity of extracellular vesicles and their engineering strategies in the treatment of skin defects [0.03%]
从实验室到临床：外泌体及其工程化策略在皮肤缺损治疗中的研究现状及应用前景
Longwei Cui,Yantao Song,Zhipeng Hou et al.
Longwei Cui et al.
Engineered extracellular vesicles (EVs), which are EVs modified to enhance certain biological properties, offer a promising therapeutic strategy for the treatment of skin defects. Conventional nanomaterials often encounter clinical translat...
Efficient delivery of small RNAs to podocytes in vitro by direct exosome transfection [0.03%]
通过直接外泌体转染高效地将小RNA递送至体外足细胞
Tim Lange,Luzia Maron,Claudia Weber et al.
Tim Lange et al.
Background: Podocytes are a crucial component of the glomerular filtration barrier, and changes in their 3D structure contribute to over 80% of chronic kidney disease (CKD) cases. Exosomal small RNAs play a key role in ce...
Catalase-encapsulated matrix metalloproteinase-9 responsive nanogels for modulation of inflammatory response and treatment of neutrophilic asthma [0.03%]
包封过氧化氢酶的基质金属蛋白酶9响应型纳米凝胶用于调节炎症反应和治疗中性粒细胞哮喘
Xiaoping Guo,Xu Zuo,Wenxue Zheng et al.
Xiaoping Guo et al.
Asthma is a chronic disease with typical pathological features such as airflow limitation, airway inflammation and remodeling. Of these, neutrophilic asthma is considered to be the more severe and corticosteroid-resistant subtype of asthma....
Amelioration of the rheumatoid arthritis microenvironment using celastrol-loaded silver-modified ceria nanoparticles for enhanced treatment [0.03%]
用于改善类风湿关节炎微环境的Celastrol负载银修饰氧化铈纳米颗粒的制备及其增强治疗效果研究
Xiaoru Zhang,Xiaguo Fu,Wanying Chen et al.
Xiaoru Zhang et al.
Rheumatoid arthritis (RA) is characterized by elevated levels of reactive oxygen species (ROS) and a persistent inflammatory microenvironment dominated by M1 macrophages, both of which contribute to disease progression. To address these pat...
Layered double hydroxides for regenerative nanomedicine and tissue engineering: recent advances and future perspectives [0.03%]
用于再生纳米医学和组织工程的层状双氢氧化物：近期进展与未来前景
Junsi Luo,Yiteng Cui,Laijun Xu et al.
Junsi Luo et al.
With the rapid development of nanotechnology, layered double hydroxides (LDHs) have attracted considerable attention in the biomedical field due to their highly tunable composition and structure, superior biocompatibility, multifunctional b...
Photo-controlled co-delivery of verteporfin and acriflavine via platelets achieves potentiated glioblastoma-targeted photodynamic therapy [0.03%]
基于血小板的光控协同递送 verteporfin 和 acriflavine 实现肿瘤强化光动力治疗
Jie Guo,Meng-Fei Wang,Shen-Jun Yuan et al.
Jie Guo et al.
The potential of glioblastoma (GBM) photodynamic therapy (PDT) is limited by inadequate GBM drug delivery, and the development of resistance to PDT as a result of cellular damage response that critically involves the hypoxia-inducible facto...