DNA binding effects of LDH nanozyme for aseptic osteolysis mitigation through STING pathway modulation [0.03%]
通过调节STING途径缓解无菌性骨溶解的LDH纳米酶的DNA结合效应
Zi Fu,Meng Zhang,Ying Huang et al.
Zi Fu et al.
Persistent and intense inflammation is recognized as the primary cause of wear-particle-induced aseptic osteolysis, which ultimately resulting in aseptic prosthesis loosening. Reducing inflammation plays a significant role in mitigating ost...
Extracellular vesicles from adipose-derived stromal/stem cells reprogram dendritic cells to alleviate rat TMJOA by transferring mitochondria [0.03%]
脂肪源间充质干细胞分泌的细胞外囊泡通过转移线粒体来重编程树突状细胞从而缓解大鼠TMJ骨关节炎
Ziyi Mei,Hanyue Li,Chuling Huang et al.
Ziyi Mei et al.
Temporomandibular joint osteoarthritis (TMJOA) urgently needs regenerative therapies due to the limited effects of traditional treatments. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) are considered a potent alternative fo...
Concurrent induction of pyroptosis and immunogenic cell death by capsaicin/graphene nanocomplex for enhanced breast cancer immunotherapy [0.03%]
辣椒素/石墨烯纳米复合物并发诱导焦亡和免疫细胞死亡用于增强乳腺癌免疫治疗
Silu Li,Xin Jin,Yumo Zhang et al.
Silu Li et al.
Inducing immunogenic cell death (ICD) has emerged as a promising strategy for targeting immunologically "cold" tumors. However, most current therapies focus on a single mechanism, limiting their efficacy. In this study, we propose a nano-en...
Nanoparticle-mediated SIRT1 inhibition suppresses M2 macrophage polarization and hepatocarcinogenesis in chronic hepatitis B [0.03%]
基于纳米颗粒的SIRT1抑制可下调乙肝肝炎相关肝癌中的M2型巨噬细胞极化作用
He Zhang,Feng Yuan,Nan Zhao et al.
He Zhang et al.
Hepatocellular carcinoma (HCC) is a major complication of chronic hepatitis B (CHB), with macrophage M2 polarization playing a critical role in shaping the tumor-promoting hepatic immune microenvironment. Sirtuin 1 (SIRT1) has been implicat...
Ligustrazine nano-drug delivery system ameliorates doxorubicin-mediated myocardial injury via piezo-type mechanosensitive ion channel component 1-prohibitin 2-mediated mitochondrial quality surveillance [0.03%]
川芎嗪纳米给药系统通过Piezo类机械敏感离子通道成分1- prohibitin 2介导的线粒体质量监控改善阿霉素诱导的心肌损伤
Junyan Wang,Haowen Zhuang,Chun Li et al.
Junyan Wang et al.
Background: Doxorubicin (DOX) demonstrates significant therapeutic and anticancer efficacy. Nevertheless, it demonstrates significant cardiotoxicity, resulting in permanent cardiac damage. Ligustrazine (LIG) is a bioactiv...
Pulmonary hazards of nanoplastic particles: a study using polystyrene in in vitro models of the alveolar and bronchial epithelium [0.03%]
纳米塑料颗粒的肺部危害：利用体外肺泡和气管上皮模型进行聚苯乙烯研究
Sara Michelini,Safaa Mawas,Ema Kurešepi et al.
Sara Michelini et al.
Background: Nanoplastics (NPs) are released into the environment through the degradation of plastic objects, leading to human exposure. Due to their small size, concerns have been raised about the potential hazards to the...
"Double-sided protector" Janus hydrogels for skin and mucosal wound repair: applications, mechanisms, and prospects [0.03%]
“双面保护” janus 水凝胶促进皮肤及黏膜创面修复：进展、机制与前景
Laijun Xu,Junyi Zhang,Junsi Luo et al.
Laijun Xu et al.
Skin and mucous membranes serve as crucial barrier tissues within the human body. Defective wound healing not only inflicts pain but also heightens the risk of infection and impairs immune function. Janus hydrogels possess two-sided distinc...
Advances in brain-targeted delivery strategies and natural product-mediated enhancement of blood-brain barrier permeability [0.03%]
脑靶向递送策略及天然产物介导的血脑屏障通透性增强的研究进展
Suyi Liu,Xingyue Jin,Yuanyuan Ge et al.
Suyi Liu et al.
The blood-brain barrier (BBB) represents a formidable challenge in the treatment of neurological disorders, as it restricts the passage of most therapeutic agents into the central nervous system (CNS). Research in brain-targeted delivery st...
Sequential nanoparticle therapy targeting neutrophil hyperactivation to prevent neutrophil-induced pulmonary fibrosis [0.03%]
靶向中性粒细胞过度活化以预防中性粒细胞诱导的肺纤维化的序贯纳米药物治疗
Hye-Jin Lee,Na Kyeong Lee,Jisun Kim et al.
Hye-Jin Lee et al.
Background: Pulmonary fibrosis, a major complication of severe COVID-19 and post-acute sequelae of SARS-CoV-2 infection (PASC), is driven by excessive neutrophil activation and the formation of neutrophil extracellular tr...
Multifunctional hydrogel with mild photothermal properties enhances diabetic wound repair by targeting MRSA energy metabolism [0.03%]
温和光热多功能水凝胶通过靶向MRSA代谢促进糖尿病伤口修复
Qian Gao,Fangfang Hu,Zihan Chai et al.
Qian Gao et al.
Background: Diabetic wound infections, exacerbated by multidrug-resistant pathogens like MRSA, remain a critical challenge due to biofilm persistence and dysregulated oxidative-inflammatory-metabolic crosstalk. ...