An exploration of the ocular mysteries linking nanoparticles to the patho-therapeutic effects against keratitis [0.03%]
探索纳米颗粒通过眼部神秘联系对抗角膜炎的病理治疗效果
Siying Qu,Shuihua Zheng,Sibtain Muhammad et al.
Siying Qu et al.
Microbial keratitis, a sight-threatening corneal infection, remains a significant global health concern. Conventional therapies using antimicrobial agents often suffers from limitations such as poor drug penetration, side effects, and occur...
Cerium-doped Prussian blue biomimetic nanozyme as an amplified pyroptosis inhibitor mitigate Aβ oligomer-induced neurotoxicity in Alzheimer's disease [0.03%]
铈掺杂的仿生普鲁士蓝纳米酶作为增强的热凋亡抑制剂减轻阿尔茨海默病中Aβ寡聚体诱导的神经毒性
Jing Ma,Yu Tian,Chengzhong Du et al.
Jing Ma et al.
Antioxidant enzyme therapy shows promise for treating Alzheimer's disease (AD), but significant challenges remain in achieving effective blood-brain barrier (BBB) penetration and sustained therapeutic effects. We developed a novel neutrophi...
Noninvasive molecular imaging using anti-Trop-2 aptamer for targeted therapy of small cell lung cancer [0.03%]
利用抗Trop-2适配体进行非侵入性分子成像以实现小细胞肺癌的靶向治疗
Yamei Chen,Xuwei Liu,Yang Sun et al.
Yamei Chen et al.
Recent advancements in antibody-drug conjugates (ADCs) targeting trophoblast surface cell antigen 2 (Trop-2) have brought important progress in the field of targeted therapy. This progress also holds promise for the treatment of small cell ...
Atomically-precise Au22(Lys-Cys-Lys)16 nanoclusters for radiation sensitization [0.03%]
用于辐射增敏的原子精确Au22(Lys-Cys-Lys)16纳米团簇
Elham Zeinizade,Goonay Yousefalizideh,Parimah Aminfar et al.
Elham Zeinizade et al.
Radiotherapy is a leading method for cancer treatment, effectively eliminating cancer cells but often causing collateral damage to surrounding healthy tissue. Radiosensitizers aim to enhance the therapeutic effects of radiotherapy while min...
NebulaPlate: a droplet microfluidic platform to analyze platelet aggregation [0.03%]
NebulaPlate：分析血小板聚集的液滴微流控平台
Zheyi Jiang,Meng Wei,Jiawei Zhu et al.
Zheyi Jiang et al.
The accurate assessment of platelet activity is crucial in clinical practice and scientific research owing to the pivotal role of platelets in the progression of cardiovascular conditions, such as arterial thrombotic diseases. However, conv...
Responsive nanoparticles synergize with Curcumin to break the "reactive oxygen Species-Neuroinflammation" vicious cycle, enhancing traumatic brain injury outcomes [0.03%]
响应型纳米颗粒与姜黄素协同作用，打破“活性氧-神经炎症”恶性循环，改善创伤性脑损伤结果
Xianhua Fu,Yongkang Zhang,Guojie Chen et al.
Xianhua Fu et al.
Traumatic brain injury (TBI) disrupts oxygen homeostasis in the brain, leading to excessive reactive oxygen species (ROS) production and dysregulated antioxidant mechanisms, which fail to clear excess ROS. This ROS overload promotes the exp...
An anti-CD19-exosome delivery system navigates the blood-brain barrier for targeting of central nervous system lymphoma [0.03%]
抗CD19-外泌体传输系统穿越血脑屏障靶向中枢神经系统淋巴瘤
Meifang Zhao,Qi Li,Yali Chai et al.
Meifang Zhao et al.
Background: High-dose methotrexate (HD-MTX) serves as the cornerstone of central nervous system lymphoma (CNSL) treatment, but its efficacy is limited due to low blood-brain barrier (BBB) penetration and adverse effects. ...
Nanophotonic-enhanced photoacoustic imaging for brain tumor detection [0.03%]
用于脑肿瘤检测的纳米光子增强型光电声成像技术
Ali Rizwan,Badrinathan Sridharan,Jin Hyeong Park et al.
Ali Rizwan et al.
Photoacoustic brain imaging (PABI) has emerged as a promising biomedical imaging modality, combining high contrast of optical imaging with deep tissue penetration of ultrasound imaging. This review explores the application of photoacoustic ...
Regulation of cancer-associated fibroblasts for enhanced cancer immunotherapy using advanced functional nanomedicines: an updated review [0.03%]
使用先进的功能纳米药物调控癌症相关成纤维细胞以增强癌症免疫治疗：一项最新的回顾
Tingting Liao,Xiaoxiao Chen,Fengkai Qiu et al.
Tingting Liao et al.
The tumor microenvironment (TME) is a complex and dynamic ecosystem that plays a critical role in cancer progression. It comprises various cell types, including immune cells, tumor cells, and stromal cells. Among these, cancer-associated fi...
Naringenin cationic lipid-modified nanoparticles mitigate MASLD progression by modulating lipid homeostasis and gut microbiota [0.03%]
奈林芸香碱阳离子脂质修饰的纳米粒通过调节脂质稳态和肠道微生物群来减轻MASLD的进展
Lu Dong,Wenyong Lou,Congfei Xu et al.
Lu Dong et al.
Naringenin (NAR) possesses various pharmacological activities including antioxidant, anti-inflammatory, and hepatoprotective effects. However, its therapeutic efficacy is limited by its hydrophobic and crystalline nature. This study aimed t...