HAMA-SBMA hydrogel with anti-inflammatory properties delivers cartilage organoids, boosting cartilage regeneration [0.03%]
具有抗炎性能的HAMA-SBMA水凝胶递送软骨类器官以促进软骨再生
Yuyang Gao,Qingshan Li,Zhangzhen Du et al.
Yuyang Gao et al.
Cartilage tissue lacks blood supply, which limits its ability to self-repair. Cartilage organoid (CO) technology, which replicates the structure and function of cartilage, holds significant promise. However, it is essential to maintain cell...
Correction: MicroRNA-19b-3p dysfunction of mesenchymal stem cell-derived exosomes from patients with abdominal aortic aneurysm impairs therapeutic efficacy [0.03%]
纠正：腹主动脉瘤患者间充质干细胞衍生的外泌体中microRNA-19b-3p功能障碍会降低治疗效果
Yuxiao Zhang,Xiaoran Huang,Tucheng Sun et al.
Yuxiao Zhang et al.
Published Erratum
Journal of nanobiotechnology. 2025 May 30;23(1):402. DOI:10.1186/s12951-025-03490-z 2025
Nano-formulations in disease therapy: designs, advances, challenges, and future directions [0.03%]
纳米制剂在疾病治疗中的设计、进展、挑战和未来方向
YunYan Shi,Xiao Li,Zhiyuan Li et al.
YunYan Shi et al.
Nano-formulations, as an innovative drug delivery system, offer distinct advantages in enhancing drug administration methods, improving bioavailability, promoting biodegradability, and enabling targeted delivery. By exploiting the unique si...
TRPC6-targeted dexamethasone nanobubbles with ultrasound-guided theranostics for adriamycin-induced nephropathy [0.03%]
用于多柔比星致肾病的超声引导诊疗的特异性靶向TRPC6的糖皮质激素纳米气泡
Lin Wu,Yang Liu,Ziqi Fu et al.
Lin Wu et al.
Background: Glucocorticoid (GC) intolerance and systemic toxicity pose significant challenges in the treatment of primary nephrotic syndrome (PNS), underscoring the urgent need for targeted therapies that maximize efficac...
Controllable nickel ions release from deferoxamine mesylate-triggered nickel-iron layered double hydroxide for eliciting apoptotic cell death in prostate cancer [0.03%]
硫酸米多 saxapeptidium 触发的镍铁层状双氢氧化物可控释放镍离子诱导前列腺癌细胞凋亡
Zhengbin Wang,Hui Wang,Linnan Yang et al.
Zhengbin Wang et al.
Despite their unique advantages and vast potential, nanomaterials employed in cancer therapy still encounter challenges such as uneven biodistribution, unintended drug leakage, and especially potential tissue damage caused by off-target tox...
Immunogenicity and cellular response of a herpes zoster virus gEgI fusion protein adjuvanted with CpG-emulsion in mice [0.03%]
CpG-蒙囿佐剂的水痘带状疱疹病毒gEgI融合蛋白在小鼠体内免疫原性及细胞应答反应的研究
Sibo Zhang,Yarong Zeng,Lingyan Cui et al.
Sibo Zhang et al.
Herpes zoster (HZ), commonly known as shingles, arises from the reactivation of the latent varicella-zoster virus (VZV) when VZV-specific cellular immunity declines below a critical threshold necessary for viral suppression. The current lea...
Atherosclerosis enhances the efficacy of liposome-encapsulated bromocriptine in reducing the incidence of prolactinemia in pituitary tumors [0.03%]
动脉粥样硬化增强脂质体溴隐亭治疗垂体瘤高催乳素血症的疗效
Zhe Zhang,Guangyu Jia,Qi Wang et al.
Zhe Zhang et al.
Intranasal drug delivery via nanocarriers has long been a research focus for enhancing drug concentration in the brain. However, the strategy of exploiting blood-brain barrier (BBB) alterations in atherosclerotic mouse models to enhance nan...
Carbon dots derived from Ligusticum Chuanxiong mitigate cardiac injury by disrupting the harmful oxidative stress-apoptosis cycle [0.03%]
川芎碳点通过破坏有害的氧化应激-凋亡循环来减轻心脏损伤
Yapeng Guo,Lei Yang,Li Yao et al.
Yapeng Guo et al.
Background: Myocardial ischemia-reperfusion injury (MIRI) represents a significant complication following myocardial infarction surgery, for which preventive strategies remain limited. The primary pathological characteris...
Interplay between material properties and cellular effects drives distinct pattern of interaction of graphene oxide with cancer and non-cancer cells [0.03%]
材料性质与细胞效应的相互作用决定了石墨烯氧化物与癌细胞和正常细胞相互作用的行为模式
Yingxian Chen,Vinicio Rosano,Neus Lozano et al.
Yingxian Chen et al.
Understanding how graphene oxide (GO) interacts with cells is crucial for its safe and efficient biomedical applications. Despite extensive research, a systematic investigation using a panel of cell lines, thoroughly characterized label-fre...
Myogenic nano-adjuvant for orthopedic-related sarcopenia via mitochondrial homeostasis modulation in macrophage-myosatellite metabolic crosstalk [0.03%]
线粒体稳态调控介导的巨噬细胞-肌卫星细胞代谢互作促进肌肉生长型纳米佐剂用于骨科相关肌肉减少症治疗研究
Xudong Zhang,Peng Zhang,Yunliang Zhu et al.
Xudong Zhang et al.
The decline in skeletal muscle mass and muscle strength linked to aging, also known as sarcopenia, is strongly associated with disability, traumatic injury, and metabolic disease in patients. Meanwhile, sarcopenia increases the risk of adve...