Probiotic nanocomposite materials with excellent resistance, inflammatory targeting, and multiple efficacies for enhanced treatment of colitis in mice [0.03%]
具有优异耐受性、抗炎靶向性和多种功效的益生菌纳米复合材料可提高小鼠结肠炎治疗效果
Yuewen Huang,Hongting Cai,Huipeng Liu et al.
Yuewen Huang et al.
The occurrence of inflammatory bowel disease (IBD) is relevant to impaired intestinal mucosal barrier and disordered gut microbiota, subsequently leading to excessive production of reactive oxygen species (ROS) and elevated levels of inflam...
Injectable celastrol-loading emulsion hydrogel for immunotherapy of low-immunogenic cancer [0.03%]
用于低免疫原性癌症免疫治疗的注射型载雪莲草酯乳液水凝胶
Yu Liu,Jia Zhang,Chunyu Lai et al.
Yu Liu et al.
Immunotherapy, exemplified by immune checkpoint blockade (ICB), has been extensively employed in antitumor treatments. Nevertheless, its efficacy in addressing low-immunogenic tumors has not yielded satisfactory results, primarily due to th...
SynBioNanoDesign: pioneering targeted drug delivery with engineered nanomaterials [0.03%]
合成生物纳米设计：开创工程纳米材料的靶向药物传递技术
Qian Cai,Rui Guo,Dafu Chen et al.
Qian Cai et al.
Synthetic biology and nanotechnology fusion represent a transformative approach promoting fundamental and clinical biomedical science development. In SynBioNanoDesign, biological systems are reimagined as dynamic and programmable materials ...
Efficient delivery of anlotinib and radioiodine by long circulating nano-capsules for active enhanced suppression of anaplastic thyroid carcinoma [0.03%]
长循环纳米胶囊有效输送安罗替尼和放射性碘对分化型甲状腺癌的主动增强抑制作用
Linlin Zhang,Chuanying Zhu,Shuo Huang et al.
Linlin Zhang et al.
131I therapy is clinically unfeasible for anaplastic thyroid carcinoma (ATC), due to lack of active targets and ATC's resistance to radiation. Novel radionuclide-labeled targeted nano-drug delivery systems have exhibited the potential of pr...
Regulating macrophage phenotypes with IL4I1-mimetic nanoparticles in IDD treatment [0.03%]
利用IL4I1模拟纳米颗粒调节巨噬细胞表型用于IDD治疗
Jiaying Luo,Guoxin Jin,Shaoqian Cui et al.
Jiaying Luo et al.
Intervertebral disc degeneration (IDD) is a degenerative spinal condition characterized by disc structural damage, narrowing of joint spaces, and nerve root compression, significantly reducing patients' quality of life. To address this chal...
ROS-responsive simvastatin nano-prodrug based on tertiary amine-oxide zwitterionic polymer for atherosclerotic therapy [0.03%]
基于叔胺氧化两性离子聚合物的ROS响应型辛伐他汀纳米前药用于动脉粥样硬化治疗
Haiqin Yang,Mengcheng Guo,Qingran Guan et al.
Haiqin Yang et al.
Atherosclerosis (AS) is a major cause of cardiovascular disease and is characterized by high levels of reactive oxygen species (ROS) and lipid deposition. This study utilized ROS-responsive oxalate bonds to conjugate simvastatin (SV) and te...
Overcoming ice: cutting-edge materials and advanced strategies for effective cryopreservation of biosample [0.03%]
克服冰晶问题：用于生物样本有效冻存的先进材料和策略
Miaorong Huang,Minhua Hu,Gengyuan Cai et al.
Miaorong Huang et al.
Cryopreservation techniques have been widely used, especially in biomedical applications and preservation of germplasm resources. Ideally, biological materials would maintain functional integrity as well as a normal structure and can be rec...
Oxygen-delivery nanoparticles enhanced immunotherapy efficacy monitored by granzyme B PET imaging in malignant tumors [0.03%]
氧输送纳米颗粒增强免疫治疗效果通过颗粒酶B的PET影像监测在恶性肿瘤中的应用
Xingyi Wang,Hanyi Fang,Wenzhu Hu et al.
Xingyi Wang et al.
Limited treatment response and inadequate monitoring methods stand firmly before successful immunotherapy. Recruiting and activating immune cells in the hypoxic tumor microenvironment is the key to reversing immune suppression and improving...
Sustainable nanophytosome-based therapies against multidrug-resistant Escherichia coli in urinary tract infections: an in Vitro and in vivo study [0.03%]
针对尿路感染的可持续纳米植物体疗法对抗多重耐药大肠杆菌：一项体外和体内研究
Ming Ming Wen,Ibrahim A Abdelwahab,Rania Abozahra et al.
Ming Ming Wen et al.
Background: Urinary tract infection (UTI) is a prevalent bacterial infection impacting a significant number of individuals globally. The rise in multidrug-resistant (MDR) E. coli strains as the predominant cause of UTIs p...
Multifunctional hydrogel targeting senescence to accelerate diabetic wound healing through promoting angiogenesis [0.03%]
多功能水凝胶通过促进血管生成以加速糖尿病伤口愈合针对细胞衰老的目标
Hao Yang,Yongfei Chen,Yanchao Rong et al.
Hao Yang et al.
Diabetic wound healing remains a significant clinical challenge because of hyperglycaemia-induced cellular senescence, impaired angiogenesis, and chronic inflammation. To address these issues, we developed a multifunctional hydrogel (GelMA/...