In situ and dynamic screening of extracellular vesicles as predictive biomarkers in immune-checkpoint inhibitor therapies [0.03%]
免疫检查点抑制剂治疗中外泌体的原位和动态筛查以预测生物标志物
Yihe Wang,Yue Sun,Mengqi Liu et al.
Yihe Wang et al.
Extracellular vesicles (EVs) is promising in predicting the efficacy of immune checkpoint inhibitor (ICI) therapies. But it is challenging to determine the level of circulating EVs due to their variations in spatial and temporal distributio...
Gastrointestinal exposure to silica nanoparticles induced Alzheimer's disease-like neurotoxicity in mice relying on gut microbiota and modulation through TLR4/NF-κB and HDAC [0.03%]
基于肠道菌群介导的TLR4/NF-κB和HDAC调制的小鼠类似阿尔茨海默病的大脑神经毒性诱导了硅纳米颗粒的胃肠道暴露
Lisha Du,Benjie Wang,Xinyi Wang et al.
Lisha Du et al.
Background: Silica nanoparticles (SiO2 NPs) are widely used in the food and pharmaceutical industries and dramatically increase the health risks associated with gastrointestinal exposure. However, the neurotoxicological e...
Targeted tumor cell-intrinsic CTRP6 biomimetic codelivery synergistically amplifies ferroptosis and immune activation to boost anti-PD-L1 immunotherapy efficacy in lung cancer [0.03%]
靶向肿瘤细胞固有的CTRP6仿生共输送协同增强铁死亡和免疫激活以增强肺癌抗PD-L1免疫治疗效果
Songhua Cai,Jing Huang,Hongjie Fan et al.
Songhua Cai et al.
Background: Lung adenocarcinoma (LUAD) is a refractory tumor with high incidence, high mortality, and easy development of drug resistance. Represented by PD-L1, the rise of immunotherapy and multidrug combinations offers ...
In situ radiochemical doping of functionalized inorganic nanoplatforms for theranostic applications: a paradigm shift in nanooncology [0.03%]
用于治疗诊断应用的原位放射化学掺杂功能性无机纳米平台：纳米肿瘤学中的一个范式转变
Sanchita Ghosh,Yutong Liang,Weibo Cai et al.
Sanchita Ghosh et al.
In situ radiochemical doping presents a transformative approach for synthesizing radiolabeled inorganic nanoparticles (NPs) for cancer theranostics. Traditional radiolabeling techniques rely on bifunctional chelators, which often require ha...
A minimalist self-assembly nanosystem for cancer immunotherapy via multiple immune activation [0.03%]
一种用于癌症免疫治疗的最小化自组装纳米系统实现多重免疫激活作用
Weizhe Xu,Shiyuan Wang,Jiayi Zhang et al.
Weizhe Xu et al.
In recent years, anti-tumor immunity has emerged as a central focus in cancer research, with the rapid advancement of immunotherapy heralding a new era in cancer treatment. Despite the significant potential of immunotherapy, the use of sing...
Fucoidan-decorated metal-zoledronic acid nanocomplexes suppress tumor metastasis by inducing ferroptotic cell death and enhancing cancer immunotherapy [0.03%]
岩藻糖素修饰的金属-唑来磷酸纳米复合物通过诱导铁死亡和增强癌症免疫治疗来抑制肿瘤转移
Hsin-Ting Tsai,Chi Lin,Chu-Hung Chung et al.
Hsin-Ting Tsai et al.
Metastatic tumor cells that escape from immune surveillance are a dilemma in cancer treatment, and thus developing selective targeting agents to treat metastatic tumor and reinstate immune perception is imperative for clinical applications....
ZnO colludes with C. acnes in healing delay and Scar hyperplasia by barrier destruction [0.03%]
锌氧化物通过破坏屏障与痤疮丙酸杆菌合作导致愈合延迟和瘢痕增生
Fenglan Zhang,Tianyi Wang,Wenqiao Wang et al.
Fenglan Zhang et al.
As an important component of sunscreen products for sensitive skin, the potential damage mechanism of ZnO nanoparticles on skin surface with barrier structure or function defect caused by Cutibacterium acnes (C. acnes) has not been elucidat...
Correction: PEGylated gas vesicles: a promising novel ultrasound contrast agent for diagnosis and guiding radiofrequency ablation of liver tumor [0.03%]
关于PEG修饰的气体囊泡：一种有前景的新型超声诊断和射频消融肝肿瘤引导剂（原文有误：PEGylated gas vesicles: a promising novel ultrasound contrast agent for diagnosis and guiding radiofrequency ablation of liver tumor）
Kezhi Yu,Yongquan Huang,Yuanyuan Wang et al.
Kezhi Yu et al.
Published Erratum
Journal of nanobiotechnology. 2025 May 30;23(1):394. DOI:10.1186/s12951-025-03491-y 2025
Advanced oral drug delivery systems for gastrointestinal targeted delivery: the design principles and foundations [0.03%]
口服胃肠道定位给药先进药物传递系统的设计原理与基础研究
Yafei Zhang,Yiran Wang,Yao Lu et al.
Yafei Zhang et al.
Oral administration has long been considered the most convenient method of drug delivery, requiring minimal expertise and invasiveness. Unlike injections, it avoids discomfort, wound infections, and complications, leading to higher patient ...
Carbon dots from purple sweet potato as a promising anti-inflammatory biomaterial for alleviating the LPS-induced inflammation in macrophages [0.03%]
一种有前景的抗炎生物材料：以紫心甘薯为原料制备的碳点用于缓解脂多糖诱导的小胶质细胞炎症
Jiebang Jiang,Zhiyuan Pan,Yiren Su et al.
Jiebang Jiang et al.
This study synthesizes carbon dots derived from crude extracts of purple sweet potato (CPP-CDs) and evaluates its anti-inflammatory effects in a lipopolysaccharide (LPS) -induced acute inflammation model. Characterization revealed that CPP-...