A novel tetrahedral framework nucleic acid-based antibiotic delivery system: overcoming biofilm barriers to combat chronic infections [0.03%]
一种新型四面体笼状核酸载药体系：克服生物被膜屏障以治疗慢性感染
Yue Hu,Zhou Chen,Xinggang Mao et al.
Yue Hu et al.
Background: Overcoming bacterial biofilm barriers to enhance the efficacy of antibiotics remains a major therapeutic challenge, necessitating the development of efficient and biocompatible drug delivery systems. While fra...
Stimuli-responsive smart materials enabled high-performance biosensors for liquid biopsies [0.03%]
基于刺激响应型智能材料的高性能液体活检生物传感器
Xiaoqi Gao,Bayinqiaoge Bayinqiaoge,Ming Li et al.
Xiaoqi Gao et al.
Liquid biopsies have emerged as a key tool that enables personalized medicine, enabling precise detection of biochemical parameters to tailor treatments to individual needs. Modern biosensors enable real-time detection, precise diagnosis, a...
Correction: Co-delivery of axitinib and PD-L1 siRNA for the synergism of vascular normalization and immune checkpoint Inhibition to boost anticancer immunity [0.03%]
纠正：阿昔替尼和PD-L1siRNA的共递送，以实现血管正常化和免疫检查点抑制的协同作用，以增强抗癌免疫力
Yanhong Liu,Liming Gong,Jing Feng et al.
Yanhong Liu et al.
Published Erratum
Journal of nanobiotechnology. 2025 Jun 24;23(1):461. DOI:10.1186/s12951-025-03532-6 2025
Delivery of LOXL1-AS1-siRNAs using targeting peptide-engineered extracellular vesicles with focused ultrasound to suppress medulloblastoma metastasis [0.03%]
利用聚焦超声引导的靶向肽工程外泌体递送LOXL1-AS1-siRNA抑制髓母细胞瘤转移
Anh Duy Do,Shing-Shung Chu,Le Hien Giang et al.
Anh Duy Do et al.
Background: Metastasis of medulloblastomas (MBs) is difficult to treat and remains the primary cause of death in children with this brain tumor. Current treatment focuses on radiotherapy to limit metastatic recurrence and...
Ze Yang,Chao Cheng,Zhongliang Li et al.
Ze Yang et al.
Chimeric antigen receptor (CAR)-T cell therapy targeting glypican-3 (GPC3) has shown promise in the treatment of hepatocellular carcinoma (HCC). However, the efficacy of CAR-T cells that focus solely on cell surface tumor-associated antigen...
An imaging-guided self-amplifying photo-immunotherapeutic nanoparticle for STING pathway activation and enhanced cancer therapy [0.03%]
一种成像引导的自放大的光免疫治疗纳米颗粒，用于STING途径活化和增强癌症治疗
Qiaoqi Chen,Huilin Yu,Lin Li et al.
Qiaoqi Chen et al.
The stimulator of interferon genes (STING) pathway is a promising target in cancer immunotherapy. However, current nanomedicine strategies targeting the STING pathway often suffer from limited tumor specificity and insufficient immune activ...
Bionic bearing-inspired lubricating microspheres with Immunomodulatory effects for osteoarthritis therapy [0.03%]
仿生关节软骨自适应智能润滑微球用于调节免疫的软骨保护疗法研究
Xu He,Xingzhi Liu,Xinyi Cheng et al.
Xu He et al.
Inflammatory infiltration and inappropriate friction remain the two main challenges in treating osteoarthritis (OA). An effective treatment platform is anticipated to lubricate the cartilage and ameliorate intra-articular inflammation. Here...
An oxygen-generating nanoplatform remodels the immunosuppressive tumor microenvironment via synergistic lactate depletion and sonodynamic therapy [0.03%]
一种产氧纳米平台通过协同去除乳酸和声动力治疗重塑免疫抑制肿瘤微环境
Chenchen Tang,Xinyi Tang,Jingwei Tang et al.
Chenchen Tang et al.
Lactate is an immunosuppressive molecule that plays an important role in tumor progression. Regulating lactate metabolism to remodel the immunosuppressive microenvironment represents a promising strategy for cancer therapy. However, owing t...
Curcumin-loaded PLGA microparticles integrated with ZnO/GelMA hydrogel microneedles for infectious wound healing and reduction of hypertrophic scars [0.03%]
一种用于感染性伤口愈合和减少肥厚性疤痕的微针：负载姜黄素的PLGA微粒与ZnO/GelMA水凝胶微针集成体系
Yifan Zhang,Ziyi Zhou,Na Liu et al.
Yifan Zhang et al.
Intelligent ROS therapy driven by iron-based nanozyme with controllable catalytic activity for infected wound healing [0.03%]
一种基于铁的纳米酶驱动的智能ROS疗法促进感染伤口愈合
Lixue Deng,Yanni Cheng,Jia Liu et al.
Lixue Deng et al.
Therapeutic generation of reactive oxygen species (ROS) through catalytic therapy demonstrates antibacterial efficacy against wound infections. However, prolonged and unregulated ROS production risks inducing intolerable oxidative stress al...