Nanoengineered hydrogels disrupt tumor antioxidant defense via photothermal-chemodynamic synergy and oxidative stress boosts [0.03%]
纳米工程水凝胶通过光热化学动力协同作用打破肿瘤抗氧化防御并增强氧化应激反应
Leiguang Ye,Yang Qiao,Peisan Wang et al.
Leiguang Ye et al.
By integrating photothermal and chemodynamic properties, Ru-based nanomaterials have emerged as promising agents for tumor therapy. However, their clinical translation is hindered by high systemic toxicity, suboptimal therapeutic efficacy, ...
Machine learning framework for investigating nano- and micro-scale particle diffusion in colonic mucus [0.03%]
机器学习框架在结肠粘液中纳米和微米级颗粒扩散的研究中的应用
Marco Tjakra,Kristína Lidayová,Christophe Avenel et al.
Marco Tjakra et al.
Biosimilar artificial mucus models that mimic native mucus facilitate efficient, lab-based drug diffusion studies, addressing the costly and challenging preclinical phase of drug development, especially for nano- and micro-scale particle-ba...
Ultrasound molecular imaging of M2 macrophages for early detection of chronic rejection in heart transplantation [0.03%]
超声分子影像检测M2型巨噬细胞在心脏移植后慢性排斥反应早期诊断中的应用研究
Jia Xu,Cheng Deng,Tang Gao et al.
Jia Xu et al.
Chronic rejection (CR) remains the leading cause of morbidity and mortality in heart transplantation survivors. The primary pathological features of CR encompass cardiac allograft vasculopathy and myocardial fibrosis. Currently, its diagnos...
Obesity enhances ovarian cancer chemotherapy efficacy through C1q-mediated tumor targeting and immune activation [0.03%]
C1q介导的肿瘤靶向和免疫激活增强肥胖促进卵巢癌化疗疗效
Shiyi Xu,Nana Bie,Xinzhuang Su et al.
Shiyi Xu et al.
Personalized protein corona significantly influences the biodistribution and therapeutic efficacy of nanomedicines, generating unique profiles that can impact treatment outcomes. Here, we demonstrate that pegylated liposomal doxorubicin (PL...
Natural multi-active nanoparticles integrated biological hydrogel microcarriers for wound healing [0.03%]
天然多效纳米粒子集成生物水凝胶微载体促进伤口愈合
Junyi Che,Danqing Huang,Yang Wang et al.
Junyi Che et al.
Bioactive substance-integrated hydrogels have demonstrated efficacy in diabetic wound treatment. However, challenges remain in identifying naturally derived, multifunctional active substances capable of addressing the complex pathophysiolog...
Metal-organic frameworks activate the cGAS-STING pathway for cancer immunotherapy [0.03%]
金属有机骨架通过激活cGAS-STING通路进行癌症免疫治疗
Shuxuan Zhu,Wenfei Xu,Hongxia Li et al.
Shuxuan Zhu et al.
Despite the major breakthroughs in immunotherapy, a substantial number of cancer patients continue to confront problems such as low response rates, which restrict the overall effectiveness of existing treatments. There is an urgent necessit...
Blood-brain barrier-penetrating Angiopep-2/Sirtuin 1 nanoparticles rescue sevoflurane neurotoxicity through multi-omics identified necroptosis pathways [0.03%]
穿透血脑屏障的Angiopep-2/沉默信息调节因子1纳米颗粒通过多组学识别的坏死性凋亡通路缓解异氟醚神经毒性
Yi Chang,Xue Zhang,Shuo Zhang et al.
Yi Chang et al.
Developmental neurotoxicity (DNT) induced by sevoflurane exposure poses significant risks to pediatric anesthesia, yet effective protective strategies remain limited. Here, we developed self-assembling Angiopep-2/SIRT1 nanoparticles (Ang/SI...
Self-assembled nanopeptide dendrites with high antifungal activity and protease hydrolytic stability for fungal keratitis treatment [0.03%]
一种高抗真菌活性和蛋白酶水解稳定性的纳米肽树枝状分子自组装体用于真菌性角膜炎治疗
Guoyu Li,Hongyu Chen,Wenwen Chen et al.
Guoyu Li et al.
The excessive use of antibiotics in recent years has contributed to an increase in microbial resistance, thereby compromising the health of both humans and animals and necessitating the development of innovative therapeutic strategies. In t...
Strategic advances in liposomes technology: translational paradigm in transdermal delivery for skin dermatosis [0.03%]
脂质体技术的进展在皮肤病透皮治疗中的应用研究
Anmol Choudhury,Apoorv Kirti,Sudakshya S Lenka et al.
Anmol Choudhury et al.
Liposomes, spherical vesicles made of phospholipids and cholesterol, have captivated researchers for their encapsulation abilities, biocompatibility, and versatility. This review delves into the core aspects and benefits of liposomal techno...
Bioengineered cardiovascular bypass grafts via in vivo self-assembly of scaffold-guided tubular tissue in rats [0.03%]
基于血管内支架引导组织管状结构自组装构建生物工程化心血管旁路移植血管（小鼠）
Shiqi Hu,Xiuhong Sun,Rui Zhou et al.
Shiqi Hu et al.
Cardiovascular bypass grafting remains a crucial therapeutic approach for complex atherosclerotic diseases. However, the clinical application of traditional grafts is hampered by limited autologous vessel availability, while the translation...