Dual-targeting oral nanoparticle mucosal vaccine against brucella infection: co-targeting M cells and dendritic cells [0.03%]
一种口服纳米颗粒黏膜疫苗对抗布鲁氏病感染：同时靶向M细胞和树突状细胞
Tingting Tian,Xinxin Qi,Juan Shi et al.
Tingting Tian et al.
This study designed and evaluated a chitosan nanoparticle-based mucosal vaccine (CS-CKS9-MEV-DCpep-NPs) targeting M cells and dendritic cells against Brucella. From four immunogenic outer membrane proteins (OMP10, Omp25, Omp31, BtpB), 41 sp...
Correction: Low frequency vibrating magnetic field-triggered magnetic microspheres with a nanoflagellum-like surface for cancer therapy [0.03%]
纠正：低频磁振动触发的类似纳米鞭毛的磁微球癌症治疗研究
Yuliang Guo,Wenxuan Yang,Guangjin Pu et al.
Yuliang Guo et al.
Published Erratum
Journal of nanobiotechnology. 2026 Jul 15;24(1):663. DOI:10.1186/s12951-026-04713-7 2026
Shikonin-functionalized magnetic nanoparticles mediated magnetothermodynamic therapy with synergistic antibacterial efficacy and immunomodulation for accelerated infected wound healing [0.03%]
用于加速感染伤口愈合的协同抗菌和免疫调节的紫草素修饰磁性纳米颗粒介导的磁热动力疗法
Jiajun Li,Ning Jiang,Yuqing Miao et al.
Jiajun Li et al.
Infected skin wounds healing remains a great clinical challenge due to the complexity of the wound healing process, involving infection control and subsequent immunomodulation. Magnetothermodynamic (MTD) therapy, combining the magnetotherma...
Dynamic cross-linked injectable hydrogel for combined oxaliplatin-resveratrol therapy in colorectal cancer peritoneal metastasis [0.03%]
用于结直肠癌腹膜转移的奥沙利铂-白藜芦醇联合治疗的动态交联可注射水凝胶
Haonan Huang,Haoyu Huang,Cheng Zuo et al.
Haonan Huang et al.
Peritoneal metastasis (PM) of colorectal cancer (CRC) remains a major therapeutic challenge due to the limited efficacy of current systemic and intraperitoneal treatments. To overcome these limitations, we developed an injectable, self-heal...
Navitoclax-encapsulated dual pH-responsive copolymeric nanoparticles improves hepatocellular carcinoma treatment with induction of apoptosis and immune activation [0.03%]
负载navitoclax的双重pH响应型共聚物纳米粒通过诱导凋亡和激活免疫改善肝癌治疗效果
Jiahao Wang,Tianao Xie,Heng Jiang et al.
Jiahao Wang et al.
Background: Navitoclax (ABT-263) exhibits strong cytotoxic effects against hepatocellular carcinoma cells in vitro; however, its therapeutic efficacy in vivo is limited by insufficient local drug accumulation and compensa...
Hypoxia-injured pulmonary vascular targeting and microenvironment-responsive nanoparticle to treat hypoxic pulmonary hypertension [0.03%]
缺氧损伤肺血管靶向及微环境响应型纳米药物治疗缺氧性肺动脉高压
Hongyan Wu,Ruilin Zhou,Wenting Hui et al.
Hongyan Wu et al.
Hypoxic pulmonary hypertension (HPH) is characterized by sustained pulmonary vasoconstriction and vascular remodeling caused by chronic hypoxia. The vicious cycle between hypoxia-inducible factor-1α (HIF-1α) activation and reactive oxygen...
A polyphenol-functionalized cartilage matrix bioink protects cell-laden organoid constructs under oxidative stress [0.03%]
聚酚功能化软骨基质生物墨水可在氧化应激下保护含有细胞的类器官构建体
Zhongtai Zhang,Qian Wu,Dachuan Liu et al.
Zhongtai Zhang et al.
Cartilage repair in osteoarthritis is limited not only by structural defects in articular cartilage but also by the chronic redox and immune dysregulation in the microenvironment. Acellular cartilage matrix (ACM) replicates tissue-specific ...
S2P-modified PLGA bifunctional nanodrug: inhibiting vascular senescence and foam cell formation for atherosclerosis treatment [0.03%]
用于动脉粥样硬化治疗的S2P修饰PLGA双功能纳米药物：抑制血管衰老和泡沫细胞形成
Cilin Zhao,Xiaolan Luo,Yajuan Fu et al.
Cilin Zhao et al.
The progression of atherosclerosis (AS) is closely related to endothelial senescence and abnormal lipid metabolism in macrophages. Although metformin (Met) can exert vascular endothelial protective effects by inhibiting endothelial cell sen...
VSIG3 preserves mitochondrial homeostasis and restrains CD4⁺ T-Cell infiltration in myocardial ischemia-reperfusion injury through regulation of mitochondrial-derived vesicles [0.03%]
VSIG3通过调节线粒体衍生囊泡维持线粒体稳态并抑制心肌缺血再灌注损伤中的CD4⁺T细胞浸润
Jian Hou,Liqun Shang,Zi Yan et al.
Jian Hou et al.
Myocardial ischemia-reperfusion (MI/R) injury remains an inevitable and severe clinical challenge during cardiac surgery, primarily characterized by mitochondrial dysfunction and robust CD4+ T cell infiltration. In this study, we investigat...
A biomimetic cryoprotectant preserves extracellular vesicles bioactivity for intravenous administration and potentiates wound healing [0.03%]
一种生物模拟冷冻保护剂可保存外泌体的生物活性以用于静脉给药并促进伤口愈合
Pingao Zhang,Xinkai Nie,Hongwei Mao et al.
Pingao Zhang et al.
Extracellular vesicles (EVs) have emerged as promising vehicles for drug delivery and disease therapy owing to their intrinsic biocompatibility and capacity to transfer functional biomolecules. However, limitations in current storage techno...