Tumor targeting dendritic nanocarrier with immunogenic cell death inducing and TIGIT blockade for synergistic chemo-immunotherapy against TNBC [0.03%]
一种靶向肿瘤的树突状纳米载体用于诱导免疫性细胞死亡和阻断TIGIT以协同治疗三阴性乳腺癌化学免疫疗法
Jia Wang,Zhiji Wang,Kaiming Li et al.
Jia Wang et al.
The clinical therapeutic effect of immune-checkpoint blockade (ICB) on triple-negative breast cancer (TNBC) is limited due to low tumor immunogenicity and tumor immunosuppressive microenvironment. Combination therapies of chemotherapy and I...
Targeted nanodelivery strategies for atrial fibrillation: concomitant targeting of fibrosis suppression and electrical conduction restoration through advanced nanobiotechnology [0.03%]
利用高级纳米生物技术靶向输送策略治疗房颤：同时抑制纤维化和恢复电传导
Yanxiao Liang,Haoyuan Zheng,Yuan Tian
Yanxiao Liang
Atrial fibrillation (AF), the most common form of cardiac arrhythmia, is closely associated with atrial fibrosis and electrophysiological remodeling, both of which contribute to its persistence and recurrence. Current treatment strategies r...
Advances in nanomedicine-based retinal drug delivery: mechanisms and translational applications [0.03%]
基于纳米医学的视网膜药物递送进展：机制和转化应用
Helia Nafar,Pouya Mahdavi Sharif,Nima Rezaei
Helia Nafar
Retinal diseases like age-related macular degeneration (AMD), diabetic retinopathy (DR), and diabetic macular edema (DME), alongside optic neuropathies such as glaucoma, are primary contributors to irreversible visual impairment and blindne...
Charge-mediated directed assembly of Pt nanoshell on PDA: colorimetric-catalytic co-enhanced lateral flow immunoassay for point-of-care testing [0.03%]
基于电荷介导的Pt纳米壳定向组装：用于现场快速检测的比色-催化协同增强型免疫层析试纸条
Xingsheng Yang,Lei Ren,Jing Liang et al.
Xingsheng Yang et al.
Effectively enhancing the detection sensitivity of lateral flow immunoassay (LFIA) without dependence on instruments has crucial implications for point-of-care diagnostics. Herein, we introduce a core-shell structured polydopamine (PDA)@pla...
Magnesium-doped Zr-porphyrin MOF nanoarchitecture with pH/photo dual stimuli-responsiveness for targeted pesticides and improved biosafety [0.03%]
用于靶向农药和改善生物安全的pH/光双重刺激响应镁掺杂Zr-卟啉MOF纳米结构
Hongwei Li,Yang Gao,Xiquan Ding et al.
Hongwei Li et al.
Background: Conventional pesticide formulations often exhibit poor utilization efficiency, rapid photodegradation, and ecological persistence, which severely limit their field efficacy. Herein, we report a dual pH/light s...
Recruiting T-cells toward the brain for enhanced glioblastoma chemo-immunotherapy efficacy by co-delivery of cytokines and temozolomide via ultrasound-gated redox-responsive extracellular vesicles [0.03%]
通过超声波门控还原响应型细胞外囊泡共递送细胞因子和替莫唑胺招募T细胞进行增强的胶质母细胞瘤化疗免疫治疗
Lei Dong,Qing Xu,Hanjiao Liu et al.
Lei Dong et al.
The main limitation of chemo-immunotherapy in glioblastoma (GBM) is the immunosuppressive tumor microenvironment (TME) and the restricted permeability of the blood-brain barrier (BBB). Here, we engineer redox-responsive macrophage-derived e...
Fisetin carbon dots alleviate periodontitis by enhancing mitophagy through regulation of sirtuin 3 SUMOylation [0.03%]
异鼠李素碳点通过调节SIRT3的SUMO化来增强线粒体自噬从而缓解牙周炎
Yu Deng,Xinyu Jiang,Zhenzhen Che et al.
Yu Deng et al.
Periodontitis is a chronic inflammatory disease strongly linked to the sustained accumulation of reactive oxygen species (ROS). Eliminating excessive ROS and modulating the periodontal microenvironment to suppress inflammation represents a ...
Laminin-conjugated aligned nanofiber yarns for topographical and biochemical guidance of neurite outgrowth and branching regulation [0.03%]
用于轴突生长和分支调节的层粘连蛋白共轭排列纳米纤维线
Ning Jia,Liu Yu,Hongfang Meng et al.
Ning Jia et al.
Background: Aligned nanofiber scaffolds have shown great promise in promoting neurite orientation and elongation, making them a key design strategy in peripheral nerve tissue engineering. However, most current designs lac...
Protective effects of biomimetic Cu-Zn-MOF against DOX-Induced cardiotoxicity through inhibiting oxidative stress and ferroptosis [0.03%]
仿生Cu-Zn-MOF通过抑制氧化应激和铁死亡保护DOX引起的心脏毒性作用
Jian Wang,Meng Zhao,Jian Zhang et al.
Jian Wang et al.
Background: Doxorubicin (DOX), a member of the anthracycline family, is widely recognized as an effective chemotherapeutic agent for cancer treatment. However, its clinical application is limited due to its cardiotoxicity...
A therapeutic-grade purified exosome system alleviates osteoarthritis by regulating autophagy through the BCL2-Beclin1 axis [0.03%]
一种治疗级纯化外泌体系统通过BCL2-BECLIN1轴调节自噬从而缓解骨关节炎
Gongyin Zhao,Farbod Yousefi,Ichiro Tsukamoto et al.
Gongyin Zhao et al.
Background: Osteoarthritis is a common and progressive degenerative joint disorder marked by cartilage degradation, subchondral bone remodeling, and chondrocyte apoptosis. Autophagy, a tightly regulated intracellular degr...