Self-amplifying RNA therapy encoding CNTF with disulfiram co-delivery promotes optic nerve repair through microglial pyroptosis inhibition and RGC axonal regeneration [0.03%]
Qianyue Zhang,Yusha Liu,Qin Wei et al.
Qianyue Zhang et al.
Background: Traumatic optic neuropathy (TON) is a devastating cause of irreversible vision loss for which no effective treatment currently exists. Its poor prognosis stems from two major challenges: the limited regenerati...
Therapeutic translation of traditional Chinese medicine Huangqi derived exosome like nanoparticles: targeting prostate cancer through ferroptosis activation, immune reprogramming, and microbiome modulation [0.03%]
黄芪来源的类外泌体纳米颗粒治疗翻译：通过铁死亡激活、免疫重编程和微生物组调节靶向前列腺癌
Ye An,Jin-Zhou Xu,Gui-Chen Ye et al.
Ye An et al.
Plant derived exosome-like nanoparticles (PELNs) are emerging as a powerful tool for treating cancers. Among them, PELNs derived from traditional Chinese medicines have shown great potential in treating various cancers. However, many Chines...
Carbon dot nanozymes as free radical scavengers for the management of hepatic ischemia-reperfusion injury by regulating the liver inflammatory network and inhibiting apoptosis [0.03%]
碳点纳米酶作为自由基清除剂通过调节肝脏炎症网络和抑制凋亡来管理肝缺血再灌注损伤
Haoge Geng,Jiayu Chen,Kansheng Tu et al.
Haoge Geng et al.
Development of VP30-targeted nanoparticles using DPS4 fusion peptides for the inhibition of Ebola virus [0.03%]
利用DPS4融合肽靶向VP30的纳米颗粒抑制埃博拉病毒的发展研究
Fang Wu,Yuanwei Huang,Rui Li et al.
Fang Wu et al.
Multiple outbreaks of Ebola virus in West Africa have posed significant threats to global public health owing to its high pathogenicity and fatality rates. Current treatments for Ebola Virus Disease are limited, underscoring the imperative ...
Dissolvable silk microneedles delivering minocycline-loaded ZIF-8 nanoparticles for targeted modulation of sebocyte metabolism and improved acne therapy [0.03%]
载米诺环素的ZIF-8纳米颗粒的大豆蛋白微针贴片：针对痤疮发病机制的组合疗法研究
Xuefan Yang,Dandan Ruan,Feng Ye et al.
Xuefan Yang et al.
Background: Acne Vulgaris (AV) lesions exhibit an acidic, sebum-rich, and inflammation-prone microenvironment in which conventional minocycline therapy is constrained by the stratum-corneum barrier and systemic exposure. ...
PET-microplastics trigger endothelial glycocalyx loss via ER stress and ROS unleashing IL-1β-driven SMC switching and early aortic structural impairment [0.03%]
微塑料通过内质网压力和活性氧释放触发血管内皮糖胺聚糖丢失，驱动IL-1β诱导的平滑肌细胞转化及主动脉早期结构损伤
Weixue Huo,Jin Qu,Sen Wang et al.
Weixue Huo et al.
Polyethylene terephthalate microplastics (PET-MPs), a major microplastics component identified in human vasculature, pose emerging environmental health risks. This study systemically profiled MPs in human aortic tissues and investigated the...
UBQLN1 Inhibition reduces MASH progression through downregulating SIKE/p38 MAPK pathway in hepatocyte [0.03%]
UBQLN1抑制通过下调肝细胞中的SIKE/p38 MAPK途径来减缓MASH进展
Yifei Chen,Fuji Yang,Guojun Zheng et al.
Yifei Chen et al.
Background: Metabolic dysfunction-associated steatohepatitis (MASH) is increasingly recognized as a major global contributor to cirrhosis and hepatocellular carcinoma (HCC). However, the key regulatory molecules governing...
Self-disassembling diatomic nanocluster bomb unlock reciprocal synergistic multi-pathway cancer therapy [0.03%]
自分解双原子纳米簇炸弹解锁癌症治疗互惠协同多途径疗法
Bairui Qi,Zhu Xiao,Yuntian Zhu et al.
Bairui Qi et al.
The emerging chemodynamic therapy (CDT), which leverages tumour microenvironment (TME)-specific conversion of H₂O₂ into cytotoxic reactive oxygen species (ROS), suffers from limited efficacy due to low-level endogenous H₂O₂, inefficient...
Hydrogel-extracellular vesicle engineering delivery system: a promising therapeutic strategy for wound healing [0.03%]
水凝胶-细胞外囊泡工程递送系统：伤口愈合的潜在治疗策略
Fengrui Gao,Zhuang Hu,Huazhen Xu et al.
Fengrui Gao et al.
Chronic refractory wounds, such as diabetic foot ulcers, present significant clinical challenges due to a dysregulated healing microenvironment. Extracellular vesicles (EVs) have emerged as promising therapeutic agents owing to their pro-an...
The role of natural and engineered exosomes in repairing damage to the nervous system [0.03%]
外源性和工程化外泌体在修复神经系统损伤中的作用
Tiangui Liu,Yang Fan,Qiong Zhang et al.
Tiangui Liu et al.
Following neurological injury, neuronal cell death and neuroinflammation mutually reinforce each other, further exacerbating neurological damage. Concurrently, the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) impede drug p...