Ginseng exosomes modulate M1/M2 polarisation by activating autophagy and target IKK/IкB/NF-кB to alleviate inflammatory bowel disease [0.03%]
人参外泌体通过激活自噬作用调节M1/M2极化，并靶向IKK/IкB/NF-кB以减轻炎症性肠病
Song Yang,Liangliang Fan,Lijia Yin et al.
Song Yang et al.
Background: Exosomes are involved in intercellular communication and regulation of the inflammatory microenvironment. In a previous study, we demonstrated that fresh ginseng exosomes (GEs) alleviated inflammatory bowel di...
Renal-clearable and tumor-retained nanodots overcoming metabolic reprogramming to boost mitochondrial-targeted photodynamic therapy in triple-negative breast cancer [0.03%]
可被肾脏清除并可在肿瘤内保留的纳米点克服代谢重编程以提升三阴性乳腺癌线粒体光动力治疗效果
Defan Yao,Yanshu Wang,Xue Dong et al.
Defan Yao et al.
Background: Targeting tumor metabolism reprogramming has demonstrated a synergistic antitumor effect in photodynamic therapy of triple-negative breast cancer (TNBC). However, such a combination therapeutic regimen has enc...
Recent advances and challenges in metal-based antimicrobial materials: a review of strategies to combat antibiotic resistance [0.03%]
基于金属的抗菌材料在对抗抗生素耐药性策略方面的最新进展和挑战综述
Chuanda Zhu,Zhenli Diao,Yuanyuan Yang et al.
Chuanda Zhu et al.
Despite the availability of a series of classical antibiotic drugs, bacterial infections continue to represent a significant and urgent threat to global human health. The emergence of drug-resistant bacteria and the slow pace of antibiotic ...
Platelet hitchhiking vascular-disrupting agents for self-amplified tumor-targeting therapy [0.03%]
用于自我增强的肿瘤靶向治疗的血小板结合血管破坏药物
Hongyu Chu,Yajun Xu,Yuezhan Shan et al.
Hongyu Chu et al.
The vascular-disrupting agent DMXAA (5,6-dimethylxanthone-4-acetic acid) exhibits potent anticancer activity by targeting tumor vasculature and activating immune responses via the cGAS-STING pathway. However, its clinical application is hin...
Co-delivery of axitinib and PD-L1 siRNA for the synergism of vascular normalization and immune checkpoint inhibition to boost anticancer immunity [0.03%]
轴息尼和PD-L1 siRNA的共传递用于血管正常化和免疫检查点抑制的协同作用以增强抗癌免疫
Yanhong Liu,Liming Gong,Jing Feng et al.
Yanhong Liu et al.
Immune checkpoint inhibition (ICI) has become the mainstay of immunotherapy for the treatment of renal cell carcinoma (RCC). However, only a small portion of patients exhibit a positive response to PD-1/PD-L1 blockade therapy and the key re...
Iris C Swart,Oliver J Debski-Antoniak,Aneta Zegar et al.
Iris C Swart et al.
The continued emergence and zoonotic threat posed by coronaviruses highlight the urgent need for effective antiviral strategies with broad reactivity to counter new emerging strains. Nanobodies (or single-domain antibodies) are promising al...
Microenvironment-responsive NIR-IIb multifunctional nanozyme platform for bacterial imaging and specialized anti-anaerobic bacteria periodontal therapy [0.03%]
微环境响应型近红外二区多功能纳米酶平台用于细菌成像及专性厌氧菌牙周病治疗
Suai Lin,Tiehan Cui,Yuxin Jiang et al.
Suai Lin et al.
Periodontitis is a chronic inflammatory disease caused by plaque. In order to remove pathogens and promote tissue repair, the following steps need to be taken simultaneously: localizing the diseased area, improving the anaerobic microenviro...
Extracellular vesicle-mediated bidirectional communication between the liver and other organs: mechanistic exploration and prospects for clinical applications [0.03%]
肝脏和其它器官之间通过细胞外囊泡进行的双向交流：从机理探索到临床应用展望
Wenhui Mo,Yunke Peng,Yanyi Zheng et al.
Wenhui Mo et al.
The liver, functioning as an endocrine organ, secretes a variety of substances that influence the activities of other body organs. Conversely, molecules generated by organs such as bone, the gut, and adipose tissue can also impact liver fun...
Multi-stimuli-responsive pectin-coated dendritic mesoporous silica nanoparticles with Eugenol as a sustained release nanocarrier for the control of tomato bacterial wilt [0.03%]
具有多刺激响应性的多孔硅纳米颗粒作为持续释放载体控制番茄细菌性枯萎病的研究
Xueping Guo,Huiyan Li,Zhihao Li et al.
Xueping Guo et al.
Background: Environmentally responsive nanoscale biocide delivery system enhances smart, regulated, and synergistic biocide application with precise biocide release. In this study, pectin-modified dendritic mesoporous sil...
NaHS@Cy5@MS@SP nanoparticles improve rheumatoid arthritis by inactivating the Hedgehog signaling pathway through sustained and targeted release of H2S into the synovium [0.03%]
通过持续和靶向释放H2S至滑膜，NaHS@Cy5@MS@SP纳米颗粒通过灭活刺猬信号通路改善类风湿关节炎
Xue-Xue Zhu,An-Jing Xu,Wei-Wei Cai et al.
Xue-Xue Zhu et al.
Background: Aberrant proliferation and inflammation of fibroblast-like synoviocytes (FLSs) significantly contribute to the pathogenesis of rheumatoid arthritis (RA). Deficiency of hydrogen sulfide (H2S) is a driving force...