Automatic target-seeking nanoparticle inhibiting orthotopic drug-resistant colon cancer and liver metastases via regulating cancer cell adhesion and proliferation [0.03%]
一种可自动定位的纳米药物载体颗粒通过调节癌细胞黏附和增殖抑制原位耐药结肠癌及肝转移病灶
Shaobo Bai,Yang Sun,Miao Liu et al.
Shaobo Bai et al.
Galectin-3 (Gal-3) plays an important role in adhesion and proliferation of cancer cells. The level of Gal-3 in blood and the expression of Gal-3 in colon cancer tissue are significantly increased in patient with colon cancer. The elevated ...
Orchestrated Cu2+-coordinated tetracycline-porphyrin self-assembly remodels tumor microenvironment for photo-enhanced immuno-chemodynamic therapy [0.03%]
铜离子调控四环素-卟啉自组装重构肿瘤微环境增强光免疫化学动力学治疗
Xianbin Sun,Xinyi Wang,Xudong Li et al.
Xianbin Sun et al.
An ultra-sensitive and point-of-care time-resolved fluorescence immunochromatographic platform for trace-level brucellosis antibody rapid on-site detection [0.03%]
一种超灵敏的时间分辨荧光免疫层析平台技术用于布鲁氏病抗体现场快速检测
Bin Wang,Shusen Ji,Boya Li et al.
Bin Wang et al.
Tumor-microenvironment responsive nanomodulator for near infrared photothermal immunotherapy of hepatocellular carcinoma [0.03%]
肝癌近红外光热免疫治疗的肿瘤微环境响应型纳米调控剂
Fei Kong,Tian Xia,Xiaorong Zhu et al.
Fei Kong et al.
Recurrence and metastasis remain significant challenges in the clinical treatment of hepatocellular carcinoma (HCC). The integration of photodynamic therapy and immunotherapy has emerged as a promising strategy for treating cancer in terms ...
Advancing immunomodulation in organ transplantation: the therapeutic potential of self-assembled rapamycin nanoparticles in allograft rejection [0.03%]
器官移植中免疫调节的新进展：雷帕霉素纳米颗粒在预防同种异体移植排斥中的治疗潜力研究
Ruiqi Sun,Zhi Liang,Ning Wang et al.
Ruiqi Sun et al.
Background: Transplant rejection remains a significant challenge, necessitating effective post-transplant interventions. Although rapamycin (RAPA) is a recognized immunosuppressant, its utility is limited by poor solubili...
Cell-laden biomimetic microneedles reconstruct skin rete ridge and stem cell niche [0.03%]
含细胞的类组织微针重建皮肤乳头状突和干细胞生态位
Xiaohong Zhao,Zongze Wu,Yicheng Guo et al.
Xiaohong Zhao et al.
The traditional skin graft wound repair strategy for burns is unable to reconstruct the normal anatomy of the skin, resulting in quality problems such as scarring, which have always been the bottleneck of burn medicine. The skin rete ridge ...
Biomimetic nanocomplexes loading with evolocumab and curcumin for synergistic anti-atherosclerosis therapy in ApoE-/- mice [0.03%]
一种用于协同治疗动脉粥样硬化的仿生纳米复合物（evolocumab和姜黄素）的构建及评价研究
Yi Liu,Shengchao Ma,Feng Li et al.
Yi Liu et al.
Atherosclerosis (AS), a leading contributor to global cardiovascular mortality, is primarily driven by the dual pathological processes of chronic persistent inflammation and dysregulated lipid metabolism. Current clinical interventions are ...
Targeting CD39 boosts PD-1 blockade antitumor therapeutic efficacy via strengthening CD8 + TILs function and recruiting B cells in cervical cancer [0.03%]
靶向CD39通过增强宫颈癌中CD8+t细胞的功能和募集B细胞来提高PD-1阻断的抗肿瘤疗效
Lili Jiang,Tong Wu,Xinyu Qu et al.
Lili Jiang et al.
Although the programmed cell death protein 1 (PD-1) blockade has been authorized for the treatment of recurrent and metastatic cervical cancer (CC) patients, a significant proportion of CC patients show low objective response rates (ORR) to...
Sirtuin-3 activation by honokiol attenuated anesthesia/surgery-induced cognitive impairment and neuronal ferroptosis via inhibiting mitochondrial GPX4 acetylation [0.03%]
Honokiol通过抑制线粒体GPX4乙酰化激活Sirtuin-3来缓解麻醉/手术引起的认知障碍和神经元铁死亡
Lian Zeng,Pengchao Hu,Xuan Wang et al.
Lian Zeng et al.
Background: Perioperative neurocognitive disorder (PND), a prevalent neurological complication in elderly patients following anesthesia and surgery, has recently been linked to ferroptosis as a central pathogenic mechanis...
An integrated multi-mode detection platform based on CRISPR/Cas 12a and aptamers for ultra-sensitive identification of sulfamethazine and genes associated with sulfonamide resistance [0.03%]
基于CRISPR / Cas 12a和适配体的集成多功能检测平台超灵敏鉴定磺胺二甲嘧啶和耐磺胺类药物基因相关平台
Tao Zhang,Zongwu Meng,Haoyu Yu et al.
Tao Zhang et al.
The production and buildup of sulfamethazine (SMZ) and resistance genes for sulfonamide antibiotics (sul1) pose a serious risk to environmental and public health safety. Creating advanced sensing systems that are both highly sensitive and s...