Intravesical delivery of mucoadhesive and tumor-selective-penetrating nanozymes for enhancing the PDT of bladder cancer [0.03%]
用于增强膀胱癌光动力治疗的黏膜粘附和肿瘤选择性穿透纳米酶的腔内给药
Yang Liu,Wentao Xu,Xiaowen Qin et al.
Yang Liu et al.
Intravesical photodynamic therapy (PDT) emerges as a promising modality for bladder cancer treatment, yet its efficacy is often curtailed by weak muco-adhesion, poor muco-penetration, low tumor-targeting and intra-tumoral oxygen scarcity. I...
Mechanochemically reprogrammed porous tantalum with synergistic antibacterial and osteogenic properties for the treatment of infectious bone defects [0.03%]
用于感染性骨缺损治疗的协同抗菌和成骨多孔钽的机械化学重编程
Yan Sun,Yu Zhang,Kai Zhang et al.
Yan Sun et al.
Infection and poor osseointegration following orthopedic implantation remain significant challenges that can lead to complications, including prosthesis loosening, delayed fracture healing, and even implant failure. Porous tantalum is a gam...
Carrier rocket-inspired hydrogel microspheres targeting subchondral bone osteoclast activity alleviate osteoarthritic pain and cartilage degeneration [0.03%]
载体火箭启发的水凝胶微球靶向软骨下骨破骨细胞活性缓解骨关节炎疼痛和软骨退变
Zhenglin Zhu,Yujia Luo,Pengcheng Xiao et al.
Zhenglin Zhu et al.
Background: Osteoarthritis (OA) represents a major global health challenge, characterized by progressive cartilage degeneration and subchondral bone remodeling, which culminate in debilitating pain and functional impairme...
Fabrication of a dual-stimuli-responsive mesoporous organosilica nanoplatform for co-delivery of fungicide and plant immune inducer toward synergistic disease management [0.03%]
制备一种双重刺激响应介孔有机硅纳米平台以协同管理病害递送杀菌剂和植物免疫诱导剂
Zhaolin Xue,Fangmin Liu,Bin Wang et al.
Zhaolin Xue et al.
The multifunctional nanoplatform, featuring stimuli-responsive controlled release and co-delivery of fungicides with distinct modes of action, exhibits considerable promise for plant disease control. In this study, a novel CYM@MON-SA nanopl...
Nanoliposomal PD-1 antagonist target tumor-draining lymph nodes to revitalize T cells and improve anti-tumor effect in hepatocellular carcinoma [0.03%]
靶向肿瘤引流淋巴结的纳米脂质体PD-1拮抗剂可活化T细胞并改善肝癌的治疗效果
Wanyue Cao,Kai Yang,Gaowei Jin et al.
Wanyue Cao et al.
Background: Tumor-draining lymph nodes (TdLNs) are pivotal in tumor immunotherapy, including the action of immune checkpoint inhibitors such as PD-1/PD-L1 blockade. However, fully harnessing the therapeutic potential of T...
Anni Zhang,Xu Zheng,Guangqi Yan et al.
Anni Zhang et al.
Sonodynamic therapy (SDT) represents an innovative oncological treatment modality that harnesses the synergistic effects of low-intensity ultrasound and sonosensitizers to kill tumor cells. However, this dynamic therapeutic strategy faces m...
A cell-free SHED lysate-hydrogel system for oral ulcer healing with anti-inflammatory and pro-angiogenic effects [0.03%]
一种用于口腔溃疡修复的不含细胞的SHED裂解物-水凝胶系统，具有抗炎和促血管生成作用
Na Dong,Chen Zhang,Qiao Zhang et al.
Na Dong et al.
Oral ulcer (OU) is one of the most common mucosal diseases, yet current drug treatments yield unsatisfactory outcomes. Persistent inflammatory responses and insufficient angiogenesis are the two major obstacles to OU healing. Recently, stem...
Hydrogels as advanced drug delivery platforms for cancer immunotherapy: promising innovations and future outlook [0.03%]
水凝胶在癌症免疫治疗中的应用：作为高级药物输送平台的前景和未来展望
Vahideh Mohammadzadeh,Hoda Atapour-Mashhad,Sedigheh Shahvali et al.
Vahideh Mohammadzadeh et al.
Tumor immunotherapy has appeared as a groundbreaking method in cancer therapy, which destroys cancer cells through identification and attack by stimulating the body's immune system. Despite its rapid development, there are serious challenge...
Wen Deng,Zichen Zhong,Haojie Shang et al.
Wen Deng et al.
Immunotherapy is a highly promising cancer treatment method. However, it is limited by low immunogenicity and an immunosuppressive microenvironment, which could be relieved by immunogenic cell death (ICD). Currently, effective ICD is primar...
Mesenchymal stem cell-derived extracellular vesicles attenuate periductal fibrosis by inhibiting Th17 differentiation in human liver multilineage organoids and Mdr2-/- mice [0.03%]
人肝多能类器官和Mdr2-/-小鼠模型中，间充质干细胞源性外泌体通过抑制Th17分化缓解导管周围纤维化
Wenyi Chen,Xinyi Chen,Feiqiong Gao et al.
Wenyi Chen et al.
Primary sclerosing cholangitis (PSC) pathogenesis involves immune dysregulation, genetic factors, and bile duct pathology; however, a comprehensive pathogenesis model and effective therapeutic strategies remain limited. Here, we develop a n...