Size-tuned PEGylated NIR-II fluorescent probes for high-contrast plant imaging and TMV detection [0.03%]
尺寸可调的PEG修饰的NIR-II荧光探针用于高对比度植物成像和TMV检测
Fang Zhao,Yu-Ling Xu,Meng-Jiao Lu et al.
Fang Zhao et al.
The widespread applications of fluorescence imaging in plant science still suffer from challenges including strong auto-fluorescence (chlorophyll) and tissue light scattering, resulting in low signal-to-background ratio (SBR) for in vivo bi...
Tumor microenvironment remodeling with a telomere-targeting agent and its cooperative antitumor effects with a nanovaccine [0.03%]
端粒靶向剂引起的肿瘤微环境重塑及其与纳米疫苗协同抗肿瘤作用
Jing Bai,Mengzhen Wang,Yiming Luo et al.
Jing Bai et al.
The nucleoside analogue 6-thio-2'-deoxyguanosine (6-thio-dG, also known as THIO) is a telomere-targeting agent with important clinical potency. It can selectively kill telomerase-positive tumor cells. We previously reported that THIO could ...
Lactobacillus plantarum-derived extracellular vesicles from dietary barley leaf supplementation attenuate Citrobacter rodentium infection and intestinal inflammation [0.03%]
膳食大麦叶来源的植物乳杆菌衍生的外泌体通过抑制Citrobacter rodentium感染和肠道炎症而产生抗炎作用
Yu Feng,Qian Zhao,Yifan Zhao et al.
Yu Feng et al.
Background: Inflammatory bowel disease (IBD) is a gastrointestinal inflammatory disorder characterized by disturbed interactions between gut microbiota and host immune response. Barley leaf (BL) is a traditional Chinese h...
Dynamic QSAR modeling for predicting in vivo genotoxicity and inflammation induced by nanoparticles and advanced materials: a time-dose-property/response approach [0.03%]
基于时间-剂量的定量构效关系模型用于预测纳米材料和新兴材料诱导的体内遗传毒性及炎症效应
Michalina Miszczak,Kabiruddin Khan,Pernille Høgh Danielsen et al.
Michalina Miszczak et al.
Predicting the health risks of nanoparticles (NPs) and advanced materials (AdMa) is a critical challenge. Due to the complexity and time-consuming nature of experimental testing, there is a reliance on in silico methods such as quantitative...
Targeting Dicer reprograms tumor-associated macrophages to promote anti-tumoral immunity in colorectal cancer liver metastasis [0.03%]
靶向Dicer可使肿瘤相关巨噬细胞重编程以促进结直肠癌肝转移的抗肿瘤免疫反应
Shenglong Xia,Wenwen Chen,Zhengyang Xu et al.
Shenglong Xia et al.
Background: Tumor-associated macrophages (TAMs) contribute significantly to immunosuppression in colorectal cancer liver metastasis (CRLM), leading to high aggressiveness and poor prognosis. However, the key molecules inv...
Zinc-doped curcumin carbon dots promote infected wound healing with photodynamic via the VEGF signaling pathway [0.03%]
锌掺杂姜黄素碳点通过VEGF信号通路促进感染伤口的光动力愈合
Yifan Zhao,Jia Liu,Lingxiang Sun et al.
Yifan Zhao et al.
Management of bacterial infected wounds remains challenging due to the open, susceptibility to infection and delayed healing characteristics of damaged wounds, and there is an urgent need for non-antibiotic-based wound healing strategies. H...
Remote ischemia precondition protects against renal IRI through apoptosis associated vesicles carrying MIF protein via modulating DUSP6/JNK signaling axis [0.03%]
远程缺血预处理通过携带MIF蛋白的凋亡小体调节DUSP6 / JNK信号轴来预防肾IRI
Nieke Zhang,Zhicong Huang,Yi Xia et al.
Nieke Zhang et al.
Background: Remote ischemic preconditioning (rIPC) has been reported to protect against kidney ischemia-reperfusion injury (IRI) through the delivery of extracellular vesicles (EVs). Among these, apoptosis-induced compens...
Polypyrrole-ferric phosphate-methotrexate nanoparticles enhance apoptosis/ferroptosis of M1 macrophages via autophagy blockage for rheumatoid arthritis treatment [0.03%]
聚吡咯-三氧化二铁-甲氨蝶呤纳米颗粒通过阻断自噬促进M1巨噬细胞凋亡/铁死亡以治疗类风湿关节炎
Hui Liu,Haoyu Wan,Anbiao Zhang et al.
Hui Liu et al.
Rheumatoid arthritis (RA) is an inflammatory disease that progresses from synovial inflammation to cartilage and bone destruction. Eliminating pro-inflammatory M1 macrophages is a promising strategy for RA treatment, but is impeded by cytop...
The effects of Klotho delivering mesenchymal stem cell-derived small extracellular vesicles on acute kidney injury [0.03%]
克洛托多能间充质干细胞来源的小细胞外囊泡对急性肾损伤的影响
Xiao-Hui Deng,Zi-Cong Wu,Qi Sun et al.
Xiao-Hui Deng et al.
Acute kidney injury (AKI) is a life-threating syndrome characterized by sudden loss of kidney function, and its management is challenging and often suboptimal. Mesenchymal stem cells (MSCs) have shown promise in AKI therapy in pre-clinical ...
Genetically engineered T cell membrane-camouflaged nanoparticles triggered cuproptosis for synergistic bladder cancer photothermal-immunotherapy [0.03%]
基因工程T细胞膜伪装的纳米颗粒触发铜死用于协同膀胱癌光热-免疫治疗
Wen Deng,Yuan Chen,Yongke Bai et al.
Wen Deng et al.
Immunotherapy has become a promising and transformative approach for treating advanced or treatment-resistant bladder cancer (BCa). However, its efficacy remains limited due to the immunosuppressive tumor microenvironment (TME) and insuffic...