Transdermal delivery of CRISPR/Cas9-mediated melanoma gene therapy via polyamines-modified thermosensitive hydrogels [0.03%]
聚胺修饰的热敏水凝胶介导的表皮递送CRISPR / Cas9肿瘤基因治疗
Meng Li,Songli Zhou,Suqin Zhang et al.
Meng Li et al.
The main obstacles to the clinical application of the CRISPR/Cas9 system are off-target effects and low delivery efficiency. There is an urgent need to develop new delivery strategies and technologies. Three types of in situ injectable hydr...
Nanoscale engineered exosomes for dual delivery of Sirtuin3 and insulin to ignite mitochondrial recovery in myocardial ischemia-reperfusion [0.03%]
用于心肌缺血再灌注的Sirtuin3和胰岛素协同传递的纳米工程外泌体以触发线粒体恢复
Jiaxin Yang,Xinyi Yun,Weihan Zheng et al.
Jiaxin Yang et al.
Background: Acute myocardial infarction remains a leading cause of mortality, with ischemia-reperfusion (I/R) injury causing severe myocardial damage through mitochondrial dysfunction. While mesenchymal stem cell-derived ...
Engineering a bivalent nanoparticle vaccine with PCV2 capsid protein and PRRSV epitopes [0.03%]
一种二价纳米颗粒亚单位疫苗(PCV2衣壳蛋白和PRRS抗原表位结合疫苗)的设计及评价
Jun Ma,Xun Xiao,Yanrong Zhou et al.
Jun Ma et al.
Background: Coinfection with multiple viruses is a common occurrence in the pig industry. Porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) are two significant pathogens, wit...
Polystyrene microplastics exacerbate mitophagy through mitochondrial dysfunction in the duck lung [0.03%]
聚苯乙烯微塑料通过线粒体功能障碍加重鸭肺线粒体自噬作用
Tiantian Gu,Minghua Kong,Mingcai Duan et al.
Tiantian Gu et al.
Microplastics (MPs) are widespread environmental pollutants that can enter the human body through the food chain, potentially leading to lung damage. However, the underlying mechanisms responsible for this damage remain unclear. Ducks, a co...
Coordination acid-engineered Prussian Blue affects glycometabolic reprogramming in microglia for epileptic treatment [0.03%]
调控酸催化的普鲁士蓝影响微胶质细胞的糖代谢重构用于癫痫治疗
Yao Zhao,Feixiang Chen,Chen Chen et al.
Yao Zhao et al.
Seizures induce significant immune and metabolic stress in microglia, but the interaction between these processes remains unclear. This study, utilizing single-nucleus RNA sequencing data from temporal lobe epilepsy (TLE) patients, reveals ...
Secretome enriched with small extracellular vesicles derived from human gingiva-derived mesenchymal stem cells enhances rat tongue muscle regeneration [0.03%]
人牙龈间充质干细胞源性小细胞外囊泡富集的分泌组促进舌肌再生
Qunzhou Zhang,Puhan He,Shihong Shi et al.
Qunzhou Zhang et al.
Background: Accumulating evidence demonstrates that the therapeutic effects of stem cells are most likely attributed to their secretome, composed of a myriad of bioactive factors, including small extracellular vesicles (E...
Gambogic acid-iron nanozymes as effective carriers for enhanced chemotherapy by inducing excessive autophagy and oxidative stress [0.03%]
gambogic酸-铁纳米酶通过诱导过度自噬和氧化应激增强化疗的作用机制研究
Yang Qiao,Menghui Liu,Yiqun Zhang et al.
Yang Qiao et al.
The complex dual role of autophagy provides new insights for enhancing tumor treatment efficacy. However, effectively regulating this process is key to enhancing therapeutic efficacy. To address this challenge, this study designed a gambogi...
Atractylodes macrocephala-derived extracellular vesicles-like particles enhance the recovery of ulcerative colitis by remodeling intestinal microecological balance [0.03%]
苍术大根提取的外泌体样颗粒通过重塑肠道微生态平衡促进溃疡性结肠炎修复
Xuejun Tan,Bowen Gao,Yukun Xu et al.
Xuejun Tan et al.
Current treatment of ulcerative colitis (UC) remains challenging, with the mainstay of therapy being 5-aminosalicylic acid-based drugs, which have limited and inconsistent results. Atractylodes macrocephala (AM) is a traditional Chinese med...
Sonodynamic therapy-boosted biomimetic nanoplatform targets ferroptosis and CD47 as vulnerabilities for cancer immunotherapy [0.03%]
声动力学增强的仿生纳米平台靶向铁死亡和CD47作为癌症免疫治疗的弱点
Haiqin Liao,Mingyu Chen,Zhipeng Liao et al.
Haiqin Liao et al.
The efficacy of cancer immunotherapy is frequently hindered by the immunosuppressive "cold" tumor microenvironment. Inducing immunogenic cell death (ICD) may address this limitation. Ferroptosis, a form of ICD characterized by iron-dependen...
Antitumor/anti-inflammatory effects/tissue healing as an all-in-one therapeutic strategy for nasopharyngeal carcinoma [0.03%]
集抗肿瘤/抗炎和促组织修复为一体的鼻咽癌治疗新策略
Fan Ni,Hanxin Lv,Liting Lin et al.
Fan Ni et al.
Nasopharyngeal carcinoma (NPC) is one of the most prevalent cancers in the head and neck region. The development of innovative therapies that are effective at eliminating tumors while minimizing damage to surrounding normal tissues due to p...