Bacterial extracellular biomolecules-derived multimodal manganese nanoparticles control watermelon Fusarium wilt by dysregulating fusaric acid biosynthesis pathway and precise tuning of rhizosphere metabolome [0.03%]
细菌外源生物分子衍生的多模态锰纳米颗粒通过调控菌丝代谢组精细调节和扰乱伏革酸生物合成途径控制瓜萎病
Muhammad Noman,Temoor Ahmed,Mohammad Shafiqul Islam et al.
Muhammad Noman et al.
Fusarium wilt, caused by Fusarium oxysporum f. sp. niveum (Fon), poses a significant threat to watermelon production globally. Traditional control methods often rely on chemical fungicides, which pose environmental risks and limited long-te...
Targeting circulating tumor cell‒neutrophil interactions: nanoengineered strategies for inhibiting cancer metastasis [0.03%]
靶向循环肿瘤细胞-中性粒细胞相互作用：抑制癌症转移的纳米工程技术策略
Yong Su,Mingjing Leng,Qingqing Yang et al.
Yong Su et al.
Metastasis remains the leading cause of cancer-related mortality, with a persistently poor prognosis for metastatic cancer patients despite extensive therapeutic efforts. Circulating tumor cells (CTCs), which detach from primary tumors and ...
An immune activator encapsulating PD-L1 siRNA for augmented immune checkpoint blockade immunotherapy through Zn2+ overload triggered pyroptosis [0.03%]
一种免疫激活剂，通过Zn2+超载触发细胞焦亡递送PD-L1 siRNA，以增强免疫检查点阻断免疫疗法
Liming Gong,Yanhong Liu,Jing Feng et al.
Liming Gong et al.
Breast cancer as a "cold" tumor presents an immunosuppressive microenvironment and inferior T-lymphocyte infiltration, leading to poor efficacy of immune checkpoint blockade (ICB) therapies. It is urgent to develop new effective combination...
BPQDs@Lipo-YSA Nanoplatform Triggers Mitophagy via PRKN/AKT1 to Drive Immunogenic Cell Death in Lung Adenocarcinoma [0.03%]
BPQD@Lipo-YSA纳米平台通过PRKN/AKT1触发线粒体自噬驱动肺腺癌免疫原性细胞死亡
Li Ai,Zhijuan Liu,Ran Li et al.
Li Ai et al.
Background: Lung adenocarcinoma, the most common type of non-small cell lung cancer (NSCLC), is a leading cause of cancer-related deaths globally due to its high incidence and treatment difficulty. Despite recent advancem...
Biosynthesized nanoparticles of Tibetan medicine mercuric sulfide preparation to promote endocytosis and realize drug crossing through blood brain barrier [0.03%]
藏药朱砂药材生物合成纳米颗粒促进内吞实现药物穿越血脑屏障研究
Wenjing Jia,Huilan Yue,Liying Liu et al.
Wenjing Jia et al.
β-HgS as the main component of Tibetan medicine Zuotai (ZT) is widely used in the treatment of central nervous system diseases. Although the synergism of HgS has been clinically verified for more than 2000 years, its synergetic mechanism i...
A self-adhesive hierarchical nanofiber patch for dynamic and multistage management of full-thickness cutaneous wounds [0.03%]
一种自粘分层纳米纤维补丁用于全层皮肤伤口的动态和多阶段管理
Lihuang Wu,Yuqi Wang,Xinyue Zhao et al.
Lihuang Wu et al.
Full-thickness cutaneous wounds pose a significant threat to global health due to their complex healing demands. Standard clinical wound dressings often fall short in providing the adaptability and functionality required for the entire heal...
Coptis chinensis-derived extracellular vesicle-like nanoparticles delivered miRNA-5106 suppresses NETs by restoring zinc homeostasis to alleviate colitis [0.03%]
黄连来源的类细胞外囊泡递送miRNA-5106通过恢复锌稳态抑制NETs从而缓解结肠炎
Yi Yang,Lanmengxi Yang,Haiyi Deng et al.
Yi Yang et al.
Background: Inflammatory bowel disease (IBD) is a chronic disorder marked by persistent inflammation and damage to the intestinal mucosa. Despite significant advances in treatment, there remains an unmet need for more eff...
Nano-orchestrated magnetotactic-like navigation for electromagnetic theranostics and immune enhancement via photoautotrophic oxygenation, mild hyperthermia, and ferroptosis [0.03%]
基于光自养氧供给、微波低热和铁死亡的仿磁趋性亚毫米级电磁诊疗免疫增强导航疗法
Chi-Hung Hsiao,Yung-Wei Lin,Chia-Hung Liu et al.
Chi-Hung Hsiao et al.
Overcoming the hypoxic tumor microenvironment (TME) and immune suppression remains a significant challenge in solid bladder tumor therapies. This study introduces a translational system of nano-orchestrated magnetotactic-like system, integr...
Overcoming acquired immunotherapy resistance in non-small cell lung cancer using ginsenoside Rb1-loaded, peptide-enhanced exosome delivery systems [0.03%]
基于人参皂苷Rb1的功能化外泌体递送系统克服非小细胞肺癌的免疫治疗耐药性
Xiangyuan Jin,Tanghesi Wuyun,Yu Zhang et al.
Xiangyuan Jin et al.
Non-small cell lung cancer (NSCLC) remains a major global health challenge, with limited therapeutic success due to drug resistance and the immunosuppressive tumor microenvironment (TME). This study explores a novel strategy to overcome acq...
Enzyme-sequential responsive core-satellite nanomedicine enables activatable near-infrared-II photoacoustic imaging-guided chemotherapy cascade-enhanced radiotherapy [0.03%]
酶序响应型核心卫星纳米药物实现近红外二区激活式声成像引导的化疗协同放疗
Wenjing Xiao,Xiao Yang,Mengzhen Wang et al.
Wenjing Xiao et al.
The standard treatment for various types of cancers typically involves the combination of concurrent localized radiotherapy and systemic chemotherapy. However, no treatment options have been reported that utilize chemotherapy cascade-enhanc...