Selenium nanoparticles activate selenoproteins to mitigate septic lung injury through miR-20b-mediated RORγt/STAT3/Th17 axis inhibition and enhanced mitochondrial transfer in BMSCs [0.03%]
硒纳米颗粒通过miR-20b介导的RORγt/STAT3/Th17轴抑制和增强BMSC中的线粒体转移来激活硒蛋白以减轻脓毒症肺损伤
Wan-Jie Gu,Feng-Zhi Zhao,Wei Huang et al.
Wan-Jie Gu et al.
Sepsis-induced acute lung injury (ALI) remains a critical clinical challenge with complex inflammatory pathogenesis. While bone marrow mesenchymal stem cells (BMSCs) demonstrate therapeutic potential through anti-inflammatory and cytoprotec...
Sijie Tang,Huiying Cheng,Xueyan Zang et al.
Sijie Tang et al.
Small extracellular vesicles (sEVs) play a critical role in the progression, diagnosis, and treatment of prostate cancer (PCa), particularly within the tumor microenvironment (TME). Acting as novel biomarkers and agents for targeted biologi...
ZnO-Cu/Mn nanozyme for rescuing the intestinal homeostasis in Salmonella-induced colitis [0.03%]
ZnO- Cu/Mn纳米酶用于解救沙门氏菌诱导性结肠炎中的肠道稳态失衡
Aimin Wu,Chen Liang,WenShuang Chen et al.
Aimin Wu et al.
Salmonella is one of the most common foodborne pathogens, which can cause severe enteritis and intestinal microbiota imbalance. However, there are limited strategies currently available for preventing or treating Salmonella-induced colitis....
miRNA let-7f-5p-encapsulated labial gland MSC-derived EVs ameliorate experimental Sjögren's syndrome by suppressing Th17 cells via targeting RORC/IL-17A signaling axis [0.03%]
通过靶向RORC/IL-17A信号轴封装miRNA let-7f-5p的唇腺MSC衍生外泌体通过抑制Th17细胞改善实验性干燥综合征
Yufei Xie,Maosheng Chai,Yixiao Xing et al.
Yufei Xie et al.
Sjögren's syndrome (SS) is an autoimmune disease primarily affecting salivary glands, with xerostomia as a distinct clinical manifestation. This disease also poses a significantly increased risk of lymphoma, severely impacting patients' qu...
Micro/Nanoplastics in plantation agricultural products: behavior process, phytotoxicity under biotic and abiotic stresses, and controlling strategies [0.03%]
种植农作物中的微/纳米塑料：行为过程、生物和非生物压力下的植物毒性及控制策略
Zhihao Lin,Donghui Xu,Yiming Zhao et al.
Zhihao Lin et al.
With the extensive utilization of plastic products, microplastics/nanoplastics (MPs/NPs) contamination not only poses a global hazard to the environment, but also induces a new threat to the growth development and nutritional quality of pla...
Multifunctional glycyrrhizic acid-loaded nanoplatform combining ferroptosis induction and HMGB1 blockade for enhanced tumor immunotherapy [0.03%]
兼具诱导铁死亡和阻断HMGB1功能的多功用甘草酸纳米平台可提升肿瘤免疫治疗效果
Xuan Sha,Chuanbing Wang,Yang Liu et al.
Xuan Sha et al.
Inducing ferroptotic cell death has been recognized as a promising approach in cancer therapy. However, ferroptosis can provoke tumor infiltration by myeloid-derived suppressor cells (MDSCs) through HMGB1 secretion, causing a tumor suppress...
Exosomal miR-499a-5p from human umbilical cord mesenchymal stem cells attenuates liver fibrosis via targeting ETS1/GPX4-mediated ferroptosis in hepatic stellate cells [0.03%]
人脐带间充质干细胞的外泌体miR-499a-5p通过靶向肝星状细胞中的ETS1/GPX4介导的铁死亡来减轻肝纤维化
Zheng Wang,Mengqin Yuan,Lichao Yao et al.
Zheng Wang et al.
Liver fibrosis is a leading cause of liver-related mortality worldwide, yet effective therapies remain limited. Mesenchymal stem cells (MSCs) have recently shown promise in treating liver fibrosis due to their anti-inflammatory and anti-fib...
Influence of salt solution on the physicochemical properties and in vitro/ in vivo expression of mRNA/LNP [0.03%]
盐溶液对mRNA/LNP的物理化学性质及体内外表达的影响
Siyuan Tang,Lei Huang,Jiahao Ge et al.
Siyuan Tang et al.
Lipid nanoparticles (LNPs) have revolutionized nucleic acid delivery, enabling significant advances in mRNA-based therapeutics. While extensive research has focused on lipid composition, the impact of preparation solutions on LNP performanc...
Functionalized extracellular vesicles of mesenchymal stem cells for regenerative medicine [0.03%]
用于再生医学的间充质干细胞功能化细胞外囊泡
Donghyeon Yoo,Se Young Jung,Dabin Go et al.
Donghyeon Yoo et al.
Stem cell-derived extracellular vesicles (EVs) have emerged as a safe and potent alternative to regenerative medicine in recent decades. Furthermore, the adjustment of EV functions has been recently enabled by certain stem cell precondition...
The immunogenic potential of an optimized mRNA lipid nanoparticle formulation carrying sequences from virus and protozoan antigens [0.03%]
携带病毒和原虫抗原序列的优化mRNA脂质纳米颗粒制剂的免疫潜力
Renata S Fernandes,Gabriela de Assis Burle-Caldas,Sarah Aparecida Rodrigues Sergio et al.
Renata S Fernandes et al.
Background: Lipid nanoparticles (LNP) are a safe and effective messenger RNA (mRNA) delivery system for vaccine applications, as shown by the COVID-19 mRNA vaccines. One of the main challenges faced during the development...