hUMSC-Exosomes suppress TREM1-p38 MAPK signaling via HMGB1-dependent mechanisms to reprogram microglial function and promote neuroprotection in ischemic stroke [0.03%]
人脐带源间质干细胞外泌体通过依赖于高迁移率族蛋白箱蛋白box protein 1机制抑制触发受体信号通路-1- p38丝裂原活化蛋白激酶信号转导重构缺血性卒中后的小胶质细胞功能并发挥神经保护作用
Zengyu Zhang,Rong Ji,Zhuohang Liu et al.
Zengyu Zhang et al.
Background: Ischemic stroke induces profound neuroinflammation, where microglial activation exacerbates secondary brain injury. Human umbilical mesenchymal stem cell-derived exosomes (hUMSC-Exos) exhibit therapeutic poten...
Engineered MEVs for photoreceptor-targeted delivery of USP25 to alleviate diabetic retinopathy [0.03%]
工程化MEV以视网膜靶向递送USP25缓解糖尿病视网膜病变
Yaoxiang Sun,Shenyuan Chen,Xiaoyuan Qi et al.
Yaoxiang Sun et al.
Diabetic retinopathy (DR) is the major cause of vision decline in adults worldwide. Photoreceptor loss is considered a main pathogenesis of retinal dysfunction in DR. Recently, mesenchymal stem cell-derived extracellular vesicles (MEVs) tre...
Imogolite nanotube modifications impact pulmonary toxicity in mice: implications for safe and sustainable by design (SSbD) [0.03%]
林素纳米管的改性影响小鼠肺毒性：面向可持续和安全设计（SSbD）的启示
Pernille Høgh Danielsen,Sarah Søs Poulsen,Alicja Mortensen et al.
Pernille Høgh Danielsen et al.
Background: Imogolite is a naturally occurring hollow aluminosilicate nanotube with potential for engineered applications due to its high aspect ratio, hydrophilicity, and polarization. However, these same features raise ...
Ferritin-armed extracellular vesicles with enhanced BBB penetration and tumor-targeting ability for synergistic therapy against glioblastoma [0.03%]
具有增强的血脑屏障渗透和肿瘤靶向能力并装载铁蛋白的细胞外囊泡对胶质母细胞瘤协同治疗
Guihong Lu,Peiling Zhuang,Feng Li et al.
Guihong Lu et al.
Glioblastoma multiforme (GBM) is an aggressive brain cancer with a high mortality rate and limited treatment options. Metabolism-based synergistic therapy holds promise for GBM treatment, however, its efficacy is significantly impeded by po...
The potential of plant-derived vesicles in treating periodontitis and associated systemic diseases: current advances and future directions [0.03%]
植物衍生囊泡治疗牙周病及其相关系统性疾病的应用潜力：当前进展与未来方向
Zongshuai Liu,Yonglin Guo,Yifei Deng et al.
Zongshuai Liu et al.
Background: Periodontitis, a chronic multifactorial inflammatory disease, represents a significant public health burden among global chronic non-communicable diseases. In addition to affecting oral health, periodontitis i...
A multifunctional biomimetic nanoplatform combined with immune checkpoint blockade for triple-negative breast cancer immunotherapy through inhibiting polarization of M2 macrophages [0.03%]
一种多功能仿生纳米平台联合免疫检查点阻断疗法通过抑制M2型巨噬细胞极化用于三阴性乳腺癌免疫治疗
Qianqian Zhou,Zongfang Jia,Yang Mu et al.
Qianqian Zhou et al.
Immune checkpoint inhibitor (ICI) therapy has become a hopeful treatment for triple-negative breast cancer (TNBC). However, most patients exhibit a low immune response. Tumor-associated fibroblasts (TAFs) suppress anti-tumor immune response...
Two-dimensional nanomaterials for bone disease therapy: multifunctional platforms for regeneration, anti-infection and tumor ablation [0.03%]
二维纳米材料在骨病治疗中的应用：多功能平台促进骨骼再生、抗菌和抗肿瘤
Xuejie Cai,Zehui Lv,Zhao Wang et al.
Xuejie Cai et al.
Bone diseases, encompassing defects, infections, necrosis, osteoarthritis and tumors, present persistent clinical challenges, often unmet by conventional therapies due to limited efficacy and biocompatibility. Two-dimensional (2D) nanomater...
From bench to bedside: nanomedicine development for intracerebral hemorrhage - exploring microenvironment, innovation, and translation [0.03%]
从基础到临床：针对脑出血的纳米医学开发——探索微环境、创新和转化
Gui Wan,Lingui Gu,Yangyang Chen et al.
Gui Wan et al.
Intracerebral hemorrhage (ICH) carries a substantial global disease burden, and although it occurs less frequently than ischemic stroke, it results in a greater loss of disability-adjusted life years worldwide and is associated with one of ...
Shunxiang Gao,Dongling Guo,Peirong Huang et al.
Shunxiang Gao et al.
Accurate, sensitive, and specific detection of molecular markers in intraocular fluid will facilitate the early discovery, diagnosis, and intervention of eye diseases. In this study, a total of 168 participants were recruited and divided in...
Radiocleavable rare-earth nanoactivators targeting over-expressed folate receptors induce mitochondrial dysfunction and remodel immune suppressive microenvironment in pancreatic cancer [0.03%]
可放射性切割的稀土纳米活化剂靶向过表达的叶酸受体诱导胰腺癌线粒体功能障碍和重塑免疫抑制微环境
Tanvi Gupta,Shang-Rung Wu,Li-Chan Chang et al.
Tanvi Gupta et al.
Pancreatic cancer is a fatal cancer with poor prognosis and survival rate, often diagnosed usually in the advanced stage of disease. The conventional methods are usually considered for surgery or chemotherapy, and neo-adjuvant therapies hav...