Radiotherapy-derived engineered stem cell exosomes improve anti-glioma immunotherapy by promoting the formation of tertiary lymphoid structure and improve the release of type I interferon [0.03%]
放射治疗衍生的工程化干细胞外泌体通过促进三级淋巴结构形成和提高I型干扰素的释放来改善抗胶质瘤免疫治疗
Man Li,Lisen Lu,Qiuhong Bao et al.
Man Li et al.
The absence of signaling pathways related to intrinsic immune activation in tumor cells and the immunosuppressive microenvironment limit lymphocyte infiltration, constitutes an "immune-desert" tumor displaying insensitivity to various immun...
Recombinant high-density lipoprotein targeted delivery of celastrol to promote foam cells lipophagy against early atherosclerosis [0.03%]
重组高密度脂蛋白介导雷公藤红素靶向泡沫细胞溶酶体途径治疗早发性动脉粥样硬化
Yang Li,Xiaoxia Xue,Liuchunyang Yu et al.
Yang Li et al.
Introduction: Atherosclerosis serving as the main underlying factor of cardiovascular disease (CVD) remains the primary cause of mortality and morbidity globally, while the deposition of massive cholesterol in macrophage-...
Microalgae-based biodegradable embolic agent for the treatment of hepatocellular carcinoma through transarterial embolization [0.03%]
基于微藻的可降解栓塞剂通过经动脉栓塞治疗肝细胞癌
Kaiyue Wang,Danni Zhong,Lingxiao Yang et al.
Kaiyue Wang et al.
Transarterial chemoembolization (TACE) serves as a locoregional therapy for hepatocellular carcinoma (HCC) patients. Nevertheless, the rapid dissociation of conventional TACE (cTACE) preparations, attributed to the instability of the emulsi...
Rationally designed NIR-II excitable and endoplasmic reticulum-targeted molecular phototheranostics for imaging-guided enhanced photoimmunotherapy of triple-negative breast cancer [0.03%]
合理设计的近红外二区可激发内质网靶向分子光疗诊断技术用于影像引导增强三阴性乳腺癌光免疫治疗
Fen Liu,Qiang Kang,Hao Xiao et al.
Fen Liu et al.
Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer characterized by an extremely poor prognosis. Photoimmunotherapy has emerged as a promising strategy for the treatment of TNBC. This approach works by sele...
Diselenide-based nanoparticles enhancing the radioprotection to the small intestine of mice [0.03%]
基于硒化物的纳米颗粒可增强小鼠的小肠辐射防护作用
Yichi Huang,Jiaze Li,Sen Wang et al.
Yichi Huang et al.
The widespread application of ionizing radiation (IR) in medicine, while beneficial, also poses potential risks that necessitate effective countermeasures. Both 2-(3-aminopropylamino) ethanethiol (WR-1065) and curcumin are recognized as rad...
Physical stimuli-responsive DNA hydrogels: design, fabrication strategies, and biomedical applications [0.03%]
物理刺激响应的DNA水凝胶：设计、制造策略及生物医学应用
Rumi Acharya,Sayan Deb Dutta,Hemadri Mallik et al.
Rumi Acharya et al.
Physical stimuli-responsive DNA hydrogels hold immense potential for tissue engineering due to their inherent biocompatibility, tunable properties, and capacity to replicate the mechanical environment of natural tissue, making physical stim...
DNAzyme hydrogels specifically inhibit the NLRP3 pathway to prevent radiation-induced skin injury in mice [0.03%]
DNAzyme水凝胶特异性抑制NLRP3通路以预防小鼠发生放射性皮肤损伤
Daijun Zhou,Zhihui Li,Linbo Bao et al.
Daijun Zhou et al.
Radiation-induced skin injury (RISI) is a frequent complication of radiotherapy, yet current preventive strategies exhibit suboptimal efficacy. Our previous publications have consistently demonstrated the effectiveness of biomaterials and h...
Revolutionizing lung cancer treatment: harnessing exosomes as early diagnostic biomarkers, therapeutics and nano-delivery platforms [0.03%]
revolution化的肺癌治疗：利用外泌体作为早期诊断的生物标志物、治疗药物和纳米输送平台
Qiyao Xiao,Minhong Tan,Ge Yan et al.
Qiyao Xiao et al.
Lung cancer, known for its high morbidity and mortality rates, remains one of the most critical health challenges globally. Conventional treatment options, such as chemotherapy and surgery, are often limited by high costs, significant side ...
Reducing severity of inflammatory bowel disease through colonization of Lactiplantibacillus plantarum and its extracellular vesicles release [0.03%]
通过植物乳杆菌定植及其胞外囊泡释放来降低炎症性肠病的严重程度
Yuanyuan Wu,Xinyue Huang,Qianbei Li et al.
Yuanyuan Wu et al.
Inflammatory bowel disease (IBD) is characterized by compromised intestinal barrier function and a lack of effective treatments. Probiotics have shown promise in managing IBD due to their ability to modulate the gut microbiota, enhance inte...
Intranasal delivery of engineered extracellular vesicles promotes neurofunctional recovery in traumatic brain injury [0.03%]
工程细胞外囊泡的鼻内递送促进创伤性脑损伤后的神经功能恢复
Pengtao Li,Sishuai Sun,Xingyu Zhu et al.
Pengtao Li et al.
Traumatic brain injury (TBI) is a leading cause of disability in adults, significantly affecting patients' quality of life. Extracellular vesicles (EVs) derived from human adipose-derived mesenchymal stem cells (hADSCs) have demonstrated th...