Ze Yang,Chao Cheng,Zhongliang Li et al.
Ze Yang et al.
Chimeric antigen receptor (CAR)-T cell therapy targeting glypican-3 (GPC3) has shown promise in the treatment of hepatocellular carcinoma (HCC). However, the efficacy of CAR-T cells that focus solely on cell surface tumor-associated antigen...
An imaging-guided self-amplifying photo-immunotherapeutic nanoparticle for STING pathway activation and enhanced cancer therapy [0.03%]
一种成像引导的自放大的光免疫治疗纳米颗粒，用于STING途径活化和增强癌症治疗
Qiaoqi Chen,Huilin Yu,Lin Li et al.
Qiaoqi Chen et al.
The stimulator of interferon genes (STING) pathway is a promising target in cancer immunotherapy. However, current nanomedicine strategies targeting the STING pathway often suffer from limited tumor specificity and insufficient immune activ...
Bionic bearing-inspired lubricating microspheres with Immunomodulatory effects for osteoarthritis therapy [0.03%]
仿生关节软骨自适应智能润滑微球用于调节免疫的软骨保护疗法研究
Xu He,Xingzhi Liu,Xinyi Cheng et al.
Xu He et al.
Inflammatory infiltration and inappropriate friction remain the two main challenges in treating osteoarthritis (OA). An effective treatment platform is anticipated to lubricate the cartilage and ameliorate intra-articular inflammation. Here...
An oxygen-generating nanoplatform remodels the immunosuppressive tumor microenvironment via synergistic lactate depletion and sonodynamic therapy [0.03%]
一种产氧纳米平台通过协同去除乳酸和声动力治疗重塑免疫抑制肿瘤微环境
Chenchen Tang,Xinyi Tang,Jingwei Tang et al.
Chenchen Tang et al.
Lactate is an immunosuppressive molecule that plays an important role in tumor progression. Regulating lactate metabolism to remodel the immunosuppressive microenvironment represents a promising strategy for cancer therapy. However, owing t...
Curcumin-loaded PLGA microparticles integrated with ZnO/GelMA hydrogel microneedles for infectious wound healing and reduction of hypertrophic scars [0.03%]
一种用于感染性伤口愈合和减少肥厚性疤痕的微针：负载姜黄素的PLGA微粒与ZnO/GelMA水凝胶微针集成体系
Yifan Zhang,Ziyi Zhou,Na Liu et al.
Yifan Zhang et al.
Intelligent ROS therapy driven by iron-based nanozyme with controllable catalytic activity for infected wound healing [0.03%]
一种基于铁的纳米酶驱动的智能ROS疗法促进感染伤口愈合
Lixue Deng,Yanni Cheng,Jia Liu et al.
Lixue Deng et al.
Therapeutic generation of reactive oxygen species (ROS) through catalytic therapy demonstrates antibacterial efficacy against wound infections. However, prolonged and unregulated ROS production risks inducing intolerable oxidative stress al...
MIL-53(Fe)-Glucose self-assembled complex for enhanced angiogenesis and endothelial tip cell activation [0.03%]
用于增强血管生成和内皮尖细胞活化的MIL-53(Fe)-葡萄糖自组装复合物
Jie Wu,Leyi Liu,Runze Li et al.
Jie Wu et al.
Critical bone defects continue to pose a critical challenge in clinical settings. Facilitating rapid and thorough vascularization during bone regeneration is advantageous for the repair of substantial bone defects. Presently, the applicatio...
Human serum albumin-based KBiF4@HSA nanoclusters for dual-energy computed tomography and glutathione-scavenging radiotherapy of breast cancer [0.03%]
人血清白蛋白基KBiF4@HSA纳米团簇用于乳腺癌的双能量CT和谷胱甘肽清除型放射治疗
Yuelin Huang,Zhenghai Lu,Huanhuan Liu et al.
Yuelin Huang et al.
Background: Breast cancer remains the most common malignancy among women worldwide. While traditional computed tomography (CT) scans and image-guided radiotherapy are widely used for breast cancer diagnosis and treatment,...
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acids: advances and challenges [0.03%]
外泌体作为靶向大脑递送治疗性核酸的纳米载体：进展与挑战
Nima Sanadgol,Mohsen Abedi,Masoud Hashemzaei et al.
Nima Sanadgol et al.
Recent advancements in gene expression modulation and RNA delivery systems have underscored the immense potential of nucleic acid-based therapies (NA-BTs) in biological research. However, the blood-brain barrier (BBB), a crucial regulatory ...
Baicalin targets YTHDC2 and alleviates male reproductive toxicity caused by co-exposure to nanoplastics and manganese through m6A-dependent pathway [0.03%]
靶向YTHDC2的柴胡皂苷d通过m6A依赖性通路缓解纳米塑料和锰共暴露引起的雄性生殖毒性
Yi Wen,Tingwei Pan,Lu Liu et al.
Yi Wen et al.
Nanoplastics (NPs) pollution has become a pressing global environmental issue. NPs possess the ability to adsorb heavy metals, thereby acting as vectors that facilitate the entry of these toxic substances into living organisms. However, the...