Brain targeted lipid nanoparticles with Hv1 inhibitors alleviate neuroinflammation post-ischemic stroke [0.03%]
脑靶向Hv1抑制型脂质纳米颗粒可改善缺血性卒中后的神经炎症
Zeyu Yang,Lei Jin,Longxiang Li et al.
Zeyu Yang et al.
Background: Ischemic stroke (IS) represents a significant global health burden. Current therapeutic options face problems such as window narrowing and reperfusion injury risk. Moreover, with increasing aging and risk fact...
A Self-Generated Electricity-Driven Sclera reinforcement bionic piezoelectric patch for Management of High Myopia [0.03%]
自发电 sclera 强化仿生压电补丁治疗病理性近视
Lingxi Jiang,Bo Zhao,Qi Li et al.
Lingxi Jiang et al.
Background: High myopia (HM) is a progressive ocular condition characterized by excessive axial elongation and severe refractive errors, often leading to sight-threatening complications. The underlying pathological driver...
Normal stress on surface of mesenchymal stem cells boosts extracellular vesicle secretion and regenerative bioactivity [0.03%]
正常牵张应力通过促进间充质干细胞释放外泌体而增强其促心肌细胞增殖活性
Chengmeng Bai,Huifang Ren,Feng Zhang et al.
Chengmeng Bai et al.
Scalable approaches for enhancing therapeutic small extracellular vesicles (sEVs) production can facilitate the transition of sEVs from bench to bedside and beyond. Here, we present a user-friendly method to manipulate the extracellular mec...
Targeted-theranostic nanoparticles induce anti-tumor immune response in lung cancer [0.03%]
靶向治疗诊断纳米颗粒诱导肺癌抗肿瘤免疫反应
Zeinaf Muradova,Léna Carmès,Needa Brown et al.
Zeinaf Muradova et al.
High atomic number metal-based nanoparticles (NPs) enhance radiotherapy efficacy by improving tumor multimodal imaging and intensifying radiation dosage. AGuIX-Bi represents a theranostic NP comprising gadolinium and bismuth chelates grafte...
A novel carrier-free nanoparticle with stable distinctive three-dimensional structure for tumor-targeted precision chemoimmunotherapy [0.03%]
一种具有稳定三维结构的无载药纳米粒子用于肿瘤精准化疗免疫治疗
Bo Deng,Youpeng Kong,Yingying Ma et al.
Bo Deng et al.
Despite significant advancements in oncology, cancer remains a leading global health burden, necessitating innovative therapeutic strategies. Here, we present a novel carrier-free tumor-targeted nanomedicine system (DPA NPs) for tumor-targe...
Natural small molecule smart hydrogels inhibited the Hsp90/NF-κB signaling axis in inflammation to achieve sustained antipyretic effect [0.03%]
天然小分子智能水凝胶通过抑制Hsp90/NF-κB信号轴治疗炎症持续退热
Yuqin Yang,Jingyi Jiao,Xiaohui Jia et al.
Yuqin Yang et al.
In general, pseudoephedrine (PE) is a safe and universally employed in cold medicine, which displays powerful effect on antipyretic. Nonetheless, the sustained drug delivery system can effectively put an end to the above problems attributab...
Alternating magnetic field-responsive engineered probiotics for anxiety therapy via gut-brain axis modulation [0.03%]
通过调节肠道-脑轴响应交替磁场的工程益生菌治疗焦虑症
Xuejun Wang,Yuhan Zhang,Yuling Chang et al.
Xuejun Wang et al.
The discovery of the gut-brain axis demonstrated bidirectional regulation between the gut and the brain. The gastrointestinal branches of the vagal nerve have been proven to directly modulate multiple functions of the central nervous system...
Cancer cell membrane-camouflaged pH-responsive nanoparticles for enhancing siRNA effect and synergistic anti-tumor therapy [0.03%]
用于增强siRNA效果和协同抗肿瘤疗法的癌细胞膜伪装的pH响应型纳米粒子
Jie Zhang,Yun Peng Zhang,Qi Sun et al.
Jie Zhang et al.
RNA-based therapies, especially small interfering RNA (siRNA), have attracted extensive attention for tumor treatment. However, most siRNA can't exert a therapeutic effect due to a lack of targeting to tumor cells and entrapment in lysosome...
Chemotherapeutic drug scavenger-based combination therapy toward treating triple-negative breast cancer [0.03%]
基于化疗药物清除剂的联合治疗用于治疗三阴性乳腺癌
Qingqing Yin,Yutong Zhong,Mengchun Chen et al.
Qingqing Yin et al.
Triple-negative breast cancer (TNBC) is resistant to most antitumor treatments, leaving chemotherapy as the primary option. Although doxorubicin (Dox) in combination with other therapies is promising for TNBC management, the combined effect...
Novel adjuvant delivery system constructed by alum-emulsion hybrid nanoparticles with TLR9 agonists boosts vaccine immunity [0.03%]
一种新型佐剂输送系统通过构建铝基乳化混合纳米颗粒结合TLR9激动剂提高疫苗免疫效果
Yarong Zeng,Yifan Yin,Jialin Xu et al.
Yarong Zeng et al.
Vaccine Adjuvant Delivery Systems (VADSs) that integrate both delivery and adjuvancy constitute a vital strategy in modern vaccine research. Herein, we employed microfluidics to blend nanosized aluminum hydroxide (XA) and a nanoemulsion (XE...