Macrophage-mimetic liposomes co-delivering ceria and Ac2-26 peptide for penumbra protection in ischemic stroke [0.03%]
仿巨噬细胞脂质体负载二氧化铈和Ac2-26肽用于脑卒中半暗带保护
Lingyun Bai,Na Li,Huiqin Li et al.
Lingyun Bai et al.
Ischemic stroke is one of the most severe central nervous system disease with high disability and mortality rates worldwide. Effective treatment requires strategies that address the multifaceted pathophysiology of ischemic penumbra, includi...
LUPP-LAMP: one-pot multiplatform universal LAMP assay for simultaneous detection and genotyping of DENV and ZIKV [0.03%]
LUPP-LAMP：一种针对DENV和ZIKV同时进行检测与基因型分析的单管多平台通用环介导等温扩增法
Zhang Zhang,Luhao Guan,Yue Zhang et al.
Zhang Zhang et al.
Dengue virus (DENV) and Zika virus (ZIKV) are mosquito-borne viruses that cause severe health problems upon infection, necessitating timely and accurate diagnostic testing for effective prevention and control of their transmission. In this ...
Natural fish swim bladder-derived MPN-nanofibrous biomimetic system exhibit ECM-responsive signal regulation and promote robust tendon-bone healing [0.03%]
天然鱼 swim膀胱衍生的MPN纳米纤维仿生系统表现出ECM反应性信号调节并促进强大的肌腱骨骼愈合
Lei Shi,Peng Zhou,Cong Ye et al.
Lei Shi et al.
Enhanced tendon‒bone healing is of critically importance for achieving optimal postoperative recovery following a rotator cuff tendon tear (rotator cuff tears, RCTs). Although RCTs patch-augmented scaffolds demonstrate clinical potential, ...
SIRT5-modified human umbilical cord mesenchymal stem cells loaded with antioxidant polydopamine nanozyme enhance parpi resistance in ovarian cancer via fatty acid metabolism reprogramming [0.03%]
抗氧化型多巴胺纳米酶负载的SIRT5修饰人脐带间充质干细胞通过脂肪酸代谢重编程增强卵巢癌细胞对PARPi的抵抗性
Jin Zhang,Xiuluan Du,Xin Dai et al.
Jin Zhang et al.
Ovarian cancer remains one of the most aggressive cancers, and resistance to Poly (ADP-ribose) Polymerase inhibitors (PARPi) poses a major therapeutic challenge. SIRT5, a NAD + -dependent desuccinylase, plays a crucial role in regulating fa...
Liposome-encapsulated AICAR hydrogel regulates macrophage metabolic reprogramming via SIK1 activation to alleviate osteoarthritis [0.03%]
脂质体封装的AICA核糖核苷酸水凝胶通过SIK1激活调节巨噬细胞代谢重编程以缓解骨关节炎
Yong Fu,Jiahui Hou,Qinmeng Yang et al.
Yong Fu et al.
Background: Osteoarthritis (OA), the most prevalent joint disorder, is characterized by a complex etiology and a lack of safe and effective therapeutic interventions. Emerging evidence suggests that immune cell dysregulat...
Starlike Au nanoparticle unleashing siDDIT3 and photothermal power to combat ferroptosis - driven osteoarthritis [0.03%]
星星状Au纳米粒子释放siDDIT3和光热效应对抗铁死亡驱动的骨关节炎
Chenfeng Wang,Shiyuan Hua,Ting Feng et al.
Chenfeng Wang et al.
Osteoarthritis (OA), the most common degenerative joint disease globally, has garnered increasing attention, and emerging evidence implicated ferroptosis played an important role in both its onset and progression. In this study, we identify...
LNP-enclosed NamiRNA inhibits pancreatic cancer proliferation and migration via dual pathways [0.03%]
LNP包裹的NamiRNA通过双重途径抑制胰腺癌增殖和迁移
Chao Yu,Zhou Fang,Qingyu Xie et al.
Chao Yu et al.
Background: Pancreatic cancer is a highly aggressive malignancy characterized by limited treatment options, poor prognosis, and high mortality rates. nuclear activating miRNA (NamiRNA) enhances gene expression by interact...
Targeting heptad repeats and fusion peptide: nanoparticle vaccine elicits mucosal immune response against SARS-CoV-2 variants [0.03%]
靶向七肽重复序列和融合多肽：纳米颗粒疫苗可诱导针对SARS-CoV-2变异株的黏膜免疫应答
Chaofeng Liang,Rong Li,Zeyu Pu et al.
Chaofeng Liang et al.
The emergence of SARS-CoV-2 variants has underscored the urgent need for innovative vaccine strategies that provide robust and enduring protection against diverse strains. Our study introduces the FP-HR5 nanoparticle vaccine, designed to ta...
TEA5K: a high-resolution and liquid-phase multiple-SNP array for molecular breeding in tea plant [0.03%]
TEA5K：一种茶树分子育种高通量液相多重SNP芯片
Dingding Liu,Chenyu Zhang,Yuanyuan Ye et al.
Dingding Liu et al.
Background: High-throughput genotyping technology has become an indispensable tool for advancing molecular breeding and genetic research in plants, facilitating large-scale exploration of genomic variation. Genotyping tec...
Ultrasmall nanoparticles for co-delivery of antisense oligonucleotides targeting miR-21 and miR-210 to treat glioblastoma [0.03%]
用于同时输送靶向miR-21和miR-210的反义寡核苷酸治疗胶质母细胞瘤的超小型纳米颗粒
Ravi Raj Singh,Ritu Kulshreshtha,Amirali Popat
Ravi Raj Singh
Glioblastoma (GBM) is the most common and aggressive type of brain tumour, with less than 5% of patients surviving more than 5 years. Despite decades of research to understand the underlying pathophysiological causes, it has witnessed very ...