USP5 inhibition via bone marrow-targeted engineered exosomes for myeloproliferative neoplasms therapy [0.03%]
针对骨髓靶向工程外体递送USP5抑制剂治疗骨髓增殖性肿瘤
Wenjun Wang,Yufeng Jiang,Donglei Zhang et al.
Wenjun Wang et al.
Myeloproliferative neoplasms (MPNs) are challenging to treat due to the complex bone marrow (BM) microenvironment and lack of curative therapies. Current treatments fail to eliminate malignant clones and face issues like drug resistance. Th...
Differences in macrophage pyroptosis and polarization induced by nano-/micro-calcium oxalate crystals [0.03%]
纳米/微米草酸钙晶体诱导的巨噬细胞焦亡和极化差异
Xin-Yi Tong,Wei-Jian Nong,Run-Min Tan et al.
Xin-Yi Tong et al.
Objective: This study aimed to compare the differences in pyroptosis and polarization of macrophages induced by different sizes of calcium oxalate monohydrate (COM) crystals and discuss the mechanism of kidney stone forma...
Revolutionizing brain‒computer interfaces: overcoming biocompatibility challenges in implantable neural interfaces [0.03%]
变革脑机接口：植入式神经接口的生物相容性挑战及突破
Weihang Gao,Zineng Yan,Hong Zhou et al.
Weihang Gao et al.
Brain‒computer interfaces (BCIs) exhibit significant potential for various applications, including neurofeedback training, neurological injury management, and language, sensory and motor rehabilitation. Neural interfacing electrodes are po...
A GSH-consuming polymeric nanoparticles drives ferroptosis amplification and combines chemotherapy to amplify breast cancer treatment [0.03%]
一种消耗GSH的聚合物纳米粒子可驱动铁死亡放大并联合化疗增强乳腺癌治疗
Mingliang Pei,Xin Guan,Xiaodong Hou et al.
Mingliang Pei et al.
Currently, given variations in the abnormal tumor microenvironment (TME), significant progress has been made in the treatment of breast cancer (BC) based on TME-responsive nanosystems-mediated ferroptosis. Due to inherent deficiencies such ...
Mitochondrial homeostasis restoring peptide-drug conjugates with ROS-responsive NO releasing ability for targeted therapy of myocardial infarction [0.03%]
具有ROS响应性NO释放能力的线粒体稳态恢复肽-药物共轭物用于靶向治疗心肌梗死
Zhaoyang Lu,Quanyou Chai,Wenbin Dai et al.
Zhaoyang Lu et al.
Myocardial infarction (MI) is the leading cause of death worldwide. Exogenous delivery of nitric oxide (NO) shows great potential in MI treatment. However, the burst generation of reactive oxygen species (ROS) in ischemic microenvironment o...
Self-assembled transdermal nanogels control scar formation by inhibiting fibroblast proliferation and fibrosis with glycolysis regulation via the PI3K/Akt/mTOR pathway [0.03%]
自组装纳米凝胶通过调节糖酵解来抑制成纤维细胞增殖和纤维化从而控制疤痕形成（PI3K/AKT/mTOR通路）
Xinxian Meng,Zhixi Yu,Shiqi Wu et al.
Xinxian Meng et al.
Hypertrophic scar (HS) is one of the most common challenges in the field of plastic and reconstructive surgery. HS formation is associated with the abnormal activation of fibroblasts. These fibroblasts exhibit excessive proliferative and fi...
PIEZO2 is the underlying mediator for precise magnetic stimulation of PVN to improve autism-like behavior in mice [0.03%]
PIEZO2是精准磁刺激PVN改善小鼠自闭症样行为的介导因子
Sha Liu,Xuan Liu,Yefan Duan et al.
Sha Liu et al.
The precision magnetic stimulation system (pMSS), mediated by superparamagnetic iron oxide nanoparticles (SPIONs), can modulate endogenous oxytocin secretion by targeting the paraventricular nucleus (PVN) and improve autistic-like behavior ...
Quercetin nanoformulation-embedded hydrogel inhibits osteopontin mediated ferroptosis for intervertebral disc degeneration alleviation [0.03%]
载有檞皮素纳米制剂的水凝胶通过抑制骨桥蛋白介导的铁死亡缓解椎间盘退变
Jitian Li,Lemeng Ren,Lei Wan et al.
Jitian Li et al.
Reactive oxygen species (ROS) play a pivotal role in multiple events during the progression of intervertebral disc degeneration (IDD). Hence, the precision treatment targets associated with ROS should be further explored to promote developi...
Recent advances of engineering cell membranes for nanomedicine delivery across the blood-brain barrier [0.03%]
近年基于细胞膜的脑靶向纳米药物载体研究进展
Shengnan Yuan,Dehong Hu,Duyang Gao et al.
Shengnan Yuan et al.
The blood-brain barrier (BBB) poses a major challenge to the effective delivery of therapeutic agents for the treatment of central nervous system (CNS) disorders. The integration of cell membrane engineering with nanotechnology has recently...
Synergizing sono-piezo with exosome suppression using doping-engineered hydroxyapatite for potentiated tumor treatment through immunoactivation [0.03%]
利用掺杂工程羟基磷灰石协同超声压电和外泌体抑制以免疫活化增强肿瘤治疗
Xinran Qu,Qin Fan,Yingying Liu et al.
Xinran Qu et al.
Piezoelectric nanomaterials that generate reactive oxygen species (ROS) through piezoelectric polarization under mechanical stimulation have emerged as a promising cancer therapy platform. However, their potential is limited by poor piezore...