Dielectrophoresis-assisted microfluidic device for high-precision and periodic single-cell capture and release [0.03%]
一种用于高精度和周期性单细胞捕获与释放的介电泳辅助微流控装置
Zhihang Yu,Wenqiang Tong,Jiaming Shi et al.
Zhihang Yu et al.
Single-cell analysis is crucial for understanding the specificity of individual cells, yet its advancement is limited by the technical challenges of precise single-cell manipulation. Microfluidics has made significant advancements in single...
Sheng Chen,Enen Chen,Jianfen Su et al.
Sheng Chen et al.
Introduction: Acute lung injury (ALI) is an acute inflammatory lung disease with high rates of morbidity and mortality. The lack of efficient pharmacological treatments for ALI resulted in poor outcomes and prognosis. ...
Clinical insight-driven micron-sized cholesterol oxidation platform for membrane lipid therapy of advanced ovarian cancer [0.03%]
临床洞察驱动的微米级胆固醇氧化平台用于晚期卵巢癌膜脂质治疗
Weidong Fei,Yu Xin,Wenqiang Qian et al.
Weidong Fei et al.
Due to the insidious onset of ovarian cancer, the majority of patients are diagnosed at advanced stages, often presenting with extensive pelvic and abdominal metastasis. A significant proportion of these patients exhibit primary or acquired...
Engineered exosomes: a promising approach for overcoming challenges in pancreatic cancer therapy [0.03%]
工程化外泌体在克服胰腺癌治疗难题中的应用前景不容小觑
Mo Sha,Yang Gao,Xu Yin et al.
Mo Sha et al.
Pancreatic cancer (PC) is among the deadliest types of cancer, with very low chances of survival. It is often asymptomatic in the early stage, making diagnosis difficult. Therefore, it is typically found at an advanced stage, resulting in p...
MiR-7683-3p from M2-exosomes attenuated atherosclerosis by activating the PPARγ-LXRα-ABCG1 pathway mediated cholesterol efflux of vascular smooth muscle cell derived foam cells [0.03%]
M2源外泌体中miR-7683-3p通过激活PPARγ-LXRα-ABCG1通路介导的血管平滑肌细胞源泡沫细胞胆固醇流出抑制动脉粥样硬化形成
Shuo Wang,Yunhui Lv,Xiaohu Wang et al.
Shuo Wang et al.
Background: Impaired excretion of lipid deposits within vascular smooth muscle cell-derived foam cells (VSMC-FCs) contributes to the ongoing expansion of the plaque necrotic core. This study aims to explore the effects an...
Aligned nanofiber-based responsive sponge scaffolds for peripheral nerve regeneration [0.03%]
用于周围神经再生的定向纳米纤维基响应性海绵支架
Sizhe Song,Ying Zhang,Dongyu Xu et al.
Sizhe Song et al.
Nerve conduits have demonstrated tremendous value in advancing nerve regeneration. The current research focuses on improving their neuro regenerative effects through structural optimization and functional enhancement. Here, an original resp...
Exosomes/MoS2 complex for targeting and effective photothermal therapy [0.03%]
用于靶向及有效光热治疗的外泌体/钼二硫化物复合材料
Liyan Wang,Huizhi Chen,Haiyan Qiu et al.
Liyan Wang et al.
Photothermal therapy (PTT) has been an attractive tumor treatment strategy in recent years. Two-dimensional molybdenum disulfide (MoS2)-based nanomaterials with high photothermal conversion efficiency is a promising candidate for PTT. Howev...
Lactobacillus johnsonii-derived extracellular vesicles restore mucosal immunity via taurine-linked Th17/Treg and IgA/IgG regulation in colitis [0.03%]
乳酸菌约翰逊氏菌来源的外泌体通过牛磺酸连接的Th17/Treg和IgA/IgG调节恢复结肠炎黏膜免疫功能
Hailan Zhao,Ningning Yue,Zhiliang Mai et al.
Hailan Zhao et al.
Background: Aberrant mucosal immune responses to gut microbiota contribute to inflammatory bowel disease (IBD), yet the mechanisms linking immunoglobulin-coated bacteria to mucosal inflammation remain unclear. Microbial e...
A two-stage transdermal drug delivery system comprising sono-phase-change transfersomes for non-invasive deep dermal delivery [0.03%]
一种经皮给药系统，该系统包含声敏相变转移体，可实现非侵入性真皮深层递送
Yi Zhang,Xiong He,Xiang Mao et al.
Yi Zhang et al.
Non-invasive deep transdermal drug delivery is required for conditions such as keloids. However, the skin's stratum corneum barrier is the primary obstacle for transdermal drug delivery methods. Most energy sources and operational controls ...
Magnetic field-induced plasmonic enhancement of near infrared fluorescence from a Magnetoplasmonic nanoplatform for bioimaging applications [0.03%]
磁場誘導等離子體近紅外光譜發射增強的磁等離子體納米影像平台
Siqi Gao,Jiantao Liu,Iuliia Golovynska et al.
Siqi Gao et al.
A phenomenon of plasmon-enhanced fluorescence (PEF) arises from interactions between fluorophores and metal nanostructures, leading to a substantial amplification of the fluorescence signal. Herein, we report a magnetic field (MF) induced o...