Alternating magnetic field-responsive engineered probiotics for anxiety therapy via gut-brain axis modulation [0.03%]
通过调节肠道-脑轴响应交替磁场的工程益生菌治疗焦虑症
Xuejun Wang,Yuhan Zhang,Yuling Chang et al.
Xuejun Wang et al.
The discovery of the gut-brain axis demonstrated bidirectional regulation between the gut and the brain. The gastrointestinal branches of the vagal nerve have been proven to directly modulate multiple functions of the central nervous system...
Cancer cell membrane-camouflaged pH-responsive nanoparticles for enhancing siRNA effect and synergistic anti-tumor therapy [0.03%]
用于增强siRNA效果和协同抗肿瘤疗法的癌细胞膜伪装的pH响应型纳米粒子
Jie Zhang,Yun Peng Zhang,Qi Sun et al.
Jie Zhang et al.
RNA-based therapies, especially small interfering RNA (siRNA), have attracted extensive attention for tumor treatment. However, most siRNA can't exert a therapeutic effect due to a lack of targeting to tumor cells and entrapment in lysosome...
Chemotherapeutic drug scavenger-based combination therapy toward treating triple-negative breast cancer [0.03%]
基于化疗药物清除剂的联合治疗用于治疗三阴性乳腺癌
Qingqing Yin,Yutong Zhong,Mengchun Chen et al.
Qingqing Yin et al.
Triple-negative breast cancer (TNBC) is resistant to most antitumor treatments, leaving chemotherapy as the primary option. Although doxorubicin (Dox) in combination with other therapies is promising for TNBC management, the combined effect...
Novel adjuvant delivery system constructed by alum-emulsion hybrid nanoparticles with TLR9 agonists boosts vaccine immunity [0.03%]
一种新型佐剂输送系统通过构建铝基乳化混合纳米颗粒结合TLR9激动剂提高疫苗免疫效果
Yarong Zeng,Yifan Yin,Jialin Xu et al.
Yarong Zeng et al.
Vaccine Adjuvant Delivery Systems (VADSs) that integrate both delivery and adjuvancy constitute a vital strategy in modern vaccine research. Herein, we employed microfluidics to blend nanosized aluminum hydroxide (XA) and a nanoemulsion (XE...
Targeting YTHDF2 with pH-responsive siRNA nanoparticles suppresses MYC m6A modification and restores antitumor immunity in hepatocellular carcinoma [0.03%]
基于pH响应的siRNA纳米颗粒靶向肝癌中YTHDF2以抑制MYC mRNA去甲基化并恢复抗肿瘤免疫功能
Ziqi Guo,Qiuling Huang,Zhenzhen Cui et al.
Ziqi Guo et al.
Hepatocellular carcinoma (HCC) is a highly heterogeneous and immunosuppressive malignancy that frequently exhibits poor responses to immunotherapy, primarily due to immune evasion mediated by myeloid-derived suppressor cells (MDSCs) in the ...
Advanced wound healing with Stimuli-Responsive nanozymes: mechanisms, design and applications [0.03%]
具有刺激响应性的nanozymes的伤口治疗：机制、设计和应用
Xiaoyang Liu,Huihui Zhang,Lianglong Chen et al.
Xiaoyang Liu et al.
Wound healing outcomes critically depend on precise regulation of oxidative and antimicrobial microenvironments. Traditional dressings have limited wound responsiveness, insufficient infection control, and limited treatment accuracy. In con...
Biomaterials mediated 3R (remove-remodel-repair) strategy: holistic management of Helicobacter pylori infection [0.03%]
用于治疗幽门螺旋杆菌感染的材料介导的3R(清除-重塑-修复)策略：整体管理
Tinglin Zhang,Yating Zheng,Tielou Chen et al.
Tinglin Zhang et al.
Helicobacter pylori (HP) is a major etiological agent of gastric cancer, with a global prevalence of around 50%. Current treatments, primarily based on antibiotics, face challenges such as increasing drug resistance and disruption of the gu...
Nanomaterial isolated extracellular vesicles enable high precision identification of tumor biomarkers for pancreatic cancer liquid biopsy [0.03%]
纳米材料隔离的细胞外囊泡能够用于高精度识别胰腺癌液体活检肿瘤生物标志物
Zachary F Greenberg,Samantha Ali,Andrew Brock et al.
Zachary F Greenberg et al.
Pancreatic cancer has the highest mortality rate among all major cancers, which highlights the urgent needs of non-invasive early detection. Circulating extracellular vesicles (EVs) have gained significant attention for discovering tumor bi...
Advanced strategy for cancer detection based on volatile organic compounds in breath [0.03%]
基于呼吸中挥发性有机化合物的癌症检测先进策略研究
Ziqi Jia,Yiwen Jiang,Tongxuan Shang et al.
Ziqi Jia et al.
The analysis of volatile organic compounds (VOCs) in exhaled breath has emerged as a promising non-invasive approach for cancer diagnosis, offering advantages in speed, safety, cost-effectiveness, and real-time monitoring. Two primary metho...
Early-life exposure to polypropylene nanoplastics induces neurodevelopmental toxicity in mice and human iPSC-derived cerebral organoids [0.03%]
聚丙烯纳米塑料的早期暴露诱导小鼠和人多能干细胞来源脑类器官的神经发育毒性
Fangfang Huang,Haizhen You,Xiaogang Tang et al.
Fangfang Huang et al.
Nanoplastics (NPs) are emerging environmental pollutants that pose growing concerns due to their potential health risks. However, the effects of inhaled NP exposure during pregnancy on fetal brain development remain poorly understood. In th...