Cu2+-doped Hollow Ca2+-polyphenol nano-therapeutics for overcoming multidrug-resistant bacteria-induced infections [0.03%]
用于克服多药耐药细菌引起的感染的Cu2+掺杂空心Ca2 + -聚酚纳米疗法
Yueyang Zhong,Wenjie Fan,Yue Huang et al.
Yueyang Zhong et al.
The abuse of antibiotics has accelerated the emergence of multidrug-resistant (MDR) bacterial strains, while the development of novel antibiotics has failed to keep pace with the evolution of bacteria. Consequently, there is an urgent need ...
Astaxanthin and Dihydroartemisinin loaded PLGA NPs for atherosclerosis therapy via regulating lipid metabolism and immune microenvironment [0.03%]
载有虾青素和二氢青蒿素的PLGA纳米粒通过调节脂质代谢和免疫微环境用于动脉粥样硬化治疗
Jiayao Hu,Hao Liu,Yizhou Wu et al.
Jiayao Hu et al.
The active ingredients of Traditional Chinese Medicine with diverse structures exhibited anti-inflammatory and lipid lowering functions, demonstrating significant therapeutic effects in inflammatory diseases of atherosclerosis. We incorpora...
MXene-integrated microneedles reprogram diabetic-associated macrophages for deep-wound infection therapy and immunoprotection [0.03%]
MXene集成的微针可重新编程糖尿病相关巨噬细胞用于深度伤口感染治疗和免疫保护
Wenshuai Li,Lulu Wang,Hui Zhao et al.
Wenshuai Li et al.
Traditional hyperthermia-boosted photothermal therapy (PTT) for infected wounds often suffers from thermal damage to healthy tissue, exacerbates immune dysregulation, and compromises antibacterial efficacy in deep tissue. Here, we developed...
Delivery of miR-29a/29c-3p by serum exosomes promotes osteogenesis through TET3-dependent Sox9 demethylation and PI3K/Akt activation [0.03%]
血清外泌体递送miR-29a/29c-3p通过TET3依赖的Sox9去甲基化和激活PI3K/Akt促进成骨作用
Qing Lin,Weipeng Sun,Biyi Zhao et al.
Qing Lin et al.
Osteoporosis (OP) is characterized by impaired bone formation, largely attributed to dysfunctional osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). Circulating factors, particularly exosomes acting as natural nanoca...
Self-activated prodrug nanocomposites reprogramming lactic acid metabolism to initiate acidosis-endoplasmic reticulum stress cascade and potentiate immunogenic cell death for enhanced liver cancer therapy [0.03%]
自激活前药纳米复合物重新编程乳酸代谢以启动酸中毒-内质网应激级联并增强免疫原性细胞死亡以改善肝癌治疗
JingQuan Chen,WeiYi Cheng,WeiYe Ren et al.
JingQuan Chen et al.
Hepatocellular carcinoma (HCC) remains a major global health challenge, with limited therapeutic efficacy and poor prognosis. To address chemoresistance and immunosuppression in HCC, we developed a lactate-modulating multifunctional prodrug...
Self-reinforcing nanomedicine orchestrates EPR effect and neutrophil hitchhiking for spatiotemporal accumulation in solid tumors [0.03%]
一种自增强型纳米药物可在实体肿瘤中调控EPR效应和中性粒细胞载运作用实现时空特异性富集
Yiqiong Liu,Dailin Xu,Jianwei Cheng et al.
Yiqiong Liu et al.
Targeted drug delivery remains pivotal for enhancing therapeutic efficacy in cancer treatment. While nanomedicines harness the enhanced permeability and retention (EPR) effect for passive tumor accumulation, their efficacy is often hindered...
IL-15 signaling via cis- and trans-presentation to progenitor-exhausted CD8+ T cells enhances radio-immunotherapy efficacy in ESCC [0.03%]
通过原位和反式呈递IL-15信号可增强祖细胞耗竭的CD8+t细胞在食管鳞癌放射免疫治疗中的疗效
Yi You,Linrui Gao,Shijia Li et al.
Yi You et al.
Background: Concurrent chemoradiotherapy (CRT) combined with PD-1/PD-L1 targeting immunotherapy (IM) has emerged as a promising treatment for locally advanced esophageal squamous cell carcinoma (ESCC). However, individual...
Active-targeting biomimetic nanosystem for prostate cancer enhances radiotherapy efficacy by inducing ferroptosis [0.03%]
主动靶向仿生纳米系统通过诱导铁死亡增强前列腺癌放射治疗疗效
Zhihao Hu,Hongji Li,Kai Gan et al.
Zhihao Hu et al.
Radioresistance and off-target toxicity remain major challenges in prostate cancer (PCa) radiotherapy. Here, we report a biomimetic nanoplatform (Au/MOF-FIN@M-gy1) that synergistically enhances radiation deposition and ferroptosis for preci...
The potential of nanotechnology for photothermal therapy-based synergistic immunotherapy: a review [0.03%]
纳米技术在基于光热疗法的协同免疫治疗中的潜力：综述
Xiao-Kai Chi,Xiao Zhang,Jin Su et al.
Xiao-Kai Chi et al.
With the continuous discovery of new materials and a deeper understanding of tumor diseases, more possibilities have been identified for the delivery of antitumor drugs and the treatment of tumors. Currently, the treatment of tumors is not ...
A metabolic reprogramming and trained immunity hydrogel mimic cluster missiles to eliminate infection and treat infected diabetic wounds [0.03%]
代谢重编和训练免疫水凝胶模拟集群导弹消除感染并治疗糖尿病感染伤口
Zirui Yu,Zhenyi Chen,Hongxia Xie et al.
Zirui Yu et al.
Excessive inflammation, infection, persistent reactive oxygen species (ROS) accumulation, hyperglycemia, and vascular lesions in diabetic chronic wounds severely impair healing. Currently, there is no treatment regimen available to improve ...