ROS-scavenging microspheres loaded with extracellular vesicles for intervertebral disc degeneration therapy [0.03%]
负载外泌体的ROS清除微球椎间盘退变治疗研究
Chunping A,Haozhe Cheng,Guangzi Chen et al.
Chunping A et al.
Intervertebral disc degeneration (IVDD), primarily driven by oxidative stress and inflammation, significantly impacts patient quality of life. Current therapies lack efficacy, highlighting the need for novel treatment strategies. This study...
Inactivation of the leukemia inhibitory factor/signal transducer and activator of transcription 3 pathway: a pivotal mechanism in adenomyosis-related embryo implantation failure [0.03%]
白血病抑制因子/信号转导子和转录激活子3通路失活在子宫腺肌病相关胚胎着床失败中的关键作用机制研究
Qianru Dou,Zhengjie Han,Wenxiao Shao et al.
Qianru Dou et al.
Background: Adenomyosis (AM) is frequently associated with compromised embryo implantation. The leukemia inhibitory factor (LIF)/signal transducer and activator of transcription 3 (STAT3) signaling pathway is crucial for ...
Transforming stroke care: the promise of feedback-guided thrombolytic nanomedicine [0.03%]
取栓机器人治疗卒中的展望：反馈导向的溶栓纳米药物疗法
Yizi Wang,Tuan Wang,Xiaohan Qu et al.
Yizi Wang et al.
Ischemic stroke and thrombotic vascular occlusion remain leading causes of mortality and disability worldwide, yet current therapies operate largely in an open-loop paradigm, delivering thrombolytics or mechanical intervention without adapt...
Emerging role of herbal nanogel formulations in skin cancer therapy: mechanistic insights and translational advances in nanomedicine [0.03%]
纳米胶体制剂在皮肤癌治疗中的新兴作用：纳米医学中的机制见解和转化进展
Suraj Kumar,Rishabha Malviya,Phool Chandra et al.
Suraj Kumar et al.
Objective: Skin cancer remains a major global health concern, necessitating the development of innovative therapeutic strategies that enhance treatment efficacy while minimizing adverse effects. This review aims to explor...
Gut-derived extracellular vesicle enriched miR-125a-5p mediates cadmium-induced intestinal injury through NF-κB pathway activation [0.03%]
肠道来源的富含miR-125a-5p的细胞外囊泡通过激活NF-κB途径介导镉诱导的肠损伤
Mengzhen Song,Lina Ping,Yulin Wang et al.
Mengzhen Song et al.
Cadmium (Cd), as a prevalent environmental heavy metal pollutant, has an incompletely elucidated mechanism of intestinal toxicity following oral ingestion. This study aims to elucidate novel mechanisms underlying cadmium-induced intestinal ...
Membrane-coated Prussian blue nanocomplex with enhanced enzyme-mimic activity alleviates senile osteoporosis by reducing osteoprogenitor cell senescence and macrophage inflammation [0.03%]
具有增强类酶活性的膜包被普鲁士蓝纳米复合材料通过减少成骨祖细胞衰老和巨噬细胞炎症来缓解老年性骨质疏松症
Yihan Lin,Yuyi Tian,Hao Liu et al.
Yihan Lin et al.
Senile osteoporosis (SOP) is a chronic age-related skeletal disorder characterized by progressive bone loss and high fracture risk, with pathogenesis linked to excessive reactive oxygen species (ROS), osteoprogenitor cell senescence, and ma...
Advanced herbal self-assembled nanoplatforms: targeted, stimuli-responsive, and precision therapeutics for human diseases [0.03%]
先进的草药自组装纳米平台：针对人类疾病的靶向、刺激响应和精确治疗
Xiao Zou,Jianxin Liu,Xuecong Ren et al.
Xiao Zou et al.
Herbal self-assembled nanoplatforms (H-SANs) represent an emerging strategy in herbal nanomedicine by integrating the intrinsic bioactivity of phytochemicals with supramolecular nanoscale organization. Unlike conventional nanocarriers that ...
Highly penetrative nanocarrier modulates tumor bacteria to enhance oxygen-free photo immunotherapy in spinal metastatic cancer [0.03%]
一种高度渗透的纳米载体调节脊柱转移性肿瘤细菌以增强无氧光免疫疗法
Chao Jia,Hongwei Lu,Jinjin Wang et al.
Chao Jia et al.
Microbiome and transcriptome analyses revealed that Fusobacterium nucleatum (F.n) in clinical samples is associated with immune suppression and poor prognosis in triple-negative breast cancer spinal metastasis. However, its preferential loc...
Integrating silver nanomaterials in wound healing: from physicochemical properties to clinical translation [0.03%]
银纳米材料在伤口愈合中的应用：从理化性质到临床转化
Haishan Zhang,Kai You,Qifang Liu et al.
Haishan Zhang et al.
Wound healing is a complex process that involves the interplay of infection, inflammation, and tissue regeneration. Nevertheless, the conventional therapies tend to treat these processes individually. Silver nanomaterials have been found to...
Immunometabolic reprogramming of macrophages by miR-423-5p-enriched small extracellular vesicles delivered via glucose/ROS-responsive hydrogel for diabetic wound healing [0.03%]
糖/ROS响应性水凝胶递送富含miR-423-5p的小细胞外囊泡对巨噬细胞进行免疫代谢重编促进糖尿病创面修复
Meihua Chen,Qianru Guo,Ziyang Qin et al.
Meihua Chen et al.
Background: Chronic diabetic wounds remain a formidable clinical challenge due to a self-sustaining immunometabolic dysfunction. The hyperglycemic and pro-oxidative microenvironment locks infiltrating macrophages in a gly...