Lipid-based nanoparticles external triggered release strategies in cancer nanomedicine [0.03%]
癌症纳米医学中基于脂质的纳米颗粒外部触发释放策略
Abdulaziz Alhussan,Louise Ho,Yao Zhang et al.
Abdulaziz Alhussan et al.
Nearly half of humanity will develop cancer in their Lifetime. Current therapies, particularly chemotherapeutic drugs, face significant challenges due to the lack of tissue-specific delivery. For example, less than 0.1% of anticancer drugs ...
Manganese-loaded carbon nanoparticles ameliorate ANCA-associated vasculitis by inhibiting ferroptosis [0.03%]
负载锰的碳纳米颗粒通过抑制铁死亡改善ANCA相关性血管炎
Yiru Wang,Yongman Lv,Chengcheng Fu et al.
Yiru Wang et al.
Antineutrophil cytoplasmic antibody-associated glomerulonephritis (ANCA-GN), a life-threatening vasculitis manifestation, involves systemic endothelial injury and rapid renal decline. Despite limited therapies, the role of ferroptosis, a ne...
Multifunctional nanoparticles in abdominal aortic aneurysm management: from basic research to clinical transformation [0.03%]
多功能纳米颗粒在腹主动脉瘤管理中的应用：从基础研究到临床转化
Gang Yuan,Weiming Wang,Xiaohui Jia et al.
Gang Yuan et al.
Abdominal aortic aneurysm (AAA) is a life-threatening vascular condition marked by localized aortic dilation and structural weakening of the vessel wall, often leading to catastrophic complications such as rupture. As one of the leading cau...
Plant-derived exosome-like nanovesicles: a novel therapeutic perspective for skin diseases [0.03%]
植物来源的类外泌体纳米囊泡：皮肤疾病的新型治疗视角
Hui Liu,Tingru Dong,Can Dong et al.
Hui Liu et al.
Plant-derived exosome-like nanovesicles (PENs) are emerging as a unique class of bioactive nanocarriers with transformative potential in dermatology. Characterized by intrinsic biocompatibility, the ability to traverse biological barriers, ...
Scientometric analysis of extracellular vesicles in vision science (up to 2024) [0.03%]
视觉科学中外泌体的科学计量分析（截至2024年）
Fei Liao,Francisco Germain,Li Ma et al.
Fei Liao et al.
Background: Extracellular vesicles (EVs) in vision science have gained significant attention. However, a comprehensive scientometric analysis of the key major contributors, the current research landscape, and development ...
Outer membrane vesicles-based nano-regulator for cancer immunotherapy by modulating neutrophils N1 polarization and hitchhiking delivery [0.03%]
基于外膜囊泡的纳米调控器通过调节中性粒细胞N1极化和搭便车递送进行癌症免疫治疗
Xiaoning Liu,Qun Niu,Haoxiang Yang et al.
Xiaoning Liu et al.
Efficient eradication of cancer cells and enhanced tumor accumulation of drug via immune cells represent promising strategies for cancer treatment, yet they remain significant challenges. Inspired by neutrophils (NEs), we designed a novel n...
Photosensitive small intestinal submucosal hydrogels loaded with the KR-12-a5 peptide promote periodontal osteogenesis and antimicrobial activity [0.03%]
载有KR-12-a5肽的感光性小型肠黏膜下水凝胶促进牙周成骨和抗菌活性
Shiqing Ma,Qiquan Yan,Le Li et al.
Shiqing Ma et al.
Background: Periodontitis, a chronic inflammatory condition, causes progressive loss of oral soft and hard tissues. Current treatments struggle to balance antimicrobial efficacy with bone regeneration. This study aimed to...
ROS-degradable hydrogel delivering LOXL2-LNPs rescues disc degeneration by synchronously suppressing cellular senescence and oxidative damage [0.03%]
一种可降解的携带LOXL2-LNPs的水凝胶通过同步抑制细胞衰老和氧化损伤来拯救椎间盘退变
Jian Zhang,Yang Li,Rui Ding et al.
Jian Zhang et al.
Background: Intervertebral disc degeneration (IDD) is a chronic degenerative disorder marked by nucleus pulposus cells (NPCs) senescence and extracellular matrix (ECM) degradation, which is a key pathological factor leadi...
Neuroprotective effects of Berberine-loaded BMSCs-apoptotic extracellular vesicles on retinal ganglion cells: therapeutic potential for glaucomatous injury [0.03%]
载小檗碱的BMSCs凋亡外泌体对视网膜神经节细胞的神经保护作用：治疗青光眼损伤的潜力
Mengling You,Xuan Zhang,Zhou Zeng et al.
Mengling You et al.
Glaucoma is a leading cause of irreversible blindness, primarily driven by the progressive degeneration of retinal ganglion cells (RGCs). In this study, we report the novel application of bone marrow mesenchymal stem cells (BMSCs)-derived a...
Plastic tableware use, microplastic accumulation, and sperm quality: from epidemiological evidence to FOXA1/p38 mechanistic insights [0.03%]
关于塑料食具使用、微塑性蓄积及精子质量的流行病学证据与FOXA1/p38机制见解之间的关系研究
Jiayuan Qu,Jiayue Zeng,Li Mou et al.
Jiayuan Qu et al.
Microplastics (MPs), as emerging contaminants, may adversely affect male reproductive health. This study investigated the potential association between MP accumulation in human semen and sperm quality. Furthermore, the molecular mechanisms ...