Injectable HAMA-CPC hydrogels loaded with high-yield 3D bioprinted adipose-derived stem cell small extracellular vesicles for increased bone repair [0.03%]
负载高收率3D生物打印脂肪源干细胞小细胞外囊泡的HAMA-CPC水凝胶促进骨修复增强效应
Wenbin Xu,Wenling Gao,Yi Zhang et al.
Wenbin Xu et al.
In the field of bone tissue engineering, the development of effective strategies for bone defect repair remains a major challenge. Herein, we report a novel approach involving the integration of high-yield 3D bioprinted adipose-derived stem...
Enhancing exosome stability and delivery with natural polymers to prevent intrauterine adhesions and promote endometrial regeneration: a review [0.03%]
利用天然聚合物增强外泌体稳定性及递送防治宫腔粘连和促进子宫内膜修复的研究进展综述
Wei Sun,Wei Xu,Miaomiao Xiao et al.
Wei Sun et al.
Intrauterine adhesions (IUAs) are defined as the formation of fibrotic scar tissue within the uterine cavity. They can lead to a range of complications, including hypomenorrhea, amenorrhea, infertility, and recurrent pregnancy loss. Convent...
Prunus mume derived extracellular vesicle-like particles alleviate experimental colitis via disrupting NEK7-NLRP3 interaction and inflammasome activation [0.03%]
梅花衍生的细胞外囊泡样颗粒通过破坏NEK7-NLRP3相互作用和凋亡小体活化来缓解实验性结肠炎
Qi Lv,Hongqiong Yang,Ying Xie et al.
Qi Lv et al.
Edible plant derived extracellular vesicle-like particles (EVLPs) have garnered attention as potential therapeutic agents for chronic inflammatory diseases. Prunus mume (PM) is a functional fruit known for its gastrointestinal benefits, yet...
Biomimetic phosphorus dendrimer multi-epitope nanovaccine enhances humoral and cellular immune response against African swine fever virus [0.03%]
类磷树形递呈多表位纳米疫苗可增强 ASFV 的体液和细胞免疫应答
Hong Duan,Aijuan Shen,Min Wang et al.
Hong Duan et al.
Using nanoparticles (NPs) as a platform for multivalent antigen display is an effective strategy to increase the immunogenicity of subunit vaccines, which can induce high levels of humoral and cellular immunity. In addition, antigens that t...
Recent advances in engineered exosome-based therapies for ocular vascular disease [0.03%]
工程化外体治疗眼血管疾病的新进展
Jian Guan,Fanhe Meng,Chuanzhuo Wang et al.
Jian Guan et al.
Ocular neovascular diseases (ONDs), including corneal neovascularization (CoNV), age-related macular degeneration (AMD) and diabetic retinopathy (DR), are among the leading causes of visual impairment worldwide. Current therapeutic strategi...
Delivery of an ERK inhibitor using bioactive lipid nanoparticles reduces angiogenesis and prevents oral squamous cell carcinoma development [0.03%]
利用生物活性脂质纳米颗粒输送ERK抑制剂可减少血管生成并预防口腔鳞状细胞癌的发生
Zixian Huang,Junyue Fang,Li Lin et al.
Zixian Huang et al.
Extracellular regulated protein kinases (ERK) signaling is aberrantly activated in oral squamous cell carcinoma (OSCC), and targeting ERK signaling with ERK1/2 inhibitors is a potential strategy for OSCC treatment. However, methods for the ...
Rapid diagnostic imaging and targeted immunotoxin delivery in aggressive prostate cancer using CEACAM5-specific nanobodies [0.03%]
采用CEACAM5特异性纳米抗体快速诊断成像及靶向免疫毒素递送治疗侵袭性前列腺癌
Zhaoming Xiao,Jingbo Ma,Jinpeng Cen et al.
Zhaoming Xiao et al.
Aggressive variant prostate cancer (AVPC) originates from metastatic prostate cancer (mPCa) following androgen receptor-targeted therapies, leading to diverse pathological subtypes, notably castration-resistant prostate cancer (CRPC). Carci...
Enhancing the potency of 5T4 mRNA vaccine by CD70 mRNA-LNPs through ADCC and T cell boosting in prostate cancer therapy [0.03%]
通过ADCC和T细胞增强提高CD70 mRNA-LNPs联合5T4 mRNA疫苗在前列腺癌治疗中的疗效
Fei Cao,Yuandong Xu,Yupeng Guan et al.
Fei Cao et al.
Background: Prostate cancer remains a significant health challenge, as conventional treatments often fail to provide long-term benefits in the advanced stages. This study explored the potential of mRNA vaccines as novel t...
Lyophilized apoptotic vesicles restore DNA damage and mitochondria dysfunction to ameliorate radiation enteritis [0.03%]
冻干的凋亡小体通过修复辐射诱发的肠道黏膜DNA损伤和线粒体功能障碍治疗放射性肠炎
Bo Yang,Huigen Luo,Xutong Yan et al.
Bo Yang et al.
Radiation therapy for malignant tumor patients often induces radiation enteritis (RE), a condition that impairs their quality of life. Currently, there is no standard treatment regimen available. In this study, we used lyophilized apoptotic...
Efficacy and safety of Fe-curcumin coordination polymer nanodots to prevent corneal neovascularization in alkali burn models [0.03%]
铁-姜黄素配位聚合物纳米点预防碱烧伤模型角膜新生血管化的有效性和安全性
Yan Huo,Lele Song,Zhihui Han et al.
Yan Huo et al.
Alkali burns pose a significant risk of corneal injury, leading to potential blindness. During the progression of alkali burns, heightened oxidation levels can induce corneal damage, resulting in diminished clarity and vision loss. In this ...