Bletilla striata polysaccharide microneedles with astragaloside Ⅳ loaded ZIF-8 nanoparticles for wound healing and anti-scar treatment [0.03%]
用于伤口愈合和抗瘢痕治疗的Bletilla striata多糖微针及其负载 Astragaloside IV 的ZIF-8纳米颗粒
Rezhemu Jimo,Jun Ma,Shixing Edi et al.
Rezhemu Jimo et al.
Pathological scars (PS) represent a common complication arising post wound healing, potentially resulting in disfigurement and impaired skin functionality in severe instances. Addressing the clinical challenge wherein conventional single tr...
Fe-MOF loaded with capmatinib to reverse immunosuppressive microenvironment and inhibit tumor metastasis after radiofrequency ablation [0.03%]
负载卡马替尼的铁基金属有机框架材料逆转射频消融后肿瘤免疫抑制微环境及转移抑制作用研究
Jinchao Zhao,Lei Lei,Cheng Zeng et al.
Jinchao Zhao et al.
Incomplete radiofrequency ablation (iRFA) of hepatocellular carcinoma (HCC) has the risk to exacerbate the tumor immunosuppressive microenvironment and promote lung metastasis. There is an urgent need to reverse the immunosuppressive microe...
Cascade-targeting copper homeostasis nano-regulators for mild-photothermal boosted cuproptosis/ferroptosis mediated breast cancer therapy [0.03%]
用于温和光热促进铜依赖性细胞死亡/铁死亡协同治疗乳腺癌的级联靶向铜稳态纳米调节器
Xuejun Liang,Shiji Fang,Yanan Xin et al.
Xuejun Liang et al.
Inducing cuproptosis in tumor cells is significantly impeded by the challenges of arduous copper ion delivery in vivo and the unbreakable intracellular copper homeostasis, which leads to insufficient mitochondrial copper accumulation. Here,...
Correction: Nanoliposomal PD-1 antagonist target tumor-draining lymph nodes to revitalize T cells and improve anti-tumor effect in hepatocellular carcinoma [0.03%]
纠正：纳米脂质体PD-1拮抗剂靶向肿瘤引流淋巴结以激活T细胞并改善肝癌的抗肿瘤作用
Wanyue Cao,Kai Yang,Gaowei Jin et al.
Wanyue Cao et al.
Published Erratum
Journal of nanobiotechnology. 2025 Oct 10;23(1):642. DOI:10.1186/s12951-025-03699-y 2025
Microneedles combining delivery of hUMSC-derived exosomes and EGCG mitigate UV-induced skin damage [0.03%]
结合hUMSC衍生的外泌体和EGCG递送的微针可减轻紫外线引起的皮肤损伤
Chenhui He,Zeqian Wang,Zhaoting Jiang et al.
Chenhui He et al.
Exposure to ultraviolet (UV) radiation compromises both the aesthetic and functional properties of the skin, accelerates aging, increases the risk of skin cancer, and significantly impairs quality of life. Exosomes derived from human umbili...
Orally ingested nanosilica causes liver-specific accumulation and induces liver senescence and fibrosis via the microbiota-gut-liver axis [0.03%]
口服摄入的纳米级二氧化硅通过微生物群-肠-肝轴引起肝脏特异性蓄积并诱导肝衰老和纤维化
Xiaofei Han,Lisha Du,Yanjie Dou et al.
Xiaofei Han et al.
Background: The increased use of nanosilica (SiO2 NPs) poses a safety risk to public health. Current research on the tissue distribution and microbiota-gut-liver crosstalk toxicity of orally ingested SiO2 NPs remains poor...
Porphyromonas gingivalis extracellular vesicles exacerbated osteoporosis by disrupting osteoblast mitochondrial dynamics and inhibiting Cpt2-regulated fatty acid oxidation [0.03%]
牙龈卟啉单胞菌细胞外囊泡通过破坏成骨细胞线粒体动力学并抑制肉碱棕榈酰转移酶2介导的脂肪酸氧化来加重骨质疏松症
Qiujing Qiu,Xiaoyuan Yan,Zeying Zhang et al.
Qiujing Qiu et al.
Background: Recent studies have implicated periodontitis (PD) as a potential risk factor for osteoporosis; however, the precise mechanisms remain unclear. Porphyromonas gingivalis (Pg), a key pathogen associated with PD, ...
Engineered exosomes conferred with ROS-regulation and immuno-suppression for ameliorating lupus nephritis [0.03%]
ROS调控和免疫抑制工程外泌体改善狼疮性肾炎
Jiang Tian,Zexin Wang,Zhicheng Tang et al.
Jiang Tian et al.
Mesenchymal stromal cell-derived exosomes (MEXs) possess inherent homing capabilities, tissue repair abilities, and anti-inflammatory and immunomodulatory functions, making them a promising alternative for treating lupus nephritis (LN). In ...
Yawen Zhu,Wanqi Yang,Zhongxia Wang et al.
Yawen Zhu et al.
Liver regeneration is a sophisticated biological process influenced by a complex microenvironment that becomes profoundly altered in various pathological conditions. Current therapeutic approaches, including liver transplantation and pharma...
Targeting JAK2 with a multifunctional nanoinhibitor for long-lasting anti-inflammatory effects and bone repair [0.03%]
靶向JAK2的多功能纳米抑制剂用于长期抗炎和骨修复
Yang Liu,Duan Wang,Wenqian Zheng et al.
Yang Liu et al.
Dysregulation of the JAK2/STAT3 pathway disrupts immune balance and tissue homeostasis, leading to persistent inflammation and subsequent bone loss. Yet, commonly used JAK2 inhibitors with hydrophobicity primarily suppress inflammation but ...