Bandgap-engineered proteinic near-infrared nanodots for localized precision cancer theranostics [0.03%]
基于能带隙工程的蛋白质近红外纳米点用于癌症精确诊断与治疗
Mou Seung Kim,In Ho Nam,Hyung Joon Cha et al.
Mou Seung Kim et al.
Hypoxia-augmented chemotherapy potentiates imaging-guided combinatorial radionuclide-sonodynamic therapy for pancreatic cancer [0.03%]
缺氧增强的化疗联合影像引导的放射性核素-声动力学治疗胰腺癌
Jie An,Kaile Chu,Xirong Li et al.
Jie An et al.
Radionuclide therapy and chemotherapy are effective for pancreatic cancer, yet their efficacy is often limited by tumor hypoxia. In this study, manganese porphyrin (MnTTP) and tirapazamine (TPZ) were encapsulated in polylactic-co-glycolic a...
Internalized polystyrene nanoplastics trigger testicular damage and promote ferroptosis via CISD1 downregulation in mouse spermatocyte [0.03%]
内源性聚苯乙烯纳米塑料通过下调CISD1诱导小鼠精母细胞睾丸损伤和促进铁死亡
Jing Lv,Guangyu Liu,Ziqi Wang et al.
Jing Lv et al.
Background: There is a growing body of research regarding the potential reproductive toxicity of microplastics and nanoplastics. However, the underlying mechanisms by which nanoplastics exposure adversely affects the test...
A comprehensive review of unlocking the potential of lignin-derived biomaterials: from lignin structure to biomedical application [0.03%]
全面解析 lignin 生物质材料的潜在应用：从结构到生物医学应用综述
Jixiang Zhao,Minyu Zhu,Wei Jin et al.
Jixiang Zhao et al.
Inspired by natural organisms, biomimetic materials with exceptional biocompatibility, degradability, and multifunctionality have emerged as promising candidates for biomedical applications. Lignin, a plant-derived organic polymer, has gain...
Quercetin combined with shTERT induces apoptosis in ovarian cancer via the P53/Bax pathway, and RGD-MSN/QR/shTERT nanoparticles enhance the therapeutic efficacy [0.03%]
槲皮素联合shTERT通过P53/Bax途径诱导卵巢癌细胞凋亡及RGD-MSN/QR/shTERT纳米颗粒增强其治疗效果
Guojie Chen,Weiwei Song,Xing Wang et al.
Guojie Chen et al.
Background: Ovarian cancer (OC) is a highly malignant gynecological tumor with poor current treatment effects. Telomerase reverse transcriptase (TERT) is an important component of telomerase and plays an important role in...
A fibrin gel-loaded Gouqi-derived nanovesicle (GqDNV) repairs the heart after myocardial infarction by inhibiting p38 MAPK/NF-κB p65 pathway [0.03%]
载地黄纳米囊泡通过抑制p38 MAPK/NF-κB p65通路修复心肌梗死后心脏组织损伤
Huan-Huan Zhou,Xiaolei Zhou,Jianqiu Pei et al.
Huan-Huan Zhou et al.
The restoration of cardiac function post-myocardial infarction (MI) remains a significant clinical challenge. Emerging evidence indicates that Goji berries ("Gouqi" in Chinese) and their extracts exhibit substantial cardioprotective propert...
CuOTeDsP nanotherapeutics enhance cuproptosis-mediated immunotherapy by modulating cholesterol metabolism in bladder cancer [0.03%]
CuOTeDsP纳米疗法通过调节胆固醇代谢增强膀胱癌中的铜死亡介导的免疫治疗
Hai Cai,Panpan Xue,Siyuan Liu et al.
Hai Cai et al.
Metal-organic nanostructures based on sono/chemo-nanodynamic synergy of TixOy/Ru reaction units: for ultrasound-induced dynamic cancer therapy [0.03%]
基于TixOy/Ru反应单元的声化学纳米动力协同金属有机纳米结构：用于超声波诱导的癌症动态治疗
Tao Jiang,Zixiang Tang,Shumiao Tian et al.
Tao Jiang et al.
Sonodynamic therapy (SDT) exhibits clinical potential for deep-tissue tumor treatment due to its deep tissue penetration and spatiotemporal controllability. Its core mechanism relies on ultrasound-activated sonosensitizers to generate react...
An adeno-associated virus gene therapy strategy for anti-obesity treatment by nanocarrier-based delivery systems [0.03%]
基于纳米载体的递送系统进行腺相关病毒肥胖治疗基因疗法策略
Li Li,Wang Wang,Rong Li et al.
Li Li et al.
Gut microbiota is increasingly recognized for its profound influence on host metabolism. However, the mechanisms underlying the distinct metabolic phenotype observed in germ-free (GF) mice are not fully understood. Here, the serum levels of...
Multifunctional nanoagent for enhanced cancer radioimmunotherapy via pyroptosis and cGAS-STING activation [0.03%]
一种多功能纳米剂通过激活细胞焦亡和cGAS-STING途径增强癌症放射免疫治疗的功效
Ziting Xu,Yang Gao,Li Zhang et al.
Ziting Xu et al.
The immunosuppressive tumor microenvironment (ITME) and inherent radioresistance of tumor cells limit the effectiveness of radioimmunotherapy and exacerbate immune evasion. To address these challenges, PEGylated Azacitidine-loaded and Mn2+-...