Hypoxia-responsive core-cross-linked supramolecular nanoprodrug based on dendritic drug-drug conjugates for synergetic anticancer therapy [0.03%]
基于树枝状药物-药物共聚物的超分子纳普药用于协同抗肿瘤治疗
Yue Ding,Yu Xie,Liangshun Zheng et al.
Yue Ding et al.
Background: Recently, the strategy of self-assembling dendritic drug-drug conjugates into supramolecular nanoprodrug was widely explored in biomedical applications. Herein, we construct a hypoxia-responsive core-cross-lin...
Carbon dot-based treatment for bacterial pneumonia by promoting a PI3K-mediated M1 polarization of macrophages [0.03%]
基于碳点的治疗细菌性肺炎的方法可促进PI3K介导的巨噬细胞M1极化反应
Xuan Jiang,Jun Wang,Lin Gan et al.
Xuan Jiang et al.
As the incessant emergence of drug-resistant bacterial strains, bacterial pneumonia poses a serious threat to the public health worldwide. There is an urgent need to explore unconventional therapeutic strategies. Carbon dots are usually des...
Erythrocyte membrane camouflaged celastrol and bilirubin self-assembly for rheumatoid arthritis immunotherapy based on STING inhibition and RONS clearance [0.03%]
基于STING抑制和RONS清除的类风湿性关节炎免疫治疗的红细胞膜伪装的青蒿素和胆红素自组装体系
Yanguo Su,Rui Chen,Bingjie Wang et al.
Yanguo Su et al.
Activation of cGAS-STING signaling pathway and accumulation of reactive oxygen and nitrogen species (RONS) are important issues facing the treatment of rheumatoid arthritis (RA). Here, we report a biomimetic nano-Chinese medicine (HA-RM-Cel...
Drug-loaded indocyanine green J-aggregates activate metalloimmunotherapy for sustained photothermal therapy of hepatocellular carcinoma [0.03%]
载药吲哚菁绿J聚集体激活金属免疫治疗以实现肝癌的持续光热治疗
Kaiming He,Desheng Chen,Dongzi Zhu et al.
Kaiming He et al.
Hepatocellular carcinoma (HCC) poses a significant therapeutic challenge, driving the need for novel treatment strategies. This study investigates the combination of photothermal therapy (PTT) and metalloimmunotherapy for HCC treatment usin...
Microglia-targeting nanosystems that cooperatively deliver Chinese herbal ingredients alleviate behavioral and cognitive deficits in Alzheimer's disease model mice [0.03%]
靶向小胶质细胞的纳米递送系统协同输送中药成分可改善阿尔茨海默病模型小鼠的行为和认知缺陷
Peng Zhou,Quan Chao,Chen Li et al.
Peng Zhou et al.
The effective treatment of Alzheimer's disease (AD) is challenging because of its complex and controversial pathological mechanisms. Moreover, multiple barriers, such as the blood-brain barrier (BBB), reduce drug delivery efficiency. Microg...
The nano-paradox: addressing nanotoxicity for sustainable agriculture, circular economy and SDGs [0.03%]
纳米悖论——解决纳米毒性以实现可持续农业、循环经济和可持续发展目标
Vijay Rani Rajpal,Byonkesh Nongthongbam,Manika Bhatia et al.
Vijay Rani Rajpal et al.
Engineered nanomaterials (ENMs) have aroused extensive interest in agricultural, industrial, and medical applications. The integration of ENMs into the agricultural systems aligns with the principles of United Nations' sustainable developme...
Bionic gene delivery system activates tumor autophagy and immunosuppressive niche to sensitize anti-PD-1 treatment against STK11-mutated lung adenocarcinoma [0.03%]
仿生基因递送系统激活肿瘤自噬和免疫抑制微环境以增强抗PD-1治疗STK11突变型肺腺癌的敏感性
Zhongquan Song,Qikai Wang,Hongjie Xiong et al.
Zhongquan Song et al.
Clinical data have shown that Serine/Threonine Kinase 11 (STK11) mutation may be associated with an immunosuppressive tumor microenvironment (ITEM) and poor prognosis and failure of anti-PD-1 (αPD1) treatment in non-small cell lung cancer ...
M2 microglia-derived small extracellular vesicles modulate NSC fate after ischemic stroke via miR-25-3p/miR-93-5p-TGFBR/PTEN/FOXO3 axis [0.03%]
缺血性卒中后M2型小胶质细胞来源的小胞外囊泡通过miR-25-3p/miR-93-5p-TGFBR/PTEN/FOXO3轴调控NSC分化命运
Qian Zhang,Yan Yi,Tiange Chen et al.
Qian Zhang et al.
Background: Endogenous neurogenesis could promote stroke recovery. Furthermore, anti-inflammatory phenotypical microglia (M2-microglia) could facilitate Neural Stem Cell (NSC)-mediated neurogenesis following Ischemic Stro...
Lactiplantibacillus plantarum -derived extracellular vesicles alleviate acute lung injury by inhibiting ferroptosis of macrophages [0.03%]
植物乳杆菌衍生的细胞外囊泡通过抑制巨噬细胞铁死亡来缓解急性肺损伤
Qiong Zhao,Jingbo Lai,Yang Jiang et al.
Qiong Zhao et al.
Despite considerable advancements in understanding the mechanisms of ALI, the therapeutic options available in clinical practice remain predominantly supportive, highlighting the urgent need for innovative treatments. In this study, we inve...
Indacenodithienothiophene-based A-D-A-type phototheranostics for immuno-phototherapy [0.03%]
基于吲哚并噻吩基A-D-A型光诊疗剂用于免疫光动力疗法
Yangtian Ye,Shaojing Zhao,E Pang et al.
Yangtian Ye et al.
The development of phototherapeutics with high photothermal conversion efficiency (PCE) and strong ability to generate reactive oxygen species under single near-infrared (NIR) laser irradiation for immuno-phototherapy applications remains a...