Nanomedicine targeting the PD-1/PD-L1 axis in autoimmune diseases: breaking conventional barriers to restore immune tolerance [0.03%]
靶向PD-1 / PD-L1轴的纳米药物在自身免疫性疾病中的应用：打破常规界限以恢复免疫耐受性
Gang Xiang,Yuanxu Cui,Pan Wang et al.
Gang Xiang et al.
Autoimmune diseases (ADs) arise from the breakdown of self-tolerance, leading to pathogenic immune responses against healthy tissues. The PD-1/PD-L1 immune checkpoint is pivotal for maintaining peripheral tolerance by suppressing autoreacti...
Customized extracellular vesicles targeting lysosomal biogenesis deliver therapeutic cargo for intervertebral disc degeneration treatment [0.03%]
定制靶向溶酶体生物发生的细胞外囊泡递送治疗 IDD 的药物载荷
Zhiwei Liao,Zixuan Ou,Bide Tong et al.
Zhiwei Liao et al.
Extracellular vesicles (EVs) have gained prominence as advanced drug delivery systems due to their inherent merits. Recent advancements highlight their utility in transporting therapeutic proteins with significant progress in targeted thera...
Spontaneous hydrogen-releasing nanoenzyme alleviates osteoarthritis via oxidative stress reduction and mitochondrial dysfunction reversal [0.03%]
一种自发释放氢的纳米酶通过减少氧化应激和逆转线粒体功能障碍来缓解骨关节炎
Qi Wang,Minyi Zhang,Weihao Jiang et al.
Qi Wang et al.
Osteoarthritis (OA), a chronic and degenerative joint disease, has become increasingly prevalent due to the aging population, posing a significant societal burden. However, despite progress, effective therapeutic options for osteoarthritis ...
Harnessing smart nanomaterials to reprogram neutrophil plasticity in immune modulation [0.03%]
利用智能纳米材料重新编程中性粒细胞的免疫调节塑性功能
Jiaxin Luo,Jingxia Chen,Jing Zhou et al.
Jiaxin Luo et al.
Neutrophils are the most abundant type of white blood cells in the immune system and play a complex and intricate regulatory role in disease progression. Their critical contribution to maintaining homeostasis through migration, activation, ...
Tungsten disulfide atomic crystals with RONS scavenging and liver targeting capabilities for acetaminophen-induced acute liver injury therapy [0.03%]
用于治疗对乙酰氨基酚致急性肝损伤的具有RONS清除和肝靶向功能的二硫化钨原子晶体
Ziwen Xiao,Yu Liu,Zhenchao Tao et al.
Ziwen Xiao et al.
The ongoing progression of acetaminophen (APAP)-induced liver injury (AILI) resulting from excessive APAP intake can lead to acute liver failure (ALF). This process involves an imbalanced antioxidant system, upregulated inflammatory respons...
Rational engineering of nanoplatforms with hierarchical targeting hepatic tumor and subcellular mitochondria for enhanced image-guided photodynamic therapy [0.03%]
用于肝肿瘤和亚细胞线粒体分层靶向的纳米平台的理性工程化，以增强图像引导的光动力疗法
Xiaofei Shang,Wenjie Shao,Wuqi Dong et al.
Xiaofei Shang et al.
The main challenge of photosensitizer in image-guided photodynamic therapy (PDT) is the balance between the high singlet oxygen yields and strong fluorescence performance, while simultaneously targeting certain types of cancer to achieve op...
A novel scalable method for the production of rennet-treated milk-derived extracellular vesicles for improved curcumin oral delivery [0.03%]
一种新型可扩展方法生产凝乳酶处理的牛奶源细胞外囊泡以改善口服黄酮素递送
Emily Schifano,Francesco Vari,Luca Buccini et al.
Emily Schifano et al.
Background: Extracellular vesicles (EVs) are lipid bilayer-enclosed nanoparticles secreted by all cell types and are gaining increasing attention as natural, biocompatible drug delivery nanovehicles. Among the various sou...
Photothermal nano-agents: an innovative trident weapon for accurate and effective treatment of alzheimer's disease [0.03%]
光热纳米剂：阿尔茨海默病精准有效治疗的创新武器
Jianfei Chen,Xiaowei Zhang,Jinpan Sun et al.
Jianfei Chen et al.
Alzheimer's disease (AD) is a degenerative neurological illness for which effective therapy alternatives are currently lacking. Photothermal therapy (PTT) employs the localized thermal effects of nano-photothermal agents (NPTAs) under near-...
Targeting ferroptosis to rescue osteogenic differentiation in BRONJ-affected jawbone mesenchymal stem cells: the role of miR-145-3p and exosome-mediated therapy [0.03%]
靶向铁死亡以拯救颌骨间充质干细胞成骨分化：miR-145-3p和外泌体介导治疗的作用
Yi Shuai,Bo Chen,Tao Jiang et al.
Yi Shuai et al.
Background: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a severe, therapy-refractory condition driven by ferroptotic disruption of jawbone-derived mesenchymal stem cells (MSCs) biology. We dissect this mech...
Drug loaded cerium oxide nanozymes prevent radiation-Induced cataracts via suppressing the cGAS-STING pathway [0.03%]
载药的二氧化铈纳米酶通过抑制cGAS-STING信号通路预防放射性白内障
Qifang Chen,Peilin Gu,Hongwei Li et al.
Qifang Chen et al.
Radiation-induced cataracts (RIC), a significant cause of blindness, arise from oxidative damage and inflammation in the lens epithelium, and there has been a lack of effective targeted therapeutic drugs in clinic. Here, we proposed and dev...