Lanthanide-specific doping in vacancy-engineered piezocatalysts induces lysosomal destruction and tumor cell pyroptosis [0.03%]
通过空位工程的压电催化剂中的稀土元素掺杂诱导溶酶体破坏和肿瘤细胞焦亡
Xiaoyan Li,Ying Wang,Xinyue Cao et al.
Xiaoyan Li et al.
Background: Reactive oxygen species (ROS)-mediated pyroptosis provides a robust strategy for overcoming apoptosis resistance in breast cancer therapy. Nevertheless, the low efficiency of pyroptosis remains an undeniable c...
Insulin/PHMB-grafted sodium alginate hydrogels improve infected wound healing by antibacterial-prompted macrophage inflammatory regulation [0.03%]
胰岛素/PHMB交联的海藻酸钠水凝胶通过促抗菌和调节巨噬细胞炎症来促进感染伤口愈合
Dan Liu,Tianyi Yu,Shan Ma et al.
Dan Liu et al.
Background: Non-healing chronic wounds with high susceptibility to infection represent a critical challenge in modern healthcare. While growth factors play a pivotal role in regulating chronic wound repair, their therapeu...
Editorial Expression of Concern: The potential use of nanozymes as an antibacterial agents in oral infection, periodontitis, and peri-implantitis [0.03%]
关于潜在利用纳米酶作为口腔感染、牙周炎和种植体周围炎抗菌剂的社论存疑意见
Mohammad Hosseini Hooshiar,Ashkan Badkoobeh,Shirin Kolahdouz et al.
Mohammad Hosseini Hooshiar et al.
Hemoglobin-loaded hollow mesoporous carbon-gold nanocomposites enhance microwave ablation through hypoxia relief [0.03%]
载血红蛋白空心介孔碳-金纳米复合材料通过缓解缺氧增强微波消融疗效
Yitian Zhang,Bitao Li,Jiawen He et al.
Yitian Zhang et al.
Microwave ablation, as a critical minimally invasive technique for tumor treatment, remains challenging in achieving an optimal balance between incomplete and excessive ablation. In addition to selectively elevating the temperature of tumor...
A novel nanomedicine for osteosarcoma treatment: triggering ferroptosis through GSH depletion and inhibition for enhanced synergistic PDT/PTT therapy [0.03%]
一种用于治疗骨肉瘤的新型纳米药物：通过耗尽和抑制GSH以增强协同PDT / PTT疗法来触发铁死亡
Tangbing Xu,Qiming Ma,Chi Zhang et al.
Tangbing Xu et al.
Osteosarcoma treatment remains challenging due to the limitations of single-modality therapies. To address this, we designed a carrier-free nanomedicine SRF@CuSO4.5H2O@IR780 (CSIR) for synergistic ferroptosis, photodynamic therapy (PDT), an...
Single BMSC-derived cartilage organoids for gradient heterogeneous osteochondral regeneration by leveraging native vascular microenvironment [0.03%]
基于天然血管微环境的单个间充质干细胞来源软骨器官体用于梯度异质性骨软骨再生
Zhenying Chen,Qitao Bo,Chao Wang et al.
Zhenying Chen et al.
Heterogeneous osteochondral regeneration remains a significant challenge due to the distinct microenvironments across the cartilage, calcified cartilage, and subchondral bone layers. The natural gradient of vascularization from the superfic...
Self-healing adhesive oxidized guar gum hydrogel loaded with mesenchymal stem cell exosomes for corneal wound healing [0.03%]
负载间充质干细胞外泌体的氧化瓜尔胶自愈性水凝胶促进角膜伤口愈合
Ruoyan Wei,Yunzhe Wang,Ziqing Feng et al.
Ruoyan Wei et al.
Hydrogels have shown great potential and value in wound healing. In this study, we construct a mesenchymal stem cell exosomes (MSC-Exos) laden natural biopolymer-based hydrogel with transparent, self-healing, injectable, and tissue adhesive...
Streptococcus mutans-derived extracellular vesicles promote skin wound healing via tRNA cargo [0.03%]
链球菌衍生的细胞外囊泡通过转运RNA促进皮肤伤口愈合
Su Young Oh,Dong Yeon Kim,Kah Young Lee et al.
Su Young Oh et al.
Background: The human oral cavity harbors a diverse microbiota, including Streptococcus species. Oral mucosal wounds heal rapidly, although the exact cause remains unclear. This study investigates the impact of Streptococ...
Ultrasmall platinum single-atom enzyme alleviates oxidative stress and macrophage polarization induced by acute kidney ischemia-reperfusion injury through inhibition of cell death storm [0.03%]
超小型铂单原子酶通过抑制细胞死亡风暴缓解急性肾脏缺血再灌注损伤诱导的氧化应激和巨噬细胞极化现象
Keng Ye,Kongwen Lin,Chengkun Wu et al.
Keng Ye et al.
Acute kidney injury (AKI), characterized by a rapid decline in renal function, is associated with impaired mitochondrial function and excessive reactive oxygen species (ROS). Therefore, the exploration of ROS scavengers provides promising n...
Macrophage-derived exosomes in cancer: a double-edged sword with therapeutic potential [0.03%]
巨噬细胞来源的外泌体在癌症中的研究进展：一把具有治疗潜力的双刃剑
Long Liu,Siying Zhang,Yuqing Ren et al.
Long Liu et al.
Solid cancer contains a complicated communication network between cancer cells and components in the tumor microenvironment (TME), significantly influencing the progression of cancer. Exosomes function as key carriers of signaling molecules...