Tumor-microenvironment triggered Mn-Gd based nanosystem for breast carcinoma suppression via synergistic radiotherapy and glutathione-depleting along with glucose oxidase combination enhanced Ros storm [0.03%]
肿瘤微环境触发的Mn-Gd基纳米系统通过协同放疗和谷胱甘肽耗尽以及葡萄糖氧化酶组合增强ROS风暴来抑制乳腺癌的发展
Yonghui Su,Dongqun Guo,Yinghao Liang et al.
Yonghui Su et al.
Background: Cancer treatment commonly involves radiation as a primary therapy, affecting nearly two-thirds of patients. The use of combination therapies is gaining traction, with the aim of achieving synergistic effects t...
Dynamic three-dimensional culture enhances tunneling nanotubes-mediated mitochondrial transfer in mesenchymal stromal cells to accelerate wound healing [0.03%]
动态三维培养促进间充质基质细胞中穿膜纳米管介导的线粒体转移以加速伤口愈合
Lin Ma,Xiaoxue Yang,Xiaoyao Huang et al.
Lin Ma et al.
Mesenchymal stromal cells (MSCs) have shown promise in treating various diseases, and optimizing their therapeutic potential is a crucial objective in MSCs-based clinical applications. The microenvironment, particularly three-dimensional (3...
Spikey biodegradable MXene nanosheets with enhanced cellular internalization and stimuli-responsive drug delivery for synergistic cancer therapy [0.03%]
具有增强的细胞内吞作用和刺激响应药物递送的spikey可生物降解MXene纳米片用于协同癌症治疗
Tiankun Hui,Chen Wang,Chenchen Fu et al.
Tiankun Hui et al.
Exo-hydrogel therapy: a revolutionary approach to managing diabetic complications [0.03%]
外凝胶疗法：一种治疗糖尿病并发症的革命性方法
Yiming Meng,Jing Sun,Yushu Ma et al.
Yiming Meng et al.
This review systematically examines the transformative potential of Exosome-hydrogel (Exo-gel) composite systems in combating diabetic complications, with a particular emphasis on their macromolecular interactions and therapeutic implicatio...
Pre-formation loading of extracellular vesicles with exogenous molecules using photoporation [0.03%]
基于光穿孔技术的外源物质装载到细胞外囊泡中研究
Jana Ramon,Cláudio Pinheiro,Charysse Vandendriessche et al.
Jana Ramon et al.
Despite the natural capacity of extracellular vesicles (EVs) to encapsulate intracellular compounds and transfer these to nearby or distant recipient cells, the intentional loading of EVs with cargo molecules remains a challenging endeavor....
Novel multifunctional targeted nanozyme as an ultrasound contrast agent for real-time monitoring and treatment of congenital hydronephrosis renal fibrosis [0.03%]
用于监测和治疗先天性肾积水肾纤维化的新型多功能靶向纳米酶超声造影剂
Qian Zhao,Di Zhang,Keyan Chen et al.
Qian Zhao et al.
Background: Congenital Hydronephrosis (CH) is a common pediatric disorder that often leads to renal fibrosis (RF), significantly impairing kidney function. Oxidative stress (OS) plays a central role in the pathogenesis of...
N6-methyladenosine-modified circDCP2 promotes carbon black nanoparticle-induced malignancy in human bronchial epithelial cells via PI3K-AKT pathway and macrophage homeostasis [0.03%]
N6-甲基腺苷修饰的circDCP2通过PI3K-AKT通路和巨噬细胞稳态促进碳黑纳米颗粒诱导的人支气管上皮细胞恶性肿瘤发生发展
Shulin Qin,Kexin Chen,Shanfeng Chen et al.
Shulin Qin et al.
Long-term exposure to environmental carbon black nanoparticles (CBNP) has been shown to increase the risk of pulmonary malignancies. However, the role of epigenetic regulation, particularly circular RNAs (circRNAs), in this process remains ...
Intravesical delivery of mucoadhesive and tumor-selective-penetrating nanozymes for enhancing the PDT of bladder cancer [0.03%]
用于增强膀胱癌光动力治疗的黏膜粘附和肿瘤选择性穿透纳米酶的腔内给药
Yang Liu,Wentao Xu,Xiaowen Qin et al.
Yang Liu et al.
Intravesical photodynamic therapy (PDT) emerges as a promising modality for bladder cancer treatment, yet its efficacy is often curtailed by weak muco-adhesion, poor muco-penetration, low tumor-targeting and intra-tumoral oxygen scarcity. I...
Mechanochemically reprogrammed porous tantalum with synergistic antibacterial and osteogenic properties for the treatment of infectious bone defects [0.03%]
用于感染性骨缺损治疗的协同抗菌和成骨多孔钽的机械化学重编程
Yan Sun,Yu Zhang,Kai Zhang et al.
Yan Sun et al.
Infection and poor osseointegration following orthopedic implantation remain significant challenges that can lead to complications, including prosthesis loosening, delayed fracture healing, and even implant failure. Porous tantalum is a gam...
Carrier rocket-inspired hydrogel microspheres targeting subchondral bone osteoclast activity alleviate osteoarthritic pain and cartilage degeneration [0.03%]
载体火箭启发的水凝胶微球靶向软骨下骨破骨细胞活性缓解骨关节炎疼痛和软骨退变
Zhenglin Zhu,Yujia Luo,Pengcheng Xiao et al.
Zhenglin Zhu et al.
Background: Osteoarthritis (OA) represents a major global health challenge, characterized by progressive cartilage degeneration and subchondral bone remodeling, which culminate in debilitating pain and functional impairme...