Visualization of HSP70-regulated mild-photothermal therapy for synergistic tumor treatment: a precise space-time mild-temperature photothermal ablation strategy [0.03%]
HSP70调控的温和光热治疗可视化用于协同肿瘤治疗：一种精准时空温控消融策略
Binyue Zhang,Yanchun Ma,Qi Liu et al.
Binyue Zhang et al.
Mild-temperature photothermal therapy (MPTT) advances anticancer management by regulating reactive oxygen species (ROS) and lipid peroxides (LPO) to inhibit the overexpression of heat shock protein 70 (HSP70), thus decreasing the cellular h...
Biomaterial-based strategies for bone cement: modulating the bone microenvironment and promoting regeneration [0.03%]
基于生物材料的骨水泥策略：调节骨微环境和促进再生
Jiawei Jiang,Juan Wang,Pan Fan et al.
Jiawei Jiang et al.
Osteoporotic bone defect and fracture healing remain significant challenges in clinical practice. While traditional therapeutic approaches provide some regulation of bone homeostasis, they often present limitations and adverse effects. In o...
Correction: Lactobacillus acidophilus extracellular vesiclescoated UiO-66-NH2@siRNA nanoparticles for ulcerative colitis targeted gene therapy and gut microbiota modulation [0.03%]
订正：乳酸菌酸杆菌胞外囊泡包被的UiO-66-NH2@siRNA纳米颗粒用于溃疡性结肠炎靶向基因治疗和肠道微生态调节
Chenyang Cui,Jiaze Tang,Jie Chen et al.
Chenyang Cui et al.
Published Erratum
Journal of nanobiotechnology. 2025 May 13;23(1):341. DOI:10.1186/s12951-025-03413-y 2025
Comprehensive wound healing using ETN@Fe7S8 complex by positively regulating multiple programmed phases [0.03%]
基于ETN@Fe7S8复合材料积极调控伤口愈合多阶段的综合促愈策略
Mengxia Chen,Ting Liu,Xiaonan Wang et al.
Mengxia Chen et al.
Wound healing requires coordinated progression through multiple programmed phases including hemostasis, infection control, inflammatory resolution, proliferation, and tissue remodeling. Many nanomaterials have shown great potential to promo...
Sequentially assembled co-delivery nanoplatform of SIRT1 protein and SOX9-expressing plasmid for multipronged therapy of intervertebral disc degeneration [0.03%]
用于多管齐下治疗椎间盘退变的SIRT1蛋白和SOX9表达质粒共递送顺序组装纳米平台
Xiaoyu Zhang,Qianping Guo,Jiawei Fang et al.
Xiaoyu Zhang et al.
Nucleus pulposus cells (NPCs) undergo metabolic disorders and matrix pathological remodeling under the influence of various adverse factors during intervertebral disc degeneration (IVDD), whereas post-translational modifications (PTMs) can ...
Inhalable biomimetic polyunsaturated fatty acid-based nanoreactors for peroxynitrite-augmented ferroptosis potentiate radiotherapy in lung cancer [0.03%]
可吸入仿生多不饱和脂肪酸纳米反应器增强辐射治疗肺癌
Yiting Chen,Xueli Huang,Ruining Hu et al.
Yiting Chen et al.
The limited efficacy and poor tumor accumulation remain crucial challenges for radiotherapy against lung cancer. To address these limitations, we rationally developed a polyunsaturated fatty acid (PUFA)-based nanoreactor (DHA-N@M) camouflag...
Dual-responsive nanoparticles targeting ACE-II senescence for therapeutic mitigation of acute lung injury [0.03%]
靶向ACE-II衰老的双重响应型纳米颗粒用于急性肺损伤的治疗干预
Linlin Gao,Fushuang Zheng,Zhiling Fu et al.
Linlin Gao et al.
Acute lung injury (ALI) is a life-threatening condition characterized by severe pulmonary dysfunction, with alveolar type II epithelial cell (ACE-II) senescence playing a pivotal role in its progression. In this study, we developed pH/react...
Improving epilepsy management by targeting P2 × 7 receptor with ROS/electric responsive nanomicelles [0.03%]
基于ROS/电响应性纳米胶束的P2×7受体靶向策略在癫痫治疗中的应用研究
Zhaohong Kong,Jian Jiang,Min Deng et al.
Zhaohong Kong et al.
Background: The intricate pathogenesis of epilepsy, characterized by abnormal neuronal discharges and neuroinflammation, underscores the critical involvement of the adenosine triphosphate (ATP)-P2X purinoceptor 7 (P2 × 7...
Microneedle-aided nanotherapeutics delivery and nanosensor intervention in advanced tissue regeneration [0.03%]
用于组织工程的微针介导的纳米药物输送和纳米传感器干预研究
Churong Xu,Fei Wu,Zhouyi Duan et al.
Churong Xu et al.
Microneedles (MNs) have been extensively used as transdermal therapeutics delivery devices since 1998 due to their capacity to penetrate physiological barriers with minimal invasiveness. Recent advances demonstrate the potential of MNs in i...
Exosome-powered neuropharmaceutics: unlocking the blood-brain barrier for next-gen therapies [0.03%]
外泌体赋能神经药学：解锁下一代疗法的血脑屏障
Sepehr Mehdizadeh,Mobin Mamaghani,Somayyeh Hassanikia et al.
Sepehr Mehdizadeh et al.
Background: The blood-brain barrier (BBB) presents a formidable challenge in neuropharmacology, limiting the delivery of therapeutic agents to the brain. Exosomes, nature's nanocarriers, have emerged as a promising soluti...