Ferritin-armed extracellular vesicles with enhanced BBB penetration and tumor-targeting ability for synergistic therapy against glioblastoma [0.03%]
具有增强的血脑屏障渗透和肿瘤靶向能力并装载铁蛋白的细胞外囊泡对胶质母细胞瘤协同治疗
Guihong Lu,Peiling Zhuang,Feng Li et al.
Guihong Lu et al.
Glioblastoma multiforme (GBM) is an aggressive brain cancer with a high mortality rate and limited treatment options. Metabolism-based synergistic therapy holds promise for GBM treatment, however, its efficacy is significantly impeded by po...
The potential of plant-derived vesicles in treating periodontitis and associated systemic diseases: current advances and future directions [0.03%]
植物衍生囊泡治疗牙周病及其相关系统性疾病的应用潜力：当前进展与未来方向
Zongshuai Liu,Yonglin Guo,Yifei Deng et al.
Zongshuai Liu et al.
Background: Periodontitis, a chronic multifactorial inflammatory disease, represents a significant public health burden among global chronic non-communicable diseases. In addition to affecting oral health, periodontitis i...
A multifunctional biomimetic nanoplatform combined with immune checkpoint blockade for triple-negative breast cancer immunotherapy through inhibiting polarization of M2 macrophages [0.03%]
一种多功能仿生纳米平台联合免疫检查点阻断疗法通过抑制M2型巨噬细胞极化用于三阴性乳腺癌免疫治疗
Qianqian Zhou,Zongfang Jia,Yang Mu et al.
Qianqian Zhou et al.
Immune checkpoint inhibitor (ICI) therapy has become a hopeful treatment for triple-negative breast cancer (TNBC). However, most patients exhibit a low immune response. Tumor-associated fibroblasts (TAFs) suppress anti-tumor immune response...
Two-dimensional nanomaterials for bone disease therapy: multifunctional platforms for regeneration, anti-infection and tumor ablation [0.03%]
二维纳米材料在骨病治疗中的应用：多功能平台促进骨骼再生、抗菌和抗肿瘤
Xuejie Cai,Zehui Lv,Zhao Wang et al.
Xuejie Cai et al.
Bone diseases, encompassing defects, infections, necrosis, osteoarthritis and tumors, present persistent clinical challenges, often unmet by conventional therapies due to limited efficacy and biocompatibility. Two-dimensional (2D) nanomater...
From bench to bedside: nanomedicine development for intracerebral hemorrhage - exploring microenvironment, innovation, and translation [0.03%]
从基础到临床：针对脑出血的纳米医学开发——探索微环境、创新和转化
Gui Wan,Lingui Gu,Yangyang Chen et al.
Gui Wan et al.
Intracerebral hemorrhage (ICH) carries a substantial global disease burden, and although it occurs less frequently than ischemic stroke, it results in a greater loss of disability-adjusted life years worldwide and is associated with one of ...
Shunxiang Gao,Dongling Guo,Peirong Huang et al.
Shunxiang Gao et al.
Accurate, sensitive, and specific detection of molecular markers in intraocular fluid will facilitate the early discovery, diagnosis, and intervention of eye diseases. In this study, a total of 168 participants were recruited and divided in...
Radiocleavable rare-earth nanoactivators targeting over-expressed folate receptors induce mitochondrial dysfunction and remodel immune suppressive microenvironment in pancreatic cancer [0.03%]
可放射性切割的稀土纳米活化剂靶向过表达的叶酸受体诱导胰腺癌线粒体功能障碍和重塑免疫抑制微环境
Tanvi Gupta,Shang-Rung Wu,Li-Chan Chang et al.
Tanvi Gupta et al.
Pancreatic cancer is a fatal cancer with poor prognosis and survival rate, often diagnosed usually in the advanced stage of disease. The conventional methods are usually considered for surgery or chemotherapy, and neo-adjuvant therapies hav...
3D cell-laden scaffold printed with brain acellular matrix bioink [0.03%]
一种含有脑无细胞基质生物墨水的负载细胞支架的3D打印技术
Aobo Zhang,Siyu Zhu,Boyu Sun et al.
Aobo Zhang et al.
Gut microbiota contributes to polystyrene nanoplastics-induced fetal growth restriction by disturbing placental nicotinamide metabolism [0.03%]
肠道微生物群通过干扰胎盘烟酸代谢参与聚苯乙烯纳米塑料诱导的胎儿生长受限
Yijing He,Qiao Li,Qinfeng Sun et al.
Yijing He et al.
Polystyrene nanoplastics (PS-NPs) are ubiquitous in the environment, eliciting significant concerns about their possible risks to human health, especially reproductive health. Various reproductive toxicities of PS-NPs have been reported, ho...
Exploring the bioactivity of MicroRNAs Originated from Plant-derived Exosome-like Nanoparticles (PELNs): current perspectives [0.03%]
植物衍生类似外泌体纳米颗粒中微小RNA生物活性的研究进展及展望
Kingsley Miyanda Tembo,Xiaohui Wang,Mansoor Bolideei et al.
Kingsley Miyanda Tembo et al.
Exosomes, nano-sized extracellular vesicles, facilitate intercellular communication by transferring biomolecules such as microRNAs (miRNAs), which are key regulators of gene expression. While mammalian-derived exosomes (MDEs) have shown the...