A spreadable self-gelling hemostatic powder sensitizes CAR-NK cell therapy to prevent hepatocellular carcinoma recurrence postresection [0.03%]
一种可涂布的自凝止血粉可使CAR-NK细胞治疗敏化以预防肝切除术后肝细胞癌复发
Yusheng Cheng,Yihang Gong,Xin Li et al.
Yusheng Cheng et al.
Adoptive natural killer cell therapy (ANKCT) harbors great potential for combating postsurgical hepatocellular carcinoma (HCC) recurrence, but its efficacy is limited by tumor microenvironment (TME)-meditated repression on NK cell function ...
NIR-responsive Cu2 - xSe@Fc nanoparticles for photothermal- ferroptosis combination therapy in esophageal cancer [0.03%]
用于食道癌光热铁死亡联合治疗的近红外响应Cu2-xSe@Fc纳米粒子
Linlin Shi,Ying Yu,Jiayi Li et al.
Linlin Shi et al.
Esophageal cancer (EC) represents a highly recurrent and aggressive malignancy within the digestive system. However, conventional therapeutic strategies exhibit notable limitations in their clinical applications. Photothermal therapy (PTT),...
Advances in microneedle-based drug delivery system for metabolic diseases: structural considerations, design strategies, and future perspectives [0.03%]
用于代谢性疾病微针给药系统的最新进展：结构考虑、设计策略和未来展望
Yao Li,Qiu Chen,Tingting Wang et al.
Yao Li et al.
As the prevalence of metabolic diseases such as diabetes and obesity continue to rise, the search for more effective and convenient treatments has become a crucial issue in medical research. Microneedles (MNs), as an innovative drug deliver...
Dual-source powered sea urchin-like nanomotors for intravesical photothermal therapy of bladder cancer [0.03%]
用于膀胱癌体内光热治疗的双源驱动海胆状纳米马达
Yixuan Mou,Zhenghong Liu,Wentao Xu et al.
Yixuan Mou et al.
Bladder cancer (BCa) ranks as the 9th most prevalent malignancy worldwide, featured by its high risk of recurrence. Intravesical therapy constitutes the most important modality to tackle BCa, but its efficiency is often compromised due to t...
M2-ApoBDs as a therapeutic strategy for systemic lupus erythematosus: targeted macrophage reprogramming and treg differentiation [0.03%]
M2-ApoBDs治疗系统性红斑狼疮的策略：靶向巨噬细胞重编程及诱导Tregs分化
Juan Ji,Shaoying Yang,Yongxin Xu et al.
Juan Ji et al.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that affects various organs and systems, significantly impacting patients' health and quality of life. Conventional drugs, including glucocorticoids and standard immunosupp...
Oxygen vacancy-engineered bimetallic nanozymes for disrupting electron transport chain and synergistic multi-enzyme activity to reverse oxaliplatin resistance in colorectal cancer [0.03%]
用于破坏电子传递链并协同多种酶活性以逆转结直肠癌顺铂耐药的氧空位工程双金属纳米酶
Dong Zhong,Xiaoxin Yang,Jinhui Yang et al.
Dong Zhong et al.
In colorectal cancer treatment, chemotherapeutic agents induce reactive oxygen species (ROS) production, which promotes NAD+ accumulation in tumor cells, reducing treatment sensitivity and worsening patient prognosis. Targeted depletion of ...
Engineered bone-targeting apoptotic vesicles as a minimally invasive nanotherapy for heterotopic ossification [0.03%]
工程化骨靶向凋亡小体作为异位骨化的微创纳米疗法
Like Tang,Yuchen Wang,Shihua Mao et al.
Like Tang et al.
Heterotopic Ossification (HO), refers to pathological extra skeletal bone formation, and there are currently no reliable methods except surgery to reverse these unexpected calcified tissues. Apoptotic vesicles (ApoEVs) are membrane-bound ve...
A novel tri-mode detection platform for ampicillin and drug resistance genes by CRISPR-driven luminescent nanozymes [0.03%]
一种新型三模式检测平台：通过CRISPR驱动的发光纳米酶检测氨苄西林和耐药基因
Tao Zhang,Guiling Liu,Siwei Sun et al.
Tao Zhang et al.
The antibiotic residues pose significant risks for bacterial resistance. To address the practical requirements for rapid, accurate, and on-site detection of antibiotic residues and monitoring the abundance of associated resistance genes, we...
Synphilin-1 regulates mechanotransduction in rigidity sensing through interaction with zyxin [0.03%]
Synphilin-1通过与Zyxin的互作调节刚度感应中的机械转导
Seok Gi Kim,Jinyan Li,Ji Su Hwang et al.
Seok Gi Kim et al.
Background: Synphilin-1 has been studied extensively in the context of Parkinson's disease pathology. However, the biophysical functions of synphilin-1 remain unexplored. To investigate its novel functionalities herein, c...
PEGylated gas vesicles: a promising novel ultrasound contrast agent for diagnosis and guiding radiofrequency ablation of liver tumor [0.03%]
聚乙二醇化气体囊泡：一种颇具潜力的新型超声诊断和射频消融肝肿瘤造影剂
Kezhi Yu,Yongquan Huang,Yuanyuan Wang et al.
Kezhi Yu et al.
Ultrasound contrast agents (UCAs) play an important role in diagnosis and the imaging-guided treatment of liver tumor in clinical settings. However, most commercially available UCAs are micro-sized and fabricated through a chemical synthesi...