PIEZO2 is the underlying mediator for precise magnetic stimulation of PVN to improve autism-like behavior in mice [0.03%]
PIEZO2是精准磁刺激PVN改善小鼠自闭症样行为的介导因子
Sha Liu,Xuan Liu,Yefan Duan et al.
Sha Liu et al.
The precision magnetic stimulation system (pMSS), mediated by superparamagnetic iron oxide nanoparticles (SPIONs), can modulate endogenous oxytocin secretion by targeting the paraventricular nucleus (PVN) and improve autistic-like behavior ...
Quercetin nanoformulation-embedded hydrogel inhibits osteopontin mediated ferroptosis for intervertebral disc degeneration alleviation [0.03%]
载有檞皮素纳米制剂的水凝胶通过抑制骨桥蛋白介导的铁死亡缓解椎间盘退变
Jitian Li,Lemeng Ren,Lei Wan et al.
Jitian Li et al.
Reactive oxygen species (ROS) play a pivotal role in multiple events during the progression of intervertebral disc degeneration (IDD). Hence, the precision treatment targets associated with ROS should be further explored to promote developi...
Recent advances of engineering cell membranes for nanomedicine delivery across the blood-brain barrier [0.03%]
近年基于细胞膜的脑靶向纳米药物载体研究进展
Shengnan Yuan,Dehong Hu,Duyang Gao et al.
Shengnan Yuan et al.
The blood-brain barrier (BBB) poses a major challenge to the effective delivery of therapeutic agents for the treatment of central nervous system (CNS) disorders. The integration of cell membrane engineering with nanotechnology has recently...
Synergizing sono-piezo with exosome suppression using doping-engineered hydroxyapatite for potentiated tumor treatment through immunoactivation [0.03%]
利用掺杂工程羟基磷灰石协同超声压电和外泌体抑制以免疫活化增强肿瘤治疗
Xinran Qu,Qin Fan,Yingying Liu et al.
Xinran Qu et al.
Piezoelectric nanomaterials that generate reactive oxygen species (ROS) through piezoelectric polarization under mechanical stimulation have emerged as a promising cancer therapy platform. However, their potential is limited by poor piezore...
Macrophage-mimetic liposomes co-delivering ceria and Ac2-26 peptide for penumbra protection in ischemic stroke [0.03%]
仿巨噬细胞脂质体负载二氧化铈和Ac2-26肽用于脑卒中半暗带保护
Lingyun Bai,Na Li,Huiqin Li et al.
Lingyun Bai et al.
Ischemic stroke is one of the most severe central nervous system disease with high disability and mortality rates worldwide. Effective treatment requires strategies that address the multifaceted pathophysiology of ischemic penumbra, includi...
LUPP-LAMP: one-pot multiplatform universal LAMP assay for simultaneous detection and genotyping of DENV and ZIKV [0.03%]
LUPP-LAMP：一种针对DENV和ZIKV同时进行检测与基因型分析的单管多平台通用环介导等温扩增法
Zhang Zhang,Luhao Guan,Yue Zhang et al.
Zhang Zhang et al.
Dengue virus (DENV) and Zika virus (ZIKV) are mosquito-borne viruses that cause severe health problems upon infection, necessitating timely and accurate diagnostic testing for effective prevention and control of their transmission. In this ...
Natural fish swim bladder-derived MPN-nanofibrous biomimetic system exhibit ECM-responsive signal regulation and promote robust tendon-bone healing [0.03%]
天然鱼 swim膀胱衍生的MPN纳米纤维仿生系统表现出ECM反应性信号调节并促进强大的肌腱骨骼愈合
Lei Shi,Peng Zhou,Cong Ye et al.
Lei Shi et al.
Enhanced tendon‒bone healing is of critically importance for achieving optimal postoperative recovery following a rotator cuff tendon tear (rotator cuff tears, RCTs). Although RCTs patch-augmented scaffolds demonstrate clinical potential, ...
SIRT5-modified human umbilical cord mesenchymal stem cells loaded with antioxidant polydopamine nanozyme enhance parpi resistance in ovarian cancer via fatty acid metabolism reprogramming [0.03%]
抗氧化型多巴胺纳米酶负载的SIRT5修饰人脐带间充质干细胞通过脂肪酸代谢重编程增强卵巢癌细胞对PARPi的抵抗性
Jin Zhang,Xiuluan Du,Xin Dai et al.
Jin Zhang et al.
Ovarian cancer remains one of the most aggressive cancers, and resistance to Poly (ADP-ribose) Polymerase inhibitors (PARPi) poses a major therapeutic challenge. SIRT5, a NAD + -dependent desuccinylase, plays a crucial role in regulating fa...
Liposome-encapsulated AICAR hydrogel regulates macrophage metabolic reprogramming via SIK1 activation to alleviate osteoarthritis [0.03%]
脂质体封装的AICA核糖核苷酸水凝胶通过SIK1激活调节巨噬细胞代谢重编程以缓解骨关节炎
Yong Fu,Jiahui Hou,Qinmeng Yang et al.
Yong Fu et al.
Background: Osteoarthritis (OA), the most prevalent joint disorder, is characterized by a complex etiology and a lack of safe and effective therapeutic interventions. Emerging evidence suggests that immune cell dysregulat...
Starlike Au nanoparticle unleashing siDDIT3 and photothermal power to combat ferroptosis - driven osteoarthritis [0.03%]
星星状Au纳米粒子释放siDDIT3和光热效应对抗铁死亡驱动的骨关节炎
Chenfeng Wang,Shiyuan Hua,Ting Feng et al.
Chenfeng Wang et al.
Osteoarthritis (OA), the most common degenerative joint disease globally, has garnered increasing attention, and emerging evidence implicated ferroptosis played an important role in both its onset and progression. In this study, we identify...