Efficient delivery of small RNAs to podocytes in vitro by direct exosome transfection [0.03%]
通过直接外泌体转染高效地将小RNA递送至体外足细胞
Tim Lange,Luzia Maron,Claudia Weber et al.
Tim Lange et al.
Background: Podocytes are a crucial component of the glomerular filtration barrier, and changes in their 3D structure contribute to over 80% of chronic kidney disease (CKD) cases. Exosomal small RNAs play a key role in ce...
Catalase-encapsulated matrix metalloproteinase-9 responsive nanogels for modulation of inflammatory response and treatment of neutrophilic asthma [0.03%]
包封过氧化氢酶的基质金属蛋白酶9响应型纳米凝胶用于调节炎症反应和治疗中性粒细胞哮喘
Xiaoping Guo,Xu Zuo,Wenxue Zheng et al.
Xiaoping Guo et al.
Asthma is a chronic disease with typical pathological features such as airflow limitation, airway inflammation and remodeling. Of these, neutrophilic asthma is considered to be the more severe and corticosteroid-resistant subtype of asthma....
Amelioration of the rheumatoid arthritis microenvironment using celastrol-loaded silver-modified ceria nanoparticles for enhanced treatment [0.03%]
用于改善类风湿关节炎微环境的Celastrol负载银修饰氧化铈纳米颗粒的制备及其增强治疗效果研究
Xiaoru Zhang,Xiaguo Fu,Wanying Chen et al.
Xiaoru Zhang et al.
Rheumatoid arthritis (RA) is characterized by elevated levels of reactive oxygen species (ROS) and a persistent inflammatory microenvironment dominated by M1 macrophages, both of which contribute to disease progression. To address these pat...
Layered double hydroxides for regenerative nanomedicine and tissue engineering: recent advances and future perspectives [0.03%]
用于再生纳米医学和组织工程的层状双氢氧化物：近期进展与未来前景
Junsi Luo,Yiteng Cui,Laijun Xu et al.
Junsi Luo et al.
With the rapid development of nanotechnology, layered double hydroxides (LDHs) have attracted considerable attention in the biomedical field due to their highly tunable composition and structure, superior biocompatibility, multifunctional b...
Photo-controlled co-delivery of verteporfin and acriflavine via platelets achieves potentiated glioblastoma-targeted photodynamic therapy [0.03%]
基于血小板的光控协同递送 verteporfin 和 acriflavine 实现肿瘤强化光动力治疗
Jie Guo,Meng-Fei Wang,Shen-Jun Yuan et al.
Jie Guo et al.
The potential of glioblastoma (GBM) photodynamic therapy (PDT) is limited by inadequate GBM drug delivery, and the development of resistance to PDT as a result of cellular damage response that critically involves the hypoxia-inducible facto...
Co-encapsulation of norcantharidin prodrugs and lomitapide in nanoparticles to regulate CCL4 expression by inhibiting Wnt/β-catenin pathway for improved anti-tumor immunotherapy [0.03%]
norcantharidin前药与lomitapide共载于纳米粒中通过抑制Wnt/β-catenin通路调控CCL4表达以增强抗肿瘤免疫治疗
Feng Zhao,Liming Gong,Ping Wang et al.
Feng Zhao et al.
In the absence of tumor antigen specificity, direct chemokine administration carries the risk of significant "on-target, off-tumor" toxicities, highlighting the need for small-molecule approaches with reduced immunogenicity. This study inve...
Correction: Hypoxia-responsive core-cross-linked supramolecular nanoprodrug based on dendritic drug-drug conjugates for synergetic anticancer therapy [0.03%]
纠正：基于树枝状药物-药物共轭物的缺氧响应型超分子纳米前药用于协同抗肿瘤治疗
Yue Ding,Yu Xie,Liangshun Zheng et al.
Yue Ding et al.
Published Erratum
Journal of nanobiotechnology. 2025 May 21;23(1):368. DOI:10.1186/s12951-025-03462-3 2025
A dual-targeting bio-liposomes nanodrug repair endothelial cell dysfunction and restore macrophage cholesterol flow homeostasis to treat early atherosclerosis [0.03%]
双重靶向生物脂质体纳米药物修复内皮细胞功能障碍并恢复巨噬细胞胆固醇流动稳态以治疗动脉粥样硬化早期病变
Qi Zhang,Shengchao Ma,Xue Kang et al.
Qi Zhang et al.
Hyperhomocysteinemia (HHy) can lead to vascular endothelial cell dysfunction, progressive inflammation and lipid metabolism disorder, which finally result in the onset and development of atherosclerosis, a major contributor to cardiovascula...
Multi-enzymatic biomimetic cerium-based MOFs mediated precision chemodynamic synergistic antibacteria and tissue repair for MRSA-infected wounds [0.03%]
用于耐甲氧西林金黄色葡萄球菌感染伤口的多酶仿生铈基MOF介导的精准化学动力学协同抗菌及组织修复研究
Shiqi Chen,Yifan Li,Qiang Ma et al.
Shiqi Chen et al.
Antibiotic-resistant pathogens represent a significant global public health challenge, particularly in refractory infections associated with biofilms. Urgent development of innovative, safe, and therapeutically adaptive strategies to combat...
Harnessing intracellular bacteria in bladder by intravesical delivery of antibiotics-loaded nanodiamonds to reduce the recurrence of urinary tract infection [0.03%]
负载抗生素的纳米金刚石用于膀胱给药以减少尿路感染的复发
Carmen Oi Kwan Law,Hoi Man Leung,Meijun Wang et al.
Carmen Oi Kwan Law et al.
Treating urinary tract infections (UTIs) effectively is a difficult task due to the emergence of antibiotic-resistant bacteria and limited antibiotic access to intracellular bacteria within the bladder lining. Numerous studies of the antibi...