Sparking angiogenesis by carbon monoxide-rich gold nanoparticles obtained by pulsed laser driven CO2 reduction reaction [0.03%]
一氧化碳富集的金纳米颗粒促进血管生成：飞秒激光脉冲引发二氧化碳还原反应制备该纳米粒子研究
Anastasia Chillà,Cecilia Anceschi,Francesca Scavone et al.
Anastasia Chillà et al.
Endothelial tissue regeneration is a major challenge in the context of vascular disorders and tissue repair. One of the most recent and promising therapies for endothelial tissue disorders is the administration of carbon monoxide (CO) by di...
Lithium-doped calcium silicate scaffolds-activated M2-polarized macrophage-derived miR-145-5p-riched extracellular vesicles to enhance osteoimmunomodulation for accelerating bone regeneration [0.03%]
锂掺杂的钙硅酸盐支架活化M2极化巨噬细胞来源的富含miR-145-5p的外泌体促进成骨免疫调节和骨再生
Ting-You Kuo,Tsung-Li Lin,Yen-Hong Lin et al.
Ting-You Kuo et al.
Bone healing is intricately associated with dynamic macrophage polarization. Modulating macrophages toward the M2 phenotype has emerged as a promising strategy in bone tissue engineering. Calcium silicate, known for its superior osteoconduc...
Injured renal cell membrane encapsulated ICG/CORM-401 for homologous targeted NIR theranostics of acute kidney injury [0.03%]
负载ICG/CORM-401的损伤肾细胞膜类囊体同源靶向诊断联合近红外光治疗急性肾损伤
Shijie Yao,Yinan Wang,Liqiang Shao et al.
Shijie Yao et al.
Acute kidney injury (AKI) is frequently attributed to the lack of effective early diagnosis and incorrect timing for treatment, resulting in a high incidence rate and mortality. Currently, there is no precise clinical treatment available fo...
Drug repurposing: isosorbide mononitrate enhances tumor accumulation to augment sonodynamic therapy for hepatocellular carcinoma [0.03%]
药物再利用：单硝酸异山梨酯增强肿瘤聚集以增强声动力疗法用于肝细胞癌治疗
Yu Peng,Zhe Li,Lei Zhou et al.
Yu Peng et al.
Hepatocellular carcinoma (HCC) remains a leading cause of cancer death worldwide. Sonodynamic therapy (SDT) offers a non-invasive, deep-penetrating approach by using ultrasound to activate sonosensitizers and generate cytotoxic reactive oxy...
Ultrasound-actuated platelet mimetic nanomotors enable targeted piezocatalytic ROS storm for precision thrombolysis [0.03%]
超声波驱动的血小板仿生纳米马达实现精准溶栓用定位型压电催化ROS风暴疗法
Ye Zhao,Jinchen He,Yuxi Liu et al.
Ye Zhao et al.
Thrombotic diseases pose life-threatening risks, yet current thrombolytic therapies face limitations including poor targeting and bleeding risks. To address this, ultrasound-activatable nanomotors (hBT-Pt@Pm) were developed through the inte...
Targeted neural stem cell-derived extracellular vesicles loaded with Sinomenine alleviate diabetic peripheral neuropathy via WNT5a/TRPV1 pathway modulation [0.03%]
延胡索酸恩夫韦肽负载靶向神经干细胞源性外泌体通过调节WNT5a/TRPV1信号通路改善糖尿病周围神经病变
Ji Chen,Lin Zhu,Yangyuxi Chen et al.
Ji Chen et al.
Background: Diabetic peripheral neuropathy (DPN) is one of the most prevalent and debilitating complications of diabetes, marked by chronic neuroinflammation, immune dysregulation, and progressive neuronal degeneration. C...
Nanoengineered hydrogels disrupt tumor antioxidant defense via photothermal-chemodynamic synergy and oxidative stress boosts [0.03%]
纳米工程水凝胶通过光热化学动力协同作用打破肿瘤抗氧化防御并增强氧化应激反应
Leiguang Ye,Yang Qiao,Peisan Wang et al.
Leiguang Ye et al.
By integrating photothermal and chemodynamic properties, Ru-based nanomaterials have emerged as promising agents for tumor therapy. However, their clinical translation is hindered by high systemic toxicity, suboptimal therapeutic efficacy, ...
Machine learning framework for investigating nano- and micro-scale particle diffusion in colonic mucus [0.03%]
机器学习框架在结肠粘液中纳米和微米级颗粒扩散的研究中的应用
Marco Tjakra,Kristína Lidayová,Christophe Avenel et al.
Marco Tjakra et al.
Biosimilar artificial mucus models that mimic native mucus facilitate efficient, lab-based drug diffusion studies, addressing the costly and challenging preclinical phase of drug development, especially for nano- and micro-scale particle-ba...
Ultrasound molecular imaging of M2 macrophages for early detection of chronic rejection in heart transplantation [0.03%]
超声分子影像检测M2型巨噬细胞在心脏移植后慢性排斥反应早期诊断中的应用研究
Jia Xu,Cheng Deng,Tang Gao et al.
Jia Xu et al.
Chronic rejection (CR) remains the leading cause of morbidity and mortality in heart transplantation survivors. The primary pathological features of CR encompass cardiac allograft vasculopathy and myocardial fibrosis. Currently, its diagnos...
Obesity enhances ovarian cancer chemotherapy efficacy through C1q-mediated tumor targeting and immune activation [0.03%]
C1q介导的肿瘤靶向和免疫激活增强肥胖促进卵巢癌化疗疗效
Shiyi Xu,Nana Bie,Xinzhuang Su et al.
Shiyi Xu et al.
Personalized protein corona significantly influences the biodistribution and therapeutic efficacy of nanomedicines, generating unique profiles that can impact treatment outcomes. Here, we demonstrate that pegylated liposomal doxorubicin (PL...