FNDC5/irisin-enriched sEVs conjugated with bone-targeting aptamer alleviate osteoporosis: a potential alternative to exercise [0.03%]
富含FNDC5/irisin的骨靶向适配体修饰的外泌体用于缓解骨质疏松症：运动疗法的潜在替代方案
Min-Zhi Mao,Ming-Hui Zheng,Bei Guo et al.
Min-Zhi Mao et al.
Exercise maintains bone health and produces protective effects on bone loss. In this study, we investigated the potential protective effects of circulating small extracellular vesicles (sEVs) generated under endurance exercise training (Exe...
Near-infrared organic nanoparticles (6BQ NPs) enhance the random flaps survival by modulating the HSP90/HIF-1α axis through mild photothermal therapy [0.03%]
近红外有机纳米粒子（6BQ NPs）通过轻微光热疗法调节HSP90 / HIF-1α轴以增强随机皮瓣的存活率
Feng Wu,Jin Zhang,Jiangtian Ye et al.
Feng Wu et al.
Random flaps are primarily employed in clinical practice for wound repair; however, the ischemic necrosis following surgery remains a significant challenge. To address this issue, we developed high-performance near-infrared (NIR) phototherm...
Extracellular vesicles derived from Schwann cells to enhance bone and dental tissue regeneration: a literature review [0.03%]
雪旺细胞源外泌体促进骨和牙组织再生：文献回顾研究
Xinyi Li,Minjia Zhu,Le Xiao et al.
Xinyi Li et al.
Background: Recently, the importance and innovative applications of extracellular vesicles in bone and dental pulp tissue engineering have attracted more attention. Moreover, the use of extracellular vesicles derived from...
Curcumin-based polymer prodrug nanoplatform for high-efficiency immunotherapy by synergistically suppression of head and neck cancer cell stemness [0.03%]
一种新型藤黄根提取物聚合物前药纳米平台协同抑制头颈癌细胞干性高效免疫治疗研究
Zhisen Shen,Hao Jiang,Shuaijun Lu et al.
Zhisen Shen et al.
Background: Immunotherapy represents a transformative advance in cancer treatment; however, its efficacy in head and neck cancer (HNC) remains constrained by tumor cell stemness and profound immunosuppression within the t...
USP5 inhibition via bone marrow-targeted engineered exosomes for myeloproliferative neoplasms therapy [0.03%]
针对骨髓靶向工程外体递送USP5抑制剂治疗骨髓增殖性肿瘤
Wenjun Wang,Yufeng Jiang,Donglei Zhang et al.
Wenjun Wang et al.
Myeloproliferative neoplasms (MPNs) are challenging to treat due to the complex bone marrow (BM) microenvironment and lack of curative therapies. Current treatments fail to eliminate malignant clones and face issues like drug resistance. Th...
Differences in macrophage pyroptosis and polarization induced by nano-/micro-calcium oxalate crystals [0.03%]
纳米/微米草酸钙晶体诱导的巨噬细胞焦亡和极化差异
Xin-Yi Tong,Wei-Jian Nong,Run-Min Tan et al.
Xin-Yi Tong et al.
Objective: This study aimed to compare the differences in pyroptosis and polarization of macrophages induced by different sizes of calcium oxalate monohydrate (COM) crystals and discuss the mechanism of kidney stone forma...
Revolutionizing brain‒computer interfaces: overcoming biocompatibility challenges in implantable neural interfaces [0.03%]
变革脑机接口：植入式神经接口的生物相容性挑战及突破
Weihang Gao,Zineng Yan,Hong Zhou et al.
Weihang Gao et al.
Brain‒computer interfaces (BCIs) exhibit significant potential for various applications, including neurofeedback training, neurological injury management, and language, sensory and motor rehabilitation. Neural interfacing electrodes are po...
A GSH-consuming polymeric nanoparticles drives ferroptosis amplification and combines chemotherapy to amplify breast cancer treatment [0.03%]
一种消耗GSH的聚合物纳米粒子可驱动铁死亡放大并联合化疗增强乳腺癌治疗
Mingliang Pei,Xin Guan,Xiaodong Hou et al.
Mingliang Pei et al.
Currently, given variations in the abnormal tumor microenvironment (TME), significant progress has been made in the treatment of breast cancer (BC) based on TME-responsive nanosystems-mediated ferroptosis. Due to inherent deficiencies such ...
Mitochondrial homeostasis restoring peptide-drug conjugates with ROS-responsive NO releasing ability for targeted therapy of myocardial infarction [0.03%]
具有ROS响应性NO释放能力的线粒体稳态恢复肽-药物共轭物用于靶向治疗心肌梗死
Zhaoyang Lu,Quanyou Chai,Wenbin Dai et al.
Zhaoyang Lu et al.
Myocardial infarction (MI) is the leading cause of death worldwide. Exogenous delivery of nitric oxide (NO) shows great potential in MI treatment. However, the burst generation of reactive oxygen species (ROS) in ischemic microenvironment o...
Self-assembled transdermal nanogels control scar formation by inhibiting fibroblast proliferation and fibrosis with glycolysis regulation via the PI3K/Akt/mTOR pathway [0.03%]
自组装纳米凝胶通过调节糖酵解来抑制成纤维细胞增殖和纤维化从而控制疤痕形成（PI3K/AKT/mTOR通路）
Xinxian Meng,Zhixi Yu,Shiqi Wu et al.
Xinxian Meng et al.
Hypertrophic scar (HS) is one of the most common challenges in the field of plastic and reconstructive surgery. HS formation is associated with the abnormal activation of fibroblasts. These fibroblasts exhibit excessive proliferative and fi...