Chinese leek-derived extracellular vesicles ameliorate sarcopenia by regulating mitochondrial biogenesis and autophagy via AMPK and maintaining myosin homeostasis [0.03%]
通过AMPK调节线粒体生物合成和自噬并维持肌球蛋白稳态以缓解肌肉减少症：来自中国韭菜的外泌体的作用
Weihui Qi,Libin Yang,Yanli Pan et al.
Weihui Qi et al.
Sarcopenia, a prevalent age-related degenerative disorder, poses significant challenges in geriatric care. Chinese leek demonstrates therapeutic potential against sarcopenia progression, with emerging evidence suggesting its extracellular v...
Inhalable targeted CD8 + T cell nanoparticles loaded ferroptosis inhibitor ferrostatin-1 alleviate acute lung injury [0.03%]
可吸入靶向CD8+T细胞纳米颗粒装载铁死亡抑制剂Fer-1缓解急性肺损伤
Chunhua Ma,Zhaocong Yang,Jing Wang et al.
Chunhua Ma et al.
Acute lung injury (ALI) is a common clinical complication of sepsis and ferroptosis plays an important role in ALI. The aim of this study was to evaluate the effects of CD8 antibodies modified PD-1 engineered CD8+ T lymphocytes (CTL) membra...
Targeting cancer stem-like cells via cholesterol modulation and ferroptosis induction using a multifunctional nanoplatform to overcome drug resistance [0.03%]
基于胆固醇调控和铁死亡诱导的多功能纳米平台靶向癌症干细胞样细胞以克服耐药性研究
Leiguang Ye,Jinying Zhu,Xiaoman Wang et al.
Leiguang Ye et al.
Overcoming therapy resistance in triple-negative breast cancer (TNBC) requires the effective targeting of cancer stem-like cells (CSCs). TNBC is characterized by hyperactivation of the mevalonate pathway, leading to cholesterol accumulation...
Engineered self-assembling hydrogel systems for advanced guided bone regeneration: structural optimization and biofunctional modulation [0.03%]
结构优化和生物功能调控的组织工程引导骨再生自组装水凝胶支架材料研究
Yu Wang,Wei Geng,Yuqing Yang et al.
Yu Wang et al.
Self-assembling hydrogels have emerged as a promising class of biomaterials for bone regeneration due to their highly tunable properties, stimulus responsiveness, and excellent biocompatibility. While current research predominantly focuses ...
An inflammation-responsive therapeutic gel for precise microbiota modulation in colitis [0.03%]
一种用于精确调节结肠炎微生物群的炎症响应性治疗凝胶
Yanchen Liu,Yang Liu,Wenpeng Huang et al.
Yanchen Liu et al.
Microbiome dysbiosis is a hallmark of inflammatory bowel disease (IBD), and its reprogramming represents a promising intervention strategy. Existing treatments are often limited by gastrointestinal instability and non-specific microbial tox...
Pre-activation of T cell immunity potentiates ferroptotic cell death through arachidonic acid hybridized nanovesicles [0.03%]
T细胞免疫的预活化通过花生四烯酸杂化的纳米囊泡促进铁死亡程序性细胞死亡
Qi Lyu,Chang Liu,Shaoyue Li et al.
Qi Lyu et al.
Ferroptotic tumor therapy is of highly significance to treat malignancies. Nevertheless, immune cells within the tumor immune microenvironment (TIME) are particularly susceptible to ferroptosis upon exposure to ferroptotic inducers, leading...
AMFR-mediated ER-phagy regulation and therapeutic targeting in osteosarcoma: a multifunctional nanoplatform strategy [0.03%]
介导软骨细胞内质网自噬调节及在骨肉瘤中进行治疗靶向的AMFR：多功能纳米平台策略
Qirui Zhao,Xiaoqing Lu,Tongtong Xu et al.
Qirui Zhao et al.
This work explores how Autocrine Motility Factor Receptor (AMFR)-driven ubiquitination of Family with Sequence Similarity 134 Member B (FAM134B) in hypoxia adaptation and endoplasmic reticulum-selective autophagy (ER-phagy) in osteosarcoma ...
Single-atom Ca nanozyme induces glioma death through Ca2+-overload-enhanced catalytic tumor nanotherapy, ferroptosis and synergistic remodeling of the immune microenvironment [0.03%]
单原子钙纳米酶通过钙超载增强的催化肿瘤纳米疗法、铁死亡和协同重塑免疫微环境诱导胶质瘤细胞死亡
Zhizhong Jin,Xinqiao Li,Xiaoyu Hou et al.
Zhizhong Jin et al.
In recent years, nanozyme-based catalytic therapy for tumors has garnered extensive attention. They combine the properties of nanomaterials and enzymes, precisely mimicking the structure of natural enzymes and exhibiting highly efficient ca...
Retraction Note: Carbon dot nanozymes as free radicals scavengers for the management of hepatic ischemia-reperfusion injury by regulating the liver inflammatory network and inhibiting apoptosis [0.03%]
撤回 notice: 碳点纳米酶作为自由基清除剂通过调节肝脏炎性网络和抑制肝缺血再灌注损伤的凋亡来对其进行管理
Haoge Geng,Jiayu Chen,Kangsheng Tu et al.
Haoge Geng et al.
Reengineering glycyrrhetinic acid into a therapeutic oligomer for targeted tumor therapy with cardioprotection [0.03%]
甘草酸衍生治疗寡糖类化合物用于心脏保护的靶向肿瘤治疗研究
Zixin Wang,Bo Su,Alu Ouyang et al.
Zixin Wang et al.
To overcome the inherent limitations of conventional nanocarriers such as therapeutic inefficacy and suboptimal drug loading capacity, a novel "polymeric nanodrug" strategy was developed. This approach redefines nanodrug design by employing...