Pulmonary hazards of nanoplastic particles: a study using polystyrene in in vitro models of the alveolar and bronchial epithelium [0.03%]
纳米塑料颗粒的肺部危害：利用体外肺泡和气管上皮模型进行聚苯乙烯研究
Sara Michelini,Safaa Mawas,Ema Kurešepi et al.
Sara Michelini et al.
Background: Nanoplastics (NPs) are released into the environment through the degradation of plastic objects, leading to human exposure. Due to their small size, concerns have been raised about the potential hazards to the...
"Double-sided protector" Janus hydrogels for skin and mucosal wound repair: applications, mechanisms, and prospects [0.03%]
“双面保护” janus 水凝胶促进皮肤及黏膜创面修复：进展、机制与前景
Laijun Xu,Junyi Zhang,Junsi Luo et al.
Laijun Xu et al.
Skin and mucous membranes serve as crucial barrier tissues within the human body. Defective wound healing not only inflicts pain but also heightens the risk of infection and impairs immune function. Janus hydrogels possess two-sided distinc...
Advances in brain-targeted delivery strategies and natural product-mediated enhancement of blood-brain barrier permeability [0.03%]
脑靶向递送策略及天然产物介导的血脑屏障通透性增强的研究进展
Suyi Liu,Xingyue Jin,Yuanyuan Ge et al.
Suyi Liu et al.
The blood-brain barrier (BBB) represents a formidable challenge in the treatment of neurological disorders, as it restricts the passage of most therapeutic agents into the central nervous system (CNS). Research in brain-targeted delivery st...
Sequential nanoparticle therapy targeting neutrophil hyperactivation to prevent neutrophil-induced pulmonary fibrosis [0.03%]
靶向中性粒细胞过度活化以预防中性粒细胞诱导的肺纤维化的序贯纳米药物治疗
Hye-Jin Lee,Na Kyeong Lee,Jisun Kim et al.
Hye-Jin Lee et al.
Background: Pulmonary fibrosis, a major complication of severe COVID-19 and post-acute sequelae of SARS-CoV-2 infection (PASC), is driven by excessive neutrophil activation and the formation of neutrophil extracellular tr...
Multifunctional hydrogel with mild photothermal properties enhances diabetic wound repair by targeting MRSA energy metabolism [0.03%]
温和光热多功能水凝胶通过靶向MRSA代谢促进糖尿病伤口修复
Qian Gao,Fangfang Hu,Zihan Chai et al.
Qian Gao et al.
Background: Diabetic wound infections, exacerbated by multidrug-resistant pathogens like MRSA, remain a critical challenge due to biofilm persistence and dysregulated oxidative-inflammatory-metabolic crosstalk. ...
Oral administration of probiotic spores-based biohybrid system for efficient attenuation of Salmonella Typhimurium-induced colitis [0.03%]
一种基于芽孢菌的生物杂化系统高效缓解鼠伤寒沙门氏菌诱导结肠炎口服给药研究
Mengya Niu,Luo Zhao,Shuang Gong et al.
Mengya Niu et al.
Salmonella Typhimurium (S. Tm), a Gram-negative pathogenic bacterium, is one of the most common causes of invasive bacterial diseases. Antibiotic therapy remains the principal therapeutic modality for treating S. Tm infection. However, due ...
An orally-administered nanotherapeutics with gold nanospheres supplying for rheumatoid arthritis therapy by re-shaping gut microbial tryptophan metabolism [0.03%]
一种口服纳米药物通过重塑肠道微生物色氨酸代谢治疗类风湿关节炎
Chuan Yang,Langlang Xie,Zihan Deng et al.
Chuan Yang et al.
Dysbiosis of gut microbiota significantly exacerbates the progression of rheumatoid arthritis (RA). Targeting gut microbiota may present a promising therapeutic strategy for RA. Gold nanospheres (GNS), known for excellent biocompatibility, ...
Tumor microenvironment responsive Mn-based nanoplatform activate cGAS-STING pathway combined with metabolic interference for enhanced anti-tumor therapy [0.03%]
基于Mn的纳米平台激活cGAS-STING信号通路联合代谢干扰响应肿瘤微环境以增强抗肿瘤治疗
E Wen,Yu Tian,Yu Chen et al.
E Wen et al.
Despite the encouraging developments in tumor immunotherapy, the complex tumor microenvironment (TME) and abnormal energy metabolism persist as key factors facilitating immune escape. Recent research has emphasized the significant potential...
A lyophilizable LNP vaccine enables STING-reinforced postoperational adjuvant immunotherapy [0.03%]
一种可冻干的LNP疫苗能够强化术后佐剂免疫疗法并激活STING信号通路
Yi Yang,Jiaxin Guo,Jialong Qi et al.
Yi Yang et al.
Immune checkpoint blockade therapy (iCBT) has revolutionized cancer treatment, however, there is a low response rate, especially in treating postsurgical reoccurring tumors. Vaccine based immunotherapy can sensitize iCBT, but its developmen...
From bench to bedside: the research status and application opportunity of extracellular vesicles and their engineering strategies in the treatment of skin defects [0.03%]
从实验室到临床：外泌体及其工程化策略在皮肤缺损治疗中的研究现状及应用前景
Longwei Cui,Yantao Song,Zhipeng Hou et al.
Longwei Cui et al.
Engineered extracellular vesicles (EVs), which are EVs modified to enhance certain biological properties, offer a promising therapeutic strategy for the treatment of skin defects. Conventional nanomaterials often encounter clinical translat...