Circadian disruption and ROS-NLRP3 signaling mediate sleep deprivation-enhanced silica nanoparticle toxicity in lacrimal glands [0.03%]
昼夜节律紊乱和ROS-NLRP3信号介导的睡眠剥夺增强的纳米硅毒性对泪腺的影响
Wenxiao Zhang,Di Qi,Xiaoting Pei et al.
Wenxiao Zhang et al.
Sleep deprivation (SD) and exposure to engineered nanomaterials such as silica nanoparticles (SiNPs) are emerging risk factors for ocular surface disorders, particularly dry eye disease. However, the molecular mechanisms underlying their co...
Nanoscale metal-organic frameworks as a versatile platform for synergistic combination tumor therapy [0.03%]
纳米金属有机骨架在协同综合肿瘤治疗中的多功能平台作用研究
Mengru Cai,Yuqing Yang,Jiahui Kong et al.
Mengru Cai et al.
As the second most common cause of death globally, tumor significantly impacts human health and quality of life. Although monotherapy has achieved remarkable progress, its therapeutic effectiveness remains less than ideal. The current strat...
Polymerase-based DNA reactions for molecularly computing cancerous diagnostic valences of multiple miRNAs [0.03%]
基于聚合酶的DNA反应，用于计算多种miRNA癌症诊断值分子式
Yumin Yan,Hongyang Zhao,Lijie Xing et al.
Yumin Yan et al.
Conventional miRNA-based diagnostic methods often treat all biomarkers equally, overlooking the fact that each miRNA contributes differently to disease classification. This differential diagnostic importance is captured by the concept of Ca...
Dectin-1-targeted pH-responsive liposomal nanoplatform delivering Plantago Asiatica L. acidic polysaccharide for immunomodulation and immunosuppressive breast cancer microenvironment reprogramming [0.03%]
以酸性多糖为目标的针对Dectin-1的pH响应型脂质体纳米递药平台用于免疫调节和免疫抑制型乳腺癌微环境重编程
Wanbing Pan,Can Li,Xiaoyu Zhou et al.
Wanbing Pan et al.
Background: The limited tumor-specific delivery and insufficient dendritic cell (DC) activation remain critical challenges in cancer immunotherapy. This research aimed to improve antitumor efficacy by developing a novel p...
Defect-engineered amorphous-like nanointerceptors for T2 MRI-Guided treatment of reperfusion injury [0.03%]
用于再灌注损伤T2 MRI引导治疗的缺陷工程类无定形纳米拦截剂
Xiaotong Ma,Xin Liang,Yixin Yu et al.
Xiaotong Ma et al.
Ischemic reperfusion (I/R) injury is dominated by excessive reactive oxygen species (ROS)-mediated oxidative damage and uncontrolled inflammation, yet effective strategies for simultaneous diagnosis and treatment remain elusive. Herein, we ...
Lipid nanoparticles-mRNA based on the consensus sequences of avian coronavirus S1 and N genes protect animals against multiple viral infections [0.03%]
基于禽冠状病毒S1和N基因共识序列的脂质纳米颗粒-mRNA对多种病毒感染具有保护作用
Hongtao Xiao,Wanyan Wu,Siyao Yu et al.
Hongtao Xiao et al.
Lipid nanoparticles-mRNA play important roles in SARS-CoV-2 infection control. Avian coronavirus infectious bronchitis virus (IBV) comprises eight genotypes with a lack of cross-protection, causing severe economic losses to the poultry indu...
Engineered MSC-EVs loaded with BDNF-enhancing neuropeptides via a non-disruptive method enhance post-stroke neuroregeneration via intranasal delivery [0.03%]
通过非破坏性方法加载脑源性神经营养因子增强神经肽的工程化间充质干细胞外泌体经鼻递送促进卒中后神经再生
Ji-Eun Kim,Ye Eun Ji,Hyeon Jun Hwang et al.
Ji-Eun Kim et al.
Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) show potential as neuroregenerative therapies. Incorporating bioactive compounds such as neuropeptides that enhance brain-derived neurotrophic factor (BDNF) expression may ampli...
Correction: N-doped carbon dots for dual-modality NIR fluorescence imaging and photothermal therapy [0.03%]
N-掺杂碳点用于双模近红外荧光成像和光热治疗的订正公告
Hui-Xian Shi,Xuan Qu,Tong-Tong Zhao et al.
Hui-Xian Shi et al.
Published Erratum
Journal of nanobiotechnology. 2025 Aug 29;23(1):591. DOI:10.1186/s12951-025-03662-x 2025
The bone marrow mesenchymal stem cells derived migrasomes induced by Titania nanotubes surface serve as chemotaxis effect for osteogenesis [0.03%]
由二氧化钛纳米管表面诱导的骨髓间充质干细胞源迁移体作为成骨趋化效应
Guangwen Li,Yan Zhang,Haochen Wang et al.
Guangwen Li et al.
The regulatory role of migrasomes (Migs) has attracted growing attentions recently. However, most of the reports only focus on the influence of donor cells on Migs contents, regarding the substrate information. In the present study, the bon...
Genetically engineered Magnesium/Manganese nanoparticles for cancer radioimmunotherapy [0.03%]
基因工程镁/锰纳米颗粒用于癌症放射免疫治疗
Jicheng Wu,Yangtao Xu,Yunjing Zhang et al.
Jicheng Wu et al.
Radiotherapy (RT) has great potential on activating antitumor immunity for combination therapy, yet this effect is limited by immunosuppressive tumor microenvironment (TME) and the potential toxicity in immune cells from high-dose radiation...