Stepwise-targeting and hypoxia-responsive liposome AMVY@NPs carrying siYAP and verteporfin for glioblastoma therapy [0.03%]
用于胶质母细胞瘤治疗的siYAP和verteporfin负载型逐步靶向及缺氧响应型脂质体AMVY@NPs
Ji Qi,Long Zhang,Zhongyu Ren et al.
Ji Qi et al.
Background: The Hippo pathway is a conserved tumour suppressor signalling pathway, and its dysregulation is often associated with abnormal cell growth and tumorigenesis. We previously revealed that the transcriptional coa...
Targeted pathophysiological treatment of ischemic stroke using nanoparticle-based drug delivery system [0.03%]
基于纳米颗粒的药物递送系统在缺血性卒中病理生理治疗中的靶向作用
Wei Liu,Lubin Liu,Hong Li et al.
Wei Liu et al.
Ischemic stroke poses significant challenges in terms of mortality and disability rates globally. A key obstacle to the successful treatment of ischemic stroke lies in the limited efficacy of administering therapeutic agents. Leveraging the...
Ambient energy harvesters in wearable electronics: fundamentals, methodologies, and applications [0.03%]
能量收集在可穿戴电子产品中的应用：基础，方法和应用
Ruoyao Yu,Shaoqing Feng,Qingwen Sun et al.
Ruoyao Yu et al.
In recent years, wearable sensor devices with exceptional portability and the ability to continuously monitor physiological signals in real time have played increasingly prominent roles in the fields of disease diagnosis and health manageme...
A thermo-sensitive hydrogel with prominent hemostatic effect prevents tumor recurrence via anti-anoikis-resistance [0.03%]
一种具有显著止血效果的热敏水凝胶可通过抗 anoikis 耐受性预防肿瘤复发
Yang Liu,Lei Ding,Gaojie Chen et al.
Yang Liu et al.
Tumor cells can survive when detached from the extracellular matrix (ECM) or lose cell-cell connections, a phenomenon known as anoikis-resistance (AR). AR is closely associated with tumor cell metastasis and recurrence, enabling tumor cells...
Bio-inspired biorthogonal compartmental microparticles for tumor chemotherapy and photothermal therapy [0.03%]
一种用于肿瘤化疗和光热治疗的仿生双正交微粒及其制备方法
Qingfei Zhang,Gaizhen Kuang,Li Wang et al.
Qingfei Zhang et al.
Microcarrier is a promising drug delivery system demonstrating significant value in treating cancers. One of the main goals is to devise microcarriers with ingenious structures and functions to achieve better therapeutic efficacy in tumors....
Au-modified ceria nanozyme prevents and treats hypoxia-induced pulmonary hypertension with greatly improved enzymatic activity and safety [0.03%]
改良金颗粒的氧化铈纳米酶可改善缺氧性肺动脉高压病理与毒理学指标
Rui Xiao,Jia Liu,Lin Shi et al.
Rui Xiao et al.
Background: Despite recent advances the prognosis of pulmonary hypertension remains poor and warrants novel therapeutic options. Extensive studies, including ours, have revealed that hypoxia-induced pulmonary hypertension...
Advancing osteoarthritis therapy with GMOCS hydrogel-loaded BMSCs-exos [0.03%]
装载了间充质干细胞外泌体的基因编辑软骨细胞水凝胶的制备及评价其治疗骨关节炎的效果
Renyi Zhou,Jiarong Guo,Zhe Jin
Renyi Zhou
This study investigated the mechanism of the extracellular matrix-mimicking hydrogel-mediated TGFB1/Nrf2 signaling pathway in osteoarthritis using bone marrow mesenchymal stem cell-derived exosomes (BMSCs-Exos). A GMOCS-Exos hydrogel was sy...
Fusiform nanoparticle boosts efficient genetic transformation in Sclerotinia sclerotiorum [0.03%]
杆状纳米颗粒可促进Sclerotinia sclerotiorum高效的遗传转化
Yijuan Ding,Nan Yang,Yi Lu et al.
Yijuan Ding et al.
Background: Sclerotinia sclerotiorum is a highly destructive phytopathogenic fungus that poses a significant threat to a wide array of crops. The current constraints in genetic manipulation techniques impede a thorough co...
Oxygen vacancy-engineered cerium oxide mediated by copper-platinum exhibit enhanced SOD/CAT-mimicking activities to regulate the microenvironment for osteoarthritis therapy [0.03%]
铜-铂介导的氧空位工程制备氧化铈可增强类SOD/CAT活性以调节骨关节炎治疗微环境
Junxu Yang,Shihui Xiao,Jiejia Deng et al.
Junxu Yang et al.
Cerium oxide (CeO2) nanospheres have limited enzymatic activity that hinders further application in catalytic therapy, but they have an "oxidation switch" to enhance their catalytic activity by increasing oxygen vacancies. In this study, ac...
VMT/ACP/Dextran composite nanosheets against dental caries through promoting mineralization of dentin tubules, pH buffering, and antibacterial [0.03%]
丝素蛋白/VTC/右旋糖酐纳米复合材料抗龋机理研究
Yanting Xu,Juan Mou,Jiewen Dai
Yanting Xu
Dental caries is a worldwide public healthcare concern, and is closely related to the acidic environment that caused by bacterial decomposition of food. In this study, a two-step ion exchange liquid-phase stripping method was applied to str...