Short cell-penetration peptide conjugated bioreducible polymer enhances gene editing of CRISPR system [0.03%]
一种短细胞穿膜肽修饰的可还原聚合物用于增强CRISPR基因编辑系统效力
Xiaobo Wang,Chengyuan Cai,Weiqi Lv et al.
Xiaobo Wang et al.
CRISPR-based gene therapy offers precise targeting and specific editing of disease-related gene sequences, potentially yielding long-lasting treatment effects. However, efficient delivery remains a significant challenge for its widespread a...
Chondrocyte-targeted exosome-mediated delivery of Nrf2 alleviates cartilaginous endplate degeneration by modulating mitochondrial fission [0.03%]
靶向软骨细胞的外泌体递送Nrf2通过调节线粒体分裂缓解椎间盘髓核端板退变
Zhidi Lin,Guangyu Xu,Xiao Lu et al.
Zhidi Lin et al.
Background: Cartilaginous endplate (CEP) degeneration, which is an important contributor to intervertebral disc degeneration (IVDD), is characterized by chondrocyte death. Accumulating evidence has revealed that dynamin-r...
Enhancing intraneural revascularization following peripheral nerve injury through hypoxic Schwann-cell-derived exosomes: an insight into endothelial glycolysis [0.03%]
缺氧施万细胞来源的外泌体通过调节内皮糖酵解促进神经损伤后的神经血管再生
Jun Sun,Qiuhua Zeng,Zhimin Wu et al.
Jun Sun et al.
Background: Endothelial cell (EC)-driven intraneural revascularization (INRV) and Schwann cells-derived exosomes (SCs-Exos) both play crucial roles in peripheral nerve injury (PNI). However, the interplay between them rem...
Aβ42 and ROS dual-targeted multifunctional nanocomposite for combination therapy of Alzheimer's disease [0.03%]
用于阿尔茨海默病联合治疗的针对Aβ42和ROS的多功能纳米复合材料
Liding Zhang,Kai Cao,Jun Xie et al.
Liding Zhang et al.
Amyloid-β (Aβ) readily misfolds into neurotoxic aggregates, generating high levels of reactive oxygen species (ROS), leading to progressive oxidative damage and ultimately cell death. Therefore, simultaneous inhibition of Aβ aggregation ...
BCMA/CD47-directed universal CAR-T cells exhibit excellent antitumor activity in multiple myeloma [0.03%]
针对BCMA/CD47的通用CAR-T细胞在多发性骨髓瘤中表现出优异的抗肿瘤活性
Qizhong Lu,Hexian Li,Zhiguo Wu et al.
Qizhong Lu et al.
Background: BCMA-directed autologous chimeric antigen receptor T (CAR-T) cells have shown excellent clinical efficacy in relapsed or refractory multiple myeloma (RRMM), however, the current preparation process for autolog...
Recent advances in the application of gasotransmitters in spinal cord injury [0.03%]
脊髓损伤中气体信号分子的应用进展近期研究进展
Xiang Gao,Bingrong Jin,Xiaozhong Zhou et al.
Xiang Gao et al.
Spinal Cord Injury (SCI) is a condition characterized by complete or incomplete motor and sensory impairment, as well as dysfunction of the autonomic nervous system, caused by factors such as trauma, tumors, or inflammation. Current treatme...
Application and advances of biomimetic membrane materials in central nervous system disorders [0.03%]
仿生膜材料在中枢神经系统疾病中的应用及进展
Weiquan Liao,Zhichao Lu,Chenxing Wang et al.
Weiquan Liao et al.
Central nervous system (CNS) diseases encompass spinal cord injuries, brain tumors, neurodegenerative diseases, and ischemic strokes. Recently, there has been a growing global recognition of CNS disorders as a leading cause of disability an...
Mild hyperthermia enhanced synergistic uric acid degradation and multiple ROS elimination for an effective acute gout therapy [0.03%]
轻度发热增强尿酸协同降解和多种ROS消除以有效治疗急性痛风
Pei Zhao,Hua-Zhong Hu,Xiao-Tong Chen et al.
Pei Zhao et al.
Background: Acute gouty is caused by the excessive accumulation of Monosodium Urate (MSU) crystals within various parts of the body, which leads to a deterioration of the local microenvironment. This degradation is marked...
Gouqi-derived nanovesicles (GqDNVs) inhibited dexamethasone-induced muscle atrophy associating with AMPK/SIRT1/PGC1α signaling pathway [0.03%]
gouqi衍生的纳米囊泡（GqDNVs）通过AMPK/SIRT1/PGC1α信号通路抑制地塞米松诱导的肌肉萎缩
Xiaolei Zhou,Shiyin Xu,Zixuan Zhang et al.
Xiaolei Zhou et al.
With the increasing trend of global aging, sarcopenia has become a significant public health issue. Goji berry, also known as "Gou qi zi" in China, is a traditional Chinese herb that can enhance the structure and function of muscles and bon...
Multiarmed DNA jumper and metal-organic frameworks-functionalized paper-based bioplatform for small extracellular vesicle-derived miRNAs assay [0.03%]
基于多臂DNA跳跃技术和金属有机骨架功能化试纸条的外泌体微RNA检测生物芯片
Xiaopei Qiu,Huisi Yang,Man Shen et al.
Xiaopei Qiu et al.
Small extracellular vesicle-derived microRNAs (sEV-miRNAs) have emerged as promising noninvasive biomarkers for early cancer diagnosis. Herein, we developed a molecular probe based on three-dimensional (3D) multiarmed DNA tetrahedral jumper...