Atherosclerosis enhances the efficacy of liposome-encapsulated bromocriptine in reducing the incidence of prolactinemia in pituitary tumors [0.03%]
动脉粥样硬化增强脂质体溴隐亭治疗垂体瘤高催乳素血症的疗效
Zhe Zhang,Guangyu Jia,Qi Wang et al.
Zhe Zhang et al.
Intranasal drug delivery via nanocarriers has long been a research focus for enhancing drug concentration in the brain. However, the strategy of exploiting blood-brain barrier (BBB) alterations in atherosclerotic mouse models to enhance nan...
Carbon dots derived from Ligusticum Chuanxiong mitigate cardiac injury by disrupting the harmful oxidative stress-apoptosis cycle [0.03%]
川芎碳点通过破坏有害的氧化应激-凋亡循环来减轻心脏损伤
Yapeng Guo,Lei Yang,Li Yao et al.
Yapeng Guo et al.
Background: Myocardial ischemia-reperfusion injury (MIRI) represents a significant complication following myocardial infarction surgery, for which preventive strategies remain limited. The primary pathological characteris...
Interplay between material properties and cellular effects drives distinct pattern of interaction of graphene oxide with cancer and non-cancer cells [0.03%]
材料性质与细胞效应的相互作用决定了石墨烯氧化物与癌细胞和正常细胞相互作用的行为模式
Yingxian Chen,Vinicio Rosano,Neus Lozano et al.
Yingxian Chen et al.
Understanding how graphene oxide (GO) interacts with cells is crucial for its safe and efficient biomedical applications. Despite extensive research, a systematic investigation using a panel of cell lines, thoroughly characterized label-fre...
Myogenic nano-adjuvant for orthopedic-related sarcopenia via mitochondrial homeostasis modulation in macrophage-myosatellite metabolic crosstalk [0.03%]
线粒体稳态调控介导的巨噬细胞-肌卫星细胞代谢互作促进肌肉生长型纳米佐剂用于骨科相关肌肉减少症治疗研究
Xudong Zhang,Peng Zhang,Yunliang Zhu et al.
Xudong Zhang et al.
The decline in skeletal muscle mass and muscle strength linked to aging, also known as sarcopenia, is strongly associated with disability, traumatic injury, and metabolic disease in patients. Meanwhile, sarcopenia increases the risk of adve...
DNA binding effects of LDH nanozyme for aseptic osteolysis mitigation through STING pathway modulation [0.03%]
通过调节STING途径缓解无菌性骨溶解的LDH纳米酶的DNA结合效应
Zi Fu,Meng Zhang,Ying Huang et al.
Zi Fu et al.
Persistent and intense inflammation is recognized as the primary cause of wear-particle-induced aseptic osteolysis, which ultimately resulting in aseptic prosthesis loosening. Reducing inflammation plays a significant role in mitigating ost...
Extracellular vesicles from adipose-derived stromal/stem cells reprogram dendritic cells to alleviate rat TMJOA by transferring mitochondria [0.03%]
脂肪源间充质干细胞分泌的细胞外囊泡通过转移线粒体来重编程树突状细胞从而缓解大鼠TMJ骨关节炎
Ziyi Mei,Hanyue Li,Chuling Huang et al.
Ziyi Mei et al.
Temporomandibular joint osteoarthritis (TMJOA) urgently needs regenerative therapies due to the limited effects of traditional treatments. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) are considered a potent alternative fo...
Concurrent induction of pyroptosis and immunogenic cell death by capsaicin/graphene nanocomplex for enhanced breast cancer immunotherapy [0.03%]
辣椒素/石墨烯纳米复合物并发诱导焦亡和免疫细胞死亡用于增强乳腺癌免疫治疗
Silu Li,Xin Jin,Yumo Zhang et al.
Silu Li et al.
Inducing immunogenic cell death (ICD) has emerged as a promising strategy for targeting immunologically "cold" tumors. However, most current therapies focus on a single mechanism, limiting their efficacy. In this study, we propose a nano-en...
Nanoparticle-mediated SIRT1 inhibition suppresses M2 macrophage polarization and hepatocarcinogenesis in chronic hepatitis B [0.03%]
基于纳米颗粒的SIRT1抑制可下调乙肝肝炎相关肝癌中的M2型巨噬细胞极化作用
He Zhang,Feng Yuan,Nan Zhao et al.
He Zhang et al.
Hepatocellular carcinoma (HCC) is a major complication of chronic hepatitis B (CHB), with macrophage M2 polarization playing a critical role in shaping the tumor-promoting hepatic immune microenvironment. Sirtuin 1 (SIRT1) has been implicat...
Ligustrazine nano-drug delivery system ameliorates doxorubicin-mediated myocardial injury via piezo-type mechanosensitive ion channel component 1-prohibitin 2-mediated mitochondrial quality surveillance [0.03%]
川芎嗪纳米给药系统通过Piezo类机械敏感离子通道成分1- prohibitin 2介导的线粒体质量监控改善阿霉素诱导的心肌损伤
Junyan Wang,Haowen Zhuang,Chun Li et al.
Junyan Wang et al.
Background: Doxorubicin (DOX) demonstrates significant therapeutic and anticancer efficacy. Nevertheless, it demonstrates significant cardiotoxicity, resulting in permanent cardiac damage. Ligustrazine (LIG) is a bioactiv...
Pulmonary hazards of nanoplastic particles: a study using polystyrene in in vitro models of the alveolar and bronchial epithelium [0.03%]
纳米塑料颗粒的肺部危害：利用体外肺泡和气管上皮模型进行聚苯乙烯研究
Sara Michelini,Safaa Mawas,Ema Kurešepi et al.
Sara Michelini et al.
Background: Nanoplastics (NPs) are released into the environment through the degradation of plastic objects, leading to human exposure. Due to their small size, concerns have been raised about the potential hazards to the...