A high-affinity CEA-targeted nanobody for 68Ga PET imaging and 177Lu-based radioisotope therapy: preclinical and first-in-human evaluation [0.03%]
一种高亲和力的CEA靶向纳米抗体，用于68Ga-PET成像和177Lu放射性核素治疗：前期研究与首次人体试验评估
Liang Zhang,Ming Zhou,Chenxi Lu et al.
Liang Zhang et al.
Carcinoembryonic antigen (CEA) is a clinically validated biomarker and therapeutic target in colorectal and other epithelial malignancies, yet current antibody-based approaches are hindered by poor pharmacokinetics, limited tumor penetratio...
AI-guided design of a CXCR4-targeted core-shell nanocarrier for co-delivery of berberine/paclitaxel in cancer therapy [0.03%]
一种基于人工智能设计的针对CXCR4的核壳型纳米载体协同递送小檗碱/紫杉醇用于癌症治疗
Yeonwoo Jang,Amal Babu,Sahil Chahal et al.
Yeonwoo Jang et al.
An integrated three-step artificial-intelligence (AI) workflow was developed to accelerate the design of a CXCR4-targeted, dual-drug nanocarrier for colorectal cancer therapy. The workflow combined AI-based drug synergy prediction, peptide ...
Biological nanoparticles from Brucella abortusΔeipB∆perΔwadC elicit protective immunity against brucellosis [0.03%]
缺失eipB、per和wadC基因的布鲁氏菌生物纳米颗粒具有保护免疫性
Yike Huang,Hengtai Wang,Xiaowei Peng et al.
Yike Huang et al.
Brucellosis, caused by bacteria of the genus Brucella, is a globally prevalent zoonotic disease that poses serious risks to both animal and human health. Brucella abortus releases the biological nanoparticles (outer-membrane-vesicles, OMVs)...
Gut microbiome restoring biogenic ferritin mineral as an effective oral iron supplement for iron deficiency anemia [0.03%]
一种有效的口服补铁剂治疗缺铁性贫血的肠道微生物恢复生物铁蛋白矿物质
Yingchun Yang,Luqiu Yang,Rong Yang et al.
Yingchun Yang et al.
Traditional iron supplements for iron deficiency anemia (IDA) have several limitations, including suboptimal absorption, gastrointestinal discomfort, and concerns regarding long-term safety. In this study, we synthesized monodisperse 6-line...
Nanopore assay for fingerprinting DNA binding and quantifying real-time cleavage by catalytically active Cas9 enzyme [0.03%]
用于表征DNA结合并实时量化由催化活性Cas9酶介导的切割的纳米孔测定法
Punitkumar Nagpure,Sarangi Suresh,Divya Shet et al.
Punitkumar Nagpure et al.
Nanopore sensing, a high-resolution DNA sequencing technology, is rapidly expanding into novel and exciting directions of probing specific DNA-enzyme interactions. Although proven excellent for the detecting structural features of bare DNA,...
Recent advances in electric-stimulus assisted microneedle patches for skin disease treatment [0.03%]
用于皮肤疾病治疗的电刺激辅助微针贴片最新进展
Xiao-Nan Tao,Lin Yao,Xiujun Cheng et al.
Xiao-Nan Tao et al.
Due to the natural barrier of skin structure, traditional topical drug utilization for skin disease management has been severely constrained by low bioavailability. While current microneedle (MN)-based systems confront challenges related to...
Simple-synthesis VO₂ nanoparticles as robust nanozymes for synergistic antibacterial therapy and abscess repair [0.03%]
简单合成的VO₂纳米颗粒作为抗菌联合治疗和脓肿修复的稳健纳米酶
Weicong Fu,Tian Huang,Yi-Xin Wang et al.
Weicong Fu et al.
Multidrug resistant (MDR) bacterial infections, particularly those involving methicillin-resistant Staphylococcus aureus (MRSA), pose a grave threat to global population health, necessitating novel therapeutic approaches capable of circumve...
3D bioprinted microneedle patches loaded with gambogic acid-iron-doxorubicin nanozymes for postoperative glioma in situ therapy via ferroptosis synergistic chemosensitization [0.03%]
负载 gambogic 酸-铁-多柔比星纳米酶的 3D 生物打印微针贴片通过促进铁死亡协同化疗作用进行术后胶质瘤原位治疗
Menghui Liu,Yang Qiao,Sheng Cheng et al.
Menghui Liu et al.
Background: Postoperative chemotherapy is essential for glioma treatment but faces two major limitations: the blood-brain barrier (BBB) restricts drug delivery, and tumor chemoresistance reduces therapeutic efficacy. To c...
Surface-engineered hyaluronic acid-coated lyotropic liquid crystalline nanoparticles for CD44-targeting of 3-Acetyl-11-keto-β-boswellic acid in rheumatoid arthritis treatment [0.03%]
表面工程透明质酸涂覆的向列型液晶纳米颗粒，用于CD44靶向输送3-乙酰-11-酮-β-乳香酸治疗类风湿性关节炎
Sakshi Priya,Vagesh Verma,Aniruddha Roy et al.
Sakshi Priya et al.
Background: In the current era of the global increase in autoimmune and inflammatory disorders, predominantly rheumatoid arthritis (RA), there is mounting interest in developing advanced, safe, and patient-compliant treat...
Multifunctional nanoagonist enhances photodynamic therapy-driven in situ cancer vaccination by inhibiting tumor thrombosis [0.03%]
多功能纳米 agonist通过抑制肿瘤血栓促进光动力治疗驱动的原位癌症疫苗接种
Cheng Liu,Xinyu Wang,Mingzhi Wang et al.
Cheng Liu et al.
Converting autologous tumors into therapeutic cancer vaccines represents an attractive strategy for achieving personalized antitumor immunity. However, the antitumor immune response is significantly compromised by the tumor microenvironment...