Neutrophil membrane-encapsulated nanosonosensitizer with ultrasound-reinforced ferroptosis in Pseudomonas aeruginosa pneumonia [0.03%]
包裹纳米声敏剂的中性粒细胞膜封装囊泡超声激活铁死亡联合抗铜绿假单胞菌肺炎研究
Chunhong Du,Shuai Wang,Yijie Cheng et al.
Chunhong Du et al.
Pneumonia caused by Pseudomonas aeruginosa (P. aeruginosa) infection remains a formidable clinical challenge due to persistent biofilm formation and intrinsic antibiotic resistance, exacerbated by bacterial iron homeostasis that stabilizes ...
Injectable responsive hydrogel with synergistic antibacterial and anti-inflammatory properties for enhanced periodontitis treatment [0.03%]
一种用于增强牙周炎治疗的具有协同抗菌抗炎性能的可注射型响应水凝胶
Xinjie Li,Zhidong Zhang,Xin Yang et al.
Xinjie Li et al.
Periodontitis is a chronic inflammatory disease driven by dysbiotic microbial biofilms and localized reactive oxygen species (ROS) accumulation, with inflammation management made challenging by recurrent infections from residual pathogenic ...
Neutrophil membrane-camouflaged SiRNA nanoplatform targeting IL-33 attenuates osteoarthritis through autophagy-dependent senescence regulation [0.03%]
中性粒细胞膜伪装的siRNA纳米平台靶向IL-33通过自噬依赖性的衰老调节来缓解骨关节炎
Zeze Fu,Jiahao Chen,Dengshuo Sun et al.
Zeze Fu et al.
Osteoarthritis (OA) imposes a substantial health and economic burden globally. Currently, there is a lack of disease-modifying osteoarthritis drugs (DMOADs). This study aimed to elucidate the relationship between chondrocyte senescence and ...
Enhanced multienzyme catalytic activity of Mn MOF induced by bioligands for efficient tumor therapy [0.03%]
生物配体诱导的锰金属有机框架增强的多酶催化活性高效肿瘤治疗中的应用
Junfeng Ke,Yuxin Tian,Tongjia Zhang et al.
Junfeng Ke et al.
Nanozymes, as substitutes for natural enzymes, are widely used in various fields, such as cancer treatment. However, most nanozymes have low catalytic activity and selectivity, greatly limiting their clinical applications. Here, we propose ...
Rapid in situ microwave-assisted fabrication of ultrabright near-infrared probe for low-dose in vivo inflammatory imaging [0.03%]
一种超亮近红外探针的快速制备方法及在低剂量活体炎症成像中的应用研究
Deqiang Ruan,Chong Hu,Zeping Yang et al.
Deqiang Ruan et al.
Fluorescent probes operating within the near-infrared second window (NIR-II, 1000-1700 nm), characterized by high tissue transparency and minimal tissue-induced photon scattering/absorption, have been widely applied for early-stage disease ...
Quadruple synergistic amplification of ferroptosis for precision glioblastoma therapy: a luteolin-coordinated ferric ion nanoplatform [0.03%]
用于精准胶质母细胞瘤治疗的铁死亡四重协同放大疗法：一种小分子协调的铁离子纳米平台
Suyi Liu,Kunhui Sun,Mengnan Li et al.
Suyi Liu et al.
Ferroptosis is emerging as a promising therapeutic strategy for glioblastoma (GBM). However, insufficient lipid peroxidation levels and blood-brain barrier (BBB) pose a significant challenge for GBM treatment. Here, we present natural produ...
Separable cryo-microneedle patches delivery with capsaicin integrated mesoporous dopamine for obesity treatment [0.03%]
一种用于肥胖症治疗的可分离冷冻微针贴片，其含有融合了介孔多巴胺的辣椒素
Jingjing Gan,Lingyu Sun,Wenjuan Tang et al.
Jingjing Gan et al.
Microneedle patch encapsulated with active medication holds significant potential promise in the realm of anti-obesity therapy. Nevertheless, the improvement of actives delivery efficiency remains a significant challenge. In this paper, we ...
Mechanically tunable fiber-based hydrogel activates PIEZO1-integrin axis for enhanced bone repair [0.03%]
机械调节的纤维基水凝胶激活PIEZO1-整合素轴以增强骨修复
Jinghong Yang,Runli Li,Xiaoshuang Wang et al.
Jinghong Yang et al.
Irregular alveolar bone defects pose persistent clinical challenges due to their complex morphology and the lack of biomaterials that simultaneously provide structural integrity, biocompatibility, and dynamic osteoinductive potential. Herei...
Spleen-targeted NeoPol-mL242 mRNA vaccine induces robust T-cell responses in a hepatocellular carcinoma model [0.03%]
脾靶向NeoPol-mL242 mRNA疫苗在肝细胞癌模型中诱导强大的T细胞反应
Yufei Wu,Gongrui Sun,Wendan Ren et al.
Yufei Wu et al.
Personalized neoantigen peptide vaccines have shown remarkable anti-tumor activity across diverse cancer types. With the rapid advancement of messenger RNA (mRNA) delivery technologies during the coronavirus disease of 2019 (COVID-19) pande...
Intraoperative application of an antioxidant nanoparticle-hydrogel targeting microglia regulates neuroinflammation in traumatic brain injury [0.03%]
术中应用针对小胶质细胞的抗氧化纳米颗粒-水凝胶可调节创伤性脑损伤中的神经炎症
Yuhan Han,Jiacheng Gu,Miaomiao Xu et al.
Yuhan Han et al.
Microglia play a critical role in neuroinflammation, a key secondary injury mechanism following traumatic brain injury (TBI). The colony-stimulating factor 1 receptor (CSF-1R) inhibitor PLX5622 has shown promise in suppressing neuroinflamma...