Engineered neutrophil membrane nanosystem for targeted siRNA therapy in myocardial ischemia-reperfusion injury [0.03%]
工程化中性粒细胞膜纳米系统在心肌缺血再灌注损伤中的靶向siRNA治疗研究
Yaohui Jiang,Zhe Wang,Penglei Chen et al.
Yaohui Jiang et al.
Despite the widespread use of emergency coronary reperfusion therapy, effectively managing reperfusion-induced myocardial injury remains a major clinical challenge. Neutrophil infiltration and the release of damage-associated molecular patt...
Deep learning-driven morphological fingerprinting: rapid, accurate and low-cost pathogen identification via the analysis of dried patterns of droplets [0.03%]
基于深度学习的形态指纹法：通过干燥液滴图案分析快速、准确和低成本地识别病原体
Shujuan Guan,Ruyue Yang,Danning Deng et al.
Shujuan Guan et al.
Bloodstream infections (BSIs) are life-threatening conditions with rising mortality, urgently requiring rapid pathogen identification to guide timely antibiotic therapy. Current methods (phenotypic identification, MALDI-TOF MS, molecular te...
Targeted blockade of extracellular vesicles-mediated profibrotic vicious circle using EVs-based dual-drug delivery system to prevent liver fibrosis [0.03%]
靶向阻断外泌体介导的促纤维化恶性循环的EVs基双重药物输送系统预防肝纤维化
Jie Sun,Yi Shen,Xiaoze Wang et al.
Jie Sun et al.
Liver fibrosis, caused by various chronic liver injuries, is one of the major causes of morbidity and mortality worldwide, but there is no efficient treatments in clinic until now. Cell-cell interactions in the injured liver microenvironmen...
A smart amphiphilic nanoplatform amplifies ROS-mediated immunogenic cell death to suppress bladder cancer growth and metastasis [0.03%]
一种智能两亲性纳米平台通过放大ROS介导的免疫原性细胞死亡来抑制膀胱癌生长和转移
Chuntao Li,Fanhu Meng,Chunbo Lu et al.
Chuntao Li et al.
Bladder cancer (BC) remains a prevalent urothelial malignancy characterized by high recurrence and mortality rates, severely compromising patients' quality of life. Current intravesical chemotherapies, although locally administered, are lim...
Plain DNA and cationic aromatics: a platform to simplify carrier-free delivery systems [0.03%]
不含载体的基因传递体系的简化平台：DNA与阳性感光性芳香烃体系
Shiji Fang,Zhongwei Zhao,Huaping Li et al.
Shiji Fang et al.
DNA nanotechnology offers a powerful alternative in biomedical areas yet a simple and general strategy to engineer DNA-based nanomedicine bearing high and adjustable drug-loading capacity and stability remains challenging. Herein, we report...
Bidirectional regulation of liver sinusoidal clearance by amino acid nanofibers and IGFBP4 complex: effects on HbA1c [0.03%]
氨基酸纳米纤维和IGFBP4复合物对肝脏窦隙清除的双向调节作用：对HbA1c的影响
Aejin Lee,Silvia de Lamo Castelli,Patrick Sellers et al.
Aejin Lee et al.
Therapies for type 2 diabetes primarily target hyperglycemia; however, complications are also triggered by advanced glycation end products (AGEs). We hypothesize that the anti-diabetic efficacy of insulin-like growth factor-binding protein ...
Platinum-doped emodin carbon dots mitigate sepsis-induced lung injury by targeting the gut-lung axis [0.03%]
铂掺杂的大黄素碳点通过靶向肠-肺轴缓解脓毒症引起的肺损伤
Honghao Song,Yuqing Ma,Lei Peng et al.
Honghao Song et al.
Spatiotemporally controlled delivery of biomacromolecules via injectable hydrogels for precision modulation of the tumor immune microenvironment [0.03%]
基于注射型水凝胶的生物大分子时空可控递送精确调控肿瘤免疫微环境
Hongxu Zhou,Hao Zheng,Wenbo Yao et al.
Hongxu Zhou et al.
The pronounced heterogeneity and immunosuppressive characteristics of the tumor immune microenvironment (TIME) substantially impede the clinical efficacy of immune checkpoint blockade (ICB) therapies. Biomacromolecules-such as antibodies, c...
Ultrasound-responsive micro/nanobubbles based intelligent theranostic systems for precision tumor therapy [0.03%]
一种基于智能诊疗系统的超声波响应微/纳米泡技术进行精准肿瘤治疗
Deng Liu,Yi Ling,Wanqian Liu et al.
Deng Liu et al.
Ultrasound-targeted micro/nanobubble cavitation (UTMC/UTNC) has emerged as a highly promising ultrasound-based strategy for precision tumor therapy. This technique harnesses microbubbles and nanobubbles as cavitation nuclei that respond to ...
Yue Gao,Jiahao Xu,Yuanqiu Lai et al.
Yue Gao et al.
Cancer therapy faces significant challenges due to the resistance of traditional apoptosis-based treatments. Ferroptosis, an iron-dependent, lipid peroxidation-driven form of programmed cell death, has emerged as a novel therapeutic strateg...