A trimer ancestral spike-based mRNA vaccine confers cross-generational protection against SADS-CoV [0.03%]
一种三聚体祖先刺突基质mrna疫苗可使后代免受猪传染性腹泻病毒的侵害
Teng Zhang,Jiale Yao,Xinchun Guo et al.
Teng Zhang et al.
The emergence of coronavirus variants that evade vaccine protection poses a serious threat to both human health and animal husbandry, including the novel SADS-CoV, an emerging bat-derived coronavirus. Herein, we introduce a "phylogenetic an...
Itaconate-functionalized tetrahedral framework nucleic acids break the dry eye vicious cycle through dual antioxidant and anti-inflammatory actions [0.03%]
衣康酸修饰的四面体框架核酸通过双重抗氧化和抗炎作用打破干眼恶性循环
Kai Jiang,Zhenyi Lin,Mingrui Cheng et al.
Kai Jiang et al.
Dry eye disease (DED) is a prevalent ocular surface disorder characterized by chronic inflammation and oxidative stress, significantly impacting vision and quality of life. Although reactive oxygen species (ROS) serve as a key upstream regu...
Smart hybrid nanomaterials for chronic infections: microbiome-responsive and sustainable therapeutic platforms [0.03%]
用于慢性感染的智能纳米杂化材料：响应微生物组且可持续治疗平台
Hina Singh,Sri Renukadevi Balusamy,Johan Sukweenadhi et al.
Hina Singh et al.
Chronic wounds remain a persistent clinical challenge due to their complex pathology involving prolonged inflammation, microbial biofilms, and impaired tissue regeneration. Emerging research highlights the dynamic role of the human microbio...
Nanocorona-engineered gold nanostars orchestrate photothermal augmented immunotherapy and durable cancer vaccination [0.03%]
纳米 coronae 工程金纳米星调节光热增强免疫治疗和持久的癌症疫苗接种
Jun Young Park,Su Hyun Lim,Gayeon Kim et al.
Jun Young Park et al.
Protein coronas inevitably cloak nanoparticles in vivo, yet their therapeutic potential remains largely untapped. Here we engineer a single-protein nanocorona by adsorbing immunoglobulin G onto PEGylated gold nanostars and reveal a dual-mod...
Apigenin regulates CCR5/JAK1/STAT1/MMPs signaling to alleviate secondary brain injury after intracerebral hemorrhage and its enhanced delivery via targeted nanoparticles [0.03%]
染料木素通过靶向纳米粒经脑内给药调节CCR5/JAK1/STAT1/MMPs信号通路缓解出血性卒中后继发性脑损伤及其增强递送机制研究
Jia-Wei Wu,Yi-Ting Zhou,Bing-Xin Wang et al.
Jia-Wei Wu et al.
Intracerebral hemorrhage (ICH), a severe cerebrovascular disorder with high mortality, leads to secondary brain injury (SBI) primarily through neuroinflammation and blood-brain barrier (BBB) disruption. Among the pathological cascades, exce...
A TEMPO-loaded DNA hydrogel enabling integrated early diagnosis and treatment of osteoarthritis [0.03%]
一种用于软骨组织精准修复的智能DNA水凝胶材料研究
Hong Huang,Mingze Tang,Pengcheng Hu et al.
Hong Huang et al.
Osteoarthritis (OA) is a chronic inflammatory disease characterized primarily by cartilage degradation. Current imaging techniques often detect OA only after irreversible cartilage damage has occurred, and no drugs are available to halt dis...
Programmed nanozyme hydrogel enabling spatiotemporal modulation of wound healing achieves skin regeneration after biofilm infection [0.03%]
程序化纳米酶水凝胶实现时空调节伤口愈合以实现生物膜感染后的皮肤再生
Ze-Ming Zhuang,Yi Wang,Fa-Wei Xu et al.
Ze-Ming Zhuang et al.
Skin regeneration after wound healing is challenging, especially following infection. Wound repair is a staged yet continuous program, necessitating distinct therapeutic approaches at each stage. Regulation of infection-induced excessive re...
Transcranial and precise optical neuromodulation mediated by NIR photoactive nanosheets [0.03%]
由近红外光活性纳米片介导的颅内和精确光学神经调控技术
Deqi Yang,Ya Zhang,Yun Yuan et al.
Deqi Yang et al.
Remote modulation of specific neurons is critical for neural circuit dissection and neurological disease therapy. Traditional neuromodulation strategies applying electrodes and external stimuli may suffer from invasive injuries and insuffic...
Enhanced atherosclerosis molecular imaging and therapy with collagen hybridizing peptide functionalized albumin nanoparticles [0.03%]
一种用于动脉粥样硬化分子影像及治疗的胶原亲和性白蛋白纳米颗粒
Jianan He,Jianxun Cai,Jingjing Zhang et al.
Jianan He et al.
Intraluminal drug coated devices, such as paclitaxel (PTX)-coated balloons, are commonly used to treat arterial occlusive diseases caused by atherosclerosis. However, their efficacy is limited by drug loss, poor drug retention, insufficient...
Recent advances in theranostic nanomaterials for overcoming traumatic brain injury [0.03%]
用于治疗创伤性脑损伤的诊疗纳米材料最新进展
Nam Cheol Hwang,Dong Min Lim,Tae Sik Goh et al.
Nam Cheol Hwang et al.
Traumatic brain injury (TBI) is a major global health challenge characterized by complex secondary injury mechanisms involving oxidative stress, inflammation, and blood-brain barrier (BBB) disruption. Traditional biosensing and therapy stra...