LNP-enclosed NamiRNA inhibits pancreatic cancer proliferation and migration via dual pathways [0.03%]
Chao Yu,Zhou Fang,Qingyu Xie et al.
Chao Yu et al.
Background: Pancreatic cancer is a highly aggressive malignancy characterized by limited treatment options, poor prognosis, and high mortality rates. nuclear activating miRNA (NamiRNA) enhances gene expression by interact...
Targeting heptad repeats and fusion peptide: nanoparticle vaccine elicits mucosal immune response against SARS-CoV-2 variants [0.03%]
Chaofeng Liang,Rong Li,Zeyu Pu et al.
Chaofeng Liang et al.
The emergence of SARS-CoV-2 variants has underscored the urgent need for innovative vaccine strategies that provide robust and enduring protection against diverse strains. Our study introduces the FP-HR5 nanoparticle vaccine, designed to ta...
TEA5K: a high-resolution and liquid-phase multiple-SNP array for molecular breeding in tea plant [0.03%]
TEA5K：一种茶树分子育种高通量液相多重SNP芯片
Dingding Liu,Chenyu Zhang,Yuanyuan Ye et al.
Dingding Liu et al.
Background: High-throughput genotyping technology has become an indispensable tool for advancing molecular breeding and genetic research in plants, facilitating large-scale exploration of genomic variation. Genotyping tec...
Ultrasmall nanoparticles for co-delivery of antisense oligonucleotides targeting miR-21 and miR-210 to treat glioblastoma [0.03%]
用于同时输送靶向miR-21和miR-210的反义寡核苷酸治疗胶质母细胞瘤的超小型纳米颗粒
Ravi Raj Singh,Ritu Kulshreshtha,Amirali Popat
Ravi Raj Singh
Glioblastoma (GBM) is the most common and aggressive type of brain tumour, with less than 5% of patients surviving more than 5 years. Despite decades of research to understand the underlying pathophysiological causes, it has witnessed very ...
Brain targeted lipid nanoparticles with Hv1 inhibitors alleviate neuroinflammation post-ischemic stroke [0.03%]
脑靶向Hv1抑制型脂质纳米颗粒可改善缺血性卒中后的神经炎症
Zeyu Yang,Lei Jin,Longxiang Li et al.
Zeyu Yang et al.
Background: Ischemic stroke (IS) represents a significant global health burden. Current therapeutic options face problems such as window narrowing and reperfusion injury risk. Moreover, with increasing aging and risk fact...
A Self-Generated Electricity-Driven Sclera reinforcement bionic piezoelectric patch for Management of High Myopia [0.03%]
自发电 sclera 强化仿生压电补丁治疗病理性近视
Lingxi Jiang,Bo Zhao,Qi Li et al.
Lingxi Jiang et al.
Background: High myopia (HM) is a progressive ocular condition characterized by excessive axial elongation and severe refractive errors, often leading to sight-threatening complications. The underlying pathological driver...
Normal stress on surface of mesenchymal stem cells boosts extracellular vesicle secretion and regenerative bioactivity [0.03%]
正常牵张应力通过促进间充质干细胞释放外泌体而增强其促心肌细胞增殖活性
Chengmeng Bai,Huifang Ren,Feng Zhang et al.
Chengmeng Bai et al.
Scalable approaches for enhancing therapeutic small extracellular vesicles (sEVs) production can facilitate the transition of sEVs from bench to bedside and beyond. Here, we present a user-friendly method to manipulate the extracellular mec...
Targeted-theranostic nanoparticles induce anti-tumor immune response in lung cancer [0.03%]
靶向治疗诊断纳米颗粒诱导肺癌抗肿瘤免疫反应
Zeinaf Muradova,Léna Carmès,Needa Brown et al.
Zeinaf Muradova et al.
High atomic number metal-based nanoparticles (NPs) enhance radiotherapy efficacy by improving tumor multimodal imaging and intensifying radiation dosage. AGuIX-Bi represents a theranostic NP comprising gadolinium and bismuth chelates grafte...
A novel carrier-free nanoparticle with stable distinctive three-dimensional structure for tumor-targeted precision chemoimmunotherapy [0.03%]
一种具有稳定三维结构的无载药纳米粒子用于肿瘤精准化疗免疫治疗
Bo Deng,Youpeng Kong,Yingying Ma et al.
Bo Deng et al.
Despite significant advancements in oncology, cancer remains a leading global health burden, necessitating innovative therapeutic strategies. Here, we present a novel carrier-free tumor-targeted nanomedicine system (DPA NPs) for tumor-targe...
Natural small molecule smart hydrogels inhibited the Hsp90/NF-κB signaling axis in inflammation to achieve sustained antipyretic effect [0.03%]
天然小分子智能水凝胶通过抑制Hsp90/NF-κB信号轴治疗炎症持续退热
Yuqin Yang,Jingyi Jiao,Xiaohui Jia et al.
Yuqin Yang et al.
In general, pseudoephedrine (PE) is a safe and universally employed in cold medicine, which displays powerful effect on antipyretic. Nonetheless, the sustained drug delivery system can effectively put an end to the above problems attributab...