Don´t fly and freeze: impact of ex vivo time, cell density and cryopreservation on allogeneic stem cell grafts [0.03%]
不要飞行和冻结：体外时间、细胞密度和冻存对同种异体干细胞移植物的影响
Igor Novitzky-Basso,Emily Fu,Mileidys Alvarez et al.
Igor Novitzky-Basso et al.
The COVID-19 pandemic brought major logistical challenges to hematopoietic stem cell transplantation, leading to the routine cryopreservation of allogeneic grafts. This study assessed the impact of ex vivo time (time from end of apheresis t...
Long-term cryopreservation of hematopoietic stem and progenitor cells: functional viability beyond two decades [0.03%]
造血干细胞和祖细胞的长期低温保存：二十年以上的功能存活率
Rebecca Axelsson-Robertson,Thomas Poiret,Lyda M Osorio et al.
Rebecca Axelsson-Robertson et al.
Due to their ability to differentiate into the full diversity of blood cells, CD34+ hematopoietic stem and progenitor cells (HSPC) can be used to treat a variety of diseases. In autologous transplantation CD34+HSPC are harvested when patien...
Cryopreservation of implantable human skeletal muscle-derived cell-microcarrier combinations for use in clinical regenerative medicine [0.03%]
人骨骼肌来源细胞-微载体组合的冷冻保存用于临床再生医学中的植入治疗
Chara Simitzi,Juzheng Zhang,Rainer Marksteiner et al.
Chara Simitzi et al.
Background aims: Regenerative medicine therapies include tissue-engineered constructs to restore tissue and organ function. Among the different approaches, implantable polymeric microcarriers have been proposed for delive...
Automated vertical wheel bioreactor integrated with process analytics for T-cell manufacturing [0.03%]
一种用于T细胞制造的集成工艺分析的自动垂直车轮生物反应器
Bryan Wang,Bharat Kanwar,Annie C Bowles-Welch et al.
Bryan Wang et al.
Background aims: Biomanufacturing of cell therapies involves highly complex and labor-intensive processes, where process parameters and biological variabilities can significantly influence product quality, reproducibility...
Impact of pre- and post-thaw processing on recovery and fitness of cord blood mononuclear cells as starting material for cell therapy [0.03%]
处理方法对细胞治疗起始材料脐带血单个核细胞复苏前后的影响研究
Laurie Coutu-Godbout,Josée Perreault,Diane Fournier et al.
Laurie Coutu-Godbout et al.
Background: Cord blood units (CBUs) are a well-established source for hematopoietic stem cell transplantation, but key challenges such as post-thaw recovery and functional integrity remain to be addressed for their broade...
Quality indicators for cell collections for immune effector cell and gene therapy: recommendations from the American Society for Apheresis [0.03%]
免疫效应细胞和基因治疗的细胞制剂质量标准：美国血液分离协会的推荐意见
Nicole A Aqui,Patricia A Shi,Yara A Park et al.
Nicole A Aqui et al.
Immune effector cell (IEC) therapies provide increasingly important treatment options for patients with certain hematologic malignancies. Apheresis comprises a critical step, providing the starting material from which peripheral-blood deriv...
Cell and gene therapy approvals in Asia: regulatory landscape, access and affordability [0.03%]
亚洲的细胞和基因疗法审批：监管格局、可及性和经济性
William Ying Khee Hwang,Sudipto Bari,Shin Kawamata et al.
William Ying Khee Hwang et al.
Cell and gene therapies (CGTs) are revolutionizing the treatment paradigm for a range of life-threatening and rare conditions, offering curative potential where conventional therapies have fallen short. In Asia, the CGT landscape has mature...
Development and qualification of a sensitive method for residual feeder cell detection in NK cell therapy products [0.03%]
用于NK细胞治疗产品的残留饲养细胞检测的敏感方法的建立与验证
Elizabeth Castro-Rivera,Alexandra Aquino-Acevedo,Li Chen et al.
Elizabeth Castro-Rivera et al.
Cellular therapies must meet stringent regulatory standards for safety and quality. These requirements include the thorough evaluation of all manufacturing components, particularly residual cellular materials, and the potential impact of th...
Universities can do more to prepare the biomedical workforce for the cell-, tissue- and gene-manufacturing industry [0.03%]
高校可以为从事细胞、组织和基因制造产业的生物医学劳动力做好更多准备
Ashley How,Min Thu Ta,Duc Tuan Thanh Phan et al.
Ashley How et al.
Background and aims: Precision medicine is poised to revolutionize the treatment of complex diseases, with cell, tissue and gene therapy products (CTGTP) emerging as a major driver of innovation. As industry demand for sk...