Lin Chen,Guang-Wei Wu,Dong Liu et al.
Lin Chen et al.
Two new polyketide derivatives, trichodermatides E (1) and F (2), are unprecedented examples of a polyketide with 6/6/6/6 tetracyclic skeleton, together with five known analogs koninginin B (3), koninginin D (4), 7-O-methylkoninginin D (5),...
Total syntheses of surinone B, alatanones A-B, and trineurone A [0.03%]
海绵生物碱苏里酮B、阿拉他那酮A和B及曲 newline內酯三内酉宁A的全合成
Narayana Rao Gundoju,Ramesh Bokam,Nageswara Rao Yalavarthi et al.
Narayana Rao Gundoju et al.
The total syntheses of four polyketides, surinone B (1), alatanones A-B (2-3), and trineurone A (4) were accomplished through an efficient and unified strategy via one-pot C-acylation reaction coupling 1,3-cyclohexadiones with EDC-activated...
Min-Hong Jiang,Yue Hu,Lin Jiao et al.
Min-Hong Jiang et al.
Five fractions prepared from the crude extract of Leonurus japonicus were examined in order to determine their cytotoxic potential. Under the bioassay guidance, a new labdane-type diterpenoid (1), and nine known ones (2-10) along with a sec...
Total synthesis and cyclization strategy of samoamide A, a cytotoxic cyclic octapeptide rich in proline and phenlalanine isolated from marine cyanobacterium [0.03%]
来源于海洋 Cyanobacterium 的 Samoamide A 全合成及环化策略研究（富含脯氨酸和苯丙氨类环肽）
Qi Chang,Yu-Lei Li,Xia Zhao
Qi Chang
Samoamide A is a cyclic octapeptide rich in proline and phenylalanine residues isolated from an American Samoa marine cyanobacterium, which exhibits potent activity against H460 human non-small-cell lung cancer cells (IC50 of 1.1 μM). The ...
Chemical study of the strain Cordyceps spp. from cell fusion between Cordyceps militaris and Cordyceps cicadae [0.03%]
虫草菌株 Cordycepsmilitaris 和 Cordyp cepsicicadae 细胞融合体的化学研究
Ning-Ning Yang,Ning Jiang,Qing-Yun Ma et al.
Ning-Ning Yang et al.
Chemical investigation on the cultures of the fungus Cordyceps spp., a strain from cell fusion between Cordyceps militaris and Cordyceps cicadae, resulted in the isolation of 13 compounds including 2 new ones named 2-(5-(3-oxobutyl) furan-2...
Chuan Qin,Di-Ya Yu,Xu-Dong Zhou et al.
Chuan Qin et al.
To improve the physical and chemical properties of phenazine-1-carboxylic acid (PCA) and find higher antifungal compounds, a series of PCA amide analogues were designed and synthesized and their structures were confirmed by 1H NMR, HRMS, an...
Intestinal permeability of mitragynine in rats using in situ absorption model [0.03%]
利用原位吸收模型研究了 kratom 主要生物碱（氯化镁因碱）在大鼠体内的肠道通透性
J D Yuvenesan Jagabalan,Vikneswaran Murugaiyah,Hadzliana Zainal et al.
J D Yuvenesan Jagabalan et al.
The intestinal permeability of mitragynine was investigated in situ using a single pass intestinal perfusion (SPIP) absorption model, in small intestine of rat using mitragynine in the absence/presence of the permeability markers, P-gp and/...
3α,19-Dihydroxyl-ent-pimara-8(14),15-diene, a new diterpenoid from the rhizomes of Ricinus communis [0.03%]
从蓖麻根中提取的新的二萜烯化合物3α,19-二羟基-ent-皮马-8(14),15-二烯
Sheng-Nan Zhang,Jin Zeng,Ya-Nan Tan et al.
Sheng-Nan Zhang et al.
A new natural product, 3α,19-dihydroxyl-ent-pimara-8(14),15-diene (1), which possesses an α-orientation hydroxymethyl at C-4 and ∆8,14 groups, as well as eight known compounds, was isolated from the rhizomes of Ricinus communis. The stru...
Vibralactones U-W, three vibralactone derivatives from cultures of the basidiomycete Boreostereum vibrans [0.03%]
拟无融色孔菌培养物中三种vibralactone衍生生物活性化合物的研究
Kai-Ting Duan,Zheng-Hui Li,Wen-Xuan Wang et al.
Kai-Ting Duan et al.
Three new vibralactone derivatives, namely vibralactones U-W (1-3), together with vibralactone (4), have been isolated from cultures of the basidiomycete Boreostereum vibrans. Their structures were determined on the basis of spectroscopic m...
Synthesis and Antibacterial Activity of Novel 4″- O-desosaminyl clarithromycin derivatives with 11, 12-arylalkyl side chains [0.03%]
11，12-烯丙基侧链克拉霉素脱糖类似物的合成及抗菌活性研究
Zhe-Hui Zhao,Di Zhu,Xiao-Xi Zhang et al.
Zhe-Hui Zhao et al.
A series of novel 4″-O-desosaminyl clarithromycin derivatives with 11, 12-arylalkyl side chains was synthesized by coupling 6-deoxy-desosamine donors (18, 19) with 4″-OH of compounds 5a-c. The activities of the target compounds were teste...