Jie Ma,Hua Sun,Hui Liu et al.
Jie Ma et al.
Three new C-methylated phenylpropanoid glycosides (1, 2), a new 8-4'-oxyneolignan (3), together with two known analogs (4, 5), were isolated from the rhizomes of Imperata cylindrical Beauv. var. major (Nees) C. E. Hubb. Their structures wer...
Isoscoparins R and S, two new ent-clerodane diterpenoids from Isodon scoparius [0.03%]
Isocephalanthus A及其衍生物抑制JAK2-STAT3信号通路的研究
Xing-Ren Li,Qiang Fu,Min Zhou et al.
Xing-Ren Li et al.
Two new ent-clerodane diterpenoids, named isoscoparins R and S (1 and 2), were isolated from the aerial parts of Isodon scoparius. Their structures were characterized mainly by analyzing the NMR and HRESIMS data, and the relative configurat...
Design, synthesis of a novel 4-O-methylsaucerneol analogue LXY7824 as potent HIF-1 inhibitor and anti-cancer agent [0.03%]
新型4-O-甲基沙克奈醇类似物LXY7824作为高效HIF-1抑制剂和抗肿瘤药物的设计与合成
Xiao-Yu Liu,Xiao-Yu Li,Fei-Long Yang et al.
Xiao-Yu Liu et al.
Hypoxia-inducible factor-1 (HIF-1), an important transcription factor for tumor survival, is an attractive target for anti-cancer treatment. Herein, we present the design and synthesis of LXY7824, a simplified analogue of 4-O-methylsaucerne...
Synthesis of novel tetrandrine derivatives and their inhibition against NSCLC A549 cells [0.03%]
新型四脱因衍生物的合成及其对NSCLC A549细胞的抑制作用研究
Qian-Hao Yang,Cheng-Shi Jiang,Tao Jin et al.
Qian-Hao Yang et al.
A series of novel tetrandrine (Tet) derivatives were synthesized through Suzuki -Miyaura reaction and evaluated for their cytotoxicity against human non-small cell lung carcinoma (NSCLC) A549 cells. Interestingly, most of derivatives showed...
Biosynthesis of 7,8-dihydroxyflavone glycosides via OcUGT1-catalyzed glycosylation and transglycosylation [0.03%]
OcUGT1介导的糖基化和转糖基化催化合成7，8-二羟基黄酮糖苷
Shuai Yuan,Yan Yang,Jian-Qiang Kong
Shuai Yuan
Herein, a flavonoid glycosyltransferase (GT) OcUGT1 was determined to be able to attack C-8 position of 7,8-dihydroxyflavone (7,8-DHF) via both glycosylation and transglycosylation reactions. OcUGT1-catalyzed glycosylation of 7,8-DHF result...
Acylphloroglucinols as kinase inhibitors from Sargassum nigrifoloides [0.03%]
浒苔属褐藻中活性二聚菲醌酰氯化松醇的抗肿瘤活性及机制研究
Cheng-Shi Jiang,Yin-Yin Wang,Jin-Tong Song et al.
Cheng-Shi Jiang et al.
Three new acylphloroglucinols (1-3) and four known biosynthetically related analogs (4-7) were isolated from the ethanol extract of a brown alga Sargassum nigrifoloides. Structures for 1-7 were characterized via detailed spectroscopic analy...
You-Yuan Zhang,Pei Wang,Xi-Qiang Song et al.
You-Yuan Zhang et al.
A new phenolic derivative (1) and a new dihydrophenanthrene (2) were isolated from the aerial part of Dendrobium hainanense rofe, along with 12 known compounds. The structures of the new compounds were elucidated by spectroscopic analysis，an...
Three new polyketides from Ascotricha sp. ZJ-M-5 by the OSMAC strategy [0.03%]
通过OSMAC策略从Ascotricha sp. ZJ-M-5中分离的三个新聚酮类化合物
Ya-Jing Dong,Guo-Mei Hou,Bin Lin et al.
Ya-Jing Dong et al.
Three new compounds, ascotrichols A-B (1-2) and ascotrichrone A (3), along with two known isocoumarin derivatives (4-5), were isolated from the solid culture of a sea mud-derived fungus, Ascotricha sp. ZJ-M-5 on rice media. The structures w...
Four new C20-diterpenoid alkaloids from Aconitum rotundifolium [0.03%]
Aconitum rotundifolium中新C20-二萜类生物碱的研究
Ji-Fa Zhang,Yu Li,Feng Gao et al.
Ji-Fa Zhang et al.
Four new C20-diterpenoid alkaloids, rotundifosines D-G (1-4), along with eight known ones (5-12) were isolated from the whole plant of Aconitum rotundifolium Kar. & Kir. The structures of the compounds were elucidated on the basis of spectr...