Blumeatin inhibits LPS-induced inflammation of TLR4/NF-κB signaling pathway via targeting TLR4/MD-2 [0.03%]
Blumeatin通过靶向TLR4/MD-2抑制LPS诱导的TLR4/NF-κB信号通路炎症反应
Jun-Chao Peng,Wei-Jin Qi,Hong-Ying Wang et al.
Jun-Chao Peng et al.
TLR4/MD-2, a protein complex to recognize LPS, has become an ideal target for the treatment of inflammation-related diseases. Blumeatin (BL), which is isolated from Blumea balsamifera (L.) DC has rarely been reported in the inflammation fie...
Monoterpenoid indole alkaloids from the stems and leaves of Tabernaemontana bovina and their potential antiproliferative activities [0.03%]
半边莲科植物Tabernaemontana bovina的茎叶中的单萜吲哚生物碱及其潜在的抗增殖活性
Shu-Ri Li,Xiao-Ya Fu,Ye-Ping Liu et al.
Shu-Ri Li et al.
A phytochemical study on the stems and leaves of Tabernaemontana bovina led to the isolation and identification of a new monoterpenoid indole alkaloid, taberboviline (1), together with seven known monoterpenoid indole alkaloids (2-8). The c...
Bioactive steroids from marine-derived fungi: a review (2015-2023) [0.03%]
海洋来源真菌中的生物活性类固醇：综述（2015-2023）
Xue-Yang Ma,Huan-Nan Wang,Li-Xiang Sun et al.
Xue-Yang Ma et al.
Marine fungi, rich in unique secondary metabolites with diverse activities, are a valuable source for novel lead compounds. Steroids, a prominent class of bioactive compounds from marine fungi, have been extensively studied for their divers...
Optimization of ultrasonic-assisted extraction of flavonoids from Ficus carica leaves and its chemical composition, antioxidant and UVB-protective properties [0.03%]
无花果叶中超声辅助黄酮提取的优化及其化学成分、抗氧化和抗UVB性能
Wei Liu,Meriem Fizir,Jia-Wei Shi et al.
Wei Liu et al.
This study explored the protective effects of Ficus carica leaves (FCLs) against UVB radiation. Using response surface methodology (RSM), optimal extraction conditions for flavonoids were established, yielding 35.28 mg/g. HPLC-MS/MS analysi...
Design, synthesis, and inhibition of novel ferulic acid derivatives on free fatty acid induced cellular lipid accumulation [0.03%]
新型肉桂酸衍生物的设计、合成及其对游离脂肪酸诱导的细胞脂质堆积的抑制作用
Ying-Ying Liu,Yi-Fan Xu,Xin-Ru Li et al.
Ying-Ying Liu et al.
Abnormal accumulation of hepatocyte lipids is a hallmark feature of NAFLD. Ferulic acid (FA), an ingredient with antioxidant activity in Chinese herbs, can be used to treat NAFLD by activating AMPK phosphorylation. In this study, we synthes...
Eriodictyol inhibits the proliferation and inflammatory response in keratinocytes in psoriasis through inactivating DYRK1A-mediated endoplasmic reticulum stress [0.03%]
eriodytol通过失活DYRK1A介导的内质网应激抑制银屑病角质形成细胞的增殖和炎症反应
Rui Yuan,Qi-Chao Sun,Yue-Peng An et al.
Rui Yuan et al.
Our work is conducted to reveal the impacts of eriodictyol on psoriasis. CCK-8 and EdU assays measured HaCaT cell proliferation. ELISA detected the activities of inflammatory cytokines and chemokines. Western blot examined the expressions o...
Two new tetralones from the endophytic fungus Annulohypoxylon stygium A888 [0.03%]
内生真菌Annulohypoxylon stygium A888中新发现的两个四酮类化合物
Zhi-Shen Shao,Yu-Chan Chen,Wei-Peng Ma et al.
Zhi-Shen Shao et al.
Two new tetralones, annulohyporins A (1) and B (2), along with thirteen known compounds (3-15), were isolated from the ethyl acetate extract of solid fermentation of the endophytic fungus Annulohypoxylon stygium A888, which was isolated fro...
Genistein resists castration-resistant prostate cancer by inhibiting the androgen receptor pathway [0.03%]
染料木黄酮通过抑制雄性激素受体通路抵抗前列腺癌复发
Xiao-Ping Yu,Lu-Jie Zheng,Jia-Li Yan et al.
Xiao-Ping Yu et al.
Prostate cancer is a prevalent malignancy, often diagnosed at advanced stages and associated with poor prognosis. Genistein, a soybean isoflavone, has demonstrated antitumor effects against castration-resistant prostate cancer in vivo. Our ...
Exploring sulphated polysaccharides from marine bivalves: Unveiling potent anti-gastric cancer activity through cell cycle arrest and apoptosis [0.03%]
探索来自海洋双壳类的硫酸化多糖：通过细胞周期阻滞和凋亡揭示对胃癌的潜在抑制作用
Deepakrajasekar Padmanaban,Pavithra Rajkumar,Mahalakshmi Vijayakumar et al.
Deepakrajasekar Padmanaban et al.
This study investigates the extraction of partially purified sulphated polysaccharides from marine bivalves through enzymatic digestion followed by sequential deproteinization and evaluates their anti-gastric cancer activity. Chemical analy...
Shan-Bin Li,Tong-Shi-Yao Zhao,Zhen Ye et al.
Shan-Bin Li et al.
Esculetin is a coumarin compound with anticancer, antioxidant, and anti-inflammatory activities. In this study, we synthesized an esculetin derivative, 6,7-bis(Pentyloxy)-2H-Chromen-2-One (BPCO), through etherification. BPCO inhibited the p...