New alkaloids from the twigs and leaves of tabernaemontana divaricata and their neuroprotective effects [0.03%]
来自夹竹桃亚科_divaricata藤的树枝和叶子的新生物碱及其神经保护作用
Dong-Hao Lu,Fei-Yan Wu,Nan Zhou et al.
Dong-Hao Lu et al.
Two novel monoterpenoid quinoline alkaloids, tabernacatines A and B (1 and 2), and a new monoterpenoid indole alkaloid, tabernacatine C (3), along with three known alkaloids (4 - 6), were isolated from the twigs and leaves of Tabernaemontan...
Immunohistochemical and metabolomic analysis of Tibetan medicine triphala in response to pancreatic tissues of diabetic rats [0.03%]
藏药特布哈对糖尿病大鼠胰腺组织免疫组化及代谢组学影响分析
Xue-Yan Li,Xiao-Mei Long,Tao Liu et al.
Xue-Yan Li et al.
Tibetan Medicine Triphala (THL), consisting of Emblica officinalis, Terminalia bellerica, and Terminalia chebula, is a traditional Tibetan remedy for diabetes mellitus (DM). This study investigated THL's pancreatic metabolomic effects and i...
Panax ginseng nanoemulsion: a promising pre-clinical modality for ameliorating male infertility via manipulation of PI3K/AKT/mTOR signaling pathway [0.03%]
人参纳米乳剂：通过操纵PI3K/AKT/mTOR信号通路改善男性不育的潜在临床方法
Basma I El-Shimi,Rafat M Mohareb,Hanaa H Ahmed et al.
Basma I El-Shimi et al.
The study investigates Panax ginseng nanoemulsion role in counteracting male infertility in rats. Nanoemulsion was prepared by oil in water method, then it was characterized by transmission electron microscope (TEM), Zeta sizer, Fourier tra...
Xin-Yu Cai,Ji-Mei Liu,Jun-Gui Dai
Xin-Yu Cai
Two new metabolites, 29-demethyl-3-ene-cycloastragenol (2) and 1α,12α-dihydroxy-cycloastragenone (3), along with six known compounds (4-9) were obtained from the microbial transformation of cycloastragenol (1) by Penicillium spinulosum AS...
Lig nans and phenylpropanoids from the edible roots of Codonopsis pilosula [0.03%]
党参根中的倍半萜和苯丙素类成分研究
Xi-Lan Jiang,Lun Wang,Fu Li et al.
Xi-Lan Jiang et al.
Chemical investigation of the edible roots of Codonopsis pilosula yielded a new lignan (1), together with twenty-nine known compounds, including twenty-one lignans (2-22) and eight phenylpropanoids (23-30). The structure of the new lignan, ...
Design, synthesis, and biological evaluation of 7-O-methyesculin esters as potent inhibitors of renal fibrosis [0.03%]
7-氧甲基埃斯酮酯的设计、合成及作为肾纤维化有效抑制剂的生物评估研究
Yu-Zhi Lin,Hao-Wen Luo,Xin-Yi Chen et al.
Yu-Zhi Lin et al.
Renal fibrosis is a global health challenge with limited therapies. 7-O-methyesculin (7-ME), derived from Cortex Fraxini (Qinpi), shows notable anti-inflammatory and anti-fibrotic properties. To enhance its membrane permeability and biologi...
Ephedrae Herba and Armeniacae Semen Amarum combination alleviates LPS-induced acute lung injury by targeting the TLR4/NF-κB and NLRP3 pathways [0.03%]
麻黄与苦杏仁配伍通过靶向TLR4/NF-κB和NLRP3信号通路缓解脂多糖诱导的大鼠急性肺损伤
Yu-Wei Ma,Zhan-Tao Li,Meng-Hui Jia et al.
Yu-Wei Ma et al.
ALI is a severe clinical syndrome with limited treatment options beyond corticosteroids, which cause significant adverse effects. This study demonstrates that the herbal combination EAC significantly attenuates LPS-induced ALI through dual ...
Comprehensive metabolite profiling of 10-methoxycamptothecin in rats by ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry [0.03%]
超高效液相色谱-四极杆飞行时间质谱法全面分析rats中10-甲氧基喜树碱代谢产物profiling
Chen-Xue Song,Zi-Ming Wang,Mei-Jia Yan et al.
Chen-Xue Song et al.
10-Methoxycamptothecin (MCPT), a natural camptothecin derivative, shows notable anticancer activity. Using UPLC-QTOF-MS, this study characterized MCPT metabolite profiles in rats, detecting 14 metabolites in urine, 5 in bile, 7 in feces, an...
Effect-constituent index-based quality assessment of Anemarrhenae Rhizoma before and after processing [0.03%]
基于效标指数法的知母炮制品质量评价研究
De-Min Li,Rui Yuan,Xue Bai et al.
De-Min Li et al.
Anemarrhenae Rhizoma was investigated to establish an effect-constituent index (ECI) for quality control by analyzing its chemical and bioactivity changes after processing. Antiinflammatory effects were assessed via COX-2 inhibition. Chemic...
Pham Thi Cham,Le Thi Vien,Ninh Thi Ngoc et al.
Pham Thi Cham et al.
Phytochemical investigation of M. pteleifolia branches and leaves led to the isolation of seven benzopyran derivatives, including five new ones named melicopols A - E (2 - 6). The chemical structures were confirmed by extensive analysis of ...