Transcriptome analysis and molecular docking reveal the activation of FOXO4, TNFSF15 and CASP9 in HeLa cells treated with DCM fraction from Clinacanthus nutans (C. nutans) [0.03%]
转录组分析和分子对接揭示了从Clinacanthus nutants(DC M分数的处理对HeLa细胞中FOXO4，TNFSF15和CASP9激活的影响
Kristine Sandra Pey Adum,Nor Hasyimah Haron,Zaleha Md Toha et al.
Kristine Sandra Pey Adum et al.
Clinacanthus nutans (C. nutans) is a well-known herb in tropical Asia. Previous studies have reported the anticancer activity of C. nutans but the molecular mechanisms on cervical cancer are not fully understood. Therefore, our study aims t...
Lifei Qingchang Tang attenuates acute lung injury via the NF-κB and MAPK signaling pathways [0.03%]
清肺凉汤通过NF-κB和MAPK信号通路减轻急性肺损伤
Qi-Fen Huang,Jia-Min Zeng,Yuan-Long Hu et al.
Qi-Fen Huang et al.
Acute lung injury (ALI) has high morbidity and mortality. Lifei Qingchang Tang (LFQCT), a traditional Chinese medicine, has antioxidant and anti-inflammatory properties but its mechanism in ALI remains unclear. In vitro, LFQCT reduced intra...
Hui Liu,Yu-Xin Fan,Rui-Wen Xu et al.
Hui Liu et al.
A new pyrrolopyrazine alkaloid, named lycipyrazine A (1), alone with seven known alkaloids (2-8), were isolated from the fruit of Lycium chinense. The structure of new compound 1 was determined using extensive 1D and 2D spectroscopic analys...
Resveratrol: a potential alternative therapeutic agent for patients suffering from chronic obstructive pulmonary disease (COPD) [0.03%]
白藜芦醇：慢性阻塞性肺病（COPD）患者的潜在替代治疗药物
Ong Yan Ren,Yasmeen Siddiqui,Mohammed Tahir Ansari et al.
Ong Yan Ren et al.
This review explores the therapeutic potential of resveratrol, focusing on its molecular and cellular effects on Chronic Obstructive Pulmonary Disease (COPD), bioavailability enhancement strategies, and development challenges for applicatio...
Ming-Hui Sun,Jie Zhou,Guo-Ru Shi et al.
Ming-Hui Sun et al.
Two new cyclopentanoid monoterpenes, catalpovatins A-B (1-2), together with nine known compounds (3-11), were isolated from the fruits of Catalpa ovate G. Don. The structures of these compounds were elucidated based on their spectroscopic d...
Synthesis and evaluation of Calenduloside E against drug-resistant Candida albicans [0.03%]
Calenduloside E的合成及其对药物抵抗性白色念珠菌的抑制作用评价
Fei Zou,Shan Yin,Yan-Dan Wu et al.
Fei Zou et al.
Calenduloside E (CE), also known as a triterpenoid saponin, has demonstrated diverse biological activities. This paper investigates the chemical synthesis of CE, focusing on the key step of glucuronidation of oleanolic acid benzylate. Among...
Magnoflorine ameliorates cartilage degradation in osteoarthritis through inhibition of mitochondrial reactive oxygen species-mediated activation of the NLRP3 inflammasome [0.03%]
Magnoflorine通过抑制线粒体活性氧介导的NLRP3炎性小体激活，改善骨关节炎中的软骨降解
Yi Peng,Yue-Hui Huang,Xiao Luo et al.
Yi Peng et al.
This study investigated the role of magnoflorine (MAG) on cartilage protection in osteoarthritis. In vitro studies showed that MAG decreased the expression of inflammatory factors and inhibited extracellular matrix degradation in lipopolysa...
Utilizing network pharmacology and experimental validation to explore the mechanisms of the Qijiafuzheng formula promoting CD8+ T-cell infiltration in the microenvironment of lung adenocarcinoma through STAT1/CXCL10 [0.03%]
利用网络药理学和实验验证探索岐桀扶正方通过STAT1/CXCL10促进肺腺癌微环境中CD8+T细胞浸润的机制
Tao Yang,Jian Chen,Zhao-Nan He et al.
Tao Yang et al.
Qijiafuzheng formula (QJFZF), a Traditional Chinese Medicine used to treat lung cancer and mitigate chemotherapy side effects, was studied to clarify its impact on the tumor immune microenvironment (TIME). Using network pharmacology and exp...
Unveiling the neuroprotective mystery of Kaixinsan: identifying and validating the neuroprotective ingredients under the perspective of gut - brain axis regulation [0.03%]
揭开凯欣散神经保护之谜：从肠道-大脑轴调控的角度识别和验证神经保护成分
Jia-Le Ren,Xiao-Li Zhang,Li-Juan Zhao et al.
Jia-Le Ren et al.
Kaixinsan (KXS) shows potential in treating cognitive dysfunction and can regulate the gut-brain axis. However, its effective components remain unclear. In this study, the components of KXS extract distributed in serum, brain, heart, liver,...
Xiexin Tang restores gut barrier function by regulating the differentiation of CD4+ T cells via GPRs and HDACs in T2DM rats [0.03%]
谢辛唐通过调控T2DM大鼠的GPRs和HDACs来调节CD4+ T细胞分化以修复肠道屏障功能
Mei-Juan Liu,Yun Zhang,Ke Zhu et al.
Mei-Juan Liu et al.
This study aimed to explore the potential mechanism of Xiexin Tang in improving type 2 diabetes mellitus from the perspective of intestinal barrier function. The results indicated that Xiexin Tang could notably promote the expression of GPR...