Schisandrin A can promote the anti-tumor effect of 5-Fu by reversing the immunosuppressive state of the body in rat [0.03%]
五味子甲素通过逆转机体免疫抑制状态增强5-氟尿嘧啶的抗肿瘤效果研究
Xiao-Hui Wang,Peng-Fei Dong,Feng Wang et al.
Xiao-Hui Wang et al.
In this study, based on Walker 256 in vitro experiments, CCK-8 assay, clone formation assay, wound healing assay, and flow cytometry were used to detect cell apoptosis and cell cycle. It was found that schisandrin may have significant anti-...
Chromomycins from soil-derived Streptomyces sp. inhibit the growth of human non-small cell lung cancer cells by targeting c-FLIP [0.03%]
土壤链霉菌产生的色烯霉素通过靶向c-FLIP抑制人非小细胞肺癌细胞的生长
Gao-Jie Li,Chen Wang,Wen-Die Wang et al.
Gao-Jie Li et al.
Three chromomycin derivatives, chromomycins A3 (1, CA3), A5 (2, CA5), and monodeacetylchromomycin A3 (3, MDA-CA3), were identified from the soil-derived Streptomyces sp. CGMCC 26516. A reinvestigation of the structure of CA5 is reported, of...
Mechanisms and therapeutic potential of chinonin in nervous system diseases [0.03%]
秦碱素治疗神经系统疾病的机制及潜在价值研究
Zhang Hui,Wang Lai-Fa,Wang Xue-Qin et al.
Zhang Hui et al.
The flavonoid compound chinonin is one of the main active components of Rhizoma anemarrhena with multiple activities, including anti-inflammatory and antioxidant properties, protection of mitochondrial function and regulation of immunity. I...
Two new diterpenoid alkaloids from the roots of Aconitum nagarum and their cytotoxic activity [0.03%]
Aconitum nagarum根中两种新的二萜类生物碱及其体外细胞毒性作用研究
Jiang Hu,Ren Ji,Guang-Rong Yang et al.
Jiang Hu et al.
A chemical investigation on the roots of Aconitum nagarum afforded two undescribed C19-diterpenoid alkaloids nagarumines D and E (1 and 2). The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (1H-1H COS...
Two new cucurbitane-type triterpenoid saponins from the fruit of Citrullus colocynthis [0.03%]
Citrullus colocynthis果实中的2个瓜儿利定型三萜皂苷成分
Si-Qi Liu,Zi-Ming Feng,Xiang Yuan et al.
Si-Qi Liu et al.
Two new cucurbitane-type triterpenoid saponins, 2,20β,22β-trihydroxy-16α,23(R)-epoxycucurbita-1,5,24-triene-3,11-dione 2-O-β-D-glucopyranoside (1), 2,20β,22α-trihydroxy-16α,23(S)-epoxycucurbita-1,5,11,24-tetraene-3-one 2-O-β-D-gluco...
Discovery of sesquiterpene lactones with anti-inflammatory effect from Youngia japonica [0.03%]
从日本旋覆花中发现具有抗炎作用的倍半萜内酯类化合物
Xian-Sheng Ye,Kuan Lin,Chang-Long Leng et al.
Xian-Sheng Ye et al.
The preliminary study revealed that the ethyl acetate eluate of Youngia japonica (YJ-E) could inhibit the expression of key proteins of p-p65, p-IκBα, p-IKKα/β, and p-AKT in LPS stimulated BV2 cell. Further phytochemical study led to th...
Bao Zhang,Hai-Hua Yuan,Jia Sun et al.
Bao Zhang et al.
Five new glycosides, namely methyl 3-methoxybenzoate-4,5-di-O-β-D-glucopyranoside (1), (1aS,3aS,3R)-3-(4'-O-β-D-glucopyranosyl-3'-methoxyphenyl)-5,6-dioxa-bicyclo[3.3.0]octane-1-one (2), quinolin-4(1H)-one-3-O-β-D-glucopyranoside (3), 3-...
Exploring the mechanism of Si-Miao-Yong-An decoction on heart failure based on molecular docking and network pharmacology [0.03%]
基于分子对接和网络药理学的四妙勇安汤治疗心力衰竭机制探讨
Han Qiu,Sheng-Nan Zhao,Jin-Ling Han et al.
Han Qiu et al.
The SwissTargetPrediction was employed to predict the potential drug targets of the active component of Si-Miao-Yong-An decoction (SMYAD). The therapeutic targets for HF were searched in the Genecard database, and Cytoscape3.9.1 software wa...
Atramacronoid A induces the PANoptosis-like cell death of human breast cancer cells through the CASP-3/PARP-GSDMD-MLKL pathways [0.03%]
Atramacronoid A通过CASP-3/PARP-GSDMD-MLKL途径诱导人乳腺癌细胞类似PANoptosis的细胞死亡
Jing-Rong Li,Ling-Yu Li,Hai-Xin Zhang et al.
Jing-Rong Li et al.
Breast cancer is the most common malignant tumor and a major cause of mortality among women worldwide. Atramacronoid A (AM-A) is a unique natural sesquiterpene lactone isolated from the rhizome of Atractylodes macrocephala Koidz (known as B...
Fuzheng Huayu recipe inhibits bleomycin-induced pulmonary fibrosis in rats by inhibiting M2 polarization of macrophages via the oxidative phosphorylation pathway [0.03%]
扶正化瘀方通过抑制氧化磷酸化解系巨噬细胞M2极化抑制博来霉素诱导的大鼠肺纤维化
Xing-Hua Yuan,Su-Fang Zhang,Yu Hang et al.
Xing-Hua Yuan et al.
Fuzheng Huayu recipe (FZHYR) is a Chinese patent medicine for the treatment of fibrosis. The effects of FZHYR on pulmonary fibrosis and macrophage polarization were investigated in vitro. FZHYR inhibited pulmonary inflammation and fibrosis ...