Direct de/carboxylation of cannabidiolic acid (CBDA) and cannabidiol (CBD) from hemp plant material under supercritical CO2 [0.03%]
以超临界二氧化碳从工业大麻原料直接脱羧制备 cannabinoid 酸和 cannabinoid 素
Bao-Chang Gao,Yu-Feng Sun,Yuan Tian et al.
Bao-Chang Gao et al.
Many organic reactions rely on CO2 sources to generate important structural units and valuable chemicals. In this study, we compared the effects of cannabidiol (CBD) and cannabidiolic acid (CBDA) on the supercritical CO2 (scCO2)-induced de/...
Nicotine improves DSS-induced colitis by inhibiting NLRP3 and altering gut microbiota [0.03%]
尼古丁通过抑制NLRP3和改变肠道微生物群来改善葡聚糖硫酸钠引起的结肠炎
Yi-Xiang Zhang,Xiao-Qian Chi,Meng Li et al.
Yi-Xiang Zhang et al.
Ulcerative colitis (UC) is a chronic recurrent inflammatory disease affecting the rectum and colon. Numerous epidemiological studies have identified smoking as a protective factor for UC. Dysbiosis of intestinal microbiota and release of in...
Flavonoids as potential KRAS inhibitors: DFT, molecular docking, molecular dynamics simulation and ADMET analyses [0.03%]
基于DFT、分子对接、分子动力学模拟和ADMET分析的潜在KRAS抑制剂类黄酮化合物的研究
Prinsa,Supriyo Saha,Md Zahidul Haque Bulbul et al.
Prinsa et al.
KRAS mutations linked with cancer. Flavonoids were docked against KRAS G12C and G12D receptors. Abyssinone III, alpha naphthoflavone, beta naphthoflavone, abyssinone I, abyssinone II and beta naphthoflavone, genistin, daidzin showed good do...
Thiostrepton suppresses triple-negative breast cancer through downregulating c-FLIP/SMAD2/3 signaling pathway [0.03%]
硫环素通过下调c-FLIP/SMAD2/3信号通路抑制三阴性乳腺癌
Wen-Die Wang,Chao-Yang Zeng,Yue Shang et al.
Wen-Die Wang et al.
Triple-negative breast cancer (TNBC) is an aggressive subtype with poor prognosis of breast cancer. Thiostrepton exerts anti-tumor activities against several cancers including TNBC. Herein we discussed the new molecular mechanisms of thiost...
Effect and mechanism of gomisin D on the isoproterenol induced myocardial injury in H9C2 cells and mice [0.03%]
gomisin D对异丙肾上腺素诱导的H9C2细胞及小鼠心肌损伤的影响及机制研究
Zi-Han Chen,Yan-Xin Liu,Zhi-Wei Chen et al.
Zi-Han Chen et al.
We established myocardial injury models in vivo and in vitro to investigate the cardioprotective effect of gomisin D obtained from Schisandra chinensis. Gomisin D significantly inhibited isoproterenol-induced apoptosis and hypertrophy in H9...
Characterization of the metabolic contributions of cytochrome P450 isoforms to bicyclol using the relative activity factor method [0.03%]
应用相对活性因子法研究双环醇在体外代谢中的CYP表型特征
Li-Jun Luo,Xiao Liu,Yan Li et al.
Li-Jun Luo et al.
Bicyclol is a hepatoprotective agent widely used for treating chronic hepatitis and drug-induced liver injuries in clinics. The purpose of the study was to elucidate the contribution of CYP450 enzymes to the metabolism of bicyclol using the...
A new resorcylic acid lactone from the endophytic fungus Chaetosphaeronema sp [0.03%]
一种内生真菌Chaetosphaeronema sp. 的新环状酸内酯化合物
Min Wang,Gui-Yang Xia,Yong-Xin Liang et al.
Min Wang et al.
A new 14-membered resorcylic acid lactone (RAL14), chaetolactone A (1), along with three known ones (2-4), was obtained from the fermentation of the soil-derived fungus Chaetosphaeronema sp. SSJZ001. Their structures were established based ...
Discovery of palmatine derivatives as potent neuroprotective agents [0.03%]
一种新型掌叶防己碱衍生物神经保护剂的发现与机制研究
Shuo Pang,Na Chen,Zhuo Li et al.
Shuo Pang et al.
Alzheimer's disease is a neurodegenerative disorder characterized by the presence of neurodegenerative lesions and cognitive impairment. In this study, a series of novel palmatine derivatives were designed and synthesized through the introd...
Ganonorsterone A, a norsteroid from the medicinal fungus Ganoderma lingzhi [0.03%]
灵芝中新倍半孢子酸 Ganonorsterol A
Jia-Hui Du,Xuan Zhao,Fei Zhang et al.
Jia-Hui Du et al.
Phytochemical investigation on the fruiting bodies of the medicinal fungus Ganoderma lingzhi led to the isolation of a new norsteroid, namely ganonorsterone A (1), together with one known steroid, cyathisterol (2). The structure and absolut...
Four new tirucallane-type triterpenoids from Aphanamixis polystachya [0.03%]
毛叶四数木中新 tirucallane 型三萜化合物
Yan-Wu Chen,Shi-Li Wu,Fa-Wu Dong et al.
Yan-Wu Chen et al.
Four new tirucallane-type triterpenoids, polystanins H-K (1-4), were obtained from the stems and leaves of Aphanamixis polystachya. Their structures were elucidated by analysis of the spectroscopic data and comparison with literature data. ...