Leptols A and B, one meroterpenoid and one coumarin hybrid from the leaves of Melicope pteleifolia and its anti-inflammation in BV2 cells [0.03%]
来自化橘红叶中的一个倍半萜木脂素和香豆素木脂素杂合物及其抗炎活性
He-Lin Wei,Jing-Jing Sun,Jia-Qi Chen et al.
He-Lin Wei et al.
One meroterpenoid and one coumarin hybrid, namely leptols A (1) and B (2), respectively, and seven known chromone analogues have been isolated from the leaves of Melicope pteleifolia. The structures were elucidated on the basis of spectrosc...
Total synthesis of albafuran B and its osteogenic differentiation promoting effect on human mesenchymal stem cells [0.03%]
阿尔巴弗urans B的全合成及其对人骨髓间充质干细胞成骨分化的促进作用研究
Wan-Dong Liu,Yue Jing,Bin Wang et al.
Wan-Dong Liu et al.
In the current project, the total synthesis of albafuran B was achieved in four steps and 19.3% overall yield, involving two key reactions of the one-pot Corey-Fuchs reaction and Suzuki coupling. Using the same protocol, two analogs, moraci...
Expanding the role of alpha lipoic acid for psychiatric and neurological health [0.03%]
扩大α-硫辛酸在精神健康和神经健康中的作用
Ishu Garg,Harish Kumar,Raj Kumari et al.
Ishu Garg et al.
With the rise in health and neurological concerns around the globe, nutraceuticals are surpassing the harms of drug treatment. Alpha-lipoic acid, an organosulfur naturally abundant biomolecule that has potent protective and therapeutic effe...
Xue Ma,Zhi-Long He,Bao Zhang et al.
Xue Ma et al.
Two new abietane diterpenoids, massonianene A (1) and massonianene B (2), were isolated from the extract of Pinus massoniana. Their structures were elucidated based on HR-ESI-MS, IR, UV, NMR, ECD and X-ray diffraction analysis. Compound 2 e...
Sesquiterpenes with anti-inflammatory activity from the stems and branches of Melicope patulinervia [0.03%]
毛脉印防风茎枝中的抗炎倍半萜类化合物
Sai Li,En-Lian Du,Qi Gong et al.
Sai Li et al.
Five new sesquiterpenes comprising three zieranes, melicopatulones A-C (1-3) and two guaianes, melicopatulones D-E (5-6), were isolated from the stems and branches of Melicope patulinervia, together with melicodenones B (4), C (7) and D (8)...
Prenylated flavones with potential antiproliferative activities from the stems and leaves of Mycetia hainanensis [0.03%]
海南马籽藤茎叶中具有抗增殖活性的茋类成分研究
Shu-Ri Li,Lin-Xuan Li,Tian-Yu Wang et al.
Shu-Ri Li et al.
A phytochemical study on the stems and leaves of Mycetia hainanensis led to the isolation and identification of a new prenylated flavone, mycehainanone (1), as well as seven known analogs (2 - 8). The chemical structure of 1 was determined ...
Endophytic microorganisms in lichen: rising stars in the biomedicine field deserving broader recognition [0.03%]
地衣内生微生物：值得获得更广泛认可的生物医药领域新星
Jia-Na Zhu,Meng-Long Liu,Qiu-Hua He et al.
Jia-Na Zhu et al.
Lichens are renowned for their ability to thrive in extreme environments and for producing unique metabolites with considerable bioactive potential. However, their medicinal value remains largely underexplored, primarily due to slow growth ...
Chlorogenic acid targets SLC37A2 to inhibit macrophage activation via ER-dependent NF-κB and NLRP3 signaling pathways against sepsis-induced acute lung injury [0.03%]
氯ogenic酸通过内质网依赖的NF-κB和NLRP3信号通路靶向SLC37A2抑制巨噬细胞活化对抗脓毒症诱导急性肺损伤
Yang Chen,Xiao-Wen Zhang,Mei-Mei Zhao et al.
Yang Chen et al.
Sepsis-induced acute lung injury (SI-ALI) requires urgent treatment due to severe inflammation. Our study found chlorogenic acid (CGA) suppressed LPS-induced macrophage activation by lowering NO, TNF-α, and IL-6. TPP-based strategies ident...
Mi Li,Guo-Zhu Su,Hai-Qiang Wang et al.
Mi Li et al.
Three previously undescribed monoterpene derivatives, illisimoncins A-C (1-3) and one undescribed 2-formylpyrrole alkaloid (4) were isolated from the fruits of Illicium simonsii together with five known monoterpenes (5-9). Structural elucid...
Jia-Qi Chen,Ling-Zhi Zhang,Jie Ma et al.
Jia-Qi Chen et al.
Three new diterpenes, named pinusins D-F (1-3), were isolated from the Chinese medicine "Pini Lignum Nodi" (the dried tuberculate or branched nodes of Pinus massoniana), along with twelve known diterpenes. The structures of these new compou...